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DraftKings, FanDuel Daily Fantasy Basketball Picks (4/5/22): Today's Top NBA DFS Lineups

The top daily fantasy basketball lineup picks for DraftKings and FanDuel on April 5, 2022. Euan Leith provides NBA DFS analysis and sleeper picks for building optimal DFS rosters.

Happy Tuesday, Rotoballers! After an NBA-less Monday (how about that Kansas comeback?!), we return to the pros with 12 games. Fortunately, almost every contest has something to play for, whether it be playoff qualification, seeding, or downright tanking. As DFS managers, it helps us guesstimate a more reliable starting five and what kind of rotations we can expect to see from these teams.

Immediately, a few games jump off the page as DFS targets. Houston-Brooklyn has an over/under sitting at 243.5 points at the time of writing and the fourth-fastest projected pace among the 12 games. We've also got Washington-Minnesota, San Antonio-Denver, and Lakers-Suns as the other games to heavily invest in for this action-packed Tuesday.

This article will provide you with my daily fantasy basketball lineup picks for DraftKings and FanDuel on 4/5/22, with the slate locking at 7:00 pm E.T. Remember to monitor NBA injury news and our live-updating NBA injury updates tool as the slate can completely change before lineups lock.

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DraftKings and FanDuel Guards - NBA DFS Lineup Picks

Anthony Edwards - SG/SF, MIN vs. WAS ($7,500 DraftKings; $7,000 FanDuel)

Edwards burst into the 2021-22 season with such ferocity that it had NBA fans wondering if he was making the leap. However, as the Timberwolves got healthier, the second-year guard came down to Earth slightly. Still, the team is winning and heading towards the playoffs for only the second time since 2004, and that's a massive success. However, the 2020 No. 1 overall pick can still show flashes of his early-season form, and he's done that over the last five games.

Since Mar. 25, Edwards averages 22.2 points on 51.2 percent shooting, with 6.2 rebounds, 5.2 assists, and 3.2 three-pointers for 41.2 DK points, including a 52.5-point outing versus the Rockets in his last game. Tonight's matchup versus the Wizards is the second-fastest projected pace game on my sheet. Adding Washington's inability to stop shooting guards (50.66 DK points allowed over their last seven) means Edwards will be in for a great evening.

Jalen Green - PG/SG, HOU at BKN ($7,400 DK; $6,700 FD)

This year's rookie class has been incredible. Many top-10 guys had phenomenal starts to their NBA careers, so you'll be forgiven if Jalen Green's monster March slipped through your watchful DFS gaze. However, now is the time to jump on the No. 2 overall pick and allow him to guide you toward the green line in your NBA contests. In March and April, The 20-year old guard averages 22 points, 3.7 boards, 3.3 dimes, and 3.2 triples. More recently, he's been on an unconscious tear from three-point land and joined some legendary company within the franchise.

Tonight, he meets a Brooklyn defense allowing the fourth-most D.K. points per game to point guards in a contest with a 243.5-point over/under. Sign. Me. Up.

Tre Jones - PG, SAS at DEN ($4,000 DK; $3,700 FD)

Dejounte Murray (illness) will miss his third consecutive game on Tuesday, and it keeps the door wide open for Tre Jones to be a DFS darling. The second-year guard started the previous two games (both versus Portland) in Murray's absence and balled out to the tune of 13.5 points, 8.0 assists, 6.0 rebounds, and 1.5 steals per game for 36.5 DraftKings points. Considering his price tag is $4,000, and he's facing a porous Denver defense (worst team vs. P.G.s over their last seven games), it's a recipe for DFS delight. If you need salary relief, there isn't a better option among the 12 games than Tre Jones.

Others to consider: James Harden ($10,400; $9,800), CJ McCollum ($8,700; $8,100), De'Anthony Melton ($5,700; $5,700)

 

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DraftKings and FanDuel Forwards - NBA DFS Lineup Picks

Kevin Durant - SF/PF, BKN vs. HOU ($11,600 DK; $11,200 FD)

Slotting Kevin Durant into your DFS lineup shouldn't need much explanation. In his previous five games, K.D. puts up 58.4 DK points a night thanks to 34.4 points, 7.2 rebounds, 6.2 assists, 3.6 threes, and 2.6 stocks (steals+blocks). The man is on absolute fire at the moment, and the only thing stopping him seems to be how many shots he decides to take each night. It's a fair question to consider, given the Nets being heavily favored against the Rockets tonight, but with Brooklyn needing every win they can get, I would expect a 100 percent effort from K.D. Whether that involves three or four quarters is still to be seen, but if it's the full four, he will have a spectacular evening for our DFS rosters.

Scottie Barnes - SF/PF, TOR vs. ATL ($7,200 DK; $6,400 FD)

Toronto is a DFS goldmine. The way Head Coach Nick Nurse deploys his players gives them so many chances to contribute, and it's very tempting each night the Raptors fall on a slate. Just take Scottie Barnes, for example. He's a rookie, yet he's gained the coaching staff's trust and consistently plays 35 minutes a night for a playoff team. It's allowed him to grow in his first pro season, and now it's helping the Raptors and DFS managers down the regular season's final stretch. With OG Anunonby (thigh) questionable for Tuesday's contest, Barnes will have many chances to do DFS damage. In his last two games, the former Florida State standout produces 19.0 points, 7.5 boards, 4.5 assists, 2.0 three-pointers, and 1.0 swipes. If his teammate, Anunoby, remains out, Scottie will blow the barn doors off against Hawks and their second-worst defense versus small forwards.

Isaiah Roby - PF/C, OKC vs. POR ($6,800 DK; $7,000 FD)

These days, Roby is one of the last men standing in the Thunder locker room, and it means he gets his fair share of DFS point-scoring opportunities. The third-year forward is impressing down the stretch for Oklahoma City as he averages 17.3 points, 8.0 rebounds, 3.0 assists, and 2.3 stocks over his last six contests. In addition, he dominated Portland the last time he saw them. On Mar. 28, Roby piled up 30 points, eight rebounds, four assists, two steals, two blocks, and four triples in 38 minutes against the Trail Blazers. All those stats added up to a smooth 55 D.K. points. If he comes within shouting distance of that tonight, he will be a massive steal at $6,800.

Others to consider: Brandon Ingram ($8,000; $8,600), Tobias Harris ($6,800; $6,700), Devin Vassell ($5,500; $5,300)

 

DraftKings and FanDuel Centers - NBA DFS Lineup Pics

Deandre Ayton - C, PHX vs. LAL ($7,100 DK; $6,500 FD)

Ayton is one of the centers I always look forward to rostering when Phoenix is on the slate because he's always underpriced. Even tonight against the down-and-(almost)out Lakers, he remains at $7,100. The duo of Nikola Jokic and Joel Embiid will, rightfully, dominate the manager's lineups tonight. Still, I like Ayton as a discounted pivot if you're not averse to some risk in your lineups. The Bahamas native has had great success against Los Angeles this season, and it will continue tonight even if Anthony Davis and LeBron James suit up. In three games between the divisional foes, Ayton supplies 16.7 points, 14.0 rebounds, 1.7 steals, and 41.8 DK points. His $7,100 price tag means he averages a six times return on investment when he plays L.A. With almost $5,000 in savings versus Jokic and Embiid, I don't mind taking a flyer on Ayton at all.

Andre Drummond - C, BKN vs. HOU ($6,800 DK; $6,700 FD)

Drummond makes the third recommendation out of eight players in today's article to be a part of this Brooklyn-Houston shootout. So I suppose you could say I'm a big fan of this matchup. Tonight, Brooklyn is a 17-point favorite against the team with all their draft picks for the foreseeable future. Over his last five games, Drummond is averaging 11.8 points, 12.6 rebounds, 2.0 steals, and 1.0 blocks a night for 36.2 DK points. Meanwhile, Houston is the fifth-worst defense versus centers over their last seven games.

Others to consider: Nikola Jokic ($12,500; $12,000), Joel Embiid ($12,000; $11,600), Damian Jones ($6,600; $5,500)



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REAL-TIME FANTASY NEWS

Keegan Murray

Underwent Ankle Procedure
Josh Giddey

Undergoes Ankle Surgery
Pete Fairbanks

Returns From Injured List
Christian Yelich

Out With Back Tightness on Wednesday Night
Nathan MacKinnon

Chasing History Wednesday
Ryan Poehling

Won't Be an Option for Game 6
Sam Malinski

Set to Miss Second Straight Game
Artturi Lehkonen

Unlikely to Play Wednesday
Matthew Schaefer

Wins Calder Trophy
TOR

Maple Leafs Fire Head Coach Craig Berube
Jalen Hurts

Can Jalen Hurts Bounce Back as a Rusher in 2026?
Robby Snelling

Placed on 15-Day Injured List with Elbow Sprain
Zach Charbonnet

Dynasty Value in Question Entering 2026
DeVonta Smith

Poised to Reach a New Level of Production in 2026?
Chris Olave

Facing Increased Target Competition in New Orleans Entering 2026
Chris Bell

Dynasty Stock Rising Following NFL Draft
Ted Hurst

Facing Uphill Battle for Playing Time in Tampa Bay
Francisco Alvarez

Mets Place Francisco Alvarez on Injured List With Torn Meniscus
Max Fried

Dealing With Left Elbow Posterior Soreness
CFB

NFL Veteran Tom Moore Joins Iowa Coaching Staff
CFB

Can Cam Cook Dominate in Return to Big 12?
Chris Brazzell II

Is Chris Brazzell II the Top Deep Threat in Carolina's Receiver Room?
Kaelon Black

a Threat to Win Backup RB Job in San Fran?
CFB

ACC, Big 12 Support 24-Team College Football Playoff
De'Zhaun Stribling

to be 49ers' New "F" Receiver?
CFB

Anthony Colandrea Looking to Elevate Nebraska Back to National Contention
Drew Allar

Steelers "Uninstalling" Everything Drew Allar Learned in College
CFB

Kwazi Gilmer Set for Big Impact at Nebraska
Ja'Kobi Lane

Is Ja'Kobi Lane the Pass-Catching Answer the Ravens Have Been Seeking?
Zachariah Branch

Does Zachariah Branch Have a Path to Immediate Production?
Max Klare

Can Max Klare Separate Himself in Rams' Tight End Room?
Eli Stowers

the Tight End of the Future in Philadelphia?
Justin Thomas

Trending Well Ahead of PGA Championship Despite Concerning Form
J.J. Spaun

Trending Up Ahead of PGA Championship
Adam Scott

Riding Strong Form Into PGA Championship
Patrick Reed

Looking to Make Another Run at PGA Championship
PGA

Sungjae Im Looks to Build on Strong Finish at Truist Championship
Sam Burns

Must Keep Ball in Play at PGA Championship
Jordan Spieth

Looks to Complete Career Grand Slam at Aronimink
Brandt Snedeker

Not the Best Option for the PGA Championship
Rasmus Hojgaard

a Volatile Option at PGA Championship
Germie Bernard

Already in a Tough Spot to Hold Dynasty Value
Ayo Dosunmu

Has Busy Night in Game 5
Maverick McNealy

Seeking Better Start in Philadelphia
Harry Hall

a Boom-or-Bust Option at Aronimink
Jaden McDaniels

Notches 17 Points in Game 5 Loss
Denzel Boston

a Smart Bet to Meet or Exceed Value in Dynasty Rookie Drafts
Hideki Matsuyama

Attempts to Improve Over 2025 PGA Championship
Scottie Scheffler

Looks to Defend PGA Championship at Aronimink
Julius Randle

Posts a Double-Double in Losing Effort
Matthew Stafford

a Sell Candidate with Touchdown Regression Likely on its Way
Nicolai Hojgaard

Wants to Keep Momentum Rolling in Philadelphia
Anthony Edwards

Held to 20 Points in Game 5 Loss
Ben Griffin

Attempting to Bounce Back After Truist Championship
CFB

Transfer Defensive Lineman Devarrick Woods Commits to Clemson
Keldon Johnson

Comes Alive in Game 5 Against Timberwolves
Jayden Reed

Dynasty Value Tethered to His Underwhelming Usage
Harris English

Will Need His Putter to Thrive at Aronimink
Stephon Castle

Makes All-Around Impact in Game 5
Kenyon Sadiq

Is Kenyon Sadiq the Next Great Rookie Tight End?
Victor Wembanyama

Leads Spurs to Big Win in Game 5
Akshay Bhatia

Creative Flair Could Show Itself in Philadelphia
Keegan Bradley

Knows the Aronimink Golf Club Well
Mason McTavish

Delivers Two Assists Tuesday Night
Pavel Dorofeyev

Pots Two Goals in Vital Game 5 Win
Josh Doan

Records Two Assists in Game 4 Victory
Evgeni Malkin

Penguins Want Evgeni Malkin Back
Sidney Crosby

Joins Team Canada for World Championship
Ryan Poehling

Suffers Upper-Body Injury in Game 5 Loss
Si Woo Kim

Struggles at Truist Championship
Gary Woodland

Can Continue Incredible 2026 Season at PGA Championship
Xander Schauffele

In Excellent Form Heading to PGA Championship
Cade Klubnik

Becoming Fan Favorite, in Play to Win Backup QB Job?
Michael Penix Jr.

Throwing During Offseason Program
Brandon Nimmo

Leaves Game on Tuesday with Apparent Ankle Injury
Philadelphia 76ers

76ers Part Ways With Daryl Morey
Kevin Huerter

Iffy for Game 5 Against Cavaliers
Dylan Harper

Cleared for Action Tuesday
De'Aaron Fox

Available for Game 5 Against Timberwolves
Caris LeVert

Remains on Injury Report With Heel Issue
Duncan Robinson

Listed as Questionable for Game 5
Memphis Grizzlies

Brandon Clarke Dies at Age 29
Charlie McAvoy

Slapped With Six-Game Suspension
Jonas Brodin

Unavailable for Game 5 Against Avalanche
Joel Eriksson Ek

to Remain Out Wednesday
Sam Malinski

Day-to-Day With Upper-Body Injury
Jacob Wilson

A's Place Jacob Wilson on Injured List With Shoulder Subluxation
Artturi Lehkonen

Considered Day-to-Day
Charlie Coyle

Lands Six-Year Extension
Ukko-Pekka Luukkonen

to Start Game 4 Against Canadiens
Drew Helleson

Unavailable for Game 5
Radko Gudas

Still Out Tuesday
Christian Yelich

Brewers Reinstate Christian Yelich From Injured List
Luka Dončić

Luka Doncic Admits He Wasn't Close to Returning Before Season Ended
CFB

Isaac Brown Has All-American Upside in 2026
LeBron James

Uncertain About Future After Season-Ending Loss
Ajay Mitchell

Continues to Excel for Thunder
CFB

Nyck Harbor Heading into Breakout Year?
Shai Gilgeous-Alexander

Posts 35 Points in Series Clincher
CFB

Notre Dame, USC in Discussions to Resume Rivalry Series
Cade Cunningham

Struggles in Game 4 Loss
CFB

Jaron-Keawe Sagapolutele Has Eyes on ACC Title
CFB

Ahmad Hardy's Gunshot Wound Not Viewed as Career-Threatening
A.J. Ewing

Mets to Call Up Top Prospect A.J. Ewing
Mookie Betts

is Officially Back on Monday
Nathan Eovaldi

Scratched From Monday's Start With Side Tightness
Henry Bolte

Athletics to Promote Top Outfield Prospect Henry Bolte to Major Leagues
Khamzat Chimaev

Suffers his First Loss
Sean Strickland

Recaptures Middleweight Title
Tatsuro Taira

Suffers Fifth-Round TKO Loss
Joshua Van

Defends Flyweight Title
MMA

Waldo Cortes-Acosta Drops Decision
Alexander Volkov

Wins Back-To-Back Fights
Shane Van Gisbergen

Dominates Watkins Glen for First Win of 2026
Michael McDowell

Finishes Second for Best Run of the Year At Watkins Glen
Ty Gibbs

Scores New Career-Best Finish of Third at Watkins Glen
Tyler Reddick

Continues His Strong Season With Fifth-Place Run at Watkins Glen
Austin Dillon

Earns his First Top-10 Finish of 2026 at Watkins Glen
Mookie Betts

Dodgers Expect Mookie Betts to Return on Monday
CFB

Ahmad Hardy Sustains Gunshot Wound, in Stable Condition
Connor Zilisch

Will Start Fifth in his First Watkins Glen Cup Series Race
Tyler Reddick

Is A Top DFS Option for Watkins Glen Lineups
Christopher Bell

Is Likely to Bounce Back This Week at Watkins Glen
Carlos Rodón

Carlos Rodon Activated for Season Debut on Sunday
William Byron

Is William Byron Playable in DFS Lineups at Watkins Glen?
Kyle Larson

May have A Positive Day at Watkins Glen
Chase Briscoe

May Compete for A Top-10 Finish at Watkins Glen
NASCAR

A.J. Allmendinger May have Another Solid Outing at Watkins Glen
Ty Gibbs

Should Fantasy Managers Roster Ty Gibbs at Watkins Glen?
Ross Chastain

Is Ross Chastain Worth Rostering for Watkins Glen Lineups?
Austin Cindric

Could Austin Cindric be A Sneaky Tournament Play for Watkins Glen?
Shane Van Gisbergen

Shane van Gisbergen the Heavy Favorite at Watkins Glen
Chase Elliott

Is Chase Elliott a No-Brainer DFS Pick at Watkins Glen?
Chris Buescher

Qualifies 14th at Watkins Glen
Ryan Blaney

Has Upside at Watkins Glen After Signing Contract Extension
Michael McDowell

Still Searching for First Top-Five Finish at Watkins Glen
Carson Hocevar

Is Carson Hocevar Too Aggressive for Road-Course Racing?
Luis Castillo

Mariners Intend to Piggyback Luis Castillo, Bryce Miller
Logan Webb

Placed on 15-Day Injured List With Knee Bursitis
Bryce Miller

is Set to Return on Wednesday
Jeff Hoffman

Could Return to Closer Role
Taj Bradley

Hits the Injured List With Pectoral Inflammation
Kyle Bradish

has Nice Bounce-Back Performance With 10 K's
Casey Mize

Throws Bullpen on Friday, Return Not Imminent
Sean Strickland

An Underdog At UFC 328
Khamzat Chimaev

Set For UFC 328 Main Event
Tatsuro Taira

Can Become The New Flyweight Champion
Joshua Van

Set For His First Title Defense
Alexander Volkov

Looks To Win Back-To-Back Fights
MMA

Waldo Cortes-Acosta Looks To Extend His Win Streak
CFB

Walker Lyons Could be Go-To Target for Bear Bachmeier
CFB

Ty Benefield a Potential Game-Changer for LSU Defense
CFB

Hayden Lowe Set for Significant Role Following Miami's NFL Departures
CFB

Taylor Wein in Position for Big Season on Oklahoma's Defensive Line
CFB

Rasheem Biles an Instant Impact Player for Texas
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF