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Week 5 Thursday Night NFL Matchups Analysis: Start/Sit for Fantasy Football

Ben Ruppert's Thursday Night Football (TNF) matchups analysis and lineup starts/sits for Week 5 of the 2016 NFL season. Players to target or avoid for fantasy football lineups.

It's time for the Week 5 installment of Thursday night matchups with my start/sit recommendations. This week, a pair of 1-3 teams meet, with the Cardinals heading into San Francisco to take on the 49ers.

Each week of the NFL season, we will be breaking down every game and providing you with some fantasy football advice and lineup recommendations based on matchups that we love, matchups that we hate, and injury information as well. Later this week, you will find parts one and two of our Week 5 NFL matchups, which should help you prepare your lineups to win this week. It’s essential to analyze the weekly NFL matchups to find lineup sleepers and gems, while also avoiding those players who may turn out to be busts.

Editor's Note: Be sure to check out FantasyAces DFS contests. New users that sign up on Fantasy Aces and make a $20 deposit will receive RotoBaller's full season NFL Premium Pass for free (including Premium DFS), normally a $59.99 value. Expert DFS research, sample lineups, matchup ratings and lots more!

Editor's Note: The FFPC Baby Gorilla Tournament is now open, featuring a $100,000 grand prize and a $675,450 total prize pool! This 12-team, Tight End Premium contest uses a 20-round draft format, with the overall winners determined by total points scored during Weeks 15–17. Get $25 to use toward your first entry by signing up through our link. Grab your team now! Sign Up Now!

 

Cardinals @ 49ers - Thursday 10/6 @ 8:25 PM EST

Matchups We Love:

David Johnson, RB, ARI

David Johnson will produce against any team he faces. Johnson has been one of the top scoring fantasy RBs to date. He can do it all, and there will be even more room in the backfield with backup RB Chris Johnson being placed on IR. The 49ers also recently lost stud LB Navarro Bowman to a torn Achilles, which means more running room up the middle for Johnson. Last week Ezekiel Elliott ran all over this defense, rushing 23 times for 138 yards and a score. Expect another huge day from Johnson.

Larry Fitzgerald, WR, ARI

Larry Fitzgerald has been the most consistent WR the Cardinals have had this season, with at least five catches and 60 yards in every game this season. As long as Carson Palmer remains at the helm, expect a good game from Fitz. However, if Drew Stanton ends up starting then temper expectations in this game mightily. In 2014 when Stanton started multiple games for the Cardinals, Fitz averaged four receptions on eight targets for only 38 yards over eight games. He did not score a TD in any of the eight games. Fitz falls as low as the ‘hate’ category this week if Stanton is behind center.

Carlos Hyde, RB, SF

Carlos Hyde has looked much better than advertised so far in 2016. He is averaging 20 touches per game, 4.1 YPC, and has five TDs through his first four games of the season. What is surprising about these numbers is that no matter what the situation was in the game, Hyde was used. In Week 1 when they dominated the Rams, Hyde was in all game, and when they were getting trounced by the Seahawks in Week 3, Hyde was in until the end getting carries. Even though this Cardinals defense has done well defending the run, Hyde is the 49ers' best offensive weapon and will get touches no matter the situation. Fire him up on Thursday night.

 

Matchups We Hate:

Carson Palmer, QB, ARI

Carson Palmer may not be playing in this game on Thursday due to a concussion sustained in the fourth quarter of last Sunday’s game against the Rams. If he doesn’t play, it affects the entire offense in different ways. If he does play, he has all the potential and weapons to have a great game, but he has struggled as of late. Palmer has averaged 288 yards over the past two weeks with a 1:5 TD:INT ratio. At this point you can drop Palmer, but I would bench him for another option until he turns his game around. It is never easy coming back from a concussion; I would not start Palmer in this matchup.

Michael Floyd, WR, ARI

Michael Floyd lost a ton of snaps to John Brown last week against the Rams. After out-snapping Brown 90% to 57% in Week 3, Brown dominated Week 4's count, 91% to 45%. Brown also went out and put up better numbers then Floyd has all season. This week they face the 49ers and may have Stanton at the helm. In 2014 when Stanton started, Floyd had some games where he caught one pass, and then had others where he caught five passes for over 100 yards and multiple TDs. Floyd is so wildly unpredictable that it is tough to recommend starting him. No matter who plays QB for the Cardinals this week, you’re rolling the dice trotting Floyd out there.

 

Notable Players:

John Brown, WR, ARI

John Brown has seen a huge resurgence over the past two weeks. After barely being able to get on the field over the first two weeks, Brown has caught 16 passes for 214 yards over the past two weeks. He out-snapped Michael Floyd 91% to 45% last week. Back in 2014, Brown’s rookie season, he had consistent play while Stanton was under center. Brown looks like he has fully recovered from the concussion he suffered earlier in the year, and as long as his snap count remains high, expect solid production from the 26-year-old WR.

Jeremy Kerley, WR, SF

Jeremy Kerley had himself a solid game last week, catching 6-of-9 targets for 88 yards and his first TD of 2016. This was Kerley’s best game since Week 1 when he caught seven passes for 61 yards. He didn’t do much in Weeks 2 or 3, but he does lead the 49ers in targets this season with 32 over four games (8 targets per game). Kerley would be a fine play in PPR formats given all of these targets, but he is a risk in standard leagues. It’s tough to know what you will get from Blaine Gabbert each week, so keep expectations in check after Kerley’s big week last week.

 




REAL-TIME FANTASY NEWS

Josh Giddey

Undergoes Ankle Surgery
Pete Fairbanks

Returns From Injured List
Christian Yelich

Out With Back Tightness on Wednesday Night
Nathan MacKinnon

Chasing History Wednesday
Ryan Poehling

Won't Be an Option for Game 6
Sam Malinski

Set to Miss Second Straight Game
Artturi Lehkonen

Unlikely to Play Wednesday
Matthew Schaefer

Wins Calder Trophy
TOR

Maple Leafs Fire Head Coach Craig Berube
Jalen Hurts

Can Jalen Hurts Bounce Back as a Rusher in 2026?
Robby Snelling

Placed on 15-Day Injured List with Elbow Sprain
Zach Charbonnet

Dynasty Value in Question Entering 2026
DeVonta Smith

Poised to Reach a New Level of Production in 2026?
Chris Olave

Facing Increased Target Competition in New Orleans Entering 2026
Chris Bell

Dynasty Stock Rising Following NFL Draft
Ted Hurst

Facing Uphill Battle for Playing Time in Tampa Bay
Francisco Alvarez

Mets Place Francisco Alvarez on Injured List With Torn Meniscus
Max Fried

Dealing With Left Elbow Posterior Soreness
CFB

NFL Veteran Tom Moore Joins Iowa Coaching Staff
CFB

Can Cam Cook Dominate in Return to Big 12?
Chris Brazzell II

Is Chris Brazzell II the Top Deep Threat in Carolina's Receiver Room?
Kaelon Black

a Threat to Win Backup RB Job in San Fran?
CFB

ACC, Big 12 Support 24-Team College Football Playoff
De'Zhaun Stribling

to be 49ers' New "F" Receiver?
CFB

Anthony Colandrea Looking to Elevate Nebraska Back to National Contention
Drew Allar

Steelers "Uninstalling" Everything Drew Allar Learned in College
CFB

Kwazi Gilmer Set for Big Impact at Nebraska
Ja'Kobi Lane

Is Ja'Kobi Lane the Pass-Catching Answer the Ravens Have Been Seeking?
Zachariah Branch

Does Zachariah Branch Have a Path to Immediate Production?
Max Klare

Can Max Klare Separate Himself in Rams' Tight End Room?
Eli Stowers

the Tight End of the Future in Philadelphia?
Justin Thomas

Trending Well Ahead of PGA Championship Despite Concerning Form
J.J. Spaun

Trending Up Ahead of PGA Championship
Adam Scott

Riding Strong Form Into PGA Championship
Patrick Reed

Looking to Make Another Run at PGA Championship
PGA

Sungjae Im Looks to Build on Strong Finish at Truist Championship
Sam Burns

Must Keep Ball in Play at PGA Championship
Jordan Spieth

Looks to Complete Career Grand Slam at Aronimink
Brandt Snedeker

Not the Best Option for the PGA Championship
Rasmus Hojgaard

a Volatile Option at PGA Championship
Germie Bernard

Already in a Tough Spot to Hold Dynasty Value
Ayo Dosunmu

Has Busy Night in Game 5
Maverick McNealy

Seeking Better Start in Philadelphia
Harry Hall

a Boom-or-Bust Option at Aronimink
Jaden McDaniels

Notches 17 Points in Game 5 Loss
Denzel Boston

a Smart Bet to Meet or Exceed Value in Dynasty Rookie Drafts
Hideki Matsuyama

Attempts to Improve Over 2025 PGA Championship
Scottie Scheffler

Looks to Defend PGA Championship at Aronimink
Julius Randle

Posts a Double-Double in Losing Effort
Matthew Stafford

a Sell Candidate with Touchdown Regression Likely on its Way
Nicolai Hojgaard

Wants to Keep Momentum Rolling in Philadelphia
Anthony Edwards

Held to 20 Points in Game 5 Loss
Ben Griffin

Attempting to Bounce Back After Truist Championship
CFB

Transfer Defensive Lineman Devarrick Woods Commits to Clemson
Keldon Johnson

Comes Alive in Game 5 Against Timberwolves
Jayden Reed

Dynasty Value Tethered to His Underwhelming Usage
Harris English

Will Need His Putter to Thrive at Aronimink
Stephon Castle

Makes All-Around Impact in Game 5
Kenyon Sadiq

Is Kenyon Sadiq the Next Great Rookie Tight End?
Victor Wembanyama

Leads Spurs to Big Win in Game 5
Akshay Bhatia

Creative Flair Could Show Itself in Philadelphia
Keegan Bradley

Knows the Aronimink Golf Club Well
Mason McTavish

Delivers Two Assists Tuesday Night
Pavel Dorofeyev

Pots Two Goals in Vital Game 5 Win
Josh Doan

Records Two Assists in Game 4 Victory
Evgeni Malkin

Penguins Want Evgeni Malkin Back
Sidney Crosby

Joins Team Canada for World Championship
Ryan Poehling

Suffers Upper-Body Injury in Game 5 Loss
Si Woo Kim

Struggles at Truist Championship
Gary Woodland

Can Continue Incredible 2026 Season at PGA Championship
Xander Schauffele

In Excellent Form Heading to PGA Championship
Cade Klubnik

Becoming Fan Favorite, in Play to Win Backup QB Job?
Michael Penix Jr.

Throwing During Offseason Program
Brandon Nimmo

Leaves Game on Tuesday with Apparent Ankle Injury
Philadelphia 76ers

76ers Part Ways With Daryl Morey
Kevin Huerter

Iffy for Game 5 Against Cavaliers
Dylan Harper

Cleared for Action Tuesday
De'Aaron Fox

Available for Game 5 Against Timberwolves
Caris LeVert

Remains on Injury Report With Heel Issue
Duncan Robinson

Listed as Questionable for Game 5
Memphis Grizzlies

Brandon Clarke Dies at Age 29
Charlie McAvoy

Slapped With Six-Game Suspension
Jonas Brodin

Unavailable for Game 5 Against Avalanche
Joel Eriksson Ek

to Remain Out Wednesday
Sam Malinski

Day-to-Day With Upper-Body Injury
Jacob Wilson

A's Place Jacob Wilson on Injured List With Shoulder Subluxation
Artturi Lehkonen

Considered Day-to-Day
Charlie Coyle

Lands Six-Year Extension
Ukko-Pekka Luukkonen

to Start Game 4 Against Canadiens
Drew Helleson

Unavailable for Game 5
Radko Gudas

Still Out Tuesday
Christian Yelich

Brewers Reinstate Christian Yelich From Injured List
Luka Dončić

Luka Doncic Admits He Wasn't Close to Returning Before Season Ended
CFB

Isaac Brown Has All-American Upside in 2026
LeBron James

Uncertain About Future After Season-Ending Loss
Ajay Mitchell

Continues to Excel for Thunder
CFB

Nyck Harbor Heading into Breakout Year?
Shai Gilgeous-Alexander

Posts 35 Points in Series Clincher
CFB

Notre Dame, USC in Discussions to Resume Rivalry Series
Cade Cunningham

Struggles in Game 4 Loss
CFB

Jaron-Keawe Sagapolutele Has Eyes on ACC Title
James Harden

Records 40th Postseason Double-Double
CFB

Ahmad Hardy's Gunshot Wound Not Viewed as Career-Threatening
A.J. Ewing

Mets to Call Up Top Prospect A.J. Ewing
Mookie Betts

is Officially Back on Monday
Nathan Eovaldi

Scratched From Monday's Start With Side Tightness
Henry Bolte

Athletics to Promote Top Outfield Prospect Henry Bolte to Major Leagues
Khamzat Chimaev

Suffers his First Loss
Sean Strickland

Recaptures Middleweight Title
Tatsuro Taira

Suffers Fifth-Round TKO Loss
Joshua Van

Defends Flyweight Title
MMA

Waldo Cortes-Acosta Drops Decision
Alexander Volkov

Wins Back-To-Back Fights
Shane Van Gisbergen

Dominates Watkins Glen for First Win of 2026
Michael McDowell

Finishes Second for Best Run of the Year At Watkins Glen
Ty Gibbs

Scores New Career-Best Finish of Third at Watkins Glen
Tyler Reddick

Continues His Strong Season With Fifth-Place Run at Watkins Glen
Austin Dillon

Earns his First Top-10 Finish of 2026 at Watkins Glen
Mookie Betts

Dodgers Expect Mookie Betts to Return on Monday
CFB

Ahmad Hardy Sustains Gunshot Wound, in Stable Condition
Connor Zilisch

Will Start Fifth in his First Watkins Glen Cup Series Race
Tyler Reddick

Is A Top DFS Option for Watkins Glen Lineups
Christopher Bell

Is Likely to Bounce Back This Week at Watkins Glen
Carlos Rodón

Carlos Rodon Activated for Season Debut on Sunday
William Byron

Is William Byron Playable in DFS Lineups at Watkins Glen?
Kyle Larson

May have A Positive Day at Watkins Glen
Chase Briscoe

May Compete for A Top-10 Finish at Watkins Glen
NASCAR

A.J. Allmendinger May have Another Solid Outing at Watkins Glen
Ty Gibbs

Should Fantasy Managers Roster Ty Gibbs at Watkins Glen?
Ross Chastain

Is Ross Chastain Worth Rostering for Watkins Glen Lineups?
Austin Cindric

Could Austin Cindric be A Sneaky Tournament Play for Watkins Glen?
Shane Van Gisbergen

Shane van Gisbergen the Heavy Favorite at Watkins Glen
Chase Elliott

Is Chase Elliott a No-Brainer DFS Pick at Watkins Glen?
Chris Buescher

Qualifies 14th at Watkins Glen
Ryan Blaney

Has Upside at Watkins Glen After Signing Contract Extension
Michael McDowell

Still Searching for First Top-Five Finish at Watkins Glen
Carson Hocevar

Is Carson Hocevar Too Aggressive for Road-Course Racing?
Luis Castillo

Mariners Intend to Piggyback Luis Castillo, Bryce Miller
Logan Webb

Placed on 15-Day Injured List With Knee Bursitis
Bryce Miller

is Set to Return on Wednesday
Jeff Hoffman

Could Return to Closer Role
Taj Bradley

Hits the Injured List With Pectoral Inflammation
Kyle Bradish

has Nice Bounce-Back Performance With 10 K's
Casey Mize

Throws Bullpen on Friday, Return Not Imminent
Sean Strickland

An Underdog At UFC 328
Khamzat Chimaev

Set For UFC 328 Main Event
Tatsuro Taira

Can Become The New Flyweight Champion
Joshua Van

Set For His First Title Defense
Alexander Volkov

Looks To Win Back-To-Back Fights
MMA

Waldo Cortes-Acosta Looks To Extend His Win Streak
CFB

Walker Lyons Could be Go-To Target for Bear Bachmeier
CFB

Ty Benefield a Potential Game-Changer for LSU Defense
CFB

Hayden Lowe Set for Significant Role Following Miami's NFL Departures
CFB

Taylor Wein in Position for Big Season on Oklahoma's Defensive Line
CFB

Rasheem Biles an Instant Impact Player for Texas
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF