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Oct 11, 2025, 8:50 AM ET

Indianapolis Colts running back Jonathan Taylor has been one of the best players in fantasy through the first five weeks of the season. The veteran running back has accumulated 480 rushing yards while adding seven all-purpose touchdowns so far. He will look to stay hot in a Week 6 home matchup against the Arizona Cardinals. The Cardinals have struggled against opposing running backs this season, allowing the 12th-most fantasy points per game to the position through five games. Taylor is dominating the work in Indy's backfield this season and should continue to see the majority of the touches in Week 6. He sets up as a top-three overall running back in fantasy this weekend.--Matt Terelle
Source: NFL.com
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