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Week 5 Thursday Night NFL Matchups Analysis: Start/Sit for Fantasy Football

Ben Ruppert's Thursday Night Football (TNF) matchups analysis and lineup starts/sits for Week 5 of the 2016 NFL season. Players to target or avoid for fantasy football lineups.

It's time for the Week 5 installment of Thursday night matchups with my start/sit recommendations. This week, a pair of 1-3 teams meet, with the Cardinals heading into San Francisco to take on the 49ers.

Each week of the NFL season, we will be breaking down every game and providing you with some fantasy football advice and lineup recommendations based on matchups that we love, matchups that we hate, and injury information as well. Later this week, you will find parts one and two of our Week 5 NFL matchups, which should help you prepare your lineups to win this week. It’s essential to analyze the weekly NFL matchups to find lineup sleepers and gems, while also avoiding those players who may turn out to be busts.

Editor's Note: Be sure to check out FantasyAces DFS contests. New users that sign up on Fantasy Aces and make a $20 deposit will receive RotoBaller's full season NFL Premium Pass for free (including Premium DFS), normally a $59.99 value. Expert DFS research, sample lineups, matchup ratings and lots more!

Editor's Note: The FFPC Baby Gorilla Tournament is now open, featuring a $100,000 grand prize and a $675,450 total prize pool! This 12-team, Tight End Premium contest uses a 20-round draft format, with the overall winners determined by total points scored during Weeks 15–17. Get $25 to use toward your first entry by signing up through our link. Grab your team now! Sign Up Now!

 

Cardinals @ 49ers - Thursday 10/6 @ 8:25 PM EST

Matchups We Love:

David Johnson, RB, ARI

David Johnson will produce against any team he faces. Johnson has been one of the top scoring fantasy RBs to date. He can do it all, and there will be even more room in the backfield with backup RB Chris Johnson being placed on IR. The 49ers also recently lost stud LB Navarro Bowman to a torn Achilles, which means more running room up the middle for Johnson. Last week Ezekiel Elliott ran all over this defense, rushing 23 times for 138 yards and a score. Expect another huge day from Johnson.

Larry Fitzgerald, WR, ARI

Larry Fitzgerald has been the most consistent WR the Cardinals have had this season, with at least five catches and 60 yards in every game this season. As long as Carson Palmer remains at the helm, expect a good game from Fitz. However, if Drew Stanton ends up starting then temper expectations in this game mightily. In 2014 when Stanton started multiple games for the Cardinals, Fitz averaged four receptions on eight targets for only 38 yards over eight games. He did not score a TD in any of the eight games. Fitz falls as low as the ‘hate’ category this week if Stanton is behind center.

Carlos Hyde, RB, SF

Carlos Hyde has looked much better than advertised so far in 2016. He is averaging 20 touches per game, 4.1 YPC, and has five TDs through his first four games of the season. What is surprising about these numbers is that no matter what the situation was in the game, Hyde was used. In Week 1 when they dominated the Rams, Hyde was in all game, and when they were getting trounced by the Seahawks in Week 3, Hyde was in until the end getting carries. Even though this Cardinals defense has done well defending the run, Hyde is the 49ers' best offensive weapon and will get touches no matter the situation. Fire him up on Thursday night.

 

Matchups We Hate:

Carson Palmer, QB, ARI

Carson Palmer may not be playing in this game on Thursday due to a concussion sustained in the fourth quarter of last Sunday’s game against the Rams. If he doesn’t play, it affects the entire offense in different ways. If he does play, he has all the potential and weapons to have a great game, but he has struggled as of late. Palmer has averaged 288 yards over the past two weeks with a 1:5 TD:INT ratio. At this point you can drop Palmer, but I would bench him for another option until he turns his game around. It is never easy coming back from a concussion; I would not start Palmer in this matchup.

Michael Floyd, WR, ARI

Michael Floyd lost a ton of snaps to John Brown last week against the Rams. After out-snapping Brown 90% to 57% in Week 3, Brown dominated Week 4's count, 91% to 45%. Brown also went out and put up better numbers then Floyd has all season. This week they face the 49ers and may have Stanton at the helm. In 2014 when Stanton started, Floyd had some games where he caught one pass, and then had others where he caught five passes for over 100 yards and multiple TDs. Floyd is so wildly unpredictable that it is tough to recommend starting him. No matter who plays QB for the Cardinals this week, you’re rolling the dice trotting Floyd out there.

 

Notable Players:

John Brown, WR, ARI

John Brown has seen a huge resurgence over the past two weeks. After barely being able to get on the field over the first two weeks, Brown has caught 16 passes for 214 yards over the past two weeks. He out-snapped Michael Floyd 91% to 45% last week. Back in 2014, Brown’s rookie season, he had consistent play while Stanton was under center. Brown looks like he has fully recovered from the concussion he suffered earlier in the year, and as long as his snap count remains high, expect solid production from the 26-year-old WR.

Jeremy Kerley, WR, SF

Jeremy Kerley had himself a solid game last week, catching 6-of-9 targets for 88 yards and his first TD of 2016. This was Kerley’s best game since Week 1 when he caught seven passes for 61 yards. He didn’t do much in Weeks 2 or 3, but he does lead the 49ers in targets this season with 32 over four games (8 targets per game). Kerley would be a fine play in PPR formats given all of these targets, but he is a risk in standard leagues. It’s tough to know what you will get from Blaine Gabbert each week, so keep expectations in check after Kerley’s big week last week.

 




REAL-TIME FANTASY NEWS

Jalen Chatfield

Delivers Two Assists in Crucial Win
Mark Jankowski

Contributes Two Assists in Game 2 Victory
Eric Robinson

Scores in Second Consecutive Game
Nikolaj Ehlers

Tallies Two Goals as Hurricanes Bounce Back Saturday
Giannis Antetokounmpo

Magic Reportedly Have Giannis Antetokounmpo on Their Radar
Ajay Mitchell

Won't Play Sunday
Dylan Harper

Not on Injury Report for Game 4
De'Aaron Fox

Off the Injury Report Ahead of Game 4
Jalen Williams

Questionable for Sunday Night
Ja'Tavion Sanders

a Dynasty Dart Throw With Potential Untapped Upside
Geno Smith

a Low-Cost Dynasty Add Who Still Comes with Risk
C.J. Stroud

Still a Capable and Undervalued Dynasty QB2
Bhayshul Tuten

More Big Plays in 2026 Could Transform Bhayshul Tuten into a Dynasty Steal
Joe Mixon

Is Joe Mixon's NFL Career Over?
MLB

Orioles-Tigers Game Postponed on Saturday
RJ Harvey

to be Relegated to Third-Down Role After Rookie RB Addition?
Baker Mayfield

A Lot of Uncertainty Surrounding Baker Mayfield Going into Fourth Year in Tampa
Brian Robinson Jr.

a Must-Have Handcuff in Dynasty Leagues?
Sam LaPorta

Could be Excellent Buy-Low Candidate for Risk-Tolerant Managers
Jordyn Tyson

on a "Maintenance Plan" During Offseason Workouts
Kenneth Walker III

One of Dynasty's Biggest Risers for 2026
D'Andre Swift

an Underappreciated Dynasty Buy Candidate
Ray Davis

Still a Dynasty Stash Despite a Lack of Standalone Value
Travis Kelce

Now a Low-Cost Dynasty Rental
DJ Moore

a Reasonable Buy Candidate Now That Dynasty Market Has Cooled
MLB

Rays-Yankees Postponed on Saturday
Devin Vassell

Posts 20 Points in Game 3 Loss
De'Aaron Fox

Struggles From Deep in Friday's Loss
Victor Wembanyama

Held to Four Rebounds in Game 3 Loss
Jaylin Williams

Catches Fire From Deep Friday
Jared McCain

Drops Playoff-High 24 Points in Game 3
Nazem Kadri

Contributes an Assist in Losing Effort
Shai Gilgeous-Alexander

Guides Thunder to 2-1 Series Lead
Ajay Mitchell

Does Not Return in Game 3 Win
Ross Colton

Nets Lone Avalanche Goal Friday Night
Rasmus Andersson

Extends Assist Streak to Four Games
Pavel Dorofeyev

Focuses on Playmaking in Friday's Win
Jack Eichel

Enjoys Multi-Point Outing in Game 2 Win Friday
Ivan Barbashev

Amasses Three Points as Golden Knights Grab 2-0 Series Lead
Jordan James

Most Likely to be 49ers' RB2 in 2026
Mickey Moniak

Heads to Injured List With Ankle Sprain
Rudy Gobert

Earns Eighth All-Defensive First-Team Selection
Victor Wembanyama

Headlines 2025-26 All-Defensive First Team
Ajay Mitchell

Starting Game 3 Against Spurs
Dylan Harper

Available for Game 3 Against Thunder
De'Aaron Fox

Returns to Action Friday
Jalen Williams

Won't Play Friday Night
Derrick Henry

Remains in RB1 Discussion
Ladd McConkey

is Solid Buy-Low Candidate
Ryan Flournoy

an Intriguing Dynasty Stash Option
Jalen Nailor

is Expected to Have Larger Role in Las Vegas
Frederik Andersen

Hurricanes Keep Faith in Frederik Andersen
Devon Levi

Attracting Interest From Senators
Jacoby Brissett

Cardinals Not Close to a Reworked Deal
Scott Wedgewood

Starting Game 2 Against Golden Knights
Ben Hutton

Scratched for Game 2 Against Avalanche
Mark Stone

Won't Play Friday
Jackson Merrill

has Sore Ribs, Expected to Avoid Injured List
Cale Makar

Remains Out Friday
CFB

Jaron-Keawe Sagapolutele Looking to Take Sophomore Leap
CFB

Jadan Baugh Primed to Lead Florida Offense in 2026
CFB

LSU Hires Ed Orgeron As Special Assistant
CFB

North Carolina and South Carolina Cancel Home-And-Home Series
CFB

Confidence High in Mississippi State's Kamario Taylor
MLB

Reds-Cardinals Game Postponed on Friday
Trevor Story

has Hernia Surgery, Expected to Miss 6-10 Weeks
Roman Anthony

Dealing With Sprained Ligament in his Finger
Evan Mobley

Fills the Box Score in Game 2 Loss
James Harden

Held to Two Assists Thursday
Donovan Mitchell

Leads Cavaliers in Scoring in Game 2 Defeat
Sebastian Aho

Picks Up an Assist in Series-Opening Loss
Seth Jarvis

Needs 33 Seconds to Score in Game 1 Loss
Jaccob Slavin

Struggles in Game 1 Against Canadiens
Jakub Dobes

Sharp in Game 1 Victory
Cole Caufield

Bags Two Points in Impressive Road Win
Ronald Acuña Jr.

Ronald Acuna Jr. Exits Early, X-Rays Come Back Negative
Robby Snelling

Will Undergo Tommy John Surgery
Jackson Merrill

Tweaks his Back on Wednesday, Pulled Early
CFB

Lincoln Riley Believes USC is Ready for Playoff Run
CFB

Notre Dame-Stanford Rivalry Renewed Through 2028
CFB

Ahmad Hardy Says He's "Back to the Road to Success"
CFB

Texas Tech Graduate Judge Recuses Himself from Brendan Sorsby Case
CFB

UCLA Tackle Jordan Davis Officially Eligible for 2026 Season
CFB

Bret Bielema Supports Significant College Football Playoff Expansion
Michael Thorbjornsen

Brings High Upside to CJ Cup Byron Nelson
Luke List

Carrying Poor Form Into CJ Cup Byron Nelson
Tom Kim

Hoping to Build on Strong Myrtle Beach Finish
PGA

Sungjae Im Brings Upside to TPC Craig Ranch
Billy Horschel

Looking for Turnaround at CJ Cup Byron Nelson
Adam Hadwin

Difficult to Trust at TPC Craig Ranch
Tony Finau

Looking for Consistency at TPC Craig Ranch
Luke Clanton

Searching for Form at CJ Cup Byron Nelson
Aaron Rai

Withdraws From CJ Cup Byron Nelson
Wyndham Clark

Can Wyndham Clark Find Form at CJ Cup?
Si Woo Kim

Looks To Stay Hot at CJ Cup
Scottie Scheffler

to Defend CJ Cup Byron Nelson Title This Week
Jordan Spieth

Looking For Victory at TPC Craig Ranch
PGA

Matti Schmid Looks to Keep Recent Momentum Going at TPC Craig Ranch
Brooks Koepka

a High-Upside Play at CJ Cup Byron Nelson
Yandy Díaz

Yandy Diaz Exits Early on Tuesday After Being Hit By Pitch
Chris Kirk

Continues Search For Putting Form at TPC Craig Ranch
Rasmus Hojgaard

Looking to Shake Off Poor Major Showing at TPC Craig Ranch
Joel Dahmen

is of No DFS Consideration This Week in Dallas
Pierceson Coody

is Not The Fun DFS Play He Used to Be
Gerrit Cole

to Make Season Debut on Friday Against Rays
Drake Baldwin

Braves Place Drake Baldwin on Injured List With Oblique Strain
CFB

Ezavier Crowell has Immediate Opportunity at Alabama
CFB

Mark Bowman a Day 1 Impact Player for USC?
CFB

Bill Belichick Says Relationship with First North Carolina Team "Wasn't Great"
CFB

Kemario Taylor a Breakout Candidate at Quarterback
CFB

Trinidad Chambliss the Undisputed Top SEC Quarterback Entering 2026?
CFB

Rocco Becht The "Unifier" of Penn State's Roster
Jackson Holliday

Orioles Reinstate Jackson Holliday From Injured List on Monday
Ronald Acuña Jr.

Braves Reinstate Ronald Acuna Jr. From Injured List on Monday
Jose Altuve

Astros Put Jose Altuve on Injured List With Oblique Strain
Corey Seager

Going on Injured List With Back Injury
Jeremy Peña

Jeremy Pena Reinstated and Starting on Monday Against Twins
Melquizael Costa

Drops Decision At UFC Vegas 117
Arnold Allen

Bounces Back
Daniel Santos

Suffers Second-Round TKO Loss
MMA

Dohoo Choi Wins His Third Consecutive Fight
Malcolm Wellmaker

Suffers His Second Loss In A Row
Juan Diaz

Scores Second-Round Submission
Christian Edwards

Defeated At UFC Vegas 117
CFB

Transfer Running Back Arnold Barnes Visiting Iowa State on Monday
Modestas Bukauskas

Gets Split-Decision Win
Jhostynxon Garcia

Expected to Join the Pirates on Tuesday
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF