X
Lost password?

Don't have an account?
Gain Access Now

X

Receive free daily analysis

NFL
NBA
NHL
NASCAR
CFB
MLB
MMA
PGA
ESPORTS
BETTING

Already have an account? Log In

X

Forgot Password


DraftKings, FanDuel Daily Fantasy Baseball Picks (9/21/22): Today's Top MLB DFS Lineups

Triston McKenzie fantasy baseball rankings draft sleepers MLB injury news

The top daily fantasy baseball lineup picks for FanDuel and DraftKings on September 21st, 2022. Juan Carlos Blanco's MLB DFS analysis and sleepers for building optimal DFS rosters.

Welcome back to another edition of the FREE DraftKings and FanDuel MLB DFS picks. As customary, we have an all-day ledger on tap Wednesday, and although DraftKings does not have a full-day slate, FanDuel does. Consequently, today's article will feature picks on both sites for games throughout the day, as even on DK, the suggestions will prove viable for someone playing one of the site's split slates.

We have an interesting pitching pool on Wednesday's slate, as there aren't a lot of clear-cut options to choose from. Additionally, some scenarios that would appear to be favorable matchups on the surface, such as Luis Severino's turn against the Pirates in the Bronx, carry an asterisk, as the right-hander could be on a pitch count in his first start off the 60-day IL. However, there are three options I'm confident in, as well as a solid selection of hitters we can target the numerous questionable arms that are taking the hill with.

This article will provide my daily fantasy baseball lineup picks for FanDuel and DraftKings on 9/21/2022 that includes a FanDuel main slate locking at 12:20 pm ET. The lineup will range from some elite players to mid-priced options and value plays. You can also read more DFS advice and lineup picks for other sports. It's also essential to monitor injury news and today's MLB starting lineups. If you have any questions or comments, find me on Twitter and ask away!

 

DraftKings, FanDuel Pitchers - MLB DFS Lineup Picks

Triston McKenzie - CLE at CWS ($10,100 DK, $9,600 FD)

McKenzie may only have a 10-11 record, but it's accompanied by an impressive 3.08 ERA, 0.97 WHIP, and solid 8.7 K/9. The big right-hander has really hit his stride down the stretch as well, pitching to a 2.41 ERA, 0.92 WHIP, 9.3 K/9, and improved 1.0 HR/9 over the 52.1 innings covering his last eight starts. That sample includes a gem of a quality start against the White Sox on Aug. 19th where he struck out 14 over seven frames.

McKenzie had also been very effective against Chicago in two prior starts this season, allowing just two runs over 10 innings in that pair of outings. Current ChiSox bats only have a collective .217 average and .611 OPS against McKenzie in 117 career encounters as well, and the White Sox, despite their abundance of big names, have just a middling .316 wOBA and .159 ISO against right-handed pitching in September.

Robbie Ray - SEA at OAK ($9,600 DK, $10,000 FD)

Ray has had his share of troubles on the road and comes into Wednesday's start with back-to-back rocky starts against the Braves and Angels. However, the southpaw has a favorable matchup in a pitcher's park against a team he's already enjoyed success against on multiple occasions this season, making him worthy of consideration in both cash games and tournaments as he aims for a bounce-back performance.

Ray has pitched to a 2.41 ERA across 18.2 innings in three starts against Oakland this season, and current A's bats own a collective .163 average and .466 OPS against him in 50 career plate appearances, a sample in which Ray has compiled 20 strikeouts. Oakland has also been the AL's worst team against left-handed pitching at home in the second half of the season, producing a .214 average, .604 OPS, .264 wOBA, and -9.1 wRAA in a sample of 260 plate appearances. The A's even have just a 5.8 percent walk rate in that split, which helps guard against Ray's occasional control issues.

Other options: Miles Mikolas - STL at SDP ($9,100 DK, $8,800 FD)

Want more MLB DFS tools and content? Our MLB Premium package includes our daily DFS Cheat Sheets, Research Station, Optimizer, and access to our Premium Slack Chatrooms, where members can chat with our MLB analysts. Check out this recent big win from RotoBaller's Jon Anderson on DraftKings - join in on the winning!

 

DraftKings, FanDuel Infielders - MLB DFS Lineup Picks

Matt Olson - 1B, ATL vs. Josiah Gray ($4,900 DK, $3,000 FD)

Olson entered Tuesday's action with a whopping 70 extra-base hits, including 28 homers, and 91 RBI in his first season for the defending champions. While a high strikeout rate is part of the package with Olson, deploying his powerful left-handed swing against a right-hander in Gray who's been absolutely incapable of keeping the ball in the park certainly makes sense, especially at very reasonable salaries on both sites.

Olson has slugged 22 of his 28 round trippers off right-handed pitching, and he owns a .339 wOBA and .234 ISO against that handedness at home. Meanwhile, Gray has given up a jaw-dropping 37 home runs across 136.2 innings. He's allowed 22 of those to left-handed hitters, which have tagged him for a .268 average, .987 OPS, and .417 wOBA, along with a 21.6 percent HR/FB rate.

Jeff McNeil - 2B, NYM at Adrian Houser ($4,200 DK, $2,900 FD)

Houser hasn't been anywhere near as effective as during his career-best 10-6 season in 2021, generating a 6-9 mark, 4.85 ERA, and 1.49 WHIP across 94.2 innings. The veteran right-hander has been better at home, but he's still enduring his usual struggles against left-handed bats; the highly reliable McNeil, who entered Tuesday with a .320 average and .822 OPS, therefore makes for an excellent option to deploy against him.

Houser has given up a .313 average and .379 wOBA to left-handed hitters overall, and although he's had more trouble against them on the road, he still carries a bloated 5.89 BB/9 and 4.76 xFIP against them at home. Then, McNeil has been at his best when facing right-handed pitching on the road, where he owns a .341 average, .880 OPS, and .380 wOBA against that handedness.

He also went into Tuesday's action with a .328 average and .359 wOBA in 80 plate appearances across 18 September games. Then, the matchup remains favorable for McNeil when Houser exits, as Milwaukee relievers have pitched to a .278 BAA and .351 wOBA against lefty bats in September.

Trea Turner - SS, LAD vs. Madison Bumgarner ($5,600 DK, $4,100 FD)

Turner is in the midst of yet another MVP-caliber season, entering Tuesday with a .304 average, .829 OPS, 20 homers, 97 RBI, and 25 steals. The veteran shortstop has been very effective against either handedness of pitcher as those numbers imply, but he's been at his best versus southpaws and faces an aging, struggling one in Bumgarner. MadBum's last double-digit win season came in 2016, and he enters Wednesday's start with a career-high 15 losses along with a 5.01 ERA and 1.48 WHIP.

Turner boasted a .329 average, .944 OPS, .404 wOBA, and .233 ISO against left-handed pitching at Dodger Stadium going into Tuesday night's action, as well as a .346 wOBA and modest 15.5 percent strikeout rate in 71 plate appearances in September. He's also been an outstanding clutch hitter all season with a .307 average with runners on base, including a .325 figure with men in scoring position, a trait that comes in especially handy in a star-studded lineup that offers so many RBI opportunities.

For his part, Bumgarner has been victimized by right-handed bats on the road for a .311 average, .386 wOBA, and 5.17 xFIP, while also surrendering an elevated 39.8 percent hard-contact rate in that split.

Josh Jung - 3B, TEX vs. Tucker Davidson ($2,200 DK, $3,100 FD)

Jung has been a bright spot overall during his brief time in the majors after a promising minor-league career, holding his own against big-league arms early with a respectable .250 average and impressive .800 OPS across his first 40 big-league plate appearances entering Tuesday.

The rookie has been particularly effective against left-handed pitching, continuing a trend he exhibited during his minors days at multiple stops, and he draws an appealing matchup against a southpaw in the favorable hitting environment of his home park Wednesday.

Jung went into Tuesday's game hitting .316 with a 1.053 OPS and .443 wOBA over his first 19 plate appearances versus lefties, a sample in which he'd quickly belted a pair of doubles and two homers on the strength of a 50.0 percent hard contact rate. Davidson seemingly makes for a good target to pick on, considering he's pitched to a .291 average and .353 wOBA against right-handed hitters, along with a 1.68 WHIP and 5.47 xFIP when facing them on the road.

Other options: Dansby Swanson - SS, ATL vs. Josiah Gray ($5,500 DK, $3,600 FD); Ryan McMahon - 3B, COL vs. SFG ($5,200 DK, $3,100 FD)

 

DraftKings, FanDuel Outfielders - MLB DFS Lineup Picks

Charlie Blackmon - COL vs. Logan Webb ($5,100 DK, $3,000 FD)

Blackmon is enjoying another impressive season in Colorado despite his club being a non-contender yet again. The veteran outfielder entered Tuesday's action with a solid .263 average, .734 OPS, 42 XBH, and 76 RBI. Blackmon is also thriving as usual in his home park, and he's facing a right-hander in Webb that he's enjoyed plenty of success against before and that's shown some vulnerability in a couple of recent starts.

Blackmon has tagged Webb for a .450 average with three doubles, a homer, and only three strikeouts in 23 career encounters, and he's teed off on right-handed pitching at Coors Field for a .803 OPS, .341 wOBA, and .221 ISO. Webb has allowed an elevated .282 average and .437 slugging percentage to the 73 batters he's faced thus far in September, including a .355 average, 1.020 OPS, and .432 wOBA to 32 lefty bats in that sample. Webb has allowed a .276 average and .344 wOBA to lefty hitters on the road this season overall, and the Coors Field environment only makes it a more dangerous scenario for him. Giants relievers also have a .341 wOBA against lefty hitters in September, furthering Blackmon's case.

Joc Pederson - SFG at German Marquez ($5,100 DK, $2,700 FD)

Pederson has put together quite the comeback season during his first year in San Francisco, taking a career-high .260 average into Tuesday night's action and complementing it with an excellent .841 OPS. The lefty-swinging slugger has slugged 13 of his 22 homers outside his pitcher-friendly home park, and Wednesday, he makes for an excellent way to gain access to Marquez at Coors and his vast struggles against left-handed hitters.

Marquez has yielded a .326 average, .397 wOBA, and 2.2 HR/9 to left-handed hitters at Coors Field, partly the byproduct of the fact he's conceded a 27.0 percent line-drive rate and 40.1 percent hard-contact rate in that split. Pederson is therefore a highly dangerous opponent for him, considering his prodigious power and the fact he's posted a .272 average, .903 OPS, and .380 wOBA versus right-handed pitching on the road, along with a 44.4 percent hard-contact rate.

Julio Rodriguez -  SEA at James Kaprielian ($5,500 DK, $4,100 FD)

Rodriguez jumped back into the lineup Tuesday night after missing three games with a tight lower back, so he should be good to go for this favorable matchup against Kaprielian. The AL Rookie of the Year frontrunner has already tormented the A's right-hander on numerous occasions in the past, posting a .500 average with two triples and a homer over 12 plate appearances without striking out once in that sample. Rodriguez also came into Tuesday's game on quite the tear, having generated a .447 average, five homers, and a 1.428 OPS over the previous 10 games.

Kaprielian has had plenty of positive moments this season, but he's still given up a .299 average, .407 wOBA, and .951 OPS to right-handed hitters at home, along with a 1.9 HR/9 and 6.19 xFIP. Rodriguez has thrived against right-handed pitching on the road as well, as evidenced by his .281 average, .825 OPS, and .357 wOBA in that split, as well as a 37.0 percent hard-contact rate.

Other options: Mike Yastrzemski - SFG at German Marquez ($4,200 DK, $3,100 FD); Mike Trout - LAA at Dane Dunning ($6,200 DK, $4,300 FD)

 

DraftKings, FanDuel MLB DFS Stacks

  • Braves vs. Josiah Gray, WAS, RHP
  • Rockies vs. Logan Webb, SFG, RHP
  • Giants at German Marquez, COL, RHP



Download Our Free News & Alerts Mobile App

Like what you see? Download our updated fantasy baseball app for iPhone and Android with 24x7 player news, injury alerts, sleepers, prospects & more. All free!




MLB DFS News and Injury Alerts


More DFS Lineup Picks and Analysis




REAL-TIME FANTASY NEWS

Juan Soto

Exits Wednesday's Game Early with Ankle Injury
Tim Patrick

Jets Agree to Terms With Veteran Receiver Tim Patrick
Malik Nabers

Undergoes Second Knee Surgery
De'Von Achane

Dolphins, De'Von Achane Agree to Four-Year Contract Extension
Kevin Huerter

is Cleared to Return for Game 5
Caris LeVert

is Available for Game 5 on Wednesday
Duncan Robinson

is Out for Game 5
Keegan Murray

Undergoes Ankle Procedure
Josh Giddey

Undergoes Ankle Surgery
Pete Fairbanks

Returns From Injured List
Christian Yelich

Out With Back Tightness on Wednesday Night
Nathan MacKinnon

Chasing History Wednesday
Ryan Poehling

Won't Be an Option for Game 6
Sam Malinski

Set to Miss Second Straight Game
Artturi Lehkonen

Unlikely to Play Wednesday
Matthew Schaefer

Wins Calder Trophy
TOR

Maple Leafs Fire Head Coach Craig Berube
Jalen Hurts

Can Jalen Hurts Bounce Back as a Rusher in 2026?
Robby Snelling

Placed on 15-Day Injured List with Elbow Sprain
Zach Charbonnet

Dynasty Value in Question Entering 2026
DeVonta Smith

Poised to Reach a New Level of Production in 2026?
Chris Olave

Facing Increased Target Competition in New Orleans Entering 2026
Chris Bell

Dynasty Stock Rising Following NFL Draft
Ted Hurst

Facing Uphill Battle for Playing Time in Tampa Bay
Francisco Alvarez

Mets Place Francisco Alvarez on Injured List With Torn Meniscus
Max Fried

Dealing With Left Elbow Posterior Soreness
CFB

NFL Veteran Tom Moore Joins Iowa Coaching Staff
CFB

Can Cam Cook Dominate in Return to Big 12?
Chris Brazzell II

Is Chris Brazzell II the Top Deep Threat in Carolina's Receiver Room?
Kaelon Black

a Threat to Win Backup RB Job in San Fran?
CFB

ACC, Big 12 Support 24-Team College Football Playoff
De'Zhaun Stribling

to be 49ers' New "F" Receiver?
CFB

Anthony Colandrea Looking to Elevate Nebraska Back to National Contention
Drew Allar

Steelers "Uninstalling" Everything Drew Allar Learned in College
CFB

Kwazi Gilmer Set for Big Impact at Nebraska
Ja'Kobi Lane

Is Ja'Kobi Lane the Pass-Catching Answer the Ravens Have Been Seeking?
Zachariah Branch

Does Zachariah Branch Have a Path to Immediate Production?
Max Klare

Can Max Klare Separate Himself in Rams' Tight End Room?
Eli Stowers

the Tight End of the Future in Philadelphia?
Justin Thomas

Trending Well Ahead of PGA Championship Despite Concerning Form
J.J. Spaun

Trending Up Ahead of PGA Championship
Adam Scott

Riding Strong Form Into PGA Championship
Patrick Reed

Looking to Make Another Run at PGA Championship
PGA

Sungjae Im Looks to Build on Strong Finish at Truist Championship
Sam Burns

Must Keep Ball in Play at PGA Championship
Jordan Spieth

Looks to Complete Career Grand Slam at Aronimink
Brandt Snedeker

Not the Best Option for the PGA Championship
Rasmus Hojgaard

a Volatile Option at PGA Championship
Germie Bernard

Already in a Tough Spot to Hold Dynasty Value
Ayo Dosunmu

Has Busy Night in Game 5
Maverick McNealy

Seeking Better Start in Philadelphia
Harry Hall

a Boom-or-Bust Option at Aronimink
Jaden McDaniels

Notches 17 Points in Game 5 Loss
Denzel Boston

a Smart Bet to Meet or Exceed Value in Dynasty Rookie Drafts
Hideki Matsuyama

Attempts to Improve Over 2025 PGA Championship
Scottie Scheffler

Looks to Defend PGA Championship at Aronimink
Julius Randle

Posts a Double-Double in Losing Effort
Matthew Stafford

a Sell Candidate with Touchdown Regression Likely on its Way
Nicolai Hojgaard

Wants to Keep Momentum Rolling in Philadelphia
Anthony Edwards

Held to 20 Points in Game 5 Loss
Ben Griffin

Attempting to Bounce Back After Truist Championship
CFB

Transfer Defensive Lineman Devarrick Woods Commits to Clemson
Keldon Johnson

Comes Alive in Game 5 Against Timberwolves
Jayden Reed

Dynasty Value Tethered to His Underwhelming Usage
Harris English

Will Need His Putter to Thrive at Aronimink
Stephon Castle

Makes All-Around Impact in Game 5
Victor Wembanyama

Leads Spurs to Big Win in Game 5
Akshay Bhatia

Creative Flair Could Show Itself in Philadelphia
Keegan Bradley

Knows the Aronimink Golf Club Well
Mason McTavish

Delivers Two Assists Tuesday Night
Pavel Dorofeyev

Pots Two Goals in Vital Game 5 Win
Josh Doan

Records Two Assists in Game 4 Victory
Evgeni Malkin

Penguins Want Evgeni Malkin Back
Sidney Crosby

Joins Team Canada for World Championship
Ryan Poehling

Suffers Upper-Body Injury in Game 5 Loss
Si Woo Kim

Struggles at Truist Championship
Gary Woodland

Can Continue Incredible 2026 Season at PGA Championship
Xander Schauffele

In Excellent Form Heading to PGA Championship
Brandon Nimmo

Leaves Game on Tuesday with Apparent Ankle Injury
Philadelphia 76ers

76ers Part Ways With Daryl Morey
Kevin Huerter

Iffy for Game 5 Against Cavaliers
Dylan Harper

Cleared for Action Tuesday
De'Aaron Fox

Available for Game 5 Against Timberwolves
Caris LeVert

Remains on Injury Report With Heel Issue
Duncan Robinson

Listed as Questionable for Game 5
Memphis Grizzlies

Brandon Clarke Dies at Age 29
Charlie McAvoy

Slapped With Six-Game Suspension
Jonas Brodin

Unavailable for Game 5 Against Avalanche
Joel Eriksson Ek

to Remain Out Wednesday
Sam Malinski

Day-to-Day With Upper-Body Injury
Jacob Wilson

A's Place Jacob Wilson on Injured List With Shoulder Subluxation
Artturi Lehkonen

Considered Day-to-Day
Charlie Coyle

Lands Six-Year Extension
Ukko-Pekka Luukkonen

to Start Game 4 Against Canadiens
Drew Helleson

Unavailable for Game 5
Radko Gudas

Still Out Tuesday
Christian Yelich

Brewers Reinstate Christian Yelich From Injured List
Luka Dončić

Luka Doncic Admits He Wasn't Close to Returning Before Season Ended
CFB

Isaac Brown Has All-American Upside in 2026
LeBron James

Uncertain About Future After Season-Ending Loss
CFB

Nyck Harbor Heading into Breakout Year?
CFB

Notre Dame, USC in Discussions to Resume Rivalry Series
CFB

Jaron-Keawe Sagapolutele Has Eyes on ACC Title
CFB

Ahmad Hardy's Gunshot Wound Not Viewed as Career-Threatening
A.J. Ewing

Mets to Call Up Top Prospect A.J. Ewing
Mookie Betts

is Officially Back on Monday
Nathan Eovaldi

Scratched From Monday's Start With Side Tightness
Henry Bolte

Athletics to Promote Top Outfield Prospect Henry Bolte to Major Leagues
Khamzat Chimaev

Suffers his First Loss
Sean Strickland

Recaptures Middleweight Title
Tatsuro Taira

Suffers Fifth-Round TKO Loss
Joshua Van

Defends Flyweight Title
MMA

Waldo Cortes-Acosta Drops Decision
Alexander Volkov

Wins Back-To-Back Fights
Shane Van Gisbergen

Dominates Watkins Glen for First Win of 2026
Michael McDowell

Finishes Second for Best Run of the Year At Watkins Glen
Ty Gibbs

Scores New Career-Best Finish of Third at Watkins Glen
Tyler Reddick

Continues His Strong Season With Fifth-Place Run at Watkins Glen
Austin Dillon

Earns his First Top-10 Finish of 2026 at Watkins Glen
Mookie Betts

Dodgers Expect Mookie Betts to Return on Monday
CFB

Ahmad Hardy Sustains Gunshot Wound, in Stable Condition
Connor Zilisch

Will Start Fifth in his First Watkins Glen Cup Series Race
Tyler Reddick

Is A Top DFS Option for Watkins Glen Lineups
Christopher Bell

Is Likely to Bounce Back This Week at Watkins Glen
Carlos Rodón

Carlos Rodon Activated for Season Debut on Sunday
William Byron

Is William Byron Playable in DFS Lineups at Watkins Glen?
Kyle Larson

May have A Positive Day at Watkins Glen
Chase Briscoe

May Compete for A Top-10 Finish at Watkins Glen
NASCAR

A.J. Allmendinger May have Another Solid Outing at Watkins Glen
Ty Gibbs

Should Fantasy Managers Roster Ty Gibbs at Watkins Glen?
Ross Chastain

Is Ross Chastain Worth Rostering for Watkins Glen Lineups?
Austin Cindric

Could Austin Cindric be A Sneaky Tournament Play for Watkins Glen?
Shane Van Gisbergen

Shane van Gisbergen the Heavy Favorite at Watkins Glen
Chase Elliott

Is Chase Elliott a No-Brainer DFS Pick at Watkins Glen?
Chris Buescher

Qualifies 14th at Watkins Glen
Ryan Blaney

Has Upside at Watkins Glen After Signing Contract Extension
Michael McDowell

Still Searching for First Top-Five Finish at Watkins Glen
Carson Hocevar

Is Carson Hocevar Too Aggressive for Road-Course Racing?
Luis Castillo

Mariners Intend to Piggyback Luis Castillo, Bryce Miller
Logan Webb

Placed on 15-Day Injured List With Knee Bursitis
Bryce Miller

is Set to Return on Wednesday
Jeff Hoffman

Could Return to Closer Role
Taj Bradley

Hits the Injured List With Pectoral Inflammation
Kyle Bradish

has Nice Bounce-Back Performance With 10 K's
Sean Strickland

An Underdog At UFC 328
Khamzat Chimaev

Set For UFC 328 Main Event
Tatsuro Taira

Can Become The New Flyweight Champion
Joshua Van

Set For His First Title Defense
Alexander Volkov

Looks To Win Back-To-Back Fights
MMA

Waldo Cortes-Acosta Looks To Extend His Win Streak
CFB

Walker Lyons Could be Go-To Target for Bear Bachmeier
CFB

Ty Benefield a Potential Game-Changer for LSU Defense
CFB

Hayden Lowe Set for Significant Role Following Miami's NFL Departures
CFB

Taylor Wein in Position for Big Season on Oklahoma's Defensive Line
CFB

Rasheem Biles an Instant Impact Player for Texas
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF