MLB DFS Picks Today: Daily Fantasy Baseball Strategy and Tips For FanDuel, DraftKings (6/21/25)

June 21, 2025

Koby's top DraftKings and FanDuel MLB DFS picks for today, Saturday, 6/21/25. His favorite daily fantasy baseball lineup sleepers and value picks for DFS on DraftKings and FanDuel.

Welcome Back, RotoBallers! We have a small six-game slate on this lovely Saturday evening. Let's make some dough tonight, shall we?

It should be some good hitting weather today, and there looks to be no rain, so there are no delays or postponements to worry about. It will be hot in Colorado again, so all the cash lineups should be filled with Rockies and Diamondbacks.

This article will provide my daily fantasy baseball lineup picks for DraftKings and FanDuel on 6/21/2025, with the slate starting at 7:15 p.m. EDT. The lineup picks will showcase elite players, mid-priced options, and value plays. You can also read more DFS advice and lineup picks for other sports here. Monitoring injury news and today's MLB starting lineups is always essential.

DraftKings, FanDuel Pitchers - MLB DFS Lineup Picks

Dustin May- LAD vs. WSN (DK: $7.6K; FD: $8.9K)

We likely aren't going to get a ton of strikeouts from May in this spot with the Nationals having the lowest K% to RHP this month. But May offers a solid floor the rest of the way around. The Nationals have been the worst-hitting team against RHP this month with a wRC+ of 66. I also like the price we are getting on him here.

The Dodgers are the biggest favorites on the slate, and May should be good for at least six innings here.

Noah Cameron - KCR at SDP (DK: $8.8K; FD: $9.1K)

Noah Cameron is having a fantastic start to his career. He has a quality start in five of his seven starts and has only had one bad outing, which was against the Yankees, which is understandable. Otherwise, he has a 1.91 ERA on the season with a respectable 19.6% K%. Noah Cameron is likely one of the highest I pay for in pitching on this slate.

Noah Cameron, Dirty Curveballs. 😨 pic.twitter.com/JLURZMnQxP

— Rob Friedman (@PitchingNinja) June 15, 2025

The Padres, on the other hand, have been terrible against LHP this month. They have a wRC+ of 65 and a 24.4% K%. They have been awful this month, and I think Cameron has all the stuff to put up a solid start against them.

Carson Palmquist - COL vs. ARI (DK: $8K; FD: $8.3K)

I know what you are thinking, "Palmquist, really?" This is a punt play if I have ever seen one. Although Palmquist has been atrocious this season, he gets a sneaky matchup against the Diamondbacks, who have been equally poor in their own way.

They have the worst wRC+ in the MLB against LHP with a 51! They have the lowest wOBA at .244 and an ISO of .092 that will make you cringe. They are also striking out 26.4% of the time against LHP.

Carson has had decent outings against the Cubs and Mets this season, and at his price, he makes for a sneaky option at SP2 on DK. It's a risk, but who knows, it might pay off in this spot and provide ultimate leverage against those who stack Arizona's offense.

Also Consider: Dylan Cease vs. KCR, Brandon Walter vs. LAA

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DraftKings, FanDuel Infielders - MLB DFS Lineup Picks

Jeremy Pena,  SS - HOU vs. Jose Soriano (DK: $4.8K, FD: $3.3K)

Jeremy Pena has been one of the best-hitting infielders in the AL. He isn't hitting for a lot of power, but he is getting on base quite a bit. He has a .369 wOBA and a SLG of .470 against RHP. He has 9+ fantasy points in nine of his last twelve games.

Jose Soriano has been solid this season, but has also shown he can lose control and get blown up. I think this Houston offense gets to him early and gets into a poor Angels bullpen that ranks fourth worst in the league.

Ryan McMahon, 3B - COL vs. Merrill Kelly (DK: $3.8K, FD: $3.3K)

With the weather looking like it is, it could be a home run derby in Colorado. I like Ryan McMahon quite a bit in this spot against Merrill Kelly, whom he has stung twice for home runs in the past. McMahon is much better against RHP and at home, where he has a 171 wRC+. This is lining up to be a great spot, and it will likely be that way for a lot of guys in this game.

Nick Kurtz, 1B - ATH vs. Luis L. Ortiz (DK: $3.7K, FD: $3.1K)

Nick Kurtz continues to be cheap even with his recent success. He is getting an excellent opportunity here against Luis L. Ortiz. Ortiz has lost the plot a bit over his last two starts, getting blown up by Seattle and Cincinnati. LHH especially hurt him, which lines up perfectly for Nick Kurtz and Lawrence Butler.

Nick Kurtz has 5 HR and 9 RBI over his last 6 games for the @Athletics. pic.twitter.com/x9NEnabv3S

— MLB (@MLB) June 21, 2025

Kurtz has a .586 SLG and .394 wOBA against RHP this season. On top of that, he is at home where it is only getting hotter in Sacramento. Everything is lining up perfectly for a big showing from Kurtz.

Also Consider: Geraldo Perdomo, SS (ARZ), Mookie Betts, 2B/SS/OF (LAD), Hunter Goodman, C/1B/OF (COL)

DraftKings, FanDuel Outfielders - MLB DFS Lineup Picks

Lawrence Butler, OF - ATH vs. Luis L. Ortiz (DK: $4.8K, FD: $3.4K)

Like I mentioned above with Nick Kurtz, Lawrence Butler is also in a great spot as a lefty. Lawrence is so much better against RHP, where he has a 130 wRC+ and a SLG of .469. These Athletic lefties should be able to crush in this matchup. Lawrence has also found some recent success.

He has five hits in his last two games at home with one home run. If it wasn't for Coors on this slate, the Athletics would be one of my top stacks for today.

Teoscar Hernandez, OF - LAD vs. Jake Irvin (DK: $5.1K, FD: $3.6K)

Teoscar is having a solid season for the Dodgers so far. He has 13 homers on the season with a SLG of .489 and a .337 wOBA. He also has good splits against Nationals Pitcher Jake Irvin, whom he has slapped for two home runs in 10 ABs. LHH seems to have the better splits against Irvin, but I like getting different with Teoscar here, who has seen success against Irvin in the past.

Brandon Marsh, OF - PHI vs. Griffin Canning  (DK: $2.9K, FD: $2.6K)

Brandon Marsh has flown under the radar a bit this year, but he has been sneaky good recently. He has 15 hits in his last 11 games, and in only one of those games was he hitless. He has been low-key cruising and is also a threat on the basepaths with his speed.

Griffin Canning hasn't been anything special and has been hit harder by LHH this season. Philadelphia lefties could be a sneaky stack on this slate, with Coors being the main focus.

Brandon Marsh is hitting a nice .333 since May 1st pic.twitter.com/pGJ7enU6gy

— Philly Archive (@PhillyArchive) June 21, 2025

Also Consider: Maikel Garcia (KCR), Tyler Freeman (COL), Lourdes Gurriel Jr. (ARZ)

DraftKings, FanDuel MLB DFS Stacks

Los Angeles Dodgers (5.8 run total) vs. Jake Irvin (WSN)

Jake Irvin has been in rough shape in his last four starts. He has given up three or more runs in all four games, and now he is getting one of the best offenses in the league. He has been specifically hit pretty hard by LHH this season.

So fire up Ohtani, Freeman, and Muncy, because all are in for what could be a big game. Both Mookie and Teoscar have played well against Jake Irvin in the past, making them solid plays as well.

Colorado Rockies (5.1 run total) vs. Merrill Kelly (ARI)

The Diamondbacks will be chalk, but the Rockies have been doing well, too. They have an above-average wRC+ at 108 against RHP this month. They just scored eight runs in last night's game as well. They aren't projected for 7+ runs like the Diamondbacks are, but anything is possible in Coors.

Also Consider: Athletics vs. Luis L. Ortiz, Philadelphia Phillies vs. Griffin Canning

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