November 21, 2025
Indianapolis Colts running back
Jonathan Taylor should be well-rested coming out of his Week 11 bye. Taylor has been one of the top players in fantasy this season, racking up 17 all-purpose touchdowns in just 10 games. The star running back will look to stay hot in a Week 12 road matchup against the Kansas City Chiefs. The Chiefs have been tough on running backs this season, allowing just the 26th-most fantasy points per game to the position. That being said, Taylor has been too dominant this season and will continue to see the bulk of the Colts' running-back touches. He settles in as a top-three fantasy running back heading into Week 12 in a game with a 50-point over/under.
--Matt TerelleSource: NFL.com
November 21, 2025
Cincinnati Bengals quarterback
Joe Flacco (shoulder) was a full participant in Friday's practice session and has been cleared from the injury report ahead of Sunday's matchup against the New England Patriots, according to the team's official website. It's unclear
whether Flacco will be the starter or return to a backup role, given that Joe Burrow (toe) practiced in full on Wednesday and Thursday this week. However, he was limited on Friday and is officially listed as questionable for Sunday. The 40-year-old Flacco has filled in admirably for the star quarterback, totaling 2,268 passing yards, 14 touchdowns, and nine interceptions in five games as a starter, ranking as QB4 in fantasy points per game (22.1) since Week 6. Flacco could wind up making one more start in Week 12 if Burrow is unable to play and the Bengals hold him out until he is fully cleared.
--Kyle McCarthySource: Cincinnati Bengals
November 21, 2025
Green Bay Packers running back
Josh Jacobs (knee) is officially listed as questionable to play in his team's Week 12 matchup against the Minnesota Vikings. Jacobs suffered a knee contusion that forced him to exit early from his team's Week 11 win over the New York Giants and has been limited in practice this week as a result. The 27-year-old has recorded 885 scrimmage yards and 11 touchdowns on 197 touches across 10 games this season and profiles as a must-start fantasy running back against Minnesota if he's cleared to play. If Jacobs were out, Packers running back
Emanuel Wilson would likely get the majority of Green Bay's backfield touches in Week 12. Third-year back
Chris Brooks could factor into the mix as well. Wilson has recorded 289 scrimmage yards and a touchdown on 64 touches so far this season and would profile as a low-end fantasy RB2 if Jacobs is inactive against Minnesota.
--Will BradySource: Green Bay Packers
November 21, 2025
The Kansas City Chiefs defense will take on the Indianapolis Colts in Week 12. The Chiefs' defense allowed 22 points to the Denver Broncos in Week 11 while collecting two sacks. Kansas City has allowed at least 22 points in back-to-back games with no takeaways in that span. The Chiefs' defense ranked 20th in the league in sacks with 22 through 10 games. This defensive unit also ranks 11th in yards per game allowed, which will be needed against Indianapolis this week. The Colts offense has the most yards and points scored this season, which makes starting the Chiefs defense difficult. The Chiefs' defense is ranked 15th in our RotoBaller rankings this week, meaning they can be started in a pinch, but fantasy managers should try to find a better option.
--Joshua CostelloSource: ESPN.com
November 21, 2025
New York Giants wide receiver
Darius Slayton (hamstring) will not carry an injury designation into his team's Week 12 matchup against the Detroit Lions. Slayton was sidelined for New York's Week 11 loss to the Green Bay Packers, but he will make his return in Week 12 against Detroit. Across eight games this season, the 28-year-old has recorded 23 catches for 343 yards on 34 targets. Slayton was playing some of his best football before getting hurt, recording nine catches for 151 yards on 11 targets across Weeks 9 and 10. He'll be catching passes from veteran quarterback
Jameis Winston on Sunday, who is making his second straight start for the Giants with rookie quarterback
Jaxson Dart (concussion) still sidelined. Slayton profiles as a low-end WR4/flex option for deep-league fantasy managers in Week 12.
--Will BradySource: Giants.com - Dan Salomone
November 21, 2025
Kansas City Chiefs kicker
Harrison Butker will face the Indianapolis Colts on Sunday in Week 12. Butker has struggled this season, and his struggles continued last week against the Denver Broncos. Butker knocked through both of his field goal attempts, but missed one of his two extra-point attempts in Week 11. Butker has an 84.2% field goal percentage and 85.7% extra-point percentage this season, both marks rank outside the top-20 at the position. That said, Butker should be involved in a shootout against Indianapolis this week. The Colts offense has the most yards and points scored this season, which means the Chiefs will need to put a lot of points on the board to keep up. Butker should get a piece of the action and could provide value at the kicker position. Butker is ranked K9 in our RotoBaller rankings, making him worthy of a start in most leagues.
--Joshua CostelloSource: ESPN.com
November 21, 2025
Los Angeles Chargers rookie tight end
Oronde Gadsden ranks as the TE12 in half-PPR fantasy points per game through the first nine games of his NFL career. Gadsden has developed strong chemistry with quarterback
Justin Herbert and has 37 catches on 49 targets for 507 yards and two touchdowns going into the team's Week 12 bye. However, the 22-year-old hasn't scored since Oct. 19. Gadsden has cooled off a bit since back-to-back weeks of finding the end zone in Weeks 7 and 8, but he's had at least five targets in a game since all the way back in Week 5. The primary concern for Gadsden's fantasy managers going forward is the Chargers' banged-up offensive line, which might give quarterback Justin Herbert very little time to throw the football in the final stretch of the season against some tough opponents. The fifth-rounder could return with a bang in Week 13 against the Raiders, so fantasy managers shouldn't give up hope just yet.
--Keith HernandezSource: Pro Football Reference
November 21, 2025
Indianapolis Colts head coach Shane Steichen said that quarterback
Daniel Jones (leg) is "good-to-go" for his team's Week 12 matchup against the Kansas City Chiefs. Steichen also clarified that Jones' injury is actually to his fibula after it was initially reported as a calf issue, per James Boyd of The Athletic. Either way, Jones was able to practice in full on Friday after being limited on Thursday and will be active against Kansas City. Jones has played well in his first season in Indianapolis, completing 69.9% of his pass attempts for 2,659 yards, 15 touchdowns, and seven interceptions across 10 games. He's also added 143 yards and five touchdowns as a rusher. However, Jones has been particularly turnover-prone of late, recording four interceptions and six fumbles (three lost) over his last two games. That could be an issue in a tough road matchup against Kansas City, particularly if his mobility is limited in any way. Jones profiles as a low-end fantasy QB1 in Week 12.
--Will BradySource: The Athletic - James Boyd
November 21, 2025
Kansas City Chiefs tight end
Travis Kelce will face the Indianapolis Colts in Week 12. Kelce was the lone bright spot among the Chiefs pass catchers in last week's loss to the Denver Broncos. The veteran tight end hauled in nine catches for 91 yards and a touchdown on 13 targets in Week 11. Last week's totals set new season-highs in receptions and targets for Kelce, making it easily his best performance of the year. With fellow pass catcher
Xavier Worthy officially questionable for Sunday's matchup, Kelce could have another ceiling performance against the Colts. The Indianapolis defense is one of the best matchups for tight ends, allowing the fourth-most fantasy points to opposing tight ends this season. Kelce is ranked TE4 in our RotoBaller Half-PPR rankings, making him a top-end option at the position this week. Kelce has had a resurgent 2025 season, and that should continue against the Colts.
--Joshua CostelloSource: ESPN.com
November 21, 2025
Cleveland Browns quarterback
Dillon Gabriel (concussion) returned to practice on Friday but has still not fully cleared the league's concussion protocol, according to Mary Kay Cabot of Cleveland.com. Gabriel was forced to exit early from Cleveland's Week 11 loss to the Baltimore Ravens after suffering a concussion and will miss the team's Week 12 matchup against the Las Vegas Raiders as well. With Gabriel sidelined, fellow rookie quarterback
Shedeur Sanders will make his first NFL start against Las Vegas. While a monster performance from Sanders could change things, Gabriel is expected to resume starting duties in Cleveland once cleared to return from his concussion. Given that he was able to return to practice in some capacity on Friday, Gabriel's return could come when the Browns will host the San Francisco 49ers in Week 13.
--Will BradySource: Cleveland.com - Mary Kay Cabot
November 21, 2025
Kansas City Chiefs wide receiver
Marquise Brown will take on the Indianapolis Colts in Week 12. Brown had a serviceable performance in Week 11, catching four passes for 40 yards against the Denver Broncos. While he did not have a big game, Brown finished third on the team in receiving yards against a tough opponent. Fellow wide receiver
Xavier Worthy got a full practice in on Friday but is officially listed as questionable, which could boost Brown's fantasy value. Brown could fill the field-stretching role while
Rashee Rice and
Travis Kelce compete for the short and intermediate targets against Indianapolis. The Colts defense is an advantageous matchup, allowing the 10th-most fantasy points to opposing wide receivers this season. Brown is currently ranked WR64 in our RotoBaller Half-PPR rankings, making him a desperation flex candidate, but that ranking would climb dramatically if Worthy is ruled out.
--Joshua CostelloSource: Kansas City Chiefs - Twitter
November 21, 2025
Minnesota Vikings quarterback
J.J. McCarthy should be considered a volatile Superflex option when his team goes to Lambeau Field to take on the Green Bay Packers in Week 12. The former Michigan star's overall numbers are not pretty -- he's completed only 53% of his passing attempts and thrown eight interceptions in five games -- but the Vikings have continued to preach patience. The Packers rank third in yards per play allowed, which presents a difficult matchup, but McCarthy has saved his best for NFC North road games thus far, as six of his eight total touchdowns this season took place in victories at Chicago and at Detroit. Additionally, McCarthy has also shown rushing ability by compiling 110 rushing yards and two touchdowns on only 24 carries. Ultimately, however, McCarthy is on the road and has not played well lately, so managers will have to gauge their risk tolerance for playing the league's youngest starter as the fantasy playoffs approach.
--Nick PiotrowiczSource: RotoBaller
November 21, 2025
New Orleans Saints running back
Alvin Kamara (ankle) is officially listed as questionable to play in his team's Week 12 matchup against the Atlanta Falcons, per Matthew Paras of The Times-Picayune. Kamara has been listed as a limited practice participant all week as he battles a nagging ankle injury that has plagued him for much of the 2025 season. The 30-year-old had an encouraging game in his final outing before the Saints' Week 11 bye, recording 115 scrimmage yards on 25 touches against the Carolina Panthers. If he's unable to play in Week 12, rookie
Devin Neal and
Audric Estime would likely handle the backfield work for New Orleans against Atlanta on Sunday. Should Kamara be active, he profiles as a high-end fantasy RB2 and could be in for another big week against the reeling Falcons.
--Will BradySource: The Times-Picayune - Matthew Paras
November 21, 2025
Denver Broncos wide receiver
Marvin Mims Jr. probably finds himself on the waiver wire in most fantasy football leagues with the Broncos headed on their bye in Week 12. Mims caught six of seven targets for a season-high 85 yards in the team's miraculous comeback win over the New York Giants in Week 7, but then he suffered a concussion the following week against the Dallas Cowboys and missed Weeks 9 and 10. In his return to action in Sunday's big win over the Kansas City Chiefs, the 23-year-old played a season-low 24% of the offensive snaps and was not targeted at all. The former second-rounder still has plenty of big-play ability, but during his time away with a concussion,
Troy Franklin and rookie
Pat Bryant became more involved on offense, and that could continue in Week 13 for a Sunday night contest against Washington. Until further notice, Mims is off the fantasy radar as Denver's WR4.
--Keith HernandezSource: Pro Football Reference
November 21, 2025
The Minnesota Vikings have been among the most unpredictable teams in the league this season, but running back
Aaron Jones Sr. (shoulder) is off the injury report and set to get the majority of backfield work against the Green Bay Packers in Week 12. The former Green Bay draft pick is earning regular work in the Vikings' passing game with 12 targets in the past two weeks, and with 22 overall touches last week alone, he's been the team's preferred option over
Jordan Mason. The Packers are a tough matchup, ranking third in yards per carry against and 12th against PPR running backs, but Jones has finished within the top 25 at his position three weeks in a row, even as the Vikings have struggled. While the overall circumstances aren't ideal, Jones has demonstrated a reliable enough fantasy floor that he can be considered in an RB3/flex role this week.
--Nick PiotrowiczSource: RotoBaller
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