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Week 5 Thursday Night NFL Matchups Analysis: Start/Sit for Fantasy Football

Ben Ruppert's Thursday Night Football (TNF) matchups analysis and lineup starts/sits for Week 5 of the 2016 NFL season. Players to target or avoid for fantasy football lineups.

It's time for the Week 5 installment of Thursday night matchups with my start/sit recommendations. This week, a pair of 1-3 teams meet, with the Cardinals heading into San Francisco to take on the 49ers.

Each week of the NFL season, we will be breaking down every game and providing you with some fantasy football advice and lineup recommendations based on matchups that we love, matchups that we hate, and injury information as well. Later this week, you will find parts one and two of our Week 5 NFL matchups, which should help you prepare your lineups to win this week. It’s essential to analyze the weekly NFL matchups to find lineup sleepers and gems, while also avoiding those players who may turn out to be busts.

Editor's Note: Be sure to check out FantasyAces DFS contests. New users that sign up on Fantasy Aces and make a $20 deposit will receive RotoBaller's full season NFL Premium Pass for free (including Premium DFS), normally a $59.99 value. Expert DFS research, sample lineups, matchup ratings and lots more!

Editor's Note: The FFPC Baby Gorilla Tournament is now open, featuring a $100,000 grand prize and a $675,450 total prize pool! This 12-team, Tight End Premium contest uses a 20-round draft format, with the overall winners determined by total points scored during Weeks 15–17. Get $25 to use toward your first entry by signing up through our link. Grab your team now! Sign Up Now!

 

Cardinals @ 49ers - Thursday 10/6 @ 8:25 PM EST

Matchups We Love:

David Johnson, RB, ARI

David Johnson will produce against any team he faces. Johnson has been one of the top scoring fantasy RBs to date. He can do it all, and there will be even more room in the backfield with backup RB Chris Johnson being placed on IR. The 49ers also recently lost stud LB Navarro Bowman to a torn Achilles, which means more running room up the middle for Johnson. Last week Ezekiel Elliott ran all over this defense, rushing 23 times for 138 yards and a score. Expect another huge day from Johnson.

Larry Fitzgerald, WR, ARI

Larry Fitzgerald has been the most consistent WR the Cardinals have had this season, with at least five catches and 60 yards in every game this season. As long as Carson Palmer remains at the helm, expect a good game from Fitz. However, if Drew Stanton ends up starting then temper expectations in this game mightily. In 2014 when Stanton started multiple games for the Cardinals, Fitz averaged four receptions on eight targets for only 38 yards over eight games. He did not score a TD in any of the eight games. Fitz falls as low as the ‘hate’ category this week if Stanton is behind center.

Carlos Hyde, RB, SF

Carlos Hyde has looked much better than advertised so far in 2016. He is averaging 20 touches per game, 4.1 YPC, and has five TDs through his first four games of the season. What is surprising about these numbers is that no matter what the situation was in the game, Hyde was used. In Week 1 when they dominated the Rams, Hyde was in all game, and when they were getting trounced by the Seahawks in Week 3, Hyde was in until the end getting carries. Even though this Cardinals defense has done well defending the run, Hyde is the 49ers' best offensive weapon and will get touches no matter the situation. Fire him up on Thursday night.

 

Matchups We Hate:

Carson Palmer, QB, ARI

Carson Palmer may not be playing in this game on Thursday due to a concussion sustained in the fourth quarter of last Sunday’s game against the Rams. If he doesn’t play, it affects the entire offense in different ways. If he does play, he has all the potential and weapons to have a great game, but he has struggled as of late. Palmer has averaged 288 yards over the past two weeks with a 1:5 TD:INT ratio. At this point you can drop Palmer, but I would bench him for another option until he turns his game around. It is never easy coming back from a concussion; I would not start Palmer in this matchup.

Michael Floyd, WR, ARI

Michael Floyd lost a ton of snaps to John Brown last week against the Rams. After out-snapping Brown 90% to 57% in Week 3, Brown dominated Week 4's count, 91% to 45%. Brown also went out and put up better numbers then Floyd has all season. This week they face the 49ers and may have Stanton at the helm. In 2014 when Stanton started, Floyd had some games where he caught one pass, and then had others where he caught five passes for over 100 yards and multiple TDs. Floyd is so wildly unpredictable that it is tough to recommend starting him. No matter who plays QB for the Cardinals this week, you’re rolling the dice trotting Floyd out there.

 

Notable Players:

John Brown, WR, ARI

John Brown has seen a huge resurgence over the past two weeks. After barely being able to get on the field over the first two weeks, Brown has caught 16 passes for 214 yards over the past two weeks. He out-snapped Michael Floyd 91% to 45% last week. Back in 2014, Brown’s rookie season, he had consistent play while Stanton was under center. Brown looks like he has fully recovered from the concussion he suffered earlier in the year, and as long as his snap count remains high, expect solid production from the 26-year-old WR.

Jeremy Kerley, WR, SF

Jeremy Kerley had himself a solid game last week, catching 6-of-9 targets for 88 yards and his first TD of 2016. This was Kerley’s best game since Week 1 when he caught seven passes for 61 yards. He didn’t do much in Weeks 2 or 3, but he does lead the 49ers in targets this season with 32 over four games (8 targets per game). Kerley would be a fine play in PPR formats given all of these targets, but he is a risk in standard leagues. It’s tough to know what you will get from Blaine Gabbert each week, so keep expectations in check after Kerley’s big week last week.

 




REAL-TIME FANTASY NEWS

Jackson Holliday

Orioles Reinstate Jackson Holliday From Injured List on Monday
Ronald Acuña Jr.

Braves Reinstate Ronald Acuna Jr. From Injured List on Monday
Jose Altuve

Astros Put Jose Altuve on Injured List With Oblique Strain
Larry Nance Jr.

is Questionable for Game 1 on Tuesday
OG Anunoby

is Probable for Tuesday's Game 1
Luke Kornet

is Cleared for Game 1
New Orleans Pelicans

Jamahl Mosley Agrees to Become Pelicans Next Head Coach
De'Aaron Fox

is Ruled Out for Game 1 on Monday
Ukko-Pekka Luukkonen

Set to Start Game 7
Corey Seager

Going on Injured List With Back Injury
Tage Thompson

Can Match Franchise Record With Another Multi-Point Game
Nick Suzuki

Seeks More Road Success Monday
Lane Hutson

Riding a Five-Game Assist Streak Into Game 7
Filip Gustavsson

Needs Offseason Surgery
Jeremy Peña

Jeremy Pena Reinstated and Starting on Monday Against Twins
Cam Skattebo

Dynasty Stock Rising Following NFL Draft
Kaleb Johnson

Logging First-Team Reps in OTAs
Evan Engram

Dynasty Value Fading After Production Decline in 2025
TreVeyon Henderson

Dynasty Outlook Clouded By Split Backfield in New England
Caleb Williams

' Dynasty Upside Remains Sky-High Entering 2026
Bijan Robinson

Is Bijan Robinson the No. 1 Overall Player in Dynasty Formats?
Woody Marks

Should Have Plenty of Opportunities to Catch Passes
Drew Allar

Working as QB4 in First OTA Session
Aaron Rodgers

Reports to Steelers Facilities on Monday
Alvin Kamara

Saints Remain Non-Committal on Alvin Kamara's Future
Chris Olave

Saints Continue to Work on Extension With Chris Olave
Parker Washington

a Sneaky Trade Target in Dynasty Leagues?
Melquizael Costa

Drops Decision At UFC Vegas 117
Jarquez Hunter

Can Jarquez Hunter's Dynasty Outlook Improve in Year 2?
Arnold Allen

Bounces Back
James Conner

Off the Dynasty Radar Entirely?
Elijah Arroyo

Will Elijah Arroyo Continue to Have Trouble Getting on the Field?
Daniel Santos

Suffers Second-Round TKO Loss
Tre Tucker

Not a Long-Term Solution in Dynasty Leagues
MMA

Dohoo Choi Wins His Third Consecutive Fight
Malcolm Wellmaker

Suffers His Second Loss In A Row
Juan Diaz

Scores Second-Round Submission
Christian Edwards

Defeated At UFC Vegas 117
CFB

Transfer Running Back Arnold Barnes Visiting Iowa State on Monday
Modestas Bukauskas

Gets Split-Decision Win
Jack Bech

a Dynasty Hold as New-Look Raiders Offense Takes Shape
Jaydon Blue

a Low-Value Dynasty Stash Until Depth Charts are Settled
Makai Lemon

a Top-Five Pick in Dynasty Rookie Drafts
George Kittle

a Dynasty Buy with League-Winning Potential
Jhostynxon Garcia

Expected to Join the Pirates on Tuesday
Chris Rodriguez Jr.

a Dynasty Sleeper with High Touchdown Potential
Tobias Harris

Goes Cold in Game 7 Loss
Quinn Hughes

Open to Signing Extension This Offseason
Jalen Duren

Finishes Game 7 with Quiet Line
Cade Cunningham

Endures Cold Shooting Night Sunday
Joel Eriksson Ek

Misses Second Round Due to Heel Injury
Sam Merrill

Catches Fire in Game 7 Win
Evan Mobley

Posts Versatile Double-Double in Game 7
Jonas Brodin

Sits Out Round 2 Due to Toe Injury
Donovan Mitchell

Guides Cavaliers Into East Finals
Sam Malinski

Practices Fully Sunday
Jarrett Allen

Scores 23 Points in Cavs' Game 7 Rout of Pistons
Josh Manson

Rejoins Practice
Kevin Huerter

Active on Sunday Night
Caris LeVert

Duncan Robinson, Caris LeVert Available Sunday
Dean Wade

Max Strus Replaces Dean Wade in Starting Lineup Sunday
Luke Kornet

Iffy for Monday
Larry Nance Jr.

Won't Play Sunday
De'Aaron Fox

Listed as Questionable for Monday's Action
Jalen Williams

Officially Available for Game 1 Against Spurs
Shai Gilgeous-Alexander

Named MVP for Second Straight Year
Colt Emerson

Mariners Promoting Top Prospect Colt Emerson to Major Leagues
Bones Hyland

Wants to Stay in Minnesota
Munetaka Murakami

Fantastic First Season Continues With Two More Homers
Cristopher Sánchez

Cristopher Sanchez Dazzles With 13-Strikeout Complete Game on Saturday
Blake Snell

to Undergo Elbow Surgery on Tuesday
Clay Holmes

Could Miss Around Three Months
Jose Altuve

Exits After Swing
Corey Seager

Absent With Back Spasms on Saturday
Jeremy Lauzon

Misses Saturday's Practice
Mark Stone

Doesn't Practice Saturday
Josh Manson

Misses Practice, Considered Day-to-Day
Brent Burns

Day-to-Day Ahead of Conference Finals
Cale Makar

Considered Day-to-Day
Alex Lyon

Likely to Start Game 6 Against Canadiens
Owen Power

Available Saturday
Trevor Story

Hits the Injured List With Groin Injury
Blake Snell

Likely to Need Elbow Surgery
Kyle Schwarber

on a Heater, Hits Two More Homers to Take Major-League Lead
Clay Holmes

Suffers Fractured Fibula on Friday Night
Blake Snell

Heads to 15-Day Injured List
Blake Snell

Scratched From Start on Friday for Undisclosed Reasons
Max Fried

Heading to Injured List With Elbow Bone Bruise
CFB

Julian Sayin Looking To Build Off Of Strong Debut Season
CFB

College GameDay Set for First Three Weeks
CFB

Jeremiah Smith Aiming For Ohio State Receiving Records
CFB

Keshaun Singleton Projects as Auburn's WR1
CFB

Jeremiah Cobb Impresses New Auburn Staff
CFB

Alberto Mendoza Very Likely to Start for Georgia Tech
CFB

Charles Woodson Jr. Commits to Michigan
Jordan Westburg

to Have Season-Ending Elbow Surgery
Melquizael Costa

Set For UFC Vegas 117 Main Event
Arnold Allen

A Favorite At UFC Vegas 117
Daniel Santos

Set For UFC Vegas 117 Co-Main Event
MMA

Dohoo Choi Returns At UFC Vegas 117
Juan Diaz

Set To Make His UFC Debut
Malcolm Wellmaker

Looks To Bounce Back
Christian Edwards

Set For His UFC Debut
Modestas Bukauskas

Looks To Get Back In The Win Column
Lane Hutson

Contributes Two Assists in Game 5 Victory
Nick Suzuki

Amasses Three Points in Crucial Victory Thursday
Juraj Slafkovsky

Dishes Out Three Assists in Game 5 Win
Carter Hart

Stops 31 Pucks in Series-Clinching Win
CFB

Virginia Tech Lands Commitment from Four-Star QB Peter Bourque
CFB

NFL Veteran Tom Moore Joins Iowa Coaching Staff
CFB

Can Cam Cook Dominate in Return to Big 12?
CFB

ACC, Big 12 Support 24-Team College Football Playoff
CFB

Anthony Colandrea Looking to Elevate Nebraska Back to National Contention
CFB

Kwazi Gilmer Set for Big Impact at Nebraska
Justin Thomas

Trending Well Ahead of PGA Championship Despite Concerning Form
J.J. Spaun

Trending Up Ahead of PGA Championship
Adam Scott

Riding Strong Form Into PGA Championship
Patrick Reed

Looking to Make Another Run at PGA Championship
PGA

Sungjae Im Looks to Build on Strong Finish at Truist Championship
Sam Burns

Must Keep Ball in Play at PGA Championship
Jordan Spieth

Looks to Complete Career Grand Slam at Aronimink
Brandt Snedeker

Not the Best Option for the PGA Championship
Rasmus Hojgaard

a Volatile Option at PGA Championship
Maverick McNealy

Seeking Better Start in Philadelphia
Harry Hall

a Boom-or-Bust Option at Aronimink
Hideki Matsuyama

Attempts to Improve Over 2025 PGA Championship
Scottie Scheffler

Looks to Defend PGA Championship at Aronimink
Nicolai Hojgaard

Wants to Keep Momentum Rolling in Philadelphia
Ben Griffin

Attempting to Bounce Back After Truist Championship
CFB

Transfer Defensive Lineman Devarrick Woods Commits to Clemson
Harris English

Will Need His Putter to Thrive at Aronimink
Akshay Bhatia

Creative Flair Could Show Itself in Philadelphia
Keegan Bradley

Knows the Aronimink Golf Club Well
Si Woo Kim

Struggles at Truist Championship
Gary Woodland

Can Continue Incredible 2026 Season at PGA Championship
Xander Schauffele

In Excellent Form Heading to PGA Championship
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF