May 16, 2026, 12:55 PM ET

Wide receiver Brandon Aiyuk's (knee) tenure with the San Francisco 49ers is most likely coming to an end sooner rather than later, but since we don't yet know his next destination, it's extremely difficult to gauge his value in dynasty/keeper leagues. The 28-year-old former 25th overall pick in 2020 out of Arizona State is still on the 49ers' roster, but they are hoping to get something in return for him in a trade. If nothing works out, Aiyuk will be released despite signing a four-year, $120 million extension with the team in August of 2024 after two straight 1,000-yard seasons in the Bay Area with 15 total touchdowns. Aiyuk played in only seven games in 2024 and caught just 25 passes for 374 yards and no TDs before suffering a season-ending torn ACL. He didn't play at all in 2025 and wore out his welcome with the organization when he stopped showing up for his rehab. The Nevada native clearly has high-end talent, but in addition to the mystery of where he'll be playing in 2026, we also don't know how he'll rebound from a serious knee injury. Theoretically, Aiyuk's buy-low window in dynasty leagues is wide open, but there's obviously plenty of risk. He's been rumored as a candidate to reunite with college teammate Jayden Daniels in Washington, where he would team up with wideout Terry McLaurin. That would be a best-case landing spot.--Keith Hernandez
Source: Pro Football Reference