👉 TAP TO SAVE 50% WITH CODE SPRING
X
Lost password?

Don't have an account?
Gain Access Now

X

Receive free daily analysis

NFL
NBA
NHL
NASCAR
CFB
MLB
MMA
PGA
ESPORTS
BETTING

Already have an account? Log In

X

Forgot Password


POPULAR FANTASY TOOLS

Expert Advice
Articles & Tools
Import Your Leagues
Draft Rankings
Draft Simulator
Compare Any Players
24x7 News and Alerts

Titans vs 49ers Start 'Em, Sit 'Em: A.J. Brown, Brandon Aiyuk, Jeff Wilson, D'Onta Foreman

Deebo Samuel - Fantasy Football Rankings, NFL Injury News, DFS Lineup Picks

Fantasy football start em, sit em and lineups advice for the Titans vs 49ers Thursday game in Week 16 (2021). Ellis Johnson analyzes the TNF matchups with a detailed breakdown.

We are officially in the fantasy playoffs for all leagues. For those of you who made it, congratulations. To those of you joining us after a bye week, I hope you didn’t get too comfortable. Lastly, to those of us that missed playoffs, let’s focus on the holiday season and enjoy the NFL playoff push.

Last week was wildly mediocre for fantasy. In what was most fantasy manager’s worst nightmare, we had one of the lowest scoring Week 15’s of all time. This included star fantasy players such as Ja'Marr Chase, Alvin Kamara, Najee Harris, and many others, posting season-low fantasy weeks. On top of this, we had a few monster games from the usual suspects (Travis Kelce and Mark Andrews for example) as well as Tyler Huntley and Duke Johnson Jr. 

Going into Week 16, we can only hope for a better fantasy output. To start the week off we have two teams that are both on the verge of making the postseason. The revitalized 49ers are traveling to Nashville to take on a hobbled Titans team. As always, my name is Ellis Johnson, and this is your RotoBaller Thursday Night Preview.

Editor's Note: The FFPC Baby Gorilla Tournament is now open, featuring a $100,000 grand prize and a $675,450 total prize pool! This 12-team, Tight End Premium contest uses a 20-round draft format, with the overall winners determined by total points scored during Weeks 15–17. Get $25 to use toward your first entry by signing up through our link. Grab your team now! Sign Up Now!

 

San Fransisco 49ers @ Tennessee Titans - 8:20 pm ET 

Notable Injuries

 

Must-Starts for Fantasy Football Lineups

A.J. Brown (WR, TEN): He’s back baby. Well, hopefully he is back. After being activated from the Injured Reserve earlier this week, all signs are pointing in the right direction. The young superstar has been very disappointing for fantasy this season. Not only has he missed a significant portion of the season due to injuries, but he also had five of his nine games under 10 fantasy points. Thankfully we have seen stretches this season that showcase the upside of Brown, with two consecutive weeks with 130+ receiving yards and a score. The Titans are taking on a 49ers team that ranks 11th in fantasy points allowed to the position. The Titans offense has been struggling, and Brown just might be the spark they need to get back on track. I would start AJB as a solid WR1 this week.

UPDATE: A.J. Brown has officially been activated from IR and will return this week.

Deebo Samuel (WR, SF): Speaking of WR1’s, holy smokes is Deebo Samuel having a year. Whether he is a receiver or running back, Samuel has become the best in the league at yards after the catch. He is currently the WR2 on the season and has the second most touchdowns at the position. In both of the categories, he is only trailing Cooper Kupp and of his 12 touchdowns, seven are rushing touchdowns. With the 49ers backfield being a revolving door, Samuel has become not only their leading receiver but the team's lead back when necessary. Samuel is one of the most versatile players in the league and should continue to carry your fantasy team this week against the team that allows the second-most fantasy points to the WR position. 

George Kittle (TE, SF): Here we transition from one yards after the catch monster to another. Ironically on the same team, Kittle has put his athletic abilities on full display these last few weeks. Since returning from injury, Kittle has been on a tear. Over this seven-week period, he only has one week below ten fantasy points, averaging 89 receiving yards and 0.86 touchdowns. Oh, and also he is the TE-one over the last seven weeks. Unless you are against Andrews or Kelce, Kittle is a massive fantasy advantage at the position. I would look for him to continue his dominance in this good matchup. 

 

Solid Options for Fantasy Football Lineups

D'Onta Foreman (RB, TEN): From the depths of the fantasy underworld, Foreman has resurfaced himself and taken over one of the league’s most prolific rushing offenses. For those of you who believe his resurgence has come out of nowhere, here is a little history. The 2016 Doak Walker Award Winner (given to the best college running back) entered the league with a lot of buzz. After being drafted to the Texans in 2017 in the third round, he found himself sitting behind the veteran Lamar Miller. In his limited work, he displayed explosiveness and promise. Unfortunately with an Achilles tear in 2018, he found himself being picked up by the Colts off of waivers in 2019. He then had to leave after tearing his bicep in the preseason and tried out for the Titans in 2020. Flash forward to now, and we have ourselves the RB10 over the last two weeks. All of that was to say that this kid had promise and has had to overcome devastating injuries. Over his last three games, he has 100 yards rushing twice and found the endzone in the third game. If you managed to pick him up from your waivers you are most likely playing him out of necessity, however, he is a solid play against a mild-tier 49er run defense. 

Jimmy Garoppolo (QB, SF): Since Week 12, Jimmy G has quietly snuck his way into the QB-one category. Over these last three games, he is the QB11 and is the QB18 on the season. In the last four games, he has torched teams for 230+ yards in each game, including two games narrowly missing the 300-yard mark. When you have weapons like Samuel and Kittle, managers have been relieved to see the veteran QB start airing out the ball. Tennessee's defense is in the top half in most points allowed to the QB position this season. If you are desperate for a playoff QB or need a solid QB-two this week, Jimmy Garoppolo is a solid play this Thursday.

 

Flex Considerations for Fantasy Football Lineups

Ryan Tannehill (QB, TEN): Unfortunately, Tannehill just hasn’t been cutting it for fantasy teams. It’s hard to blame the veteran after losing key players in Derrick Henry, A.J. Brown, and Julio Jones for most of the year. It came as no surprise that losing Henry slowed the entire fantasy offense, but ironically, the loss of the star running back has impacted Tannehill the most. Failing to score 10 fantasy points in three of his last four games, it’s hard to trust Tannehill this week. Thankfully, he possesses upside with his legs, as he has scored twice on the ground over the last two weeks. Plus, the return of A.J. Brown does spark some optimism. However, he is no more than a high-upside/low-floor play this week against a very solid 49ers defense.

Brandon Aiyuk (WR, SF): If there was an award for the scariest player to start in fantasy, Aiyuk would have to be in the running. After being praised all offseason, he literally disappeared at the start of the season. Then, seemingly out of the blue, he started seeing starter snap counts and six or more targets in six of the last eight games. Then, once you finally feel comfortable playing him, he catches one of two targets for 36 yards against a poor Falcons secondary last week. Thankfully he gets the chance to redeem himself against another exploitable opponent. The Titans are allowing the second-most fantasy points to the position and could provide some life for the young receiver. However, because we saw a good matchup last week and it did not translate for Aiyuk’s fantasy success, he is hard to trust as more than a high-upside flex play this week.

 

Consider Sitting for Fantasy Football Lineups

Jeff Wilson Jr. (RB, SF): Yes, Elijah Mitchell has been ruled out. Yes, Wilson Jr. is coming off a monster game. No, I don’t think you should play him if you have other alternative options. Well, at least I think you should be careful if you do decide to start him. This “sit” is a result of Tennessee being the best fantasy defense against running backs on the season. They have managed to shut down the run all season, and that continued last week as they stiffed Najee Harris. Wilson Jr. finally had the game managers had been waiting for, however, I don’t want to rely on one good performance in the fantasy playoffs, especially against a very tough opponent. I would look elsewhere this week if possible.

Other Titans pass-catchers: Whether you are holding onto Julio Jones or are taking a shot at Anthony Firkser, Nick Westbrook-Ikhine, or Chester Rogers, I don’t think you can play any of them this week. Not only have the 49ers been very solid on defense these last few weeks, but these players also have not been reliable for fantasy. Although it is tough to sit Julio Jones if he is active, I would not want to risk the possibility of reinjury this week. My favorite player of this group has to be Westbrook-Ikhine as he has seen six or more targets in three of the last four games, but I would try to find the higher upside in another flyer this week.

 

As soon as we were heating up, we cooled right down. Thanks to a massive fourth quarter and an overtime touchdown, we missed on both of our picks last week. Nevertheless, we go into this week with fresh eyes. The Titans have been playing miserable football recently, while the 49ers could be argued to be one of the hottest teams in the league right now. Additionally, with the Titan's lack of passing defense and desperation to turn their season around at home, this could be a fun game to start Week 16. I wish you all the best of luck this week and happy holidays! 

Ellis’ Picks: 49ers -3.0 (12-5), Over 44.0 (11-6)

Career record: Spread (21-14), Over/Under (20-15)



Download Our Free News & Alerts Mobile App

Like what you see? Download our updated fantasy football app for iPhone and Android with 24x7 player news, injury alerts, rankings, starts/sits & more. All free!

More Fantasy Football Analysis




POPULAR FANTASY TOOLS

Expert Advice
Articles & Tools
Import Your Leagues
Draft Rankings
Draft Simulator
Compare Any Players
24x7 News and Alerts

REAL-TIME FANTASY NEWS

Bryson DeChambeau

a High-Upside Play With Risk at PGA Championship
Isaiah Davis

' Dynasty Value Takes a Hit Thanks to Teammate's Extension
Kaleb Johnson

Will Kaleb Johnson Have a Bigger Role Under New Coaching Staff?
Draymond Green

Set to Stay With Warriors
Trey McBride

an Elite Fantasy TE Any Way You Slice it
Stephen Curry

Warriors Looking to Extend Stephen Curry in Offseason
Brock Purdy

All Signs Point to Bounce-Back Season for Brock Purdy in 2026
Giannis Antetokounmpo

Bucks Listening to Offers for Giannis Antetokounmpo
Jalen McMillan

has a Path to Bigger Role, But There Will be Target Competition
OG Anunoby

Expected to Be Ready for Game 1 of East Finals
De'Aaron Fox

Listed as Questionable for Game 5
A.J. Ewing

Mets to Call Up Top Prospect A.J. Ewing
Kevin Huerter

to Remain Sidelined in Game 4
Caris LeVert

is Cleared for Game 4 on Monday
Thomas Bryant

is Available to Play in Game 4
Victor Wembanyama

Won't be Suspended Following Game 4 Ejection
Mookie Betts

is Officially Back on Monday
Nathan Eovaldi

Scratched From Monday's Start With Side Tightness
Mark Jankowski

Signs Two-Year Extension With Hurricanes
Joel Kiviranta

Cleared to Play Monday
Josh Manson

Available for Game 4 Monday
Mackenzie Blackwood

Expected to Start Monday
Jonas Brodin

Won't Play Monday
Joel Eriksson Ek

Remains Out Monday
Justin Jefferson

Dynasty Stock on the Rise With New QB in Minnesota
J.J. McCarthy

Injuries, QB Addition in Minnesota Deal Big Blow to J.J. McCarthy's Dynasty Value
Aaron Rodgers

Doesn't Meet With Steelers Over the Weekend
Chris Boswell

Steelers Agree With Kicker Chris Boswell on Four-Year Extension
Henry Bolte

Athletics to Promote Top Outfield Prospect Henry Bolte to Major Leagues
Khamzat Chimaev

Suffers his First Loss
Sean Strickland

Recaptures Middleweight Title
Tatsuro Taira

Suffers Fifth-Round TKO Loss
Harold Fannin Jr.

Offers Tantalizing Dynasty Upside Despite Uncertain Offense
Joshua Van

Defends Flyweight Title
Dalton Kincaid

Is Dalton Kincaid's Long-Term Dynasty Upside Fading Due to Health Concerns?
MMA

Waldo Cortes-Acosta Drops Decision
Alexander Volkov

Wins Back-To-Back Fights
Jordan James

Could Emerge as a Must-Roster Handcuff Option for Dynasty Managers
Jaylen Waddle

Dynasty Stock Rising After Offseason Move to Denver
Josh Downs

in Line for Expanded Role in Indianapolis
Shane Van Gisbergen

Dominates Watkins Glen for First Win of 2026
Mike Evans

Could Be Well-Positioned for a Resurgent Season in San Francisco
Michael McDowell

Finishes Second for Best Run of the Year At Watkins Glen
Ty Gibbs

Scores New Career-Best Finish of Third at Watkins Glen
Tyler Reddick

Continues His Strong Season With Fifth-Place Run at Watkins Glen
Austin Dillon

Earns his First Top-10 Finish of 2026 at Watkins Glen
Ameer Abdullah

Jaguars Sign Running Back Ameer Abdullah for Backfield Depth
Mookie Betts

Dodgers Expect Mookie Betts to Return on Monday
NFL

Ahmad Hardy in Stable Condition After Suffering Gunshot Wound on Sunday
CFB

Ahmad Hardy Sustains Gunshot Wound, in Stable Condition
Kayshon Boutte

in a Likely No-Win Scenario for 2026
Anthony Edwards

Powers Wolves to Game 4 Win
Tetairoa McMillan

Can Tetairoa McMillan Become a Dynasty Cornerstone?
De'Aaron Fox

Posts 24 Points as Spurs Drop Game 4 to Wolves
Justin Herbert

One of Fantasy's Biggest Offseason Winners
Victor Wembanyama

Ejected in Game 4 Loss
VJ Edgecombe

Struggles with Shot in Game 4
Oronde Gadsden

Breakout Chances Dealt a Serious Blow
Paul George

Held to Seven Points in 76ers' Game 4 Loss
Josh Hart

Helps Knicks Reach East Finals
Jalen Brunson

Finishes Game 4 Sweep with 22 Points
Rasmus Dahlin

Records Two Points in Game 3 Loss
Tage Thompson

Comes Alive in Game 3 Against Canadiens
Cole Caufield

Ends Dry Spell Sunday
Alex Newhook

Nets Two More Goals in Sunday's Victory
Mitchell Marner

Notches Three Assists in Losing Effort
Beckett Sennecke

Extends Goal Streak to Three Games
Cutter Gauthier

Records Hat Trick of Assists in Game 4 Win
Karl-Anthony Towns

Logs Sixth Double-Double of Postseason
Mike Conley

Ayo Dosunmu Replaces Mike Conley in Starting Unit Sunday
Miles McBride

Tallies Game-High 25 Points in Series-Clincher
Tyrese Maxey

Settles for 17 Points Sunday
Joel Embiid

Scores Efficient 24 Points in Season-Ending Loss
Auston Matthews

Uncertain About Future With Maple Leafs
Frederik Andersen

Enjoying Special Postseason
Josh Manson

"Close" to Returning
Joel Kiviranta

Could Return to Action Monday
Radko Gudas

a Game-Time Call Sunday
Mark Stone

Unavailable Sunday
Connor Zilisch

Will Start Fifth in his First Watkins Glen Cup Series Race
Tyler Reddick

Is A Top DFS Option for Watkins Glen Lineups
Christopher Bell

Is Likely to Bounce Back This Week at Watkins Glen
Carlos Rodón

Carlos Rodon Activated for Season Debut on Sunday
William Byron

Is William Byron Playable in DFS Lineups at Watkins Glen?
Kyle Larson

May have A Positive Day at Watkins Glen
Chase Briscoe

May Compete for A Top-10 Finish at Watkins Glen
NASCAR

A.J. Allmendinger May have Another Solid Outing at Watkins Glen
Ty Gibbs

Should Fantasy Managers Roster Ty Gibbs at Watkins Glen?
Ross Chastain

Is Ross Chastain Worth Rostering for Watkins Glen Lineups?
Austin Cindric

Could Austin Cindric be A Sneaky Tournament Play for Watkins Glen?
Shane Van Gisbergen

Shane van Gisbergen the Heavy Favorite at Watkins Glen
Chase Elliott

Is Chase Elliott a No-Brainer DFS Pick at Watkins Glen?
Chris Buescher

Qualifies 14th at Watkins Glen
Ryan Blaney

Has Upside at Watkins Glen After Signing Contract Extension
Michael McDowell

Still Searching for First Top-Five Finish at Watkins Glen
Carson Hocevar

Is Carson Hocevar Too Aggressive for Road-Course Racing?
Luis Castillo

Mariners Intend to Piggyback Luis Castillo, Bryce Miller
Logan Webb

Placed on 15-Day Injured List With Knee Bursitis
Bryce Miller

is Set to Return on Wednesday
Jeff Hoffman

Could Return to Closer Role
CHI

Blackhawks Bring in Roman Kantserov for Next Season
Mason McTavish

Set to Rejoin Ducks Lineup Sunday
Taj Bradley

Hits the Injured List With Pectoral Inflammation
Kyle Bradish

has Nice Bounce-Back Performance With 10 K's
Casey Mize

Throws Bullpen on Friday, Return Not Imminent
Ronald Acuña Jr.

Ronald Acuna Jr. Optimistic About Returning Next Wednesday
Tyler Glasnow

Dodgers Put Tyler Glasnow on Injured List With Back Spasms
Blake Snell

to Make Season Debut for Dodgers on Saturday
Cole Ragans

Royals Place Cole Ragans on Injured List With Elbow Impingement
Sean Strickland

An Underdog At UFC 328
Khamzat Chimaev

Set For UFC 328 Main Event
Tatsuro Taira

Can Become The New Flyweight Champion
Joshua Van

Set For His First Title Defense
Alexander Volkov

Looks To Win Back-To-Back Fights
MMA

Waldo Cortes-Acosta Looks To Extend His Win Streak
Nick Lodolo

Officially Activated, Making Season Debut on Friday
CFB

Walker Lyons Could be Go-To Target for Bear Bachmeier
CFB

Ty Benefield a Potential Game-Changer for LSU Defense
CFB

Hayden Lowe Set for Significant Role Following Miami's NFL Departures
CFB

Taylor Wein in Position for Big Season on Oklahoma's Defensive Line
CFB

Rasheem Biles an Instant Impact Player for Texas
Roman Anthony

Heading for the Injured List
CFB

Sam Leavitt Expected to Be Full-Go for Fall Camp
Tarik Skubal

Could Return in 4-6 Weeks After Successful Elbow Surgery
Cole Ragans

Royals Hopeful That Cole Ragans Makes his Next Start
CFB

Brauntae Johnson the Next Star in Notre Dame's Secondary?
CFB

Ethan Barbour a Name to Know in Georgia's Tight End Room
CFB

Payton Pierce Next Up at Linebacker for Ohio State
CFB

Javin Gordon to Play Significant Role for Tennessee?
CFB

Tanook Hines Stepping into WR1 Role for USC
CFB

Rueben Owens II has "Star Potential" in Fourth Campaign
Collin Morikawa

Withdraws From Truist Championship
Xander Schauffele

Carries Elite Form Into Quail Hollow
Hideki Matsuyama

Looks to Bounce Back at Truist Championship
Matt Fitzpatrick

Secures Third Win of 2026 Season
Patrick Cantlay

Continues Playing Well Heading to Truist Championship
Ludvig Aberg

Returns to Action For Truist Championship
Justin Thomas

Searching for Consistency at Quail Hollow
Jordan Spieth

Looks to Break Through at Quail Hollow
Adam Scott

Brings Strong Form to Quail Hollow
Robert MacIntyre

a Steady Option at Truist Championship
Jason Day

Looks to Overcome Approach Struggles at Quail Hollow
Akshay Bhatia

Looks for Complete Game at Truist Championship
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF