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DraftKings Daily Fantasy Baseball Picks (5/22/19): MLB DFS Lineups

The top daily fantasy baseball lineup picks for DraftKings on May 22nd, 2019. Austyn Varney's MLB DFS analysis and sleepers for building optimal DFS rosters.

Tonight's main slate starts at 7:05pm eastern and covers 11 games. There's also an all day slate starting at 1:05pm eastern that includes a few extra early games. We'll be focusing on the main slate, where we have plenty of pricey options to look through and some value plays to fit in as well. Let's dive in to each position!

In this article, I will be providing you with my daily fantasy baseball lineup picks for DraftKings on 5/22/2019. These picks will range from some of the elite players to mid-priced options and value plays.

We also provide DFS lineup picks for DraftKings and other sports. If you have any questions or comments, feel free to contact me on Twitter @varneydfs.

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DraftKings DFS Pitchers

Gerrit Cole, HOU (vs. CWS) ($12,000)

Gerrit Cole, Max Scherzer, and Jacob deGrom make up your top three pitching options. Scherzer and deGrom will be dueling and neither are a clear favorite. Cole on the other hand, is an insane -350 favorite. That’s as big as it gets in baseball. The White Sox aren’t a terrible team, but rank 17th against right-handers and strikeout at a healthy 26% clip. Gerrit Cole has been great over his last few starts and this isn’t the matchup to mess up his groove. Cole is expensive, but the top option in both formats if you can fit him.

Max Fried, ATL (@ SFG) ($8,500)

If you’re wanting to save a few dollars for your SP2, look no further than Max Fried. Fried can be a bit up and down, but he’s held both lefties and righties under a .285 wOBA. He’s striking out 8.5 batters per nine and has his command under control down to 1.5 BB/9. He enters one of the biggest ballparks in the game in AT&T Park to face off with an underwhelming Giants lineup that strikes out and struggles to hit for power. The Braves are favorites on the road and I could see a big day out of Fried for an affordable tag.

 

DraftKings DFS Infielders

C - Gary Sanchez, NYY (@BAL) ($5,500)

It doesn’t get much worse than Dan Straily. Through 8 starts this season, he’s gone 30.2 innings and has given up 29 earned runs. He now faces a tough Yankees lineup that has been hitting well without their best players. Gary Sanchez is still around, though, and he’s making his presence known. He may be expensive, but he’s so much stronger than any other catcher and has legitimate 2-HR upside every night. If you don’t want to spend much at the position, Buster Posey is always worth a look against a lefty.

1B - Yuli Gurriel, HOU (vs. CWS) ($3,900)

It’s starting to look like the career of Ivan Nova is coming to a close. Unless he dramatically changes his approach, he’s not going to last long. He’s been teed off on by both sides of the plate and hasn’t shown any signs of unluckiness or regression. He now faces off with the Astros, who’ll give him no break. If you want to save at 1B, Yuli Gurriel is consistent and will get a ton of RBI opportunities. He’s also only $3,900 on DraftKings and gives you cheap exposure to the top offense of the night. You can play him at third as well.

2B - Starlin Castro, MIA (@ DET) ($2,900)

Starlin Castro is extremely cheap on DK and I don't see the reason for it. Yes, he's not the greatest hitter, but he's in the heart of a Marlins lineup that's projected to put up 4.5 runs tonight. Castro has also always destroyed lefties. He's currently sporting a .390 wOBA and has shown no signs of slowing down. Daniel Norris has struggled against righties and the Marlins are better against southpaws. Castro and Anderson are both extremely cheap and I love pairing them with a more expensive combo from another team.

SS - Jorge Polanco, MIN (@LAA) ($4,700)

Jorge Polanco is one of my favorites hitters in baseball to roster. He seems to always com through in one way or another, and always has a big game when the Twins put up runs. He’s hitting .335 on the season with 8 home runs and a .400+ wOBA. Tonight, he faces off against Matt Harvey and the Angels. Harvey has been pitiful against lefties, allowing a .395 wOBA and 7 homers in just over 40 innings. The Twins are a juggernaut offense and Polanco himself is a tough out every time. As a switch-hitter, he always has the platoon advantage and will never see huge mismatch. He’s expensive, but cheaper than a lot of the other SS’s and he shouldn’t be. He’s my favorite of all, no matter the price.

3B - Alex Bregman, HOU (vs. CWS) ($5,500)

Bregman is expensive, but he may be worth paying up for on this slate. He’s one of the all-around best hitters in baseball and has slaughtered righties with a .427 wOBA followed by 11 homers. Ivan Nova will be lucky to last four innings tonight and it’s safe to expect five at-bats out of the Astros tonight. Now can Nova go through a CGSO? Yes, it’s baseball, but the Astros have the highest implied total on the night and are certainly safe to plant your flag on. If you want to go cheap here, just move to Gurriel.

 

DraftKings DFS Outfielders

OF - Mike Trout, LAA (vs. MIN) ($5,700)

If you’re going to pay up for an outfielder, Mike Trout is facing off against a lefty that likes to throw low in the zone. We know Trout lives in the lower third and he will make Perez pay for every mistake he makes. Perez has been pretty good this year on the surface, but a 4.23 xFIP and .263 BABIP tell a different story. He’s been a bit lucky, but by no means bad. He’s just no match for Mike Trout, who’s sported a .400+ wOBA against lefties for years now. There isn’t a ton of money to spend for fun on this slate, but Trout is the way to go if you can and I doubt he’s higher than 10% owned.

OF - Josh Reddick, HOU (vs. CWS) ($4,400)

We’ll close out our Astros love with Josh Reddick. For whatever reason, he’s cheaper than Marisnick and lets you spend up elsewhere while maintaining huge upside. It’s not like Reddick is having a bad year, either. His power numbers are a bit off, but he’s had four hit the warning track and could easily be at 8. Ivan Nova has always struggled against lefties, but a .425 wOBA is just unacceptable. He doesn’t have a strikeout pitch and can’t hold a runner. The Astros are the top offense of the night and it just comes down to fitting them in. There’s a reason for the price.

OF - Brian Anderson, MIA (@ DET) ($3,100)

This one may come out of left field, or third base, but you know what I mean. Brian Anderson has cooled off from his rookie season, but is still holding a wOBA over .340 against lefties. He has a power stroke and is the most consistent bat in the lineup with RISP. Daniel Norris is terrible against right-handers and struggles with the long ball. The Marlins aren’t a very exciting offense, but they’re better against lefties and Anderson has been swinging the bat nicely. He’s also extremely cheap and has solid positional versatility.

MLB DFS News and Injury Alerts




REAL-TIME FANTASY NEWS

Cal Raleigh

Exits With Apparent Side Injury on Wednesday Night
Juan Soto

X-Rays Come Back Negative on Juan Soto's Ankle
Jacob Misiorowski

Pulled Early With Possible Leg Injury
Juan Soto

Exits Wednesday's Game Early with Ankle Injury
Tim Patrick

Jets Agree to Terms With Veteran Receiver Tim Patrick
Malik Nabers

Undergoes Second Knee Surgery
De'Von Achane

Dolphins, De'Von Achane Agree to Four-Year Contract Extension
Kevin Huerter

is Cleared to Return for Game 5
Caris LeVert

is Available for Game 5 on Wednesday
Duncan Robinson

is Out for Game 5
Keegan Murray

Undergoes Ankle Procedure
Josh Giddey

Undergoes Ankle Surgery
Pete Fairbanks

Returns From Injured List
Christian Yelich

Out With Back Tightness on Wednesday Night
Nathan MacKinnon

Chasing History Wednesday
Ryan Poehling

Won't Be an Option for Game 6
Sam Malinski

Set to Miss Second Straight Game
Artturi Lehkonen

Unlikely to Play Wednesday
Matthew Schaefer

Wins Calder Trophy
TOR

Maple Leafs Fire Head Coach Craig Berube
Jalen Hurts

Can Jalen Hurts Bounce Back as a Rusher in 2026?
Robby Snelling

Placed on 15-Day Injured List with Elbow Sprain
Zach Charbonnet

Dynasty Value in Question Entering 2026
DeVonta Smith

Poised to Reach a New Level of Production in 2026?
Chris Olave

Facing Increased Target Competition in New Orleans Entering 2026
Chris Bell

Dynasty Stock Rising Following NFL Draft
Ted Hurst

Facing Uphill Battle for Playing Time in Tampa Bay
Francisco Alvarez

Mets Place Francisco Alvarez on Injured List With Torn Meniscus
Max Fried

Dealing With Left Elbow Posterior Soreness
CFB

NFL Veteran Tom Moore Joins Iowa Coaching Staff
CFB

Can Cam Cook Dominate in Return to Big 12?
Chris Brazzell II

Is Chris Brazzell II the Top Deep Threat in Carolina's Receiver Room?
Kaelon Black

a Threat to Win Backup RB Job in San Fran?
CFB

ACC, Big 12 Support 24-Team College Football Playoff
De'Zhaun Stribling

to be 49ers' New "F" Receiver?
CFB

Anthony Colandrea Looking to Elevate Nebraska Back to National Contention
Drew Allar

Steelers "Uninstalling" Everything Drew Allar Learned in College
CFB

Kwazi Gilmer Set for Big Impact at Nebraska
Ja'Kobi Lane

Is Ja'Kobi Lane the Pass-Catching Answer the Ravens Have Been Seeking?
Zachariah Branch

Does Zachariah Branch Have a Path to Immediate Production?
Max Klare

Can Max Klare Separate Himself in Rams' Tight End Room?
Eli Stowers

the Tight End of the Future in Philadelphia?
Justin Thomas

Trending Well Ahead of PGA Championship Despite Concerning Form
J.J. Spaun

Trending Up Ahead of PGA Championship
Adam Scott

Riding Strong Form Into PGA Championship
Patrick Reed

Looking to Make Another Run at PGA Championship
PGA

Sungjae Im Looks to Build on Strong Finish at Truist Championship
Sam Burns

Must Keep Ball in Play at PGA Championship
Jordan Spieth

Looks to Complete Career Grand Slam at Aronimink
Brandt Snedeker

Not the Best Option for the PGA Championship
Rasmus Hojgaard

a Volatile Option at PGA Championship
Germie Bernard

Already in a Tough Spot to Hold Dynasty Value
Ayo Dosunmu

Has Busy Night in Game 5
Maverick McNealy

Seeking Better Start in Philadelphia
Harry Hall

a Boom-or-Bust Option at Aronimink
Jaden McDaniels

Notches 17 Points in Game 5 Loss
Denzel Boston

a Smart Bet to Meet or Exceed Value in Dynasty Rookie Drafts
Hideki Matsuyama

Attempts to Improve Over 2025 PGA Championship
Scottie Scheffler

Looks to Defend PGA Championship at Aronimink
Julius Randle

Posts a Double-Double in Losing Effort
Matthew Stafford

a Sell Candidate with Touchdown Regression Likely on its Way
Nicolai Hojgaard

Wants to Keep Momentum Rolling in Philadelphia
Anthony Edwards

Held to 20 Points in Game 5 Loss
Ben Griffin

Attempting to Bounce Back After Truist Championship
CFB

Transfer Defensive Lineman Devarrick Woods Commits to Clemson
Keldon Johnson

Comes Alive in Game 5 Against Timberwolves
Jayden Reed

Dynasty Value Tethered to His Underwhelming Usage
Harris English

Will Need His Putter to Thrive at Aronimink
Stephon Castle

Makes All-Around Impact in Game 5
Victor Wembanyama

Leads Spurs to Big Win in Game 5
Akshay Bhatia

Creative Flair Could Show Itself in Philadelphia
Keegan Bradley

Knows the Aronimink Golf Club Well
Mason McTavish

Delivers Two Assists Tuesday Night
Pavel Dorofeyev

Pots Two Goals in Vital Game 5 Win
Josh Doan

Records Two Assists in Game 4 Victory
Evgeni Malkin

Penguins Want Evgeni Malkin Back
Sidney Crosby

Joins Team Canada for World Championship
Ryan Poehling

Suffers Upper-Body Injury in Game 5 Loss
Si Woo Kim

Struggles at Truist Championship
Gary Woodland

Can Continue Incredible 2026 Season at PGA Championship
Xander Schauffele

In Excellent Form Heading to PGA Championship
Brandon Nimmo

Leaves Game on Tuesday with Apparent Ankle Injury
Philadelphia 76ers

76ers Part Ways With Daryl Morey
Kevin Huerter

Iffy for Game 5 Against Cavaliers
Dylan Harper

Cleared for Action Tuesday
De'Aaron Fox

Available for Game 5 Against Timberwolves
Caris LeVert

Remains on Injury Report With Heel Issue
Duncan Robinson

Listed as Questionable for Game 5
Memphis Grizzlies

Brandon Clarke Dies at Age 29
Charlie McAvoy

Slapped With Six-Game Suspension
Jonas Brodin

Unavailable for Game 5 Against Avalanche
Joel Eriksson Ek

to Remain Out Wednesday
Sam Malinski

Day-to-Day With Upper-Body Injury
Jacob Wilson

A's Place Jacob Wilson on Injured List With Shoulder Subluxation
Artturi Lehkonen

Considered Day-to-Day
Charlie Coyle

Lands Six-Year Extension
Ukko-Pekka Luukkonen

to Start Game 4 Against Canadiens
Drew Helleson

Unavailable for Game 5
Radko Gudas

Still Out Tuesday
Christian Yelich

Brewers Reinstate Christian Yelich From Injured List
Luka Dončić

Luka Doncic Admits He Wasn't Close to Returning Before Season Ended
CFB

Isaac Brown Has All-American Upside in 2026
LeBron James

Uncertain About Future After Season-Ending Loss
CFB

Nyck Harbor Heading into Breakout Year?
CFB

Notre Dame, USC in Discussions to Resume Rivalry Series
CFB

Jaron-Keawe Sagapolutele Has Eyes on ACC Title
CFB

Ahmad Hardy's Gunshot Wound Not Viewed as Career-Threatening
A.J. Ewing

Mets to Call Up Top Prospect A.J. Ewing
Mookie Betts

is Officially Back on Monday
Nathan Eovaldi

Scratched From Monday's Start With Side Tightness
Henry Bolte

Athletics to Promote Top Outfield Prospect Henry Bolte to Major Leagues
Khamzat Chimaev

Suffers his First Loss
Sean Strickland

Recaptures Middleweight Title
Tatsuro Taira

Suffers Fifth-Round TKO Loss
Joshua Van

Defends Flyweight Title
MMA

Waldo Cortes-Acosta Drops Decision
Alexander Volkov

Wins Back-To-Back Fights
Shane Van Gisbergen

Dominates Watkins Glen for First Win of 2026
Michael McDowell

Finishes Second for Best Run of the Year At Watkins Glen
Ty Gibbs

Scores New Career-Best Finish of Third at Watkins Glen
Tyler Reddick

Continues His Strong Season With Fifth-Place Run at Watkins Glen
Austin Dillon

Earns his First Top-10 Finish of 2026 at Watkins Glen
Mookie Betts

Dodgers Expect Mookie Betts to Return on Monday
CFB

Ahmad Hardy Sustains Gunshot Wound, in Stable Condition
Connor Zilisch

Will Start Fifth in his First Watkins Glen Cup Series Race
Tyler Reddick

Is A Top DFS Option for Watkins Glen Lineups
Christopher Bell

Is Likely to Bounce Back This Week at Watkins Glen
Carlos Rodón

Carlos Rodon Activated for Season Debut on Sunday
William Byron

Is William Byron Playable in DFS Lineups at Watkins Glen?
Kyle Larson

May have A Positive Day at Watkins Glen
Chase Briscoe

May Compete for A Top-10 Finish at Watkins Glen
NASCAR

A.J. Allmendinger May have Another Solid Outing at Watkins Glen
Ty Gibbs

Should Fantasy Managers Roster Ty Gibbs at Watkins Glen?
Ross Chastain

Is Ross Chastain Worth Rostering for Watkins Glen Lineups?
Austin Cindric

Could Austin Cindric be A Sneaky Tournament Play for Watkins Glen?
Shane Van Gisbergen

Shane van Gisbergen the Heavy Favorite at Watkins Glen
Chase Elliott

Is Chase Elliott a No-Brainer DFS Pick at Watkins Glen?
Chris Buescher

Qualifies 14th at Watkins Glen
Ryan Blaney

Has Upside at Watkins Glen After Signing Contract Extension
Michael McDowell

Still Searching for First Top-Five Finish at Watkins Glen
Carson Hocevar

Is Carson Hocevar Too Aggressive for Road-Course Racing?
Luis Castillo

Mariners Intend to Piggyback Luis Castillo, Bryce Miller
Logan Webb

Placed on 15-Day Injured List With Knee Bursitis
Bryce Miller

is Set to Return on Wednesday
Sean Strickland

An Underdog At UFC 328
Khamzat Chimaev

Set For UFC 328 Main Event
Tatsuro Taira

Can Become The New Flyweight Champion
Joshua Van

Set For His First Title Defense
Alexander Volkov

Looks To Win Back-To-Back Fights
MMA

Waldo Cortes-Acosta Looks To Extend His Win Streak
CFB

Walker Lyons Could be Go-To Target for Bear Bachmeier
CFB

Ty Benefield a Potential Game-Changer for LSU Defense
CFB

Hayden Lowe Set for Significant Role Following Miami's NFL Departures
CFB

Taylor Wein in Position for Big Season on Oklahoma's Defensive Line
CFB

Rasheem Biles an Instant Impact Player for Texas
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF