👉 TAP TO SAVE 30% WITH CODE NEW
X
Lost password?

Don't have an account?
Gain Access Now

X

Receive free daily analysis

NFL
NBA
NHL
NASCAR
CFB
MLB
MMA
PGA
ESPORTS
BETTING

Already have an account? Log In

X

Forgot Password


POPULAR FANTASY TOOLS

Expert Advice
Import Your Leagues
Weekly Rankings
Compare Any Players
Projections
Articles & Tools
Weekly Planner
24x7 News and Alerts

FanDuel, DraftKings CFB DFS Picks: Daily Fantasy College Football Advice for 9/21/19 (Early Slate)

Week 4 college football DFS lineups, sleepers and value picks for the early slate on FanDuel and DraftKings on September 21st. Target these NCAA players in CFB daily fantasy tournaments and cash games.

Welcome to Week 4 of the college football season! After three extremely fun weeks of football, this fourth week is looking like the best one yet. FanDuel and DraftKings have given us very different slates and while we'll be focusing on DraftKings, I'll do my best to throw in some FanDuel plays as well.

It's certainly a fun slate and we have plenty to dive into. I think QB may be as cut and dry as we've seen to this point, but there's plenty of other spots to get weird and different in tournaments. Let's dive in!

In this article, I will be providing you with my daily fantasy college football lineup picks for the early slate of games on FanDuel and DraftKings on 9/21/19. The lineup picks will range from some of the elite players to mid-priced options and value plays.

Featured Promo! Save 30% on any Premium Pass using discount code NEW. Win more with our DFS, Betting and Season-Long Pass, get expert tools and advice from proven winners! GAIN ACCESS

It's an extremely fun slate ahead of us, with more than enough offense to go around. I'll be breaking down the later slate in a different article, so make sure to keep an eye out for that as well. Let's dive into some of the top plays at each position. You can follow me on Twitter @VarneyDFS. I will be around all day to answer questions.

 

FanDuel, DraftKings DFS Quarterbacks

Joe Burrow - LSU - FD $10,200 DK $8,500

With a 62 point over/under and LSU favored by 24, we can expect at least 40 out of the Tigers here. Vanderbilt has been absolutely terrible against the pass, allowing Elijah Sindelar to throw for 504 yards in their last game. Joe Burrow will continue climbing the Heisman ladder and I could see him throwing for five touchdowns with ease. If Orgeron doesn’t let off the peddle or if Vandy can muster together a couple scores, Burrow could throw for even more. He has three deadly weapons on the outside and an extremely efficient offense. Burrow is the easy cash game morning QB. 

Kelly Bryant - Missouri - FD $9,300 DK $7,500

Missouri is a nine-point favorite at home against South Carolina, who was just pummeled by Alabama. It’s not fair to judge a team by their performance against Bama, but the line more so has to do with Jake Bentley remaining out and the Gamecocks defense struggling. Kelly Bryant hasn’t been needed much in the last two weeks, but he showed what he’s capable of in week one. The hype has cooled back down and we’ll be able to get him for under 10% like we did in the opening slate. I expect this game to be close and South Carolina is a lot better against the run than they are the pass. Bryant is a dual-threat option with a ton of GPP upside. 

Also Consider - Kellen Mond (TAMU), Dillon Gabriel (UCF)

 

FanDuel, DraftKings DFS Running Backs

Cam Akers - FSU - FD $9,800 DK $7,800

Akers has been a volume hog for FSU, and you can expect him to keep eating this week. Excluding a tough week one match-up against Virginia, Akers has 58 touches in two games for 376 yards and four touchdowns. It doesn’t get any tougher this week, as FSU hosts a cupcake Louisville defense that’s given up 100 yards to the only offense that tested them. Akers gets involved through the air as well, so the floor and ceiling are just so high. In cash games, Akers is the highest priced back I’m paying for. 

Lamical Perine - UF - FD $8,800 DK $6,500

We got Ty’Son Williams a couple weeks ago for 1% owned against the Tennessee defense and it brought me to the top of a few tournaments. I doubt Perine is less than 10% here, but he’s a great play nonetheless. Malik Davis hasn’t been involved all that much and Perine has been getting all of the red zone work. Tennessee ranked in the bottom 10 of the entire nation last season against the run and they haven’t gotten off to any better of a start. Florida is still figuring out the QB situation with listed co-starters, so expect them to establish the run game early and often. Perine is a lock for a score. 

Greg McRae - UCF - FD $7,900 DK $6,100 

UCF is a solid 12-point favorite, meaning the game script sets up perfectly for these running backs. I don’t have much of a preference between Killins Jr. and McRae, but McRae is cheaper and has been getting a few more carries. I do expect a fair share of points to be scored through the air in this one, but the running game is something UCF never forgets about. McRae is too cheap on both sites and an excellent play in both formats. 

Also Consider - Isaiah Spiller (TAMU), John Emery Jr. (LSU), Jonathan Taylor (WISC)

 

FanDuel, DraftKings DFS Wide Receivers

Justin Jefferson - LSU - FD $10,000 DK $7,600

This LSU WR trio is extremely talented and you really can’t go wrong. Justin Jefferson and Terrace Marshall Jr. are the two top guys and both should have great games. If I’m picking between the two, I still think Justin Jefferson is the number one option and will end up having the best season. We already touched on this Vanderbilt pass defense that looked anemic against Purdue just a week ago. Jefferson is expensive on both sites, but I’m willing to pay up as I think 150 yards and a touchdown isn’t unlikely. 

Darrell Stewart Jr. - Michigan State - FD $8,600 DK $6,300

I know the total isn’t great in this game, but I really don’t care at this point. Until I see Brian Lewerke throw the ball to anyone else, Darrell Stewart Jr. has 25 catches through three weeks, with Cody White second at 12. This Northwestern defense is a good one, but it mostly relies on the pace of their offense. Michigan State will shut them down and the Northwestern defense will get worn down. Stewart Jr. will get leaned on heavily and you can expect another 8-10 catches and 15 targets. 

Bryan Edwards - South Carolina - FD $7,400 DK $6,300

While I talked down a bit on South Carolina, Ryan Hilinski did fill in last week and threw for over 300 yards against Alabama. A lot of it had to do with playing from behind and throwing the ball every time, but you will still see plenty of guys fail to eclipse 200 yards - even in a blowout. Hilinski and South Carolina now draw a Missouri defense that’s far from scary and as a nine-point underdog, they should be throwing a lot. If we’re expecting another 250+ yards out of Hilinski, Bryan Edwards is too cheap. He’s going to see double digit target and he has as much talent as any of these corners. I’m hoping Edwards flies under the radar here. 

Also Consider - Jerry Jeudy (BAMA), Aaron Fuller (UW), Tamorrion Terry (FSU)

More DFS Analysis




POPULAR FANTASY TOOLS

Expert Advice
Articles & Tools
Import Your Leagues
Draft Rankings
Draft Simulator
Enter League Settings
Compare Any Players
Rookies & Call-Ups
24x7 News and Alerts

REAL-TIME FANTASY NEWS

Zach Collins

to Miss Rest of 2025-26 Season
De'Andre Hunter

to Undergo Season-Ending Eye Surgery
Tristan Vukcevic

Exits Early vs. Pacers
John Collins

Leaves Game with Head Injury
Kawhi Leonard

Exits Early Friday Night
Devin Booker

Sidelined vs. Orlando
Joel Embiid

Out Saturday vs. Pelicans
Kevin McGonigle

Starting at Shortstop in Grapefruit League Opener
Bo Bichette

Batting Third in Mets Spring Training Debut
J.J. Wetherholt

JJ Wetherholt Playing Second, Batting Fifth in Grapefruit League Opener
Kazuma Okamoto

Hitting Third in Grapefruit League Opener
Jorge Polanco

Expected to See a Lot of Time as Designated Hitter
Blake Coleman

Activated From Injured Reserve
Ramón Urías

Ramon Urias Agrees on One-Year Deal With Cardinals
Matt Rempe

Heading to Injured Reserve After Second Thumb Procedure
Roman Anthony

Expected to Hit Leadoff for Boston
Sidney Crosby

a Game-Time Call for Olympic Final
Edwin Uceta

has Shoulder Inflammation, Slight Impingement
Josh Morrissey

Won't Play Sunday
Filip Chytil

Out Indefinitely With Facial Fracture
Connor McDavid

Makes History With Another Multi-Point Outing
Tage Thompson

Expected to Play in Olympic Final
Shohei Ohtani

Might Not be Fully Built Up as a Pitcher by Opening Day
Travis Etienne Jr.

has "Legitimate Interest" in Joining Chiefs
Zach Charbonnet

Undergoes Knee Surgery on Friday
Austin Reaves

Back in Starting Five
Matisse Thybulle

Kris Murray, Matisse Thybulle Suit Up Friday
Scoot Henderson

No Longer Limited
Ben Joyce

Throws Successful Bullpen Session on Friday
Jamal Murray

Jalen Pickett Available Friday vs. Portland
Yoshinobu Yamamoto

to Start on Saturday
LeBron James

Upgraded to Available Friday vs. Clippers
Bryan Ramos

Orioles Claim Bryan Ramos Off Waivers From Cardinals
Max Scherzer

Blue Jays Have Intensified Talks With Max Scherzer
Marcelo Mayer

Likely Out for a Few More Days
Yimi García

Yimi Garcia Won't be Ready for Opening Day
Max Christie

is Downgraded to Out
Evan Mobley

is Unavailable for Friday's Game
Tyler Herro

to Make his Return on Friday
Norman Powell

is Cleared to Play on Friday
Nicolas Claxton

to Remain Out on Friday
Kyshawn George

Won't Play on Friday
Andrew Nembhard

is Ruled Out on Friday
T.J. McConnell

is Available on Friday
Lauri Markkanen

Won't Suit up on Friday
Gerrit Cole

Hits 96.9 MPH in First Live Session
Nolan Schanuel

Improves Bat Speed, Hoping for More Power
Tyler Mahle

Expected to Face Hitters Next Week
Félix Bautista

Orioles Place Felix Bautista on 60-Day Injured List
Sung-Mun Song

to Make Spring Training Debut Soon
Jason Adam

to be Ready for Opening Day?
CFB

Curt Cignetti Agrees to New Deal With Indiana, Will Earn $13.2 Million Per Year
Ukko-Pekka Luukkonen

Returns to Practice
Josh Morrissey

Remains Out Against Finland
Sidney Crosby

Won't Play Friday
Anthony Hernandez

Set For UFC Houston Main Event
Sean Strickland

Looks To Get Back In The Win Column
Uros Medic

Set For UFC Houston Co-Main Event
Geoff Neal

Looks To Get Back In The Win Column
Melquizael Costa

A Favorite At UFC Houston
Dan Ige

An Underdog At UFC Houston
Logan Cooley

Sheds Non-Contact Jersey
Maxwell Crozier

to Miss 10 Weeks After Surgery
Kirill Marchenko

Dealing With Lower-Body Injury
Petr Mrazek

Undergoes Season-Ending Surgery
Victor Hedman

Suffers Lower-Body Injury
Sidney Crosby

Considered Day-to-Day
Rashee Rice

Accused of Assault by Long-Time Girlfriend
Ben Griffin

Looking to Return to Top Form at Riviera
Keegan Bradley

Looking to Build Momentum at Riviera
J.J. Spaun

Putting a Major Concern at Riviera
Sepp Straka

May Have Tough Time at The Genesis Invitational
Shane Lowry

Trending Up Entering the Genesis Invitational
Justin Rose

Off Most Radars at The Genesis Invitational
Robert MacIntyre

a Long Hitter to Watch at Riviera Country Club
Jake Knapp

Red-Hot Heading to Riviera
Min Woo Lee

Attempts to Build Momentum After Pebble Beach
Harry Hall

an Unknown for The Genesis Invitational
Matt Fitzpatrick

Has Favorable Path to Success at Riviera This Week
Wyndham Clark

Not Likely to Contend at Genesis Invitational
Ludvig Aberg

Might Find the Genesis Invitational More Challenging
Harris English

Carries Strong Form to Riviera
Patrick Cantlay

Eyes Another Strong Week at The Genesis Invitational
Daniel Berger

Needs Short Game to Show Up at Riviera
Sam Burns

Hopes Return to Form Continues at Riviera
Collin Morikawa

Riding Wave of Victory Into Riviera
Hideki Matsuyama

Looks to Have Repeat Success at The Genesis Invitational
Scottie Scheffler

Looks to Find Paydirt at Riviera
Xander Schauffele

Rounding into Form Before Genesis Invitational
Morgan Rielly

Available After Olympic Break
Charlie Lindgren

Practices Fully Tuesday
John Carlson

Ready to Rock After Olympics
Radek Faksa

Unavailable Against Team Canada
Anton Lundell

Good to Go Wednesday
Mike Evans

Will Return in 2026
Kenneth Walker III

Seahawks Not Expected to Use Franchise Tag on Kenneth Walker III
Bucky Irving

Undergoes Offseason Shoulder Surgery
Tyreek Hill

Says he Will Play in 2026
Joey Logano

Finishes Third in the 2026 Daytona 500
Ricky Stenhouse Jr

. Finishes as the Runner-Up in the Daytona 500
Chase Elliott

Falls Short of His First Daytona 500 Victory Again
Brad Keselowski

Ends Daytona 500 With a Top-Five Finish
Tyler Reddick

Wins the Daytona 500 for the First Time with 23XI Racing
Tyreek Hill

Released by Dolphins
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF