November 21, 2025
The Indianapolis Colts defense should be well-rested coming out of their Week 11 bye. The team will now head on the road to take on the Kansas City Chiefs in Week 12. The Chiefs have been a tough matchup for D/STs in fantasy, allowing just the 29th-most fantasy points per game to the position this season. While Indianapolis' defense has been one of the better fantasy units this season, this is a tough week to trust them going up against
Patrick Mahomes and company as 3.5-point road underdogs in a game with a 50-point over/under. Fantasy managers should look to stream a defense with a better matchup for Week 12.
--Matt TerelleSource: NFL.com
November 21, 2025
Seattle Seahawks running back
Kenneth Walker III (glute) popped up with a new injury on Friday's injury report and is now listed as questionable for Sunday's matchup against the Tennessee Titans, per Michael-Shawn Dugar of The Athletic. Seahawks head coach Mike Macdonald said that Walker "should be fine" for Sunday despite the questionable tag, noting that the team is being precautionary. It's never good to see a player show up with a new injury late in the practice week, but signs point to the 25-year-old back playing in Week 12. The timing is quite unfortunate, as Macdonald hinted earlier this week at Walker seeing his opportunities increase moving forward, so ideally, this injury doesn't impact those plans.
Zach Charbonnet will likely continue to be a thorn in his side, but Walker gets a dream matchup against the Titans on Sunday and could deliver for fantasy managers who have been waiting all season.
--Kyle McCarthySource: Michael-Shawn Dugar
November 21, 2025
Indianapolis Colts tight end
Tyler Warren comes out of his bye week to take on the Kansas City Chiefs on the road in Week 12. Warren is putting together an impressive rookie season, leading the Colts with 617 receiving yards. He has added 50 catches and four all-purpose touchdowns along the way. Warren draws a tough matchup against a Kansas City defense that is allowing the 26th-most fantasy points per game to opposing tight ends this season. That being said, the Colts have been explosive on offense, and the team has made it a point to get the ball into the hands of their first-round rookie, making Warren a top-six fantasy tight end this weekend.
--Matt TerelleSource: NFL.com
November 21, 2025
Indianapolis Colts wide receiver
Josh Downs should be well-rested as he comes out of a Week 11 bye to take on the Kansas City Chiefs on the road in Week 12. Downs has been up and down this season as he is not enjoying the high volume that he has in past seasons. That being said, he scored a touchdown in three straight games in October and early November. The Chiefs have been tough on receivers this season, allowing just the 27th-most fantasy points per game to the position thus far. Downs isn't exactly a safe play but he's worth a look as a flex option/WR5 in deeper leagues, especially if your team is dealing with several players on their bye in Week 12.
--Matt TerelleSource: NFL.com
November 21, 2025
Indianapolis Colts wide receiver
Alec Pierce will come out of his Week 11 bye to take on the Kansas City Chiefs on the road in Week 12. Pierce has enjoyed a mini-breakout in 2025, catching 28 passes for 585 yards and one touchdown in eight games, putting him on pace to set new career highs in catches and receiving yards. The veteran wideout would be garnering more notoriety, but he has only scored one touchdown despite averaging 20.9 yards per catch. Pierce is due for some positive regression in the scoring department, but remains a solid flex option in all fantasy leagues even without the TDs. Fantasy managers can insert him into starting lineups in Week 12, despite a tough matchup against a KC defense that is allowing just the 27th-most fantasy points per game to the position.
--Matt TerelleSource: NFL.com
November 21, 2025
Indianapolis Colts wide receiver
Michael Pittman Jr. will come out of a Week 11 bye to face off against the Kansas City Chiefs on the road in Week 12. Pittman is enjoying a bounce-back season after a rough 2024, catching 54 passes for 580 yards and six touchdowns in 10 games. The veteran wideout will look to break a two-game scoreless streak in Week 12 as he goes up against a Kansas City defense that is allowing just the 27th-most fantasy points per game to opposing wideouts. While this is a tough matchup, Pittman has been an excellent red-zone threat this season and should return low-end WR2 numbers for fantasy managers in Week 12.
--Matt TerelleSource: NFL.com
November 21, 2025
Arizona Cardinals running back
Trey Benson (knee) has officially been ruled out for Sunday's matchup against the Jacksonville Jaguars, according to Tyler Drake of AZSports. Benson was a limited participant in practice every day this week, but the Cardinals ultimately decided to hold him out for another week. Head coach Jonathan Gannon said that the second-year back looked good during practice this week, and that they'd "see how it goes" on Friday in regards to his chances to play in Week 12. It seems like Benson is making progress in his recovery, but he's not quite there yet. He has now been ruled out for his seventh consecutive game and has yet to practice in full capacity, which is likely the next big step for him to take to get back to the field.
Emari Demercado (ankle) has also been ruled out for Sunday, leaving
Bam Knight (ankle) and
Michael Carter to split the backfield duties against the Jaguars.
--Kyle McCarthySource: Tyler Drake
November 21, 2025
Indianapolis Colts running back
Jonathan Taylor should be well-rested coming out of his Week 11 bye. Taylor has been one of the top players in fantasy this season, racking up 17 all-purpose touchdowns in just 10 games. The star running back will look to stay hot in a Week 12 road matchup against the Kansas City Chiefs. The Chiefs have been tough on running backs this season, allowing just the 26th-most fantasy points per game to the position. That being said, Taylor has been too dominant this season and will continue to see the bulk of the Colts' running-back touches. He settles in as a top-three fantasy running back heading into Week 12 in a game with a 50-point over/under.
--Matt TerelleSource: NFL.com
November 21, 2025
Cincinnati Bengals quarterback
Joe Flacco (shoulder) was a full participant in Friday's practice session and has been cleared from the injury report ahead of Sunday's matchup against the New England Patriots, according to the team's official website. It's unclear
whether Flacco will be the starter or return to a backup role, given that Joe Burrow (toe) practiced in full on Wednesday and Thursday this week. However, he was limited on Friday and is officially listed as questionable for Sunday. The 40-year-old Flacco has filled in admirably for the star quarterback, totaling 2,268 passing yards, 14 touchdowns, and nine interceptions in five games as a starter, ranking as QB4 in fantasy points per game (22.1) since Week 6. Flacco could wind up making one more start in Week 12 if Burrow is unable to play and the Bengals hold him out until he is fully cleared.
--Kyle McCarthySource: Cincinnati Bengals
November 21, 2025
Green Bay Packers running back
Josh Jacobs (knee) is officially listed as questionable to play in his team's Week 12 matchup against the Minnesota Vikings. Jacobs suffered a knee contusion that forced him to exit early from his team's Week 11 win over the New York Giants and has been limited in practice this week as a result. The 27-year-old has recorded 885 scrimmage yards and 11 touchdowns on 197 touches across 10 games this season and profiles as a must-start fantasy running back against Minnesota if he's cleared to play. If Jacobs were out, Packers running back
Emanuel Wilson would likely get the majority of Green Bay's backfield touches in Week 12. Third-year back
Chris Brooks could factor into the mix as well. Wilson has recorded 289 scrimmage yards and a touchdown on 64 touches so far this season and would profile as a low-end fantasy RB2 if Jacobs is inactive against Minnesota.
--Will BradySource: Green Bay Packers
November 21, 2025
The Kansas City Chiefs defense will take on the Indianapolis Colts in Week 12. The Chiefs' defense allowed 22 points to the Denver Broncos in Week 11 while collecting two sacks. Kansas City has allowed at least 22 points in back-to-back games with no takeaways in that span. The Chiefs' defense ranked 20th in the league in sacks with 22 through 10 games. This defensive unit also ranks 11th in yards per game allowed, which will be needed against Indianapolis this week. The Colts offense has the most yards and points scored this season, which makes starting the Chiefs defense difficult. The Chiefs' defense is ranked 15th in our RotoBaller rankings this week, meaning they can be started in a pinch, but fantasy managers should try to find a better option.
--Joshua CostelloSource: ESPN.com
November 21, 2025
New York Giants wide receiver
Darius Slayton (hamstring) will not carry an injury designation into his team's Week 12 matchup against the Detroit Lions. Slayton was sidelined for New York's Week 11 loss to the Green Bay Packers, but he will make his return in Week 12 against Detroit. Across eight games this season, the 28-year-old has recorded 23 catches for 343 yards on 34 targets. Slayton was playing some of his best football before getting hurt, recording nine catches for 151 yards on 11 targets across Weeks 9 and 10. He'll be catching passes from veteran quarterback
Jameis Winston on Sunday, who is making his second straight start for the Giants with rookie quarterback
Jaxson Dart (concussion) still sidelined. Slayton profiles as a low-end WR4/flex option for deep-league fantasy managers in Week 12.
--Will BradySource: Giants.com - Dan Salomone
November 21, 2025
Kansas City Chiefs kicker
Harrison Butker will face the Indianapolis Colts on Sunday in Week 12. Butker has struggled this season, and his struggles continued last week against the Denver Broncos. Butker knocked through both of his field goal attempts, but missed one of his two extra-point attempts in Week 11. Butker has an 84.2% field goal percentage and 85.7% extra-point percentage this season, both marks rank outside the top-20 at the position. That said, Butker should be involved in a shootout against Indianapolis this week. The Colts offense has the most yards and points scored this season, which means the Chiefs will need to put a lot of points on the board to keep up. Butker should get a piece of the action and could provide value at the kicker position. Butker is ranked K9 in our RotoBaller rankings, making him worthy of a start in most leagues.
--Joshua CostelloSource: ESPN.com
November 21, 2025
Los Angeles Chargers rookie tight end
Oronde Gadsden ranks as the TE12 in half-PPR fantasy points per game through the first nine games of his NFL career. Gadsden has developed strong chemistry with quarterback
Justin Herbert and has 37 catches on 49 targets for 507 yards and two touchdowns going into the team's Week 12 bye. However, the 22-year-old hasn't scored since Oct. 19. Gadsden has cooled off a bit since back-to-back weeks of finding the end zone in Weeks 7 and 8, but he's had at least five targets in a game since all the way back in Week 5. The primary concern for Gadsden's fantasy managers going forward is the Chargers' banged-up offensive line, which might give quarterback Justin Herbert very little time to throw the football in the final stretch of the season against some tough opponents. The fifth-rounder could return with a bang in Week 13 against the Raiders, so fantasy managers shouldn't give up hope just yet.
--Keith HernandezSource: Pro Football Reference
November 21, 2025
Indianapolis Colts head coach Shane Steichen said that quarterback
Daniel Jones (leg) is "good-to-go" for his team's Week 12 matchup against the Kansas City Chiefs. Steichen also clarified that Jones' injury is actually to his fibula after it was initially reported as a calf issue, per James Boyd of The Athletic. Either way, Jones was able to practice in full on Friday after being limited on Thursday and will be active against Kansas City. Jones has played well in his first season in Indianapolis, completing 69.9% of his pass attempts for 2,659 yards, 15 touchdowns, and seven interceptions across 10 games. He's also added 143 yards and five touchdowns as a rusher. However, Jones has been particularly turnover-prone of late, recording four interceptions and six fumbles (three lost) over his last two games. That could be an issue in a tough road matchup against Kansas City, particularly if his mobility is limited in any way. Jones profiles as a low-end fantasy QB1 in Week 12.
--Will BradySource: The Athletic - James Boyd
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