MLB DFS Picks Today: Daily Fantasy Baseball Strategy and Tips For FanDuel, DraftKings (4/25/25)

Dan's top DraftKings and FanDuel MLB DFS picks for today, Friday, 4/25/25. His favorite daily fantasy baseball lineup sleepers and value picks for DFS on DraftKings and FanDuel.

It's another loaded Friday full of MLB action with 12 games on both the FanDuel and DraftKings main slates tonight. We have some elite pitching matchups and a game at Coors Field, so you'll likely have to pick whether you want to spend up for pitching or to get those Coors bats.

There's some sloppy weather in Cleveland and Detroit, but the rest of the country looks pretty safe so we don't have too much weather to navigate, and that's always a good thing.

This article will provide my daily fantasy baseball lineup picks for DraftKings and FanDuel on 4/25/2025. The main slate locks at 7:05 p.m. EDT. The lineup picks will feature elite players, mid-priced options, and value plays. You can also read more DFS advice and lineup picks for other sports here. Monitoring injury news and today's MLB starting lineups is always essential.

DraftKings, FanDuel Pitchers - MLB DFS Lineup Picks

Yoshinobu Yamamoto - LAD vs. PIT ($10.5K DK; $10.8K FD) 

There are two aces tonight who are in spectacular matchups, with Yamamoto being one of them and the highest-priced arm on both sites. The Dodgers' ace enters tonight's matchup with the lowly Pirates with a superb 2.02 SIERA and 35.2 K percentage. His 2.18 xERA is further proof that he's been dominant, as he's inducing a lot of weak contact in addition to missing bats.

The Pirates have the fifth-worst wRC+ against RHP in the league right now and should be a team that Yamamoto dominates. Oneil Cruz has heated up, but the rest of the lineup continues to struggle. There is some concern about getting a win here for Yamamoto, as the Pirates can counter with their ace, Paul Skenes. Therefore, I may prefer going down to Logan Gilbert on FanDuel, where securing the win and the six FD points that come with it are important.

Logan Gilbert - SEA vs. MIA ($10.2K DK; $10.4K FD) 

Gilbert is my guy tonight on both sites. He's a tad cheaper than Yamamoto and has been every bit as good this season with an elite 1.91 SIERA and 38 percent K percentage. He's also a heavy home favorite here at -275, which makes him more appealing than Yamamoto, who could be in a pitchers' duel with Skenes.

Last 30 Days - SIERA Leaders

Logan Gilbert: 5 GS, 1.91 SIERA (2.63 ERA)
Yoshinobu Yamamoto: 4 GS, 1.92 SIERA (0.75 ERA)
MacKenzie Gore: 6 GS, 2.16 SIERA (3.34 ERA)
Max Meyer: 5 GS, 2.21 SIERA (2.1 ERA)
Cole Ragans: 6 GS, 2.36 SIERA (4.4 ERA)

While I love to point out the ineptitude of my Pirates, they are striking out three percent less often than Miami, which has a 25 percent K percentage vs. RHP. That mark is the third-worst in all of baseball. Gilbert's K prop is set at 8.5 tonight, which is a number we have only seen a few times this season. He has everything going for him in this spot, and I think he has a slightly higher floor and ceiling than Yamamoto if we hold other things equal.

Hayden Wesneski - HOU at KC ($8.2K DK; $8.3K FD) 

On DraftKings, you're going to have a hard time fitting in both aces with some decent bats, so I would consider dropping down to Wesneski as your SP2 choice in cash games.

Wesneski is having a breakout campaign for Houston. His 2.90 SIERA is the seventh-best mark of any pitcher on the bump today, and he is striking out hitters at a 27 percent clip. While the Royals don't whiff too often, they are slumping badly at the plate in terms of run production. KC has the second-lowest wRC+ vs. RHP in the league with a mark of just 72, ahead of only the Rockies - ouch!

Also Consider: Nathan Eovaldi - TEX at SFG ($9.2K DK; $8.5K FD), Justin Verlander - SFG vs. TEX ($7.3K DK; $7.2K FD)

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DraftKings, FanDuel Infielders - MLB DFS Lineup Picks

Ben Rice, 1B/C (FanDuel Only) - NYY vs. Jose Berrios ($4.6K DK; $3.6K FD)

This is an easy pick for me as Rice has been torching lefties this season to the tune of a .370 ISO and .680 SLG. He's leading off again for New York tonight and has an impressive .468 OBP against righties to start the season. He's simply doing everything well at the plate right now.

Ben Rice’s Baseball Savant page 🤣🤣🤣 pic.twitter.com/F1coWrgbwN

— The Yankee Report (@YankeeReport_) April 24, 2025

Jose Berrios is a pitcher I love to target with lefties. He's had poor splits against them for most of his career, and the short porch in right field certainly favors Rice and the Yankees' lefties in this matchup.

Luke Keaschall, 2B - MIN vs. Kyle Hendricks ($3.5K DK; $2.8K FD) 

The Twins have found something in Keaschall. The rookie has wasted no time establishing himself as the best all-around hitter in the lineup and has earned the third spot in the batting order as a result.

Keaschall has a .505 wOBA against RHP through his first five games in the majors and has hit safely in every game. He's striking out just five percent of the time and walking at a 26 percent clip. He's been a menace on the basepaths, swiping five bases and scoring four runs. He has stolen two bags in two games already and is averaging 16 FD points per game.

At some point, he will slow down, but it might not be tonight as he faces the veteran soft-tosser Hendricks. I think he's a slam-dunk cash game play based on his on-base skills and potential to steal bases. He's still badly underpriced for the skill set that he's demonstrated during his first week in the big leagues.

Noelvi Marte, 3B - CIN vs. Kyle Freeland ($3.9K DK; $2.8K FD)

I usually try to avoid Coors on big slates, but I think there's some sneaky value to be had from that game, especially if DFS players fade it based on both pitchers having respectable numbers so far this season.

Freeland has been decent, but make no mistake about it, he's not a good pitcher. He's managed to avoid the long ball, but is still surrendering a 91 percent Z-Contact rate. He's been able to keep the ball on the ground, which really helps when you have to pitch at Coors, but he will have his hands full here against a pretty good Reds lineup.

Marte has been coming on strong and looks like he might be ready to fulfill the potential he had shown two seasons ago as a prospect. He's hitting over .300 with a pair of home runs and steals. He's very affordable considering the venue, and he's got a nice lineup slot hitting in the sixth hole. I may not stack the Reds or Rockies, but I do have an interest in several hitters on both sides.

Also Consider: Cal Raleigh, C - SEA ($4.8K DK; $3.3K FD) and Tyler Soderstrom, 1B/OF (DraftKings Only)/C (FanDuel Only) - ATH ($5.2K DK; $3.7K FD)

DraftKings, FanDuel Outfielders - MLB DFS Lineup Picks

Randy Arozarena, OF - SEA vs. Cal Quantrill ($4.5K DK; $3.5K FD) 

We have to attack Cal Quantrill today and his 7.02 xERA with some Mariners bats. Quantrill can troll us from time to time, but his underlying metrics suggest he is a very poor pitcher, and he's bound to get blown up sooner or later.

Seattle has been warming up on offense after a slow start. While we usually look at the lefties first, Quantrill has shown some reverse splits now for several years and has been hit harder by righties again this season.

Aroz has a respectable .362 wOBA and .217 ISO vs. righties this season and makes for a nice one-off or piece of a Seattle stack.

Brenton Doyle, OF - COL vs. Andrew Abbott ($4.6K DK; $3.8K FD) 

I am not afraid of Andrew Abbott, and I don't care what his ERA is. He is still getting barreled at a high rate and now has to pitch in the unforgiving altitude of Coors Field.

Abbott is due for regression, and my favorite Rockies bat is Doyle, who, after a slow start, has come on to raise his average to .300 with three home runs and two steals. The Rockies have been so bad as a team that it makes them hard to stack, but I think we can still take some shots at some individual performances, with Doyle having the most upside in terms of his power and speed potential.

Fernando Tatis Jr., OF - SDP vs. Shane Baz ($6.1K DK; $4.1K FD)

There has been no one in the league who has been making more pure contact with the baseball than Tatis. He's quickly reminded everyone what he's capable of doing when healthy and is off to an incredible start in the 2025 season.

Fernando Tatis Jr. leads MLB in bWAR (2.1) and is behind only Aaron Judge in fWAR (1.9) pic.twitter.com/ma60OUCtQA

— Padres Data Daily (@PadresDataDaily) April 21, 2025

He's crushing righties to the tune of a .486 wOBA and .379 ISO while only whiffing 15 percent of the time. You have to love those metrics, and I'll take my chances of him getting the best of the youngster Shane Baz, who was roughed up by the Yankees in his last start. Baz has great stuff, but has an issue with giving up hard contact and the long ball, so he could be in for another tough matchup here with the Padres. If I am paying up for one stud today, it's Tatis.

Also Consider:

Hunter Goodman, C/OF (FanDuel Only)/1B (FanDuel Only) - COL ($4.2K DK; $3.4K FD) and Brent Rooker, OF - ATH ($5.4K DK; $3.4K FD)

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