TAP FOR 6 MONTHS OF PREMIUM FREE 💰
X
Lost password?

Don't have an account?
Gain Access Now

X

Receive free daily analysis

NFL
NBA
NHL
NASCAR
CFB
MLB
MMA
PGA
ESPORTS
BETTING

Already have an account? Log In

X

Forgot Password


POPULAR FANTASY TOOLS

Expert Advice
Import Your Leagues
Weekly Rankings
Compare Any Players
Projections
Articles & Tools
Weekly Planner
24x7 News and Alerts

FanDuel, DraftKings CFB DFS Picks: Daily Fantasy College Football Advice for 9/21/19 (Early Slate)

Week 4 college football DFS lineups, sleepers and value picks for the early slate on FanDuel and DraftKings on September 21st. Target these NCAA players in CFB daily fantasy tournaments and cash games.

Welcome to Week 4 of the college football season! After three extremely fun weeks of football, this fourth week is looking like the best one yet. FanDuel and DraftKings have given us very different slates and while we'll be focusing on DraftKings, I'll do my best to throw in some FanDuel plays as well.

It's certainly a fun slate and we have plenty to dive into. I think QB may be as cut and dry as we've seen to this point, but there's plenty of other spots to get weird and different in tournaments. Let's dive in!

In this article, I will be providing you with my daily fantasy college football lineup picks for the early slate of games on FanDuel and DraftKings on 9/21/19. The lineup picks will range from some of the elite players to mid-priced options and value plays.

Featured Promo! Save 30% on any Premium Pass using discount code NEW. Win more with our DFS, Betting and Season-Long Pass, get expert tools and advice from proven winners! GAIN ACCESS

It's an extremely fun slate ahead of us, with more than enough offense to go around. I'll be breaking down the later slate in a different article, so make sure to keep an eye out for that as well. Let's dive into some of the top plays at each position. You can follow me on Twitter @VarneyDFS. I will be around all day to answer questions.

 

FanDuel, DraftKings DFS Quarterbacks

Joe Burrow - LSU - FD $10,200 DK $8,500

With a 62 point over/under and LSU favored by 24, we can expect at least 40 out of the Tigers here. Vanderbilt has been absolutely terrible against the pass, allowing Elijah Sindelar to throw for 504 yards in their last game. Joe Burrow will continue climbing the Heisman ladder and I could see him throwing for five touchdowns with ease. If Orgeron doesn’t let off the peddle or if Vandy can muster together a couple scores, Burrow could throw for even more. He has three deadly weapons on the outside and an extremely efficient offense. Burrow is the easy cash game morning QB. 

Kelly Bryant - Missouri - FD $9,300 DK $7,500

Missouri is a nine-point favorite at home against South Carolina, who was just pummeled by Alabama. It’s not fair to judge a team by their performance against Bama, but the line more so has to do with Jake Bentley remaining out and the Gamecocks defense struggling. Kelly Bryant hasn’t been needed much in the last two weeks, but he showed what he’s capable of in week one. The hype has cooled back down and we’ll be able to get him for under 10% like we did in the opening slate. I expect this game to be close and South Carolina is a lot better against the run than they are the pass. Bryant is a dual-threat option with a ton of GPP upside. 

Also Consider - Kellen Mond (TAMU), Dillon Gabriel (UCF)

 

FanDuel, DraftKings DFS Running Backs

Cam Akers - FSU - FD $9,800 DK $7,800

Akers has been a volume hog for FSU, and you can expect him to keep eating this week. Excluding a tough week one match-up against Virginia, Akers has 58 touches in two games for 376 yards and four touchdowns. It doesn’t get any tougher this week, as FSU hosts a cupcake Louisville defense that’s given up 100 yards to the only offense that tested them. Akers gets involved through the air as well, so the floor and ceiling are just so high. In cash games, Akers is the highest priced back I’m paying for. 

Lamical Perine - UF - FD $8,800 DK $6,500

We got Ty’Son Williams a couple weeks ago for 1% owned against the Tennessee defense and it brought me to the top of a few tournaments. I doubt Perine is less than 10% here, but he’s a great play nonetheless. Malik Davis hasn’t been involved all that much and Perine has been getting all of the red zone work. Tennessee ranked in the bottom 10 of the entire nation last season against the run and they haven’t gotten off to any better of a start. Florida is still figuring out the QB situation with listed co-starters, so expect them to establish the run game early and often. Perine is a lock for a score. 

Greg McRae - UCF - FD $7,900 DK $6,100 

UCF is a solid 12-point favorite, meaning the game script sets up perfectly for these running backs. I don’t have much of a preference between Killins Jr. and McRae, but McRae is cheaper and has been getting a few more carries. I do expect a fair share of points to be scored through the air in this one, but the running game is something UCF never forgets about. McRae is too cheap on both sites and an excellent play in both formats. 

Also Consider - Isaiah Spiller (TAMU), John Emery Jr. (LSU), Jonathan Taylor (WISC)

 

FanDuel, DraftKings DFS Wide Receivers

Justin Jefferson - LSU - FD $10,000 DK $7,600

This LSU WR trio is extremely talented and you really can’t go wrong. Justin Jefferson and Terrace Marshall Jr. are the two top guys and both should have great games. If I’m picking between the two, I still think Justin Jefferson is the number one option and will end up having the best season. We already touched on this Vanderbilt pass defense that looked anemic against Purdue just a week ago. Jefferson is expensive on both sites, but I’m willing to pay up as I think 150 yards and a touchdown isn’t unlikely. 

Darrell Stewart Jr. - Michigan State - FD $8,600 DK $6,300

I know the total isn’t great in this game, but I really don’t care at this point. Until I see Brian Lewerke throw the ball to anyone else, Darrell Stewart Jr. has 25 catches through three weeks, with Cody White second at 12. This Northwestern defense is a good one, but it mostly relies on the pace of their offense. Michigan State will shut them down and the Northwestern defense will get worn down. Stewart Jr. will get leaned on heavily and you can expect another 8-10 catches and 15 targets. 

Bryan Edwards - South Carolina - FD $7,400 DK $6,300

While I talked down a bit on South Carolina, Ryan Hilinski did fill in last week and threw for over 300 yards against Alabama. A lot of it had to do with playing from behind and throwing the ball every time, but you will still see plenty of guys fail to eclipse 200 yards - even in a blowout. Hilinski and South Carolina now draw a Missouri defense that’s far from scary and as a nine-point underdog, they should be throwing a lot. If we’re expecting another 250+ yards out of Hilinski, Bryan Edwards is too cheap. He’s going to see double digit target and he has as much talent as any of these corners. I’m hoping Edwards flies under the radar here. 

Also Consider - Jerry Jeudy (BAMA), Aaron Fuller (UW), Tamorrion Terry (FSU)

More DFS Analysis




POPULAR FANTASY TOOLS

Expert Advice
Articles & Tools
Import Your Leagues
Draft Rankings
Draft Simulator
Enter League Settings
Compare Any Players
Rookies & Call-Ups
24x7 News and Alerts

REAL-TIME FANTASY NEWS

Russell Henley

Looks to Defend Title at the Arnold Palmer Invitational
Max Scherzer

Could Make Grapefruit League Debut This Weekend
Alex DeBrincat

Collects Two More Points
Andrew Benintendi

Should be Back on Thursday
Kirill Marchenko

Earns Three Points on Monday
Nicolai Hojgaard

Continues to Search for First PGA Tour Victory at API
Xander Bogaerts

the Leading Candidate to Hit Leadoff for Padres
Shane Lowry

Trying to Shake Off Last Week's Heartbreak at the API
Fernando Tatis Jr.

Moving to Middle of the Batting Order?
Kyle Stowers

Doing Baseball Activities, to Start Running Progression Soon
Matt Fitzpatrick

Continues Scorching Start to 2026 Season
Keegan Bradley

Searching for Better Results Heading to Bay Hill
Cedric Mullins

Goes Deep for First Time in Rays Uniform
Jac Caglianone

Looking Good at the Plate So Far This Spring
Isaac Paredes

Homers in Spring Debut
Logan Webb

to Start WBC Opener for Team USA on Friday
Tarik Skubal

Scheduled to Throw Around 55 Pitches Against Great Britain
Kyle Freeland

to Make Spring Debut on Wednesday
P.J. Washington

Questionable vs. Hornets
Dairon Blanco

Designated for Assignment by Royals
Egor Demin

to Miss Second Straight Game
Nicolas Claxton

Expected to Play on Tuesday
Coby White

Ruled Out vs. Dallas
Jacob deGrom

to Make Spring Debut on Wednesday
Kyle Hurt

Being Viewed as Reliever
Collin Murray-Boyles

to Miss Second Straight Game
Naji Marshall

Unavailable Versus Charlotte
Donovan Mitchell

Out Tuesday vs. Detroit
Cooper Flagg

Listed as Doubtful for Tuesday Night
Beau Brieske

Exits With Rib-Cage Injury
Shai Gilgeous-Alexander

Ruled Out for Tuesday's Matchup With Bulls
Isaiah Hartenstein

to Miss Game Against Bulls
Anthony Gill

Out, Julian Reese Set to Start Monday
Kris Dunn

Available On Monday Against Warriors
John Collins

Sidelined vs. Warriors
Giannis Antetokounmpo

Set to Suit Up Monday
Neemias Queta

Gets Rest Day vs. Milwaukee
Jayson Tatum

Reportedly Set for Friday Comeback
Tristan Vukcevic

Ruled Out Versus Houston
Denver Nuggets

Tyus Jones Inks Deal with Nuggets
Trevor Moore

Unavailable Monday
Kyshawn George

Will Face the Rockets
Drew Doughty

Could Return Thursday
Cameron Johnson

Out Monday Against Jazz
Roope Hintz

Misses Third Consecutive Game
Zach Werenski

Iffy for Monday's Action
Trae Young

Ready to Make Wizards Debut on Thursday
Travis Konecny

a Game-Time Decision Monday
John Gibson

Exits Win Early
Connor Murphy

Moving to Edmonton
Zach Neto

Scorching-Hot Early in Spring Training
Grayson Rodriguez

Happy With his Secondary Pitches
Gavin Stone

has "Setback" With his Shoulder, "Paused" From Throwing
Khalil Mack

Will Play in 2026
MMA

Lone'er Kavanagh Gets Back In The Win Column
Alex Verdugo

Padres Add Alex Verdugo on Minor-League Deal
Joe Musgrove

to Start Exhibition Game on Wednesday
Brandon Moreno

Gets Outclassed
Masyn Winn

Sits Out on Monday Due to Arm Soreness
Marlon Vera

Loses Fourth Fight In A Row
Daniel Jones

Colts Have "50/50" Chance to Get a Deal Done With Daniel Jones
David Martinez

Remains Undefeated In The UFC
Daniel Zellhuber

Loses Third Consecutive Fight
King Green

Gets Second-Round TKO Win
Felipe Bunes

Drops Decision At UFC Mexico City
Édgar Cháirez

Edgar Chairez Wins Back-To-Back Fights
Ryan Blaney

Falls to Eighth Despite Running Most of the Race in the Top Five At COTA
Ty Gibbs

Wins A Stage and Finishes Fourth At COTA
Christopher Bell

Earns First Top-Five Finish of the 2026 Season at COTA
Kyler Murray

"Repeatedly" Linked to Jets
Shane Van Gisbergen

Falls Short of Victory At COTA
Tyler Reddick

Wins At COTA and Makes NASCAR History
David Montgomery

Texans Acquire David Montgomery From Lions
Lukas Dostal

Sets New Career High With 24th Win
Cutter Gauthier

Hits Two Goals in Shootout Win
Robert Thomas

Returns to Action With Multi-Point Effort
Matthew Tkachuk

Dishes Out Three Assists Sunday
Matthew Schaefer

Has First Three-Point Outing
Teuvo Teravainen

Pots Two Goals In Sunday's Win
Arvid Soderblom

Keeps Mammoth Quiet
Bryan Rust

With a Strong Two-Point Game
Arturs Silovs

Earns a Shutout on Sunday Afternoon
Jonathan Drouin

Unavailable Sunday
Darcy Kuemper

Won't Play Monday Due to Illness
EDM

Oilers Place Andrew Mangiapane on Waivers
Kyler Murray

Likely to be Released
Travis Etienne Jr.

Not Expected to be Franchise-Tagged
Aaron Jones Sr.

Vikings Planning to Release Aaron Jones Sr.?
Tyler Reddick

Could Make History at COTA
Shane Van Gisbergen

Shane van Gisbergen Still the Favorite at COTA
Christopher Bell

Will Be Tough to Beat at COTA
AJ Allmendinger

Could Contend at COTA
Connor Zilisch

Carries Plenty of Upside for DFS at COTA
Chase Elliott

May be A Strong Contender Again at COTA
Chris Buescher

Is Nothing But Consistent at Road Courses
Ross Chastain

May Be An Underrated Competitor for the Win at COTA
William Byron

Is William Byron a Viable DFS Option for COTA?
Carson Hocevar

Needs Clean Race at COTA
Kyle Larson

Could be A Decent DFS Option for COTA Lineups
Ryan Blaney

Could Ryan Blaney be A Sleeper DFS Option for All Formats for COTA?
Chase Briscoe

Should DFS Players Roster Chase Briscoe at COTA?
NASCAR

Bubba Wallace Is A Favorable Value Option for COTA DFS Lineups
Ty Gibbs

Could Ty Gibbs Be A Rosterable DFS Play for COTA?
Michael McDowell

Is Michael McDowell A Favorable DFS Option for COTA?
A.J. Brown

Patriots "Have Explored Trade Talks" Involving A.J. Brown
Lone'er Kavanagh

Set For UFC Mexico City Main Event
Brandon Moreno

Looks To Bounce Back
David Martinez

Set For UFC Mexico City Co-Main Event
Marlon Vera

In Dire Need Of Victory
King Green

Looks To Win Back-To-Back Fights
Daniel Zellhuber

Aims To Snap Two-Fight Skid
Felipe Bunes

Looks To Get Back In The Win Column
Édgar Cháirez

Edgar Chairez A Favorite At UFC Mexico City
George Pickens

Cowboys Not Interested in Trading George Pickens
Ashton Jeanty

Not in Line for Workhorse Role in 2026?
Anthony Richardson Sr.

Colts Give Anthony Richardson Sr. Permission to Seek a Trade
Kyler Murray

Prefers to be Released
Derek Carr

"Strong Belief" That Derek Carr is "Very Serious" About Unretiring
Andy Dalton

Is Andy Dalton Available for a Trade?
Keith Mitchell

Making The Comfortable Return to PGA National
CFB

Chandler Morris Suing NCAA for Seventh Year of Eligibility
Chris Kirk

Searching for a Spark at Cognizant Classic
Brooks Koepka

Making Third PGA Tour Start at Cognizant Classic
Mackenzie Hughes

a Steady Option at Cognizant Classic
Seamus Power

Seeking More Green in Florida
PGA

Haotong Li Back From a Break as Florida Stretch Starts
Stephan Jaeger

Trying to Put Four Rounds Together in Florida
PGA

Nico Echavarria Again Attempting to Make the Weekend
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF