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DraftKings Daily Fantasy Baseball Picks (4/21/18): MLB DFS Lineups

The top daily fantasy baseball lineup picks for DraftKings on April 21, 2018. Troy Klauder's MLB DFS analysis and sleepers for building optimal DFS rosters.

We've got another day full of action ready for us on DraftKings, with an early slate starting at 1pm eastern and the featured slate kicking off at 7pm.

In this article, I will be providing you with my daily fantasy baseball lineup picks for DraftKings on 4/21/18. The lineup picks will range from some of the elite players to mid-priced options and value plays.

 You can also read more DFS advice and lineup picks for sites like FanDuel, and other sports too. If you have any questions or comments, feel free to hit me up on Twitter @TroyKlauder.

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DraftKings Starting Pitchers

Aaron Nola, PHI (vs. PIT) - $10,600

Aaron Nola has been rolling along this season, posting a 2.22 ERA through his first two starts of the season. Nola comes at a very modest price for the type of talent he has, which makes him my favorite pitcher on the early slate. While Nola hasn't been racking up many strikeouts this season, he had a 26.6% K-rate in 27 starts last year, so there's probably some positive regression on the way. The Phillies lineup has been on fire lately and should provide Nola with a win against Pirates starter Steven Brault.

Zack Godley, ARI (vs. SD) - $8,800

Godley was horrific in his last start against the Dodgers, but you shouldn't judge a pitcher based off of one bad start. Even with his blow-up start, Godley still has just a 3.00 ERA on the season, supported by a 3.24 FIP. He's a great buy-low candidate on Saturday, as many owners will probably be scared off by his last start, and he comes at a pretty cheap price. The Padres are one of the worst lineups in baseball, and Godley has huge strikeout potential against them, as the Pads strike out 27.9% of the time against righties. That's the third-highest mark in all of baseball, so I would be comfortable playing Godley in any type of contest.

 

DraftKings Infielders

C - Yadier Molina, STL (vs. CIN) - $3,500

Molina has been one of the best catchers in the league at the plate this season, with a 123 wRC+ and five homers so far. His opposition, Reds starter Homer Bailey, has a 3.42 ERA this season - but that's not fooling anybody. Bailey has a 4.74 SIERA this year, which gives a more accurate representation of the way he's pitched this season. After all, he had a 6.43 ERA last season! The Cardinals are a great lineup to stack on Saturday, but you can also use Molina as a standalone at catcher.

1B - Yuli Gurriel, HOU (@ CWS) - $4,200

Gurriel is back from the DL and batting fifth in the loaded Astros lineup, a spot where he can rack up runs and RBIs. The Astros are an expensive lineup to stack, but I would try to at least get a few of them aganist Lucas Giolito. Giolito has struggled mightily this season to the tune of a 5.50 ERA with 12 walks and just eight strikeouts. Gurriel is particularly valuable in cash games, where his high floor makes him more attractive.

2B - Jonathan Villar, MIL (vs. MIA) - $3,500

Villar is actually having himself a fantasy relevant season once again, batting .288 with four steals. His home ballpark, Miller Park, is one of the best offensive environments in all of baseball, and he's facing an awful pitcher in Jose Urena on Saturday. Urena has a 5.57 ERA through his first four starts, and Villar is coming in at a great price against him.

3B - Mike Moustakas, KC (@ DET) - $4,000

Moose has been on fire this season, so it's actually pretty crazy that his price has only gone up to $4,000. In his last 15 games, Moustakas is batting .380 with a 1.092 OPS and four homers. Yowza! Facing Mike Fiers is one of the best possible matchups you can ask for when you play Moustakas, as Fiers has a 1.54 HR/9 this year after posting a 1.88 mark in 2017. Prepare for Moose to go deep.

SS - Ketel Marte, ARI (vs. SD) - $3,500

There are lots of garbage pitchers taking the mound on Saturday, many of which I have already highlighted. We've got another one to target in Padres starter Clayton Richard, who has just a 16.5% K-rate with a 10.3% walk-rate. Unsurprisingly, he's rocking a 5.73 ERA as well. I think Marte's high-contact style of play will play well against Richard's lack of strikeout ability. If nothing else, Marte's got a solid power/speed combo and comes in at a cheap price.

 

DraftKings Outfielders

Jay Bryce, NYM (@ ATL) - $3,900

Braves starter Julio Teheran always struggles when he pitches at home, and SunTrust Park in Atlanta is a fantastic park for left-handed power. This combination gives Jay Bruce a fantastic opportunity to bust out of his slump on Saturday. Teheran's already got a 6.43 ERA at home this season after posting a 5.86 in Atlanta last season, and don't forget that Bruce knocked 36 dingers last season. He's a great value at this price.

Bradley Zimmer, CLE (@ BAL) - $3,300

Indians centerfielder Bradley Zimmer is coming in at near punt-level prices on Saturday, and it's not exactly clear why. He's batting .385 in the last 15 days with a 1.005 OPS! Zimmer has a great matchup in Oriole Park, an outstanding hitter's park, and opposing pitcher Chris Tillman might actually be the worst of the worst pitchers on today's slate. Tillman has a hilarious 11.91 ERA with only three strikeouts and 10 walks in three starts. I recommend an Indians stack, and Zimmer is an essential part of that stack.

Mitch Haniger, SEA (@ TEX) - $4,000

Don't be a goofball and avoid Mariners hitters against Bartolo Colon on Saturday. He had a fantastic start against the Astros his last time out, but he's going to have to show us much more than just that in order to take him seriously. For now, he's still a pitcher we want to target, and Haniger is a great mid-range play to consider against him. Haniger has a 131 wRC+ this season and hasn't gotten a ton of buzz despite his success.

MLB DFS News and Injury Alerts

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REAL-TIME FANTASY NEWS

Rome Odunze

Steps Into a Larger Role for 2026
Baker Mayfield

Loses Top Receiver After Subpar Season
Ray Davis

' Fantasy Managers Continue to Exercise Patience
Ja'Marr Chase

Has Overall WR1 Upside with Quarterback Healthy
Javonte Williams

Still Penciled Into Workhorse Role
Quentin Johnston

Expected to Handle More Targets in 2026?
Los Angeles Chargers

Derwin James Suffers Minor Injury
Spencer Knight

Shuts Down the Wild on Thursday
Adam Fantilli

Scores Two Goals in Victory
Francisco Alvarez

Pulled Early Thursday With Back Tightness
Amir Coffey

Exits Early with Ankle Sprain
Daeqwon Plowden

Moves Into Starting Lineup Thursday
Jaxon Smith-Njigba

the WR1 Overall in Fantasy After Career Year?
Noah Clowney

Won't Play Friday Vs. New York
Patrick Mahomes

Is Patrick Mahomes No Longer a Trustworthy QB1 in Fantasy?
GG Jackson II

Unlikely to Play Against Boston
Naz Reid

Could Sit Again Friday
Josh Hart

Ruled Out Friday Against Brooklyn
Jalen Brunson

Set to Play Against Brooklyn
Brice Sensabaugh

Out Against Milwaukee
John Konchar

Out Thursday Against Bucks
Kyle Kuzma

Ready to Play Thursday Vs. Utah
Myles Turner

Set to Return Versus Jazz
Kevin Porter Jr.

Sidelined Against Utah
Donovan Mitchell

Ruled Out, Jaylon Tyson to Start Thursday
Auston Matthews

Ruled Out for 12 Weeks
Austin Reaves

Cleared to Play Thursday
Yaroslav Askarov

Still Out Thursday
Luis Severino

to Start for A's on Opening Day
Stephon Castle

Ruled Out Thursday Against Suns
Michael Porter Jr.

to be Re-Evaluated in 2-3 Weeks
Kirill Kaprizov

Won't Play Against Blackhawks
Nique Clifford

is Downgraded to Out
Kawhi Leonard

Ruled Out Against New Orleans
Alex Tuch

Expected to Return Thursday
Grayson Allen

to Miss Second Straight Game
Luka Dončić

Luka Doncic Good to Go Against Miami
Noah Laba

Unavailable Against Blue Jackets
Daniss Jenkins

Moves into Starting Five
Andrew Copp

Returns From Three-Game Absence
Josh Anderson

Won't Play Thursday
Terry McLaurin

Commanders Still Looking for Receiver to Complement Terry McLaurin
Logan Gilbert

Named Mariners Opening Day Starter
José Ramírez

Jose Ramirez Back in Cactus League Lineup on Thursday
Hayden Birdsong

to Have Tommy John Surgery, Miss Entire 2026 Season
Zack Wheeler

to Pitch in Minor-League Game on Monday
Paul Skenes

Pirates Officially Name Paul Skenes Their Opening Day Starter
Justin Herbert

Will Justin Herbert Have Higher Fantasy Ceiling in New Offense?
Tank Bigsby

to be Valuable Handcuff Going into First Full Year in Philly
Dameon Pierce

Eagles Agree on One-Year Deal With Dameon Pierce
Jurickson Profar

Officially Suspended for Entire 2026 Season
Matthew Golden

Trending Up Despite Frustrating Rookie Season
Tee Higgins

Solidified as a Weekly Fantasy Contributor with QB Healthy
Evan Engram

Faces a New Challenge in 2026
Ladd McConkey

Has Terrific Opportunity to Bounce Back
Jaydon Blue

Destined for More Volume in Second Season?
Carson Williams

"Likely" to Be Rays Opening Day Starting Shortstop
Trey Yesavage

Will Open 2026 on the Injured List Due to Shoulder Impingement
Oronde Gadsden

Mike McDaniel to Maximize Oronde Gadsden's Skill Set?
Keaton Mitchell

Could "Thrive" in New Offensive Scheme in L.A.
Jake Elliott

Eagles Rework Jake Elliott's Contract
Jack Hughes

Posts Another Three-Point Performance in Victory
Jackson Blake

Collects Three Points on Wednesday
WAS

Cole Hutson Scores in NHL Debut on Wednesday
Max Fried

to Start on Opening Day for Yankees
Arizona Diamondbacks

Diamondbacks Not Naming a Closer to Begin the Season
Adrian Kempe

Could Return Thursday
Mason McTavish

Sits Out Second Consecutive Game
Ross Johnston

to Miss 3-4 Weeks
Jonathan Drouin

Back in Action Wednesday
Eric Robinson

Rejoins Hurricanes Lineup
Shayne Gostisbehere

Sits Out Another Game Wednesday
Sidney Crosby

Returns to Action Wednesday
Matthew Liberatore

Named Cardinals Opening Day Starter
Roki Sasaki

to be in Opening Day Starting Rotation
Akshay Bhatia

Withdraws From Valspar Championship
José Berríos

Jose Berrios has Stress Fracture, Won't be Ready for Opening Day
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Alberto Mendoza Drawing Positive Reviews at Georgia Tech
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Anthony Colandrea Impressing in Nebraska's Spring Practices
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Bags a Shutout in Vegas
J.J. Spaun

Offers Upside Despite Poor Course History at Innisbrook
Brock Boeser

Logs Three Assists Tuesday
Jeremy Peña

Opening Day "Not Ruled Out" for Jeremy Pena
Aaron Rai

Looks to Bounce Back at Valspar Championship
Johnny Keefer

Brings Ball-Striking Upside to Valspar Championship
Billy Horschel

a Volatile Play at Valspar Championship
Ben Griffin

Looks to Rebound at the Valspar Championship
Corey Conners

Brings Elite Ball-Striking to Valspar Championship
Cole Ragans

Named Royals Opening Day Starter
Xander Schauffele

Trending In The Right Direction For Valspar Championship
Sahith Theegala

Has Shot to Challenge at Valspar Championship
Mackenzie Hughes

Looking to Bounce Back at Valspar Championship
Nicolai Hojgaard

Finding Rhythm For Valspar Championship
Matt Fitzpatrick

Continues Hot Start to 2026 Heading to Valspar Championship
Pierceson Coody

Heads to Valspar Championship Following Two Missed Cuts
Shohei Ohtani

to Pitch in Cactus League Game on Wednesday
Seiya Suzuki

has Sprained Knee, Opening Day Availability Unclear
Seiya Suzuki

Diagnosed With Strained PCL
Zach Neto

Making his Return on Tuesday
Wyndham Clark

Searching for Momentum at Valspar Championship
Justin Thomas

Is Justin Thomas Back Ahead of This Week's Valspar Championship?
Jordan Spieth

to Bounce Back at Favored Valspar Championship?
Brooks Koepka

is Starting to Find His Groove Again Ahead of Valspar Championship
Viktor Hovland

is One of The Best DFS Plays at Innesbrook
Rasmus Hojgaard

to Get Back on Track at Valspar Championship
Tony Finau

is Again a Scary Option at Valspar Championship
Blades Brown

Continues PGA Tour Run at Valspar Championship
Josh Emmett

Suffers First-Round TKO Loss
Kevin Vallejos

Scores First-Round TKO
Amanda Lemos

Drops Back-To-Back Fights
Gillian Robertson

Extends Her Win Streak
Andre Fili

Drops Decision on Saturday
Denny Hamlin

Dominates and Gets His Third Career Las Vegas Win
Chase Elliott

Earns Runner-Up Finish at Las Vegas
William Byron

Wins A Stage and Finishes Third at Las Vegas
Christopher Bell

Finishes Fourth at Las Vegas After Strong Run
Kyle Larson

Fades to Seventh Despite Leading Laps Early at Las Vegas
Andre Fili

Jose Delgado Edges Andre Fili in Split-Decision Win
Oumar Sy

Suffers First-Round Submission Loss
Ion Cutelaba

Returns To The Win Column
CFB

CJ Carr Enters Sophomore Season as Heisman Favorite
CFB

Aaron Philo Not a Lock to be Florida's Starting QB?
CFB

George MacIntyre the Favorite to Win Tennessee Quarterback Battle?
CFB

Keelon Russell, Austin Mack Battling for Alabama QB1 Duties
Christopher Bell

Looking for Redemption, Wins Pole at Las Vegas
Denny Hamlin

Should Contend for Another Vegas Win
Chase Briscoe

Qualifies 18th Despite Toyota Dominating at Las Vegas
Chase Elliott

May Fly Under the Radar at Las Vegas
NASCAR

Ross Chastian Has Been As Solid As They Come at Las Vegas
Ty Gibbs

Could Ty Gibbs Finally Break Through With a Win at Las Vegas?
Brad Keselowski

a Solid DFS Pick at Las Vegas
Kyle Larson

Should Kyle Larson be Considered A Favorite for Las Vegas?
William Byron

Could Compete for a Top-Five Finish at Las Vegas
Ryan Blaney

Is Ryan Blaney Worth Rostering in Tournament DFS Lineups for Las Vegas?
Tyler Reddick

Could Continue his Top-10 Streak at Las Vegas
Joey Logano

Should DFS Managers Underestimate Joey Logano for Las Vegas?
Chris Buescher

Is Chris Buescher Worth Rostering For Las Vegas DFS Lineups?
NASCAR

Bubba Wallace is A Risky DFS Option Who Could Pay Off at Las Vegas
Josh Berry

Has Plenty of Upside for Las Vegas DFS Lineups
Ryan Preece

Scores his First Las Vegas Top-10 Starting Spot in Qualifying
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF