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DraftKings Daily Fantasy Baseball Picks (5/22/19): MLB DFS Lineups

The top daily fantasy baseball lineup picks for DraftKings on May 22nd, 2019. Austyn Varney's MLB DFS analysis and sleepers for building optimal DFS rosters.

Tonight's main slate starts at 7:05pm eastern and covers 11 games. There's also an all day slate starting at 1:05pm eastern that includes a few extra early games. We'll be focusing on the main slate, where we have plenty of pricey options to look through and some value plays to fit in as well. Let's dive in to each position!

In this article, I will be providing you with my daily fantasy baseball lineup picks for DraftKings on 5/22/2019. These picks will range from some of the elite players to mid-priced options and value plays.

We also provide DFS lineup picks for DraftKings and other sports. If you have any questions or comments, feel free to contact me on Twitter @varneydfs.

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DraftKings DFS Pitchers

Gerrit Cole, HOU (vs. CWS) ($12,000)

Gerrit Cole, Max Scherzer, and Jacob deGrom make up your top three pitching options. Scherzer and deGrom will be dueling and neither are a clear favorite. Cole on the other hand, is an insane -350 favorite. That’s as big as it gets in baseball. The White Sox aren’t a terrible team, but rank 17th against right-handers and strikeout at a healthy 26% clip. Gerrit Cole has been great over his last few starts and this isn’t the matchup to mess up his groove. Cole is expensive, but the top option in both formats if you can fit him.

Max Fried, ATL (@ SFG) ($8,500)

If you’re wanting to save a few dollars for your SP2, look no further than Max Fried. Fried can be a bit up and down, but he’s held both lefties and righties under a .285 wOBA. He’s striking out 8.5 batters per nine and has his command under control down to 1.5 BB/9. He enters one of the biggest ballparks in the game in AT&T Park to face off with an underwhelming Giants lineup that strikes out and struggles to hit for power. The Braves are favorites on the road and I could see a big day out of Fried for an affordable tag.

 

DraftKings DFS Infielders

C - Gary Sanchez, NYY (@BAL) ($5,500)

It doesn’t get much worse than Dan Straily. Through 8 starts this season, he’s gone 30.2 innings and has given up 29 earned runs. He now faces a tough Yankees lineup that has been hitting well without their best players. Gary Sanchez is still around, though, and he’s making his presence known. He may be expensive, but he’s so much stronger than any other catcher and has legitimate 2-HR upside every night. If you don’t want to spend much at the position, Buster Posey is always worth a look against a lefty.

1B - Yuli Gurriel, HOU (vs. CWS) ($3,900)

It’s starting to look like the career of Ivan Nova is coming to a close. Unless he dramatically changes his approach, he’s not going to last long. He’s been teed off on by both sides of the plate and hasn’t shown any signs of unluckiness or regression. He now faces off with the Astros, who’ll give him no break. If you want to save at 1B, Yuli Gurriel is consistent and will get a ton of RBI opportunities. He’s also only $3,900 on DraftKings and gives you cheap exposure to the top offense of the night. You can play him at third as well.

2B - Starlin Castro, MIA (@ DET) ($2,900)

Starlin Castro is extremely cheap on DK and I don't see the reason for it. Yes, he's not the greatest hitter, but he's in the heart of a Marlins lineup that's projected to put up 4.5 runs tonight. Castro has also always destroyed lefties. He's currently sporting a .390 wOBA and has shown no signs of slowing down. Daniel Norris has struggled against righties and the Marlins are better against southpaws. Castro and Anderson are both extremely cheap and I love pairing them with a more expensive combo from another team.

SS - Jorge Polanco, MIN (@LAA) ($4,700)

Jorge Polanco is one of my favorites hitters in baseball to roster. He seems to always com through in one way or another, and always has a big game when the Twins put up runs. He’s hitting .335 on the season with 8 home runs and a .400+ wOBA. Tonight, he faces off against Matt Harvey and the Angels. Harvey has been pitiful against lefties, allowing a .395 wOBA and 7 homers in just over 40 innings. The Twins are a juggernaut offense and Polanco himself is a tough out every time. As a switch-hitter, he always has the platoon advantage and will never see huge mismatch. He’s expensive, but cheaper than a lot of the other SS’s and he shouldn’t be. He’s my favorite of all, no matter the price.

3B - Alex Bregman, HOU (vs. CWS) ($5,500)

Bregman is expensive, but he may be worth paying up for on this slate. He’s one of the all-around best hitters in baseball and has slaughtered righties with a .427 wOBA followed by 11 homers. Ivan Nova will be lucky to last four innings tonight and it’s safe to expect five at-bats out of the Astros tonight. Now can Nova go through a CGSO? Yes, it’s baseball, but the Astros have the highest implied total on the night and are certainly safe to plant your flag on. If you want to go cheap here, just move to Gurriel.

 

DraftKings DFS Outfielders

OF - Mike Trout, LAA (vs. MIN) ($5,700)

If you’re going to pay up for an outfielder, Mike Trout is facing off against a lefty that likes to throw low in the zone. We know Trout lives in the lower third and he will make Perez pay for every mistake he makes. Perez has been pretty good this year on the surface, but a 4.23 xFIP and .263 BABIP tell a different story. He’s been a bit lucky, but by no means bad. He’s just no match for Mike Trout, who’s sported a .400+ wOBA against lefties for years now. There isn’t a ton of money to spend for fun on this slate, but Trout is the way to go if you can and I doubt he’s higher than 10% owned.

OF - Josh Reddick, HOU (vs. CWS) ($4,400)

We’ll close out our Astros love with Josh Reddick. For whatever reason, he’s cheaper than Marisnick and lets you spend up elsewhere while maintaining huge upside. It’s not like Reddick is having a bad year, either. His power numbers are a bit off, but he’s had four hit the warning track and could easily be at 8. Ivan Nova has always struggled against lefties, but a .425 wOBA is just unacceptable. He doesn’t have a strikeout pitch and can’t hold a runner. The Astros are the top offense of the night and it just comes down to fitting them in. There’s a reason for the price.

OF - Brian Anderson, MIA (@ DET) ($3,100)

This one may come out of left field, or third base, but you know what I mean. Brian Anderson has cooled off from his rookie season, but is still holding a wOBA over .340 against lefties. He has a power stroke and is the most consistent bat in the lineup with RISP. Daniel Norris is terrible against right-handers and struggles with the long ball. The Marlins aren’t a very exciting offense, but they’re better against lefties and Anderson has been swinging the bat nicely. He’s also extremely cheap and has solid positional versatility.

MLB DFS News and Injury Alerts




REAL-TIME FANTASY NEWS

NBA

Bulls Host Potential Lottery Picks for Workout
NBA

Wizards Considering Trading Down in Draft
Russell Wilson

Retiring From the NFL
Corbin Burnes

has Teres Major Strain, Unlikely to Return Until September
Malik Davis

Appears to be the Front-Runner for RB2 Job in Dallas
Kayshon Boutte

to Compete for Snaps in Three-Receiver Sets
Alvin Kamara

Attends OTAs on Wednesday
Andrei Iosivas

Is it Time for Dynasty Managers to Drop Andrei Iosivas?
Tyjae Spears

Is Tyjae Spears Droppable in Dynasty Formats?
Jaylen Wright

the Dynasty Handcuff Running Back to Own in Miami?
Colby Parkinson

Facing Likely Regression After Career Year in 2025
Omarion Hampton

Remains a High-End Dynasty RB1 Despite Injury History
Rickie Fowler

Looks To Continue Resurgent Season At Memorial
Ollie Gordon II

Is Ollie Gordon II Still Worthy of a Dynasty Roster Spot?
Justin Herbert

Overhauling his Footwork This Offseason
De'Von Achane

Doing Individual Drills at Minicamp
Ashton Jeanty

Raiders Emphasizing Ashton Jeanty's Progress as Their Lead Back
Marvin Harrison Jr.

Still on the Mend From 2025 Injuries
Brandon Aiyuk

Warrant Issued for Brandon Aiyuk's Arrest in California
Blake Corum

Remains an Elite Handcuff in Dynasty Leagues
Chris Godwin Jr.

Consistency the Key for Chris Godwin Jr. in Dynasty Leagues
David Montgomery

Can Managers Look to Sell High on David Montgomery This Year?
Malik Willis

a Low-Cost Dynasty Target in Miami?
Terrance Ferguson

Can Terrance Ferguson Still be the Tight End to Roster in Los Angeles?
CFB

Can Eric Singleton Jr. Fully Break Out at Third School?
CFB

Katin Houser Steps into QB1 Role for Illinois
CFB

Savion Hiter an Immediate Impact Freshman for Michigan
CFB

Isaiah Horton Set to Take Over KC Concepcion's Role
CFB

UCLA Transfer Karson Gordon Signs with Austin Peay
CFB

Will Muschamp Bringing New Intensity to Texas Practices
Gary Woodland

Brings Boom-or-Bust Potential to Memorial
Jordan Spieth

Still Searching for a Breakthrough
Ted Hurst

Can Ted Hurst Find Consistent Fantasy Success in a Crowded Receiver Room?
Alex Smalley

Brings Elite Form to Memorial Tournament
Justin Rose

Looks to Recapture Memorial Tournament Success
Cameron Young

Looks to Get Back to His Contending Ways at Murifield Village
Chris Gotterup

Needs to Find Fairways at Muirfield Village
Si Woo Kim

Looks to Stay Hot at Memorial Tournament
Matt Fitzpatrick

Positioned for Success at Muirfield Village
Jalen Chatfield

Records Two Assists in Tuesday's Loss
Keegan Bradley

Looking for Another Strong Finish at Muirfield
Nikolaj Ehlers

Nets Two Goals in Game 1 Loss to Golden Knights
Shea Theodore

Notches Three Points in Game 1 Win
Brayden McNabb

Sets Up Three Goals in Game 1 Win Over Hurricanes
Justin Thomas

is an Exciting Play This Week in Ohio
Brett Howden

Starts Finals With Multi-Point Effort
Scottie Scheffler

Looks to Win Memorial Tournament for Third Consecutive Year
Tomas Hertl

Scores Game-Winner in Finals Opener
Rory McIlroy

Looking for Better Performance at Muirfield Village
Drake Baldwin

Could Return During Braves Next Homestand
Garrett Crochet

Diagnosed With Low-Grade Lat Strain
Russell Henley

Coming to Ohio on the Heels of Latest Victory
Tommy Fleetwood

Looking for Better Iron Play at Memorial Tournament
Patrick Cantlay

Looks to Continue Dominance at Muirfield Village
Ludvig Aberg

a Great Fit for Muirfield Village
Isaiah Hartenstein

Hopeful to Stay with Oklahoma City
Luguentz Dort

Wants to Remain with Thunder
Mitchell Robinson

is Questionable for Game 1
Moussa Diabaté

Moussa Diabate Has Contract Guaranteed for 2026-2027 Season
Oso Ighodaro

Gets Guaranteed Contract for Next Season
NAS

Chris MacFarland Joins Predators as President and General Manager
VAN

Canucks Name Manny Malhotra as New Head Coach
Brendan Gallagher

to Leave Canadiens This Offseason
Patrik Laine

Looking Forward to Free Agency
Jeremy Lauzon

Returns to Action Tuesday
Zach Werenski

Wins 2025-26 Norris Trophy
Aaron Judge

Out on Tuesday With Rib/Shoulder Injury
Josh Hader

Set to Return from Injured List on Tuesday
CFB

SEC Coach Calls Buster Faulkner a "Home-Run Hire"
CFB

Auburn a Sleeper in the SEC Under Alex Golesh?
CFB

Noah Fifita Primed for Strong 2026 Campaign
CFB

Oregon Assistant Coach Charged with DUII, Reckless Driving
CFB

Tight End Nick Pollack Commits to Clemson
Akshay Bhatia

Needs the Driver to be True in Ohio
Aaron Rai

Primed to take on the Memorial Tournament
J.J. Spaun

Rebounded at Charles Schwab Challenge
Xander Schauffele

One to Watch This Week in Ohio
Elly De La Cruz

to Miss 2-4 Weeks of Action
Chase Burns

is Scratched Due to Illness
Deiveson Figueiredo

Suffers Second-Round Submission Loss
Song Yadong

Gets Second-Round Submission Win
Zhang Mingyang

Suffers Back-To-Back Losses
Alonzo Menifield

Gets Back In The Win Column
Tallison Teixeira

Suffers First-Round Knockout Loss
Sergei Pavlovich

Scores First-Round Knockout Win
Cameron Smotherman

Suffers Third Loss In A Row
Edwin Arroyo

Reds Promote Top Infield Prospect Edwin Arroyo, Viewed as Priority Pick Up Ahead of MLB Debut
Kai Asakura

Earns His First UFC Win
Elly De La Cruz

Placed on IL with Right Hamstring Tightness
Denny Hamlin

Earns the first Nashville Cup Series Victory of his Career on Sunday
Christopher Bell

Finishes as the Runner-Up at Nashville
Chase Briscoe

Earns First Career Podium Finish at Nashville
Ryan Blaney

Scores A Solid Top-10 Finish at Nashville
Kyle Larson

Top-10 Streak at Nashville Ends after Late Flat Tire Spin
Elly De La Cruz

Exits with Hamstring Tightness
Tyler Reddick

Is One of the Top Favorites to Win at Nashville
Kyle Larson

May Continue his Top-10 Consistency at Nashville this week
Christopher Bell

Is One of the Top Competitors for the Win at Nashville
Chase Briscoe

Is A Must Start for Nashville DFS Lineups
Chase Elliott

has Plenty of Upside for Nashville DFS Lineups
William Byron

Is William Byron A Playable DFS Option for Nashville Lineups?
Carson Hocevar

Is Likely to have Another Solid Result at Nashville
NASCAR

Should Fantasy Players Roster Bubba Wallace at Nashville?
Chris Buescher

Is A Decent All-Around DFS Option for Nashville Lineups
Daniel Suarez

is Likely to Drop Positions during the Cracker Barrel 400
Garrett Crochet

Suffers Setback, Likely to Undergo MRI for Lat Tightness
Denny Hamlin

Could Denny Hamlin Dominate at Nashville?
Ryan Blaney

Is a DFS Tournament Option at Nashville
Ty Gibbs

Don't Overlook Ty Gibbs at Nashville
Joey Logano

Could Show Life at Nashville
Ross Chastain

Needs a Good Run at Nashville
Chet Holmgren

Fails to Step Up in the Season Finale
Cason Wallace

Ends Postseason with Strong Showing
Shai Gilgeous-Alexander

Caps MVP Season with Game 7 Exit
Stephon Castle

Continues Postseason Run with 16 Points
Julian Champagnie

Shines in Series-Clinching Win
De'Aaron Fox

Provides Secondary Punch in Game 7 Triumph
Victor Wembanyama

Earns Conference Finals MVP in Spurs' Game 7 Win
NBA

Warriors Prioritize Depth Around Returning Steve Kerr
Donovan Mitchell

Remains Cleveland's Top Priority
Adou Thiero

Remains a Lakers Development Project
NBA

76ers Hire Mike Gansey as President of Basketball Operations
NBA

Chicago Bulls Explore Kevin Young as Coaching Candidate
Kyrie Irving

Reports He's Nearing Full Strength in ACL Recovery
Lane Hutson

Posts a Power-Play Assist in Game 5 Loss
Cole Caufield

Nets a Power-Play Goal in Season-Ending Loss
Seth Jarvis

Closes Out East Finals With Multi-Point Game
Logan Stankoven

Notches Three Points in Big Game 5 Win
Taylor Hall

Racks Up Three Points in Series-Clinching Win
Frederik Andersen

Remains Stellar as Hurricanes Clinch Finals Berth
Jacob Gonzalez

is Heading to the Big Leagues
Munetaka Murakami

Exits with Hamstring Tightness
Mitchell Robinson

Plans to Play in Game 1 After Finger Surgery
Eury Pérez

Eury Perez is Placed on 15-Day Injured List
Deiveson Figueiredo

Set For UFC Macau Main Event
MMA

Yadong Song Returns At UFC Macau
Alonzo Menifield

An Underdog At UFC Macau
Zhang Mingyang

Set For UFC Macau Co-Main Event
Tallison Teixeira

Looks To Win Back-To-Back Fights
Sergei Pavlovich

A Favorite At UFC Macau
Cameron Smotherman

Looks To Bounce Back
Kai Asakura

Looks To Get Back In The Win Column
CFB

Faizon Brandon In Position to Start Week 1
CFB

Dane Weber Commits to Cal
CFB

Joey McGuire Attempts to Add Texas to Schedule
CFB

Mike Leach on 2027 College Football Hall of Fame Ballot
CFB

Maryland, Baylor Schedule Home-and-Home
CFB

Taron Dickens Decommits From North Carolina
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF