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FanDuel, DraftKings CFB DFS Picks: Daily Fantasy College Football Advice for 9/21/19 (Early Slate)

Week 4 college football DFS lineups, sleepers and value picks for the early slate on FanDuel and DraftKings on September 21st. Target these NCAA players in CFB daily fantasy tournaments and cash games.

Welcome to Week 4 of the college football season! After three extremely fun weeks of football, this fourth week is looking like the best one yet. FanDuel and DraftKings have given us very different slates and while we'll be focusing on DraftKings, I'll do my best to throw in some FanDuel plays as well.

It's certainly a fun slate and we have plenty to dive into. I think QB may be as cut and dry as we've seen to this point, but there's plenty of other spots to get weird and different in tournaments. Let's dive in!

In this article, I will be providing you with my daily fantasy college football lineup picks for the early slate of games on FanDuel and DraftKings on 9/21/19. The lineup picks will range from some of the elite players to mid-priced options and value plays.

Editor's Note: The FFPC Baby Gorilla Tournament is now open, featuring a $100,000 grand prize and a $675,450 total prize pool! This 12-team, Tight End Premium contest uses a 20-round draft format, with the overall winners determined by total points scored during Weeks 15–17. Get $25 to use toward your first entry by signing up through our link. Grab your team now! Sign Up Now!

It's an extremely fun slate ahead of us, with more than enough offense to go around. I'll be breaking down the later slate in a different article, so make sure to keep an eye out for that as well. Let's dive into some of the top plays at each position. You can follow me on Twitter @VarneyDFS. I will be around all day to answer questions.

 

FanDuel, DraftKings DFS Quarterbacks

Joe Burrow - LSU - FD $10,200 DK $8,500

With a 62 point over/under and LSU favored by 24, we can expect at least 40 out of the Tigers here. Vanderbilt has been absolutely terrible against the pass, allowing Elijah Sindelar to throw for 504 yards in their last game. Joe Burrow will continue climbing the Heisman ladder and I could see him throwing for five touchdowns with ease. If Orgeron doesn’t let off the peddle or if Vandy can muster together a couple scores, Burrow could throw for even more. He has three deadly weapons on the outside and an extremely efficient offense. Burrow is the easy cash game morning QB. 

Kelly Bryant - Missouri - FD $9,300 DK $7,500

Missouri is a nine-point favorite at home against South Carolina, who was just pummeled by Alabama. It’s not fair to judge a team by their performance against Bama, but the line more so has to do with Jake Bentley remaining out and the Gamecocks defense struggling. Kelly Bryant hasn’t been needed much in the last two weeks, but he showed what he’s capable of in week one. The hype has cooled back down and we’ll be able to get him for under 10% like we did in the opening slate. I expect this game to be close and South Carolina is a lot better against the run than they are the pass. Bryant is a dual-threat option with a ton of GPP upside. 

Also Consider - Kellen Mond (TAMU), Dillon Gabriel (UCF)

 

FanDuel, DraftKings DFS Running Backs

Cam Akers - FSU - FD $9,800 DK $7,800

Akers has been a volume hog for FSU, and you can expect him to keep eating this week. Excluding a tough week one match-up against Virginia, Akers has 58 touches in two games for 376 yards and four touchdowns. It doesn’t get any tougher this week, as FSU hosts a cupcake Louisville defense that’s given up 100 yards to the only offense that tested them. Akers gets involved through the air as well, so the floor and ceiling are just so high. In cash games, Akers is the highest priced back I’m paying for. 

Lamical Perine - UF - FD $8,800 DK $6,500

We got Ty’Son Williams a couple weeks ago for 1% owned against the Tennessee defense and it brought me to the top of a few tournaments. I doubt Perine is less than 10% here, but he’s a great play nonetheless. Malik Davis hasn’t been involved all that much and Perine has been getting all of the red zone work. Tennessee ranked in the bottom 10 of the entire nation last season against the run and they haven’t gotten off to any better of a start. Florida is still figuring out the QB situation with listed co-starters, so expect them to establish the run game early and often. Perine is a lock for a score. 

Greg McRae - UCF - FD $7,900 DK $6,100 

UCF is a solid 12-point favorite, meaning the game script sets up perfectly for these running backs. I don’t have much of a preference between Killins Jr. and McRae, but McRae is cheaper and has been getting a few more carries. I do expect a fair share of points to be scored through the air in this one, but the running game is something UCF never forgets about. McRae is too cheap on both sites and an excellent play in both formats. 

Also Consider - Isaiah Spiller (TAMU), John Emery Jr. (LSU), Jonathan Taylor (WISC)

 

FanDuel, DraftKings DFS Wide Receivers

Justin Jefferson - LSU - FD $10,000 DK $7,600

This LSU WR trio is extremely talented and you really can’t go wrong. Justin Jefferson and Terrace Marshall Jr. are the two top guys and both should have great games. If I’m picking between the two, I still think Justin Jefferson is the number one option and will end up having the best season. We already touched on this Vanderbilt pass defense that looked anemic against Purdue just a week ago. Jefferson is expensive on both sites, but I’m willing to pay up as I think 150 yards and a touchdown isn’t unlikely. 

Darrell Stewart Jr. - Michigan State - FD $8,600 DK $6,300

I know the total isn’t great in this game, but I really don’t care at this point. Until I see Brian Lewerke throw the ball to anyone else, Darrell Stewart Jr. has 25 catches through three weeks, with Cody White second at 12. This Northwestern defense is a good one, but it mostly relies on the pace of their offense. Michigan State will shut them down and the Northwestern defense will get worn down. Stewart Jr. will get leaned on heavily and you can expect another 8-10 catches and 15 targets. 

Bryan Edwards - South Carolina - FD $7,400 DK $6,300

While I talked down a bit on South Carolina, Ryan Hilinski did fill in last week and threw for over 300 yards against Alabama. A lot of it had to do with playing from behind and throwing the ball every time, but you will still see plenty of guys fail to eclipse 200 yards - even in a blowout. Hilinski and South Carolina now draw a Missouri defense that’s far from scary and as a nine-point underdog, they should be throwing a lot. If we’re expecting another 250+ yards out of Hilinski, Bryan Edwards is too cheap. He’s going to see double digit target and he has as much talent as any of these corners. I’m hoping Edwards flies under the radar here. 

Also Consider - Jerry Jeudy (BAMA), Aaron Fuller (UW), Tamorrion Terry (FSU)

More DFS Analysis




REAL-TIME FANTASY NEWS

Oliver Kapanen

Sitting as Healthy Scratch Monday
Max Domi

Out Indefinitely Due to Offseason Surgery Complications
Tanner Koziol

a Long-Shot Dynasty Tight End?
Dylan Cease

Heading to Injured List With Hamstring Injury
Kevin Coleman Jr.

in the Right Place for Opportunities
Josh Cameron

has Long-Term YAC Upside in Liam Coen's Offense
Rashee Rice

Chiefs Have No Plans to Sign Rashee Rice to Long-Term Extension
Daniel Suarez

Wins at Charlotte in Rain-Shortened Coca-Cola 600
Christopher Bell

Finishes as the Runner-Up in the Coca-Cola 600 at Charlotte
Denny Hamlin

Falls Short of Winning and Places Third at Charlotte
Tyler Reddick

Places Fourth After Leading Laps at Charlotte
Kyle Larson

Strong and Consistent Day Ends in Fifth at Charlotte
Cole Payton

Dynasty Managers Will Have to be Patient with Cole Payton
Taylen Green

Does Taylen Green's Speed Get Him on the Dynasty Radar?
Jack Endries

Is Jack Endries the Tight End of the Future in Cincinnati?
CJ Daniels

a Developmental Stash in Dynasty Leagues
Garrett Nussmeier

a Low-Risk Target with Upside in Dynasty Leagues?
Jam Miller

Has Sneaky Value if He Can Earn a Roster Spot
Justice Hill

a Dynasty Drop Candidate Wherever He's Still Rostered
J'Mari Taylor

Is J'Mari Taylor Worth a Taxi-Squad Spot in Deep Dynasty Leagues?
Greg Dulcich

Has a Lack of Competition Made Greg Dulcich a Dynasty Sleeper?
Carson Beck

a Worthy Investment in the Later Rounds of Rookie Drafts
Devon Toews

Logs Two Assists In Game 3 Defeat
Brett Howden

Nets 10th Postseason Goal
Mitchell Marner

Delivers Two Assists in Comeback Victory
Mark Stone

Returns With Multi-Point Effort
Valeri Nichushkin

Exits Early Sunday
Nathan MacKinnon

Hurt in Game 3 Loss
Isaiah Hartenstein

Provides Steady Production in Defeat
Chet Holmgren

Has a Quiet Offensive Night on Sunday
Shai Gilgeous-Alexander

Held Under 20 Points in Game 4
Stephon Castle

Hands Out Six Assists in Game 4 Win
Devin Vassell

Tallies 13 Points in Game 4 Win
De'Aaron Fox

Records Double-Double as Spurs Even Series
Victor Wembanyama

Sets Tone Early as Spurs Force a Pivotal Game 5
Isaac Guerendo

Could be a Drop Candidate in Dynasty Leagues in 2026
Jayden Higgins

' Dynasty Arrow is Pointing Up With Clear Path to WR2 Role in Houston
Jakobi Meyers

a Sell-High Candidate in Dynasty Formats?
Drake Maye

to Make a Big Leap in 2026 in Second Season With Josh McDaniels?
Jamal Murray

Earns First Career All-NBA Selection
Kevin Durant

Becomes First Player to Make All-NBA Team With Five Franchises
Shai Gilgeous-Alexander

Victor Wembanyama Lead All-NBA First Team
Taylor Hall

Enjoying Life in Carolina
Mark Stone

Returns to Action Sunday
Cale Makar

Rejoins Avalanche Lineup Sunday
Cason Wallace

Joins Starting Unit Sunday
De'Aaron Fox

Doesn't "Feel Great" Entering Game 4
Jalen Williams

Won't Play Sunday
Christian Watson

Is Christian Watson on the Verge of a Legitimate Breakout?
Khalil Shakir

Dynasty Value in Decline
Travis Hunter

Still a Risky Buy, Even at his Sunken Dynasty Cost
Dylan Cease

Removed From Sunday's Start With Hamstring Discomfort
Vladimir Guerrero Jr.

Exits Sunday's Game Early with Elbow Contusion
MLB

Reds-Cardinals Game Postponed on Sunday
Edward Cabrera

Cubs Place Edward Cabrera on the 15-Day Injured List
Denny Hamlin

the Favorite to Win at Charlotte
Tyler Reddick

on Pole for Coca-Cola 600
Christopher Bell

Could Break Out of Slump
Kyle Larson

May have A Solid Day at Charlotte
Ryan Blaney

Is A DFS Risk for Charlotte Lineups
William Byron

Could have A Great DFS Performance at Charlotte
Chase Briscoe

Is A Solid Tournament Option for Charlotte DFS Lineups
Ty Gibbs

May not be Worth his Salary for Charlotte DFS Lineups
Chris Buescher

May be a Sneaky Tournament Option for Charlotte Lineups
NASCAR

Bubba Wallace Has Favorable Upside for Charlotte DFS Lineups
Ross Chastain

Is A Strong Addition for DFS Lineups at Charlotte
Austin Dillon

Should Fantasy Managers Roster Austin Dillon for Charlotte DFS Lineups?
Chase Elliott

Should Be Strong at Charlotte
Carson Hocevar

Confident for Coca-Cola 600
Corey Heim

a Chalk DFS Pick at Charlotte
Michael McDowell

Is Michael McDowell A Tournament Option for Charlotte Lineups?
Evan Mobley

Tallies Series-High 24 Points on Saturday
Donovan Mitchell

Struggles at the Line Saturday
Karl-Anthony Towns

Continues Playmaking Surge on Saturday
OG Anunoby

Delivers Clean Shooting Line Saturday
Mikal Bridges

Fills Box Score in Game 3 Win
Jalen Brunson

Pushes Knicks Closer to NBA Finals
Orlando Magic

Magic Interview Jeff Van Gundy for Head-Coaching Position
Phillip Danault

Extends Point Streak to Three Games
Josh Anderson

Nets Two Goals in Painful Loss
Jalen Chatfield

Delivers Two Assists in Crucial Win
Mark Jankowski

Contributes Two Assists in Game 2 Victory
Eric Robinson

Scores in Second Consecutive Game
Nikolaj Ehlers

Tallies Two Goals as Hurricanes Bounce Back Saturday
Giannis Antetokounmpo

Magic Reportedly Have Giannis Antetokounmpo on Their Radar
MLB

Orioles-Tigers Game Postponed on Saturday
MLB

Rays-Yankees Postponed on Saturday
Nazem Kadri

Contributes an Assist in Losing Effort
Ross Colton

Nets Lone Avalanche Goal Friday Night
Rasmus Andersson

Extends Assist Streak to Four Games
Pavel Dorofeyev

Focuses on Playmaking in Friday's Win
Mickey Moniak

Heads to Injured List With Ankle Sprain
Jackson Merrill

has Sore Ribs, Expected to Avoid Injured List
CFB

Jaron-Keawe Sagapolutele Looking to Take Sophomore Leap
CFB

Jadan Baugh Primed to Lead Florida Offense in 2026
CFB

LSU Hires Ed Orgeron As Special Assistant
CFB

North Carolina and South Carolina Cancel Home-And-Home Series
CFB

Confidence High in Mississippi State's Kamario Taylor
MLB

Reds-Cardinals Game Postponed on Friday
Trevor Story

has Hernia Surgery, Expected to Miss 6-10 Weeks
Roman Anthony

Dealing With Sprained Ligament in his Finger
Ronald Acuña Jr.

Ronald Acuna Jr. Exits Early, X-Rays Come Back Negative
Robby Snelling

Will Undergo Tommy John Surgery
Jackson Merrill

Tweaks his Back on Wednesday, Pulled Early
CFB

Lincoln Riley Believes USC is Ready for Playoff Run
CFB

Notre Dame-Stanford Rivalry Renewed Through 2028
CFB

Ahmad Hardy Says He's "Back to the Road to Success"
CFB

Texas Tech Graduate Judge Recuses Himself from Brendan Sorsby Case
CFB

UCLA Tackle Jordan Davis Officially Eligible for 2026 Season
CFB

Bret Bielema Supports Significant College Football Playoff Expansion
Michael Thorbjornsen

Brings High Upside to CJ Cup Byron Nelson
Luke List

Carrying Poor Form Into CJ Cup Byron Nelson
Tom Kim

Hoping to Build on Strong Myrtle Beach Finish
PGA

Sungjae Im Brings Upside to TPC Craig Ranch
Billy Horschel

Looking for Turnaround at CJ Cup Byron Nelson
Adam Hadwin

Difficult to Trust at TPC Craig Ranch
Tony Finau

Looking for Consistency at TPC Craig Ranch
Luke Clanton

Searching for Form at CJ Cup Byron Nelson
Aaron Rai

Withdraws From CJ Cup Byron Nelson
Wyndham Clark

Can Wyndham Clark Find Form at CJ Cup?
Si Woo Kim

Looks To Stay Hot at CJ Cup
Scottie Scheffler

to Defend CJ Cup Byron Nelson Title This Week
Jordan Spieth

Looking For Victory at TPC Craig Ranch
PGA

Matti Schmid Looks to Keep Recent Momentum Going at TPC Craig Ranch
Brooks Koepka

a High-Upside Play at CJ Cup Byron Nelson
Yandy Díaz

Yandy Diaz Exits Early on Tuesday After Being Hit By Pitch
Chris Kirk

Continues Search For Putting Form at TPC Craig Ranch
Rasmus Hojgaard

Looking to Shake Off Poor Major Showing at TPC Craig Ranch
Joel Dahmen

is of No DFS Consideration This Week in Dallas
Pierceson Coody

is Not The Fun DFS Play He Used to Be
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF