X
Lost password?

Don't have an account?
Gain Access Now

X

Receive free daily analysis

NFL
NBA
NHL
NASCAR
CFB
MLB
MMA
PGA
ESPORTS
BETTING

Already have an account? Log In

X

Forgot Password


POPULAR FANTASY TOOLS

#1 Expert Projections
Save 30% Now
Import Your Leagues
Props Tool
Compare Any Players
Compare Any Players
24x7 News and Alerts

DraftKings, FanDuel Daily Fantasy Baseball Picks (9/21/22): Today's Top MLB DFS Lineups

Triston McKenzie fantasy baseball rankings draft sleepers MLB injury news

The top daily fantasy baseball lineup picks for FanDuel and DraftKings on September 21st, 2022. Juan Carlos Blanco's MLB DFS analysis and sleepers for building optimal DFS rosters.

Welcome back to another edition of the FREE DraftKings and FanDuel MLB DFS picks. As customary, we have an all-day ledger on tap Wednesday, and although DraftKings does not have a full-day slate, FanDuel does. Consequently, today's article will feature picks on both sites for games throughout the day, as even on DK, the suggestions will prove viable for someone playing one of the site's split slates.

We have an interesting pitching pool on Wednesday's slate, as there aren't a lot of clear-cut options to choose from. Additionally, some scenarios that would appear to be favorable matchups on the surface, such as Luis Severino's turn against the Pirates in the Bronx, carry an asterisk, as the right-hander could be on a pitch count in his first start off the 60-day IL. However, there are three options I'm confident in, as well as a solid selection of hitters we can target the numerous questionable arms that are taking the hill with.

This article will provide my daily fantasy baseball lineup picks for FanDuel and DraftKings on 9/21/2022 that includes a FanDuel main slate locking at 12:20 pm ET. The lineup will range from some elite players to mid-priced options and value plays. You can also read more DFS advice and lineup picks for other sports. It's also essential to monitor injury news and today's MLB starting lineups. If you have any questions or comments, find me on Twitter and ask away!

Featured Promo! Save 50% on any PGA Premium Pass using discount code MASTERS, this week only! Win more with our DFS and Betting Packages, get expert tools and advice from proven winners including the Lineup Optimizer, Research Station, betting/props cheat sheet and more. GAIN FULL ACCESS HERE

 

DraftKings, FanDuel Pitchers - MLB DFS Lineup Picks

Triston McKenzie - CLE at CWS ($10,100 DK, $9,600 FD)

McKenzie may only have a 10-11 record, but it's accompanied by an impressive 3.08 ERA, 0.97 WHIP, and solid 8.7 K/9. The big right-hander has really hit his stride down the stretch as well, pitching to a 2.41 ERA, 0.92 WHIP, 9.3 K/9, and improved 1.0 HR/9 over the 52.1 innings covering his last eight starts. That sample includes a gem of a quality start against the White Sox on Aug. 19th where he struck out 14 over seven frames.

McKenzie had also been very effective against Chicago in two prior starts this season, allowing just two runs over 10 innings in that pair of outings. Current ChiSox bats only have a collective .217 average and .611 OPS against McKenzie in 117 career encounters as well, and the White Sox, despite their abundance of big names, have just a middling .316 wOBA and .159 ISO against right-handed pitching in September.

Robbie Ray - SEA at OAK ($9,600 DK, $10,000 FD)

Ray has had his share of troubles on the road and comes into Wednesday's start with back-to-back rocky starts against the Braves and Angels. However, the southpaw has a favorable matchup in a pitcher's park against a team he's already enjoyed success against on multiple occasions this season, making him worthy of consideration in both cash games and tournaments as he aims for a bounce-back performance.

Ray has pitched to a 2.41 ERA across 18.2 innings in three starts against Oakland this season, and current A's bats own a collective .163 average and .466 OPS against him in 50 career plate appearances, a sample in which Ray has compiled 20 strikeouts. Oakland has also been the AL's worst team against left-handed pitching at home in the second half of the season, producing a .214 average, .604 OPS, .264 wOBA, and -9.1 wRAA in a sample of 260 plate appearances. The A's even have just a 5.8 percent walk rate in that split, which helps guard against Ray's occasional control issues.

Other options: Miles Mikolas - STL at SDP ($9,100 DK, $8,800 FD)

Want more MLB DFS tools and content? Our MLB Premium package includes our daily DFS Cheat Sheets, Research Station, Optimizer, and access to our Premium Slack Chatrooms, where members can chat with our MLB analysts. Check out this recent big win from RotoBaller's Jon Anderson on DraftKings - join in on the winning!

 

DraftKings, FanDuel Infielders - MLB DFS Lineup Picks

Matt Olson - 1B, ATL vs. Josiah Gray ($4,900 DK, $3,000 FD)

Olson entered Tuesday's action with a whopping 70 extra-base hits, including 28 homers, and 91 RBI in his first season for the defending champions. While a high strikeout rate is part of the package with Olson, deploying his powerful left-handed swing against a right-hander in Gray who's been absolutely incapable of keeping the ball in the park certainly makes sense, especially at very reasonable salaries on both sites.

Olson has slugged 22 of his 28 round trippers off right-handed pitching, and he owns a .339 wOBA and .234 ISO against that handedness at home. Meanwhile, Gray has given up a jaw-dropping 37 home runs across 136.2 innings. He's allowed 22 of those to left-handed hitters, which have tagged him for a .268 average, .987 OPS, and .417 wOBA, along with a 21.6 percent HR/FB rate.

Jeff McNeil - 2B, NYM at Adrian Houser ($4,200 DK, $2,900 FD)

Houser hasn't been anywhere near as effective as during his career-best 10-6 season in 2021, generating a 6-9 mark, 4.85 ERA, and 1.49 WHIP across 94.2 innings. The veteran right-hander has been better at home, but he's still enduring his usual struggles against left-handed bats; the highly reliable McNeil, who entered Tuesday with a .320 average and .822 OPS, therefore makes for an excellent option to deploy against him.

Houser has given up a .313 average and .379 wOBA to left-handed hitters overall, and although he's had more trouble against them on the road, he still carries a bloated 5.89 BB/9 and 4.76 xFIP against them at home. Then, McNeil has been at his best when facing right-handed pitching on the road, where he owns a .341 average, .880 OPS, and .380 wOBA against that handedness.

He also went into Tuesday's action with a .328 average and .359 wOBA in 80 plate appearances across 18 September games. Then, the matchup remains favorable for McNeil when Houser exits, as Milwaukee relievers have pitched to a .278 BAA and .351 wOBA against lefty bats in September.

Trea Turner - SS, LAD vs. Madison Bumgarner ($5,600 DK, $4,100 FD)

Turner is in the midst of yet another MVP-caliber season, entering Tuesday with a .304 average, .829 OPS, 20 homers, 97 RBI, and 25 steals. The veteran shortstop has been very effective against either handedness of pitcher as those numbers imply, but he's been at his best versus southpaws and faces an aging, struggling one in Bumgarner. MadBum's last double-digit win season came in 2016, and he enters Wednesday's start with a career-high 15 losses along with a 5.01 ERA and 1.48 WHIP.

Turner boasted a .329 average, .944 OPS, .404 wOBA, and .233 ISO against left-handed pitching at Dodger Stadium going into Tuesday night's action, as well as a .346 wOBA and modest 15.5 percent strikeout rate in 71 plate appearances in September. He's also been an outstanding clutch hitter all season with a .307 average with runners on base, including a .325 figure with men in scoring position, a trait that comes in especially handy in a star-studded lineup that offers so many RBI opportunities.

For his part, Bumgarner has been victimized by right-handed bats on the road for a .311 average, .386 wOBA, and 5.17 xFIP, while also surrendering an elevated 39.8 percent hard-contact rate in that split.

Josh Jung - 3B, TEX vs. Tucker Davidson ($2,200 DK, $3,100 FD)

Jung has been a bright spot overall during his brief time in the majors after a promising minor-league career, holding his own against big-league arms early with a respectable .250 average and impressive .800 OPS across his first 40 big-league plate appearances entering Tuesday.

The rookie has been particularly effective against left-handed pitching, continuing a trend he exhibited during his minors days at multiple stops, and he draws an appealing matchup against a southpaw in the favorable hitting environment of his home park Wednesday.

Jung went into Tuesday's game hitting .316 with a 1.053 OPS and .443 wOBA over his first 19 plate appearances versus lefties, a sample in which he'd quickly belted a pair of doubles and two homers on the strength of a 50.0 percent hard contact rate. Davidson seemingly makes for a good target to pick on, considering he's pitched to a .291 average and .353 wOBA against right-handed hitters, along with a 1.68 WHIP and 5.47 xFIP when facing them on the road.

Other options: Dansby Swanson - SS, ATL vs. Josiah Gray ($5,500 DK, $3,600 FD); Ryan McMahon - 3B, COL vs. SFG ($5,200 DK, $3,100 FD)

 

DraftKings, FanDuel Outfielders - MLB DFS Lineup Picks

Charlie Blackmon - COL vs. Logan Webb ($5,100 DK, $3,000 FD)

Blackmon is enjoying another impressive season in Colorado despite his club being a non-contender yet again. The veteran outfielder entered Tuesday's action with a solid .263 average, .734 OPS, 42 XBH, and 76 RBI. Blackmon is also thriving as usual in his home park, and he's facing a right-hander in Webb that he's enjoyed plenty of success against before and that's shown some vulnerability in a couple of recent starts.

Blackmon has tagged Webb for a .450 average with three doubles, a homer, and only three strikeouts in 23 career encounters, and he's teed off on right-handed pitching at Coors Field for a .803 OPS, .341 wOBA, and .221 ISO. Webb has allowed an elevated .282 average and .437 slugging percentage to the 73 batters he's faced thus far in September, including a .355 average, 1.020 OPS, and .432 wOBA to 32 lefty bats in that sample. Webb has allowed a .276 average and .344 wOBA to lefty hitters on the road this season overall, and the Coors Field environment only makes it a more dangerous scenario for him. Giants relievers also have a .341 wOBA against lefty hitters in September, furthering Blackmon's case.

Joc Pederson - SFG at German Marquez ($5,100 DK, $2,700 FD)

Pederson has put together quite the comeback season during his first year in San Francisco, taking a career-high .260 average into Tuesday night's action and complementing it with an excellent .841 OPS. The lefty-swinging slugger has slugged 13 of his 22 homers outside his pitcher-friendly home park, and Wednesday, he makes for an excellent way to gain access to Marquez at Coors and his vast struggles against left-handed hitters.

Marquez has yielded a .326 average, .397 wOBA, and 2.2 HR/9 to left-handed hitters at Coors Field, partly the byproduct of the fact he's conceded a 27.0 percent line-drive rate and 40.1 percent hard-contact rate in that split. Pederson is therefore a highly dangerous opponent for him, considering his prodigious power and the fact he's posted a .272 average, .903 OPS, and .380 wOBA versus right-handed pitching on the road, along with a 44.4 percent hard-contact rate.

Julio Rodriguez -  SEA at James Kaprielian ($5,500 DK, $4,100 FD)

Rodriguez jumped back into the lineup Tuesday night after missing three games with a tight lower back, so he should be good to go for this favorable matchup against Kaprielian. The AL Rookie of the Year frontrunner has already tormented the A's right-hander on numerous occasions in the past, posting a .500 average with two triples and a homer over 12 plate appearances without striking out once in that sample. Rodriguez also came into Tuesday's game on quite the tear, having generated a .447 average, five homers, and a 1.428 OPS over the previous 10 games.

Kaprielian has had plenty of positive moments this season, but he's still given up a .299 average, .407 wOBA, and .951 OPS to right-handed hitters at home, along with a 1.9 HR/9 and 6.19 xFIP. Rodriguez has thrived against right-handed pitching on the road as well, as evidenced by his .281 average, .825 OPS, and .357 wOBA in that split, as well as a 37.0 percent hard-contact rate.

Other options: Mike Yastrzemski - SFG at German Marquez ($4,200 DK, $3,100 FD); Mike Trout - LAA at Dane Dunning ($6,200 DK, $4,300 FD)

 

DraftKings, FanDuel MLB DFS Stacks

  • Braves vs. Josiah Gray, WAS, RHP
  • Rockies vs. Logan Webb, SFG, RHP
  • Giants at German Marquez, COL, RHP



Download Our Free News & Alerts Mobile App

Like what you see? Download our updated fantasy baseball app for iPhone and Android with 24x7 player news, injury alerts, sleepers, prospects & more. All free!




MLB DFS News and Injury Alerts


More DFS Lineup Picks and Analysis




POPULAR FANTASY TOOLS

#1 Expert Projections
Save 30% Now
Import Your Leagues
Props Tool
Compare Any Players
Compare Any Players
24x7 News and Alerts

REAL-TIME FANTASY NEWS

Shai Gilgeous-Alexander

Posts 25 in Series Opener
Paul George

Delivers 17 Points Against Boston
Tyrese Maxey

Leads 76ers in Game 1 Defeat
Jaylen Brown

Scores 26 Points in Game 1 Victory
Jayson Tatum

Posts Double-Double in Game 1 Win
Peyton Watson

Still Sidelined for Game 2
Anthony Richardson Sr.

Dynasty Value at All-Time Low
NFL

David Bailey Visits Several Teams Leading Up to the NFL Draft
Anthony Edwards

Listed as Questionable for Game 2
NFL

Oscar Delp Takes Several Visits Ahead of Draft
NFL

Chiefs Talking with Cardinals About the No. 3 Pick
Carson Beck

Steelers Eyeing Carson Beck in the Draft?
Thomas Bryant

to Remain Out Monday
Juan Soto

is on Track to Return Next Homestand
Cade Cunningham

Playing Without Minutes Restriction Sunday
Corbin Carroll

Exits Sunday's Game with Back Tightness
OG Anunoby

Tagged as Probable for Monday
Onyeka Okongwu

Might Miss Game 2 Against Knicks
Immanuel Quickley

Questionable for Game 2
Jordan Goodwin

Ruled Out for Rest of Game 1
Jonathan Isaac

Ruled Out for Sunday
Desmond Bane

Available for Game 1
Artem Zub

Uncertain for Game 2
Karel Vejmelka

Makes Playoff Debut Sunday
Carter Hart

in Vegas Crease for Playoff Opener
Jeremy Swayman

Begins Fifth Postseason Campaign
Alex Lyon

Available for Game 1
Dominic James

Activated From Injured Reserve
NFL

Zachariah Branch Arrested for Misdemeanor Obstruction
New York Giants

Sonny Styles One of the Top Targets for Giants at No. 5 in NFL Draft
Renardo Green

49ers Looking to Trade Renardo Green?
Keenan Allen

Chargers Not Closing the Door on a Reunion With Keenan Allen
Grayson Allen

is Available for Game 1 on Sunday
A.J. Brown

Eagles Preparing for A.J. Brown's Departure?
Peter Skoronski

Titans to Pick Up Peter Skoronski's Fifth-Year Option
Breece Hall

Dynasty Upside Remains Limited by Offensive Environment in New York
Cincinnati Bengals

Dexter Lawrence Signing One-Year Extension With Bengals
Kristaps Porzingis

Unsure About Returning to Golden State
Drake London

Dynasty Upside Remains Limited by Quarterback Questions in Atlanta
Mark Williams

is Ruled Out for Game 1 on Sunday
Chris Olave

Dynasty Value Rising After Resurgent 2025 Season
Coby White

Hornets Want to Bring Back Coby White
Bucky Irving

Can Bucky Irving Bounce Back After Injury-Marred 2025?
Kenneth Walker III

a Major Dynasty Riser After Offseason Move to Kansas City
Desmond Bane

Considered Probable for Game 1
Bo Nix

Dynasty Value in Question Coming Off Injury?
Tarik Skubal

Fans 10 in Win Over Red Sox on Saturday
Raisel Iglesias

Dealing With Shoulder Issue
Davante Adams

Glaring Opportunity to Sell High on Davante Adams?
Jordan Addison

Can Jordan Addison Overcome Ugly Quarterback Situation?
Emeka Egbuka

a Trade Target in Some Dynasty Leagues
Kyle Larson

Should not be Underestimated for the Win at Kansas
Denny Hamlin

Can Denny Hamlin Dominate at Kansas Again?
NASCAR

Christoper Bell Should Contend for First Win at Kansas
Joel Eriksson Ek

Powers Minnesota Past Dallas in Opening Game
Tyler Reddick

Fastest in Practice and Qualifying for Kansas Race
Ryan Blaney

Could Score another Top-10 Finish at Kansas
Ty Gibbs

Poised to Continue Hot Streak at Kansas
Logan Stankoven

Makes Big Impact in Carolina's Game 1 Victory
Chris Buescher

Always Consistent, Has Speed Heading Into Kansas
William Byron

is A Solid DFS Option for Kansas Lineups
Carson Hocevar

Poised for Career-Best Run at Kansas
Porter Martone

Nets Game-Winning Goal to Defeat Pittsburgh
Frederik Andersen

Shuts Out Ottawa in Game 1
Chase Briscoe

Is Chase Briscoe Worth Rostering for DFS at Kansas?
Chase Elliott

Is A Favorable DFS Option for Kansas Lineups
Matt Boldy

Delivers Huge Game 1 Performance in Win
Joey Logano

Could Joey Logano be Considered Playable In DFS This Week at Kansas?
NASCAR

Bubba Wallace is A Favorable Driver to Consider for Kansas Lineups
Ross Chastain

Is Ross Chastain A Worthy DFS Option for Kansas?
Brad Keselowski

Could Brad Keselowski be A Sneaky DFS Option for Kansas?
Daniel Suarez

Should DFS Managers Roster Daniel Suarez at Kansas?
NHL

NHL DFS Picks and Heat Map (Premium Content) - April 19, 2026
Dylan Harper

is Ready for Sunday's Game
Stuart Skinner

Starting Game 1 Against Flyers
Alexandre Carrier

Back at Practice
Jared McCann

Undergoes Lower-Body Procedure
Andrei Kuzmenko

Activated From Injured Reserve
Victor Hedman

Out for Game 1 on Sunday
William Karlsson

Unavailable for Start of First-Round Series
Quinn Hughes

Available Saturday
Miro Heiskanen

Cleared for Game 1
Jhoan Duran

Placed on 15-Day Injured List With Oblique Strain
Kyle Stowers

Will be Activated on Sunday
Jesper Wallstedt

to Start in Goal for Minnesota on Saturday
Max Muncy

has Another Multi-Homer Game at Coors Field
Lourdes Gurriel Jr.

Expected to Make Season Debut on Saturday
Austin Riley

Hits Two Home Runs in Shutout Win Over Phillies
Daulton Varsho

Removed Early on Friday With Knee Discomfort
Edwin Uceta

Having More Shoulder Issues, "Shut Down for a Few Days"
Josh Hader

Moved to 60-Day Injured List
Willson Contreras

Returns to Red Sox Lineup on Friday
Daniel Palencia

Goes on 15-Day Injured List With Oblique Strain
Juan Soto

Still on Track to Return Next Week
Los Angeles Angels

Garret Anderson Dies at 53 Years Old
Mike Malott

A Favorite At UFC Winnipeg
Gilbert Burns

Set For UFC Winnipeg Main Event
Kyler Phillips

Set UFC Winnipeg Co-Main Event
Charles Jourdain

Looks To Extend His Win Streak
Jai Herbert

An Underdog At UFC Winnipeg
Mandel Nallo

Set For His UFC Debut
Karine Silva

Looks To Get Back In The Win Column
Jasmine Jasudavicius

Looks To Bounce Back
Parker Messick

Flirts With No-Hitter in Latest Gem Against Orioles
Mike Trout

Hits Five Homers in Series Versus Yankees
Spencer Arrighetti

Fans 10 in Season Debut, to Remain a Focal Point in Rotation?
Nick Pivetta

Dealing With Flexor Strain, Could Miss Months
Nico Hoerner

Homers, Drive in Five in Win Over Phillies
Patrick Reed

RBC Heritage PGA Betting Model and Outright Betting Picks (Premium)
Keegan Bradley

PGA DFS Expert Roundtable and Survey - 2026 RBC Heritage (Premium) - RotoBaller Team Picks
Billy Horschel

Matt Miller's 2026 RBC Heritage Longshot Bets
Jordan Spieth

PGA Betting Expert Roundtable: RotoBaller Staff Picks - 2026 RBC Heritage (Premium)
Jordan Spieth

DraftKings Core Four: PGA DFS - 2026 RBC Heritage (Premium Content)
Jason Day

RotoBaller's One And Done Picks To Consider - 2026 RBC Heritage (Premium)
CFB

Michigan Lands Commitment From Quarterback Kamden Lopati
Daniel Berger

Patrick's Picks: Top Betting Plays for 2026 RBC Heritage (Premium)
Sahith Theegala

Brings Strong Form Into Harbour Town
Wyndham Clark

Needs Putter to Show Up at RBC Heritage
Jordan Spieth

PGA Course Preview and Betting Picks: 2026 RBC Heritage (Premium)
Jacob Bridgeman

Looks to Return to Elite Form at Harbour Town
J.J. Spaun

a Volatile Option at RBC Heritage
PGA

Sungjae Im Offers High-Upside Value at RBC Heritage
Matt Fitzpatrick

Set for Another Strong Showing at RBC Heritage
Jason Day

Eyes Bounce-Back After Sunday Struggles at the Masters
Akshay Bhatia

Looking to Rebound at Harbour Town
Cameron Young

Hoping to Secure Second Win of Season at RBC Heritage
Scottie Scheffler

Looks to Win Again at RBC Heritage
Shane Lowry

Has Disappointing Final Round at Masters
Viktor Hovland

Hoping to Build on Final Round at Masters
Brian Harman

Struggling For Consistency Heading to RBC Heritage
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF