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FanDuel, DraftKings CFB DFS Picks: Daily Fantasy College Football Advice for 9/21/19 (Early Slate)

Week 4 college football DFS lineups, sleepers and value picks for the early slate on FanDuel and DraftKings on September 21st. Target these NCAA players in CFB daily fantasy tournaments and cash games.

Welcome to Week 4 of the college football season! After three extremely fun weeks of football, this fourth week is looking like the best one yet. FanDuel and DraftKings have given us very different slates and while we'll be focusing on DraftKings, I'll do my best to throw in some FanDuel plays as well.

It's certainly a fun slate and we have plenty to dive into. I think QB may be as cut and dry as we've seen to this point, but there's plenty of other spots to get weird and different in tournaments. Let's dive in!

In this article, I will be providing you with my daily fantasy college football lineup picks for the early slate of games on FanDuel and DraftKings on 9/21/19. The lineup picks will range from some of the elite players to mid-priced options and value plays.

Editor's Note: The FFPC Baby Gorilla Tournament is now open, featuring a $100,000 grand prize and a $675,450 total prize pool! This 12-team, Tight End Premium contest uses a 20-round draft format, with the overall winners determined by total points scored during Weeks 15–17. Get $25 to use toward your first entry by signing up through our link. Grab your team now! Sign Up Now!

It's an extremely fun slate ahead of us, with more than enough offense to go around. I'll be breaking down the later slate in a different article, so make sure to keep an eye out for that as well. Let's dive into some of the top plays at each position. You can follow me on Twitter @VarneyDFS. I will be around all day to answer questions.

 

FanDuel, DraftKings DFS Quarterbacks

Joe Burrow - LSU - FD $10,200 DK $8,500

With a 62 point over/under and LSU favored by 24, we can expect at least 40 out of the Tigers here. Vanderbilt has been absolutely terrible against the pass, allowing Elijah Sindelar to throw for 504 yards in their last game. Joe Burrow will continue climbing the Heisman ladder and I could see him throwing for five touchdowns with ease. If Orgeron doesn’t let off the peddle or if Vandy can muster together a couple scores, Burrow could throw for even more. He has three deadly weapons on the outside and an extremely efficient offense. Burrow is the easy cash game morning QB. 

Kelly Bryant - Missouri - FD $9,300 DK $7,500

Missouri is a nine-point favorite at home against South Carolina, who was just pummeled by Alabama. It’s not fair to judge a team by their performance against Bama, but the line more so has to do with Jake Bentley remaining out and the Gamecocks defense struggling. Kelly Bryant hasn’t been needed much in the last two weeks, but he showed what he’s capable of in week one. The hype has cooled back down and we’ll be able to get him for under 10% like we did in the opening slate. I expect this game to be close and South Carolina is a lot better against the run than they are the pass. Bryant is a dual-threat option with a ton of GPP upside. 

Also Consider - Kellen Mond (TAMU), Dillon Gabriel (UCF)

 

FanDuel, DraftKings DFS Running Backs

Cam Akers - FSU - FD $9,800 DK $7,800

Akers has been a volume hog for FSU, and you can expect him to keep eating this week. Excluding a tough week one match-up against Virginia, Akers has 58 touches in two games for 376 yards and four touchdowns. It doesn’t get any tougher this week, as FSU hosts a cupcake Louisville defense that’s given up 100 yards to the only offense that tested them. Akers gets involved through the air as well, so the floor and ceiling are just so high. In cash games, Akers is the highest priced back I’m paying for. 

Lamical Perine - UF - FD $8,800 DK $6,500

We got Ty’Son Williams a couple weeks ago for 1% owned against the Tennessee defense and it brought me to the top of a few tournaments. I doubt Perine is less than 10% here, but he’s a great play nonetheless. Malik Davis hasn’t been involved all that much and Perine has been getting all of the red zone work. Tennessee ranked in the bottom 10 of the entire nation last season against the run and they haven’t gotten off to any better of a start. Florida is still figuring out the QB situation with listed co-starters, so expect them to establish the run game early and often. Perine is a lock for a score. 

Greg McRae - UCF - FD $7,900 DK $6,100 

UCF is a solid 12-point favorite, meaning the game script sets up perfectly for these running backs. I don’t have much of a preference between Killins Jr. and McRae, but McRae is cheaper and has been getting a few more carries. I do expect a fair share of points to be scored through the air in this one, but the running game is something UCF never forgets about. McRae is too cheap on both sites and an excellent play in both formats. 

Also Consider - Isaiah Spiller (TAMU), John Emery Jr. (LSU), Jonathan Taylor (WISC)

 

FanDuel, DraftKings DFS Wide Receivers

Justin Jefferson - LSU - FD $10,000 DK $7,600

This LSU WR trio is extremely talented and you really can’t go wrong. Justin Jefferson and Terrace Marshall Jr. are the two top guys and both should have great games. If I’m picking between the two, I still think Justin Jefferson is the number one option and will end up having the best season. We already touched on this Vanderbilt pass defense that looked anemic against Purdue just a week ago. Jefferson is expensive on both sites, but I’m willing to pay up as I think 150 yards and a touchdown isn’t unlikely. 

Darrell Stewart Jr. - Michigan State - FD $8,600 DK $6,300

I know the total isn’t great in this game, but I really don’t care at this point. Until I see Brian Lewerke throw the ball to anyone else, Darrell Stewart Jr. has 25 catches through three weeks, with Cody White second at 12. This Northwestern defense is a good one, but it mostly relies on the pace of their offense. Michigan State will shut them down and the Northwestern defense will get worn down. Stewart Jr. will get leaned on heavily and you can expect another 8-10 catches and 15 targets. 

Bryan Edwards - South Carolina - FD $7,400 DK $6,300

While I talked down a bit on South Carolina, Ryan Hilinski did fill in last week and threw for over 300 yards against Alabama. A lot of it had to do with playing from behind and throwing the ball every time, but you will still see plenty of guys fail to eclipse 200 yards - even in a blowout. Hilinski and South Carolina now draw a Missouri defense that’s far from scary and as a nine-point underdog, they should be throwing a lot. If we’re expecting another 250+ yards out of Hilinski, Bryan Edwards is too cheap. He’s going to see double digit target and he has as much talent as any of these corners. I’m hoping Edwards flies under the radar here. 

Also Consider - Jerry Jeudy (BAMA), Aaron Fuller (UW), Tamorrion Terry (FSU)

More DFS Analysis




REAL-TIME FANTASY NEWS

J.J. Spaun

Trending Up Ahead of PGA Championship
Adam Scott

Riding Strong Form Into PGA Championship
Patrick Reed

Looking to Make Another Run at PGA Championship
PGA

Sungjae Im Looks to Build on Strong Finish at Truist Championship
Sam Burns

Must Keep Ball in Play at PGA Championship
Jordan Spieth

Looks to Complete Career Grand Slam at Aronimink
Brandt Snedeker

Not the Best Option for the PGA Championship
Rasmus Hojgaard

a Volatile Option at PGA Championship
Germie Bernard

Already in a Tough Spot to Hold Dynasty Value
Ayo Dosunmu

Has Busy Night in Game 5
Maverick McNealy

Seeking Better Start in Philadelphia
Harry Hall

a Boom-or-Bust Option at Aronimink
Jaden McDaniels

Notches 17 Points in Game 5 Loss
Denzel Boston

a Smart Bet to Meet or Exceed Value in Dynasty Rookie Drafts
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Attempts to Improve Over 2025 PGA Championship
Scottie Scheffler

Looks to Defend PGA Championship at Aronimink
Julius Randle

Posts a Double-Double in Losing Effort
Matthew Stafford

a Sell Candidate with Touchdown Regression Likely on its Way
Nicolai Hojgaard

Wants to Keep Momentum Rolling in Philadelphia
Anthony Edwards

Held to 20 Points in Game 5 Loss
Ben Griffin

Attempting to Bounce Back After Truist Championship
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Transfer Defensive Lineman Devarrick Woods Commits to Clemson
Keldon Johnson

Comes Alive in Game 5 Against Timberwolves
Jayden Reed

Dynasty Value Tethered to His Underwhelming Usage
Harris English

Will Need His Putter to Thrive at Aronimink
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Makes All-Around Impact in Game 5
Kenyon Sadiq

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Akshay Bhatia

Creative Flair Could Show Itself in Philadelphia
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Mason McTavish

Delivers Two Assists Tuesday Night
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Pots Two Goals in Vital Game 5 Win
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Records Two Assists in Game 4 Victory
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Joins Team Canada for World Championship
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Suffers Upper-Body Injury in Game 5 Loss
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Struggles at Truist Championship
Gary Woodland

Can Continue Incredible 2026 Season at PGA Championship
Xander Schauffele

In Excellent Form Heading to PGA Championship
Jon Rahm

Having Excellent Season On LIV Tour
Cade Klubnik

Becoming Fan Favorite, in Play to Win Backup QB Job?
Michael Penix Jr.

Throwing During Offseason Program
Bryce Young

Panthers Will Continue to Discuss Extension With Bryce Young
Brandon Nimmo

Leaves Game on Tuesday with Apparent Ankle Injury
Michael Mayer

More Opportunities Coming for Michael Mayer?
Philadelphia 76ers

76ers Part Ways With Daryl Morey
Kevin Huerter

Iffy for Game 5 Against Cavaliers
Dylan Harper

Cleared for Action Tuesday
De'Aaron Fox

Available for Game 5 Against Timberwolves
Caris LeVert

Remains on Injury Report With Heel Issue
Duncan Robinson

Listed as Questionable for Game 5
Memphis Grizzlies

Brandon Clarke Dies at Age 29
Charlie McAvoy

Slapped With Six-Game Suspension
Jonas Brodin

Unavailable for Game 5 Against Avalanche
Joel Eriksson Ek

to Remain Out Wednesday
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Day-to-Day With Upper-Body Injury
Jacob Wilson

A's Place Jacob Wilson on Injured List With Shoulder Subluxation
Artturi Lehkonen

Considered Day-to-Day
Charlie Coyle

Lands Six-Year Extension
Ukko-Pekka Luukkonen

to Start Game 4 Against Canadiens
Drew Helleson

Unavailable for Game 5
Radko Gudas

Still Out Tuesday
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Won't Play Tuesday
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Is Carnell Tate Poised for Immediate Stardom in Tennessee?
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Dynasty Stock Fading Following NFL Draft
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Zac Robinson Thinks Bucky Irving, Kenneth Gainwell Have Similar Skill Sets
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Droppable in Some Dynasty Leagues?
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Looking to Make a Year 2 Leap
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to Require Some Patience in Dynasty Leagues?
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Luka Doncic Admits He Wasn't Close to Returning Before Season Ended
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Isaac Brown Has All-American Upside in 2026
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Uncertain About Future After Season-Ending Loss
Ajay Mitchell

Continues to Excel for Thunder
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Nyck Harbor Heading into Breakout Year?
Shai Gilgeous-Alexander

Posts 35 Points in Series Clincher
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Notre Dame, USC in Discussions to Resume Rivalry Series
Cade Cunningham

Struggles in Game 4 Loss
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Jaron-Keawe Sagapolutele Has Eyes on ACC Title
James Harden

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Ahmad Hardy's Gunshot Wound Not Viewed as Career-Threatening
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Ties NBA Playoff Record With 39 Second-Half Points
A.J. Ewing

Mets to Call Up Top Prospect A.J. Ewing
Mookie Betts

is Officially Back on Monday
Nathan Eovaldi

Scratched From Monday's Start With Side Tightness
Mark Jankowski

Signs Two-Year Extension With Hurricanes
Joel Kiviranta

Cleared to Play Monday
Josh Manson

Available for Game 4 Monday
Mackenzie Blackwood

Expected to Start Monday
Jonas Brodin

Won't Play Monday
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Athletics to Promote Top Outfield Prospect Henry Bolte to Major Leagues
Khamzat Chimaev

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Sean Strickland

Recaptures Middleweight Title
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Suffers Fifth-Round TKO Loss
Joshua Van

Defends Flyweight Title
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Waldo Cortes-Acosta Drops Decision
Alexander Volkov

Wins Back-To-Back Fights
Shane Van Gisbergen

Dominates Watkins Glen for First Win of 2026
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Finishes Second for Best Run of the Year At Watkins Glen
Ty Gibbs

Scores New Career-Best Finish of Third at Watkins Glen
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Continues His Strong Season With Fifth-Place Run at Watkins Glen
Austin Dillon

Earns his First Top-10 Finish of 2026 at Watkins Glen
Mookie Betts

Dodgers Expect Mookie Betts to Return on Monday
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Ahmad Hardy Sustains Gunshot Wound, in Stable Condition
Connor Zilisch

Will Start Fifth in his First Watkins Glen Cup Series Race
Tyler Reddick

Is A Top DFS Option for Watkins Glen Lineups
Christopher Bell

Is Likely to Bounce Back This Week at Watkins Glen
Carlos Rodón

Carlos Rodon Activated for Season Debut on Sunday
William Byron

Is William Byron Playable in DFS Lineups at Watkins Glen?
Kyle Larson

May have A Positive Day at Watkins Glen
Chase Briscoe

May Compete for A Top-10 Finish at Watkins Glen
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A.J. Allmendinger May have Another Solid Outing at Watkins Glen
Ty Gibbs

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Ross Chastain

Is Ross Chastain Worth Rostering for Watkins Glen Lineups?
Austin Cindric

Could Austin Cindric be A Sneaky Tournament Play for Watkins Glen?
Shane Van Gisbergen

Shane van Gisbergen the Heavy Favorite at Watkins Glen
Chase Elliott

Is Chase Elliott a No-Brainer DFS Pick at Watkins Glen?
Chris Buescher

Qualifies 14th at Watkins Glen
Ryan Blaney

Has Upside at Watkins Glen After Signing Contract Extension
Michael McDowell

Still Searching for First Top-Five Finish at Watkins Glen
Carson Hocevar

Is Carson Hocevar Too Aggressive for Road-Course Racing?
Luis Castillo

Mariners Intend to Piggyback Luis Castillo, Bryce Miller
Logan Webb

Placed on 15-Day Injured List With Knee Bursitis
Bryce Miller

is Set to Return on Wednesday
Jeff Hoffman

Could Return to Closer Role
Taj Bradley

Hits the Injured List With Pectoral Inflammation
Kyle Bradish

has Nice Bounce-Back Performance With 10 K's
Casey Mize

Throws Bullpen on Friday, Return Not Imminent
Ronald Acuña Jr.

Ronald Acuna Jr. Optimistic About Returning Next Wednesday
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Dodgers Put Tyler Glasnow on Injured List With Back Spasms
Blake Snell

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Khamzat Chimaev

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Set For His First Title Defense
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Looks To Win Back-To-Back Fights
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Waldo Cortes-Acosta Looks To Extend His Win Streak
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Officially Activated, Making Season Debut on Friday
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Walker Lyons Could be Go-To Target for Bear Bachmeier
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Ty Benefield a Potential Game-Changer for LSU Defense
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Hayden Lowe Set for Significant Role Following Miami's NFL Departures
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Rasheem Biles an Instant Impact Player for Texas
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Sam Leavitt Expected to Be Full-Go for Fall Camp
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF