Best MLB Strikeout Props to Bet Today (4/22)

Frank Ammirante's best MLB player prop bets for today (4/22/2025). Bet his strikeout props (K props) for strikeouts thrown and win money betting on MLB player props.

We've got a few intriguing strikeout props today. Some of the highlights include Tanner Bibee trying to get his season back on track against the Yankees and Edward Cabrera looking to replicate what his teammate Max Meyer just did against the Reds.

The process behind these strikeout props focuses on several factors, including recent performance, head-to-head matchups, park factor, and weather conditions. It's also worth considering each player's hit rate on the assigned number while taking price into account. You don't want to lay too much juice on strikeout props.

In this article, I'll provide my top strikeout prop bets for the MLB games on Tuesday, April 22, 2025. Odds are courtesy of DraftKings Sportsbook, but it's a good idea to shop around for the best odds.

MLB Prop Bets - Today's Strikeout Prop Picks

Here are the starting pitchers I'll cover for Tuesday, April 22:

• Tanner Bibee, Cleveland Guardians
• Edward Cabrera, Miami Marlins
• Cristopher Sanchez, Philadelphia Phillies
• Bailey Ober, Minnesota Twins
• Kris Bubic, Kansas City Royals

Tanner Bibee UNDER 5.5 Strikeouts vs New York Yankees (+115 DraftKings)

As a Tanner Bibee fantasy owner, I’m trying to figure out how concerned I should be. Here are the things that stand out to me👇🏻

Barrel% ⬆️8%
xSLG% ⬆️.123 😳
K% ⬇️9.1% 😳
BB% ⬆️6.4% 😳
First Pitch Strike% ⬇️3.7

Cutter: this pitch is getting absolutely walloped to the tune of a… pic.twitter.com/kfFozxffw2

— Tablesetters: A Baseball Podcast (@tablesetterspod) April 18, 2025

Tanner Bibee has gotten off to a poor start to the season, putting up a 5.85 ERA and 1.50 WHIP with a 17.2 percent strikeout rate and 12.6 percent walk rate in 20 innings. It doesn't look too good under the hood, as highlighted by Bibee's abysmal 5.14 SIERA and 9.8 percent swinging-strike rate.

During this stretch, Bibee has failed to rack up six or more strikeouts in each of his four starts.

That's why I'm scratching my head when I see under 5.5 strikeouts listed at +115 odds in this spot. So the question is, why?

For one, it appears that oddsmakers are projecting that it's only a matter of time before Bibee gets back on track. After all, this is a pitcher who posted a 26.3 percent strikeout rate last season.

Secondly, Bibee has a 30.4 percent strikeout rate in 23 plate appearances vs the current Yankee lineup. This includes Austin Wells (two strikeouts in three PA), Anthony Volpe (one strikeout in six PA), and Jazz Chisholm Jr. (one strikeout in 3 PA).

It's also likely that the books are looking at the Yankees' strikeout rate in the last seven days. Heading into Monday's action, New York had a 23.2 percent strikeout rate in the last week. Gavin Williams ended up racking up eight strikeouts in 6.1 innings on Monday.

While Bibee has a strong track record in his favor, I have to take this under because of the appealing +115 price. I'm betting against Bibee until he shows that he's back to his form from last year. It also helps that the Yankees walk at a high rate (10.2 walk rate, seventh in MLB), which can elevate Bibee's pitch count, allowing us to his this under.

Edward Cabrera OVER 5.5 Strikeouts vs Cincinnati Reds (+100 DraftKings)

Edward Cabrera, Filthy 95mph Turbo Changeup. 👌 pic.twitter.com/hdDsnraRg0

— Rob Friedman (@PitchingNinja) April 11, 2025

Edward Cabrera has consistently shown the ability to be a prolific strikeout pitcher, posting a strikeout rate of 24 percent or better in each of the last four seasons. This includes a swinging-strike rate of at least 12 percent in three of those years. The problem has always been control, as he has registered double-digit walk rates throughout his major league career.

Despite the issues with walks, Cabrera has shown a high strikeout ceiling in the past. Last season, the Marlins righty had five starts with eight or more strikeouts. In his lone outing against the Reds, he racked up seven punchouts in only three 1/3 innings -- even despite allowing seven earned runs.

While the Reds came into Monday with a 21.9 percent strikeout rate vs righties (15th), we just saw teammate Max Meyer mow through this lineup, racking up an impressive 14 strikeouts in six innings.

That's why I'm confident that Cabrera can get to six or more strikeouts. It also helps that he was able to put up six strikeouts against the Diamondbacks and five strikeouts against the Nationals, two teams that are tougher to strike out.

Look for the Marlins' righty to have a good chance at getting to six+ K in this pitcher-friendly environment at home.

Cristopher Sanchez UNDER 5.5 Strikeouts at New York Mets (+115 DraftKings)

Cristopher Sanchez looks poised for a career year, putting up an impressive 30.7 percent strikeout rate, which is a significant increase from last year's 20.3 percent strikeout rate. However, it's worth noting that this rate is inflated by Sanchez's last start, in which he struck out 12 batters in seven innings against the Giants.

When looking at Sanchez's numbers, one thing that stands out is his home/away splits. This is a pitcher who put up a 16.4 percent strikeout rate on the road last year, compared to a 23.3 percent strikeout rate at home. This is a trend that has continued throughout the year so far. In Sanchez's lone away start, he put up only three punchouts in six 1/3 IP.

We should also mention that it's not like the matchup vs the Mets is easy, as they've posted a 22.7 percent strikeout rate vs. LHP this season, which ranks 8th in MLB.

When you consider Sanchez's track record on the road along with the matchup with the Mets, you have to be interested in the +120 price on under 5.5 strikeouts. This is a lefty who went under this number in 10 of 14 road starts last year.

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Bailey Ober OVER 6.5 Strikeouts vs Chicago White Sox (+110 DraftKings)

We're getting a high bar on Bailey Ober at 6.5 strikeouts considering that he has a 20.0 percent strikeout rate so far this year, but you have to love the matchup at home vs the White Sox. This is a lineup that has registered a 75 wRC+ vs righties this year, which ranks 28th in MLB.

While the strikeout rate isn't too bad for Chicago (22.9 percent strikeout rate vs RHP), this is a spot where Ober can get there in volume. Since the White Sox lineup is so weak, that means we could see a deeper outing than usual for the Twins righty. It wouldn't surprise me to see Ober pitch into the seventh inning in this spot.

Another noteworthy stat here is that Ober has a 31.4 percent strikeout rate in 70 PA against the current White Sox lineup. This includes Andrew Vaughn (nine strikeouts in 20 PA) and Luis Robert Jr. (five strikeouts in 11 PA).

The best part about taking the over here is that we're getting +110 odds, which helps mitigate the risk with the higher number. Ober has shown a high strikeout ceiling in the past, including four double-digit strikeout games last year. Don't be surprised to see him do that again in this spot.

Kris Bubic OVER 7.5 Strikeouts vs Colorado Rockies (+115 DraftKings)

Kris Bubic, Dirty 82mph Sweeper...and Sword. ⚔️ pic.twitter.com/DFLXkHH3V7

— Rob Friedman (@PitchingNinja) April 11, 2025

Here we have a similar prop to Ober, where we're targeting a high number on another pitcher in a smash spot: Kris Bubic. This is a fantastic matchup at home against the Rockies, who have a 32.5 percent strikeout rate (30th) and 49 wRC+ (30th) on the road.

Bubic has been one of the early breakouts so far, putting up an impressive 26.2 percent strikeout rate and 3.44 SIERA. Facing such a weak lineup as the Rockies at home can allow Bubic to pitch into the seventh inning, which we've seen him do already once this season.

The Royals' lefty has racked up eight or more strikeouts in two of his four outings, so this is attainable vs the Rockies. It wouldn't surprise me to see him get to 10+ strikeouts in this spot.

We just saw another lefty in MacKenzie Gore completely dominate the Rockies with 13 strikeouts in six innings. Look for Bubic to do something similar here. At +115 odds, you have to love the price given the matchup.

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