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FanDuel MLB DFS Lineup Picks (9/25/19): Daily Fantasy Baseball Advice

Joel Bartilotta highlights the top FanDuel MLB DFS lineup picks for 9/25/19, and a couple of sleepers to consider while building daily rosters.

We do have three day-games for this Wednesday slate and we’ll try to offer up a couple of plays from that slate to cater to all of you readers. It happens to be the final Wednesday article of the regular season and it’s been a treat helping you guys out all season! 

I just wanted to thank all of you for reading throughout the year, so let's finish strong!

Be sure to also check out all the Vegas Odds for today's slate. You can also read more DFS advice and lineup picks for sites like FanDuel, and other sports too. If you have any questions or comments, feel free to hit me up on Twitter @Bartilottajoel

Featured Promo! Save 50% on any PGA Premium Pass using discount code MASTERS, this week only! Win more with our DFS and Betting Packages, get expert tools and advice from proven winners including the Lineup Optimizer, Research Station, betting/props cheat sheet and more. GAIN FULL ACCESS HERE

 

FanDuel DFS Pitchers

Shane Bieber, CLE at CWS ($11,500) 

Bieber is truly one of the best pitchers in the AL. That’s evident when you see his 3.23 ERA, 1.03 WHIP, and 30.3 percent K rate, with much of that damage coming in the second half. Over his last 12 starts, Bieber is pitching to a 2.56 ERA, 1.01 WHIP, and 10.2 K/9 rate. All of those are scary numbers for an offense like this, with the White Sox ranked 24th in runs scored, 25th in K rate and 22nd in xwOBA. They’re even worse against righties, sending out hitters like Jose Abreu, Eloy Jimenez, James McCann, and Tim Anderson from the right side to oppose Bieber. All of this has the Indians entering this matchup as a –300 favorite.

Zack Greinke, HOU at SEA ($9,400) 

Greinke hasn’t quite been himself since joining the Astros but he’s still one of the best pitchers around. That’s clear when you see his 3.05 ERA and 1.01 WHIP. Those stellar numbers would put him in play against almost anyone but especially the Mariners. Not only does Seattle rank 28th in K rate, but they also sit 26th in xwOBA. Those statistics make it no surprise that this is one of the five-worst clubs in baseball since the opening month and even less surprising that Greinke enters this matchup as a –350 favorite.

 

FanDuel DFS Infielders

C.J. Cron – 1B, MIN at DET ($3,200) 

It’s amazing to see Cron’s price this low in such a good situation. The simple fact is, this dude is one of the best hitters in the Majors when he faces a lefty. That’s evident when you see his .381 OBP, .640 SLG and 1.021 OPS with the platoon advantage in his favor this season. It’s not like he has to face a tough lefty here either, with the Motor City Kitties sending out Daniel Norris and his 4.58 ERA and 1.34 WHIP. Those ugly numbers from Norris have the Twins projected for more than five runs and we anticipate Cron being a major part of that damage.

Ozzie Albies – 2B, ATL at KC ($3,700) 

This kid got a lot of crap for his team-friendly contract but he’s showing people that he means business no matter how much is on his paycheck. Over his last 21 games, Albies is hitting .387 while providing a .642 SLG and 1.069 OPS. He actually has an OPS approaching 1.000 dating all the way back to the beginning of June and it’s becoming evident that he’s one of the best second basemen in our sport. Getting to face Mike Montgomery's 5.00 ERA and 1.61 WHIP is simply the icing on the cake, with Albies generating a .390 AVG, .695 SLG and 1.103 OPS against lefties so far this year.

Alex Bregman – 3B, HOU at SEA ($4,400) 

Bregman has been the best player in baseball the last two months and it’s going to be tough to fade him in this brilliant situation. Let’s begin with this matchup, as he faces Yusei Kikuchi and his 5.55 ERA and 1.54 WHIP. That happens to give Bregman the platoon advantage, with the slugging third baseman amassing a 1.102 OPS against them this season. Not to mention, Bregman has a .373 AVG, .480 OBP, .745 SLG, and 1.225 OPS over his last 45 games played.

Jonathan Villar – SS, BAL at TOR ($3,600) 

It’s truly incredible how good Villar has been this season. He’s actually Top-5 in season-long leagues, thanks to a ridiculous second half. Over his last 55 games played, Villar has a .315 AVG, .387 OBP, .557 SLG, and .944 OPS. Those look like the numbers of an elite power hitter but he’s actually batting leadoff and has provided 21 steals in that span as well. That’s a nightmare for a guy like Jacob Waguespack, with the Toronto righty pitching to a 4.75 ERA and 1.36 WHIP.

 

FanDuel DFS Outfielders

Nelson Cruz, MIN at DET ($4,300) 

It’s crazy to see a 39-year-old mash baseballs like this guy does. It’s very reminiscent of David Ortiz near the end of his career and it’s clear Cruz has found the fountain of youth. Let’s take a look at his bonkers statistics, with Cruz being one of the league leaders with a .631 SLG and 1.018 OPS. Those are epic numbers and it doesn’t even take into consideration that he has a .402 OBP, .755 SLG and 1.156 OPS against left-handers this season. That’s terrifying news for Daniel Noris’ ugly numbers from the Cron write-up.

Tommy Pham, TB vs. NYY ($3,900) 

The Yankees are sending out J.A. Happ and that means we have to stack some Rays against him. The reason for that is because the NY southpaw is currently pitching to a 5.01 ERA and 1.30 WHIP this season. Those numbers are right up Pham’s alley, with the versatile outfielder accumulating a .467 OBP and .944 OPS against lefties so far this season.

MLB DFS News and Injury Alerts




REAL-TIME FANTASY NEWS

Deshaun Watson

Hitting it Off With Todd Monken?
Jacoby Brissett

Not Present for First OTA Practice
Tua Tagovailoa

Michael Penix Jr. Splitting First-Team Reps at OTAs
Rashee Rice

Tests Positive for Marijuana, Violating his Probation
Cam Skattebo

Says he'll be Ready for Week 1
De'Von Achane

Present for Start of OTAs This Week
Malik Washington

an Affordable Trade Target in Dynasty Leagues
Patrick Mahomes

Is Patrick Mahomes Still a Top-Five Dynasty Quarterback?
Michael Trigg

Is There a Spot for Michael Trigg in Dallas?
Seth McGowan

in the Mix for Playing Time as a Rookie?
Audric Estimé

Audric Estime Droppable in Dynasty Leagues?
Drake Baldwin

Braves Place Drake Baldwin on Injured List With Oblique Strain
Kyren Williams

Have Timeshare Concerns Sunk Kyren Williams' Dynasty Value Too Low?
Ja'Marr Chase

Is Ja'Marr Chase the Most Valuable Player in Dynasty?
Javonte Williams

' Unusual Career Path Has Left Him Undervalued in Dynasty Leagues
CFB

Ezavier Crowell has Immediate Opportunity at Alabama
Terry McLaurin

a Veteran Buy for Contending Dynasty Managers
CFB

Mark Bowman a Day 1 Impact Player for USC?
Tee Higgins

Becoming an Underappreciated Dynasty Asset
CFB

Bill Belichick Says Relationship with First North Carolina Team "Wasn't Great"
Alex Caruso

Erupts for 31 Points in Game 1 Loss to Spurs
CFB

Kemario Taylor a Breakout Candidate at Quarterback
Jalen Williams

Productive in Comeback Game
CFB

Trinidad Chambliss the Undisputed Top SEC Quarterback Entering 2026?
Shai Gilgeous-Alexander

Records First Double-Double of Postseason
CFB

Rocco Becht The "Unifier" of Penn State's Roster
Stephon Castle

Opens Conference Finals With Double-Double
Dylan Harper

Makes Outstanding Two-Way Impact in Game 1 Win
Victor Wembanyama

Dominates Game 1 Against Thunder
Mattias Samuelsson

Picks Up an Assist in Season-Ending Loss
Rasmus Dahlin

Nets Fourth Postseason Goal
Jakub Dobes

Records 37 Saves in Game 7 Win
Lane Hutson

Contributes Power-Play Assist in Game 7 Victory
Nick Suzuki

Extends Road Point Streak
Alex Newhook

Scores Series-Clincher in Overtime
Jackson Holliday

Orioles Reinstate Jackson Holliday From Injured List on Monday
Ronald Acuña Jr.

Braves Reinstate Ronald Acuna Jr. From Injured List on Monday
Jose Altuve

Astros Put Jose Altuve on Injured List With Oblique Strain
Larry Nance Jr.

is Questionable for Game 1 on Tuesday
OG Anunoby

is Probable for Tuesday's Game 1
Luke Kornet

is Cleared for Game 1
New Orleans Pelicans

Jamahl Mosley Agrees to Become Pelicans Next Head Coach
De'Aaron Fox

is Ruled Out for Game 1 on Monday
Ukko-Pekka Luukkonen

Set to Start Game 7
Corey Seager

Going on Injured List With Back Injury
Tage Thompson

Can Match Franchise Record With Another Multi-Point Game
Nick Suzuki

Seeks More Road Success Monday
Lane Hutson

Riding a Five-Game Assist Streak Into Game 7
Filip Gustavsson

Needs Offseason Surgery
Jeremy Peña

Jeremy Pena Reinstated and Starting on Monday Against Twins
Cam Skattebo

Dynasty Stock Rising Following NFL Draft
Kaleb Johnson

Logging First-Team Reps in OTAs
Evan Engram

Dynasty Value Fading After Production Decline in 2025
TreVeyon Henderson

Dynasty Outlook Clouded By Split Backfield in New England
Caleb Williams

' Dynasty Upside Remains Sky-High Entering 2026
Melquizael Costa

Drops Decision At UFC Vegas 117
Arnold Allen

Bounces Back
Daniel Santos

Suffers Second-Round TKO Loss
MMA

Dohoo Choi Wins His Third Consecutive Fight
Malcolm Wellmaker

Suffers His Second Loss In A Row
Juan Diaz

Scores Second-Round Submission
Christian Edwards

Defeated At UFC Vegas 117
CFB

Transfer Running Back Arnold Barnes Visiting Iowa State on Monday
Modestas Bukauskas

Gets Split-Decision Win
Jhostynxon Garcia

Expected to Join the Pirates on Tuesday
Tobias Harris

Goes Cold in Game 7 Loss
Quinn Hughes

Open to Signing Extension This Offseason
Jalen Duren

Finishes Game 7 with Quiet Line
Cade Cunningham

Endures Cold Shooting Night Sunday
Joel Eriksson Ek

Misses Second Round Due to Heel Injury
Sam Merrill

Catches Fire in Game 7 Win
Evan Mobley

Posts Versatile Double-Double in Game 7
Jonas Brodin

Sits Out Round 2 Due to Toe Injury
Donovan Mitchell

Guides Cavaliers Into East Finals
Sam Malinski

Practices Fully Sunday
Jarrett Allen

Scores 23 Points in Cavs' Game 7 Rout of Pistons
Josh Manson

Rejoins Practice
Kevin Huerter

Active on Sunday Night
Caris LeVert

Duncan Robinson, Caris LeVert Available Sunday
Dean Wade

Max Strus Replaces Dean Wade in Starting Lineup Sunday
Colt Emerson

Mariners Promoting Top Prospect Colt Emerson to Major Leagues
Munetaka Murakami

Fantastic First Season Continues With Two More Homers
Cristopher Sánchez

Cristopher Sanchez Dazzles With 13-Strikeout Complete Game on Saturday
Blake Snell

to Undergo Elbow Surgery on Tuesday
Clay Holmes

Could Miss Around Three Months
Jose Altuve

Exits After Swing
Corey Seager

Absent With Back Spasms on Saturday
Jeremy Lauzon

Misses Saturday's Practice
Mark Stone

Doesn't Practice Saturday
Josh Manson

Misses Practice, Considered Day-to-Day
Brent Burns

Day-to-Day Ahead of Conference Finals
Cale Makar

Considered Day-to-Day
Trevor Story

Hits the Injured List With Groin Injury
Blake Snell

Likely to Need Elbow Surgery
Kyle Schwarber

on a Heater, Hits Two More Homers to Take Major-League Lead
Clay Holmes

Suffers Fractured Fibula on Friday Night
Blake Snell

Heads to 15-Day Injured List
Blake Snell

Scratched From Start on Friday for Undisclosed Reasons
Max Fried

Heading to Injured List With Elbow Bone Bruise
CFB

Julian Sayin Looking To Build Off Of Strong Debut Season
CFB

College GameDay Set for First Three Weeks
CFB

Jeremiah Smith Aiming For Ohio State Receiving Records
CFB

Keshaun Singleton Projects as Auburn's WR1
CFB

Jeremiah Cobb Impresses New Auburn Staff
CFB

Alberto Mendoza Very Likely to Start for Georgia Tech
CFB

Charles Woodson Jr. Commits to Michigan
Melquizael Costa

Set For UFC Vegas 117 Main Event
Arnold Allen

A Favorite At UFC Vegas 117
Daniel Santos

Set For UFC Vegas 117 Co-Main Event
MMA

Dohoo Choi Returns At UFC Vegas 117
Juan Diaz

Set To Make His UFC Debut
Malcolm Wellmaker

Looks To Bounce Back
Christian Edwards

Set For His UFC Debut
Modestas Bukauskas

Looks To Get Back In The Win Column
CFB

Virginia Tech Lands Commitment from Four-Star QB Peter Bourque
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF