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Starts and Sits - All Starting Pitcher Matchups for Fantasy Baseball (September 15 - September 21)

Paul Skenes - Fantasy Baseball Rankings, MLB Injury News, DFS Lineup Picks

Nick's fantasy baseball starts/sits, expert advice for all starting pitcher matchups for September 15 - September 21 (2025). Set your winning fantasy baseball lineups.

The finish line is in sight as the final two weeks of the fantasy baseball season are upon us, which we're set to crush with our starting pitcher starts/sits for fantasy baseball Week 25 - Monday, September 15 through Sunday, September 21. This column provides readers with who is pitching, the opponent, and a confidence/startability score based on an array of metrics. Keep us bookmarked for every start/sit option and two-start decision that remains between you and the championship.

For 13 years running, we have been writing this Starting Pitcher Starts and Sits series weekly here at RotoBaller. I'm Nick Mariano, and I'll take us through the 2025 season. All types of firepower go into bringing you this piece each week, as we provide a must-read series for our readers.

Newcomers should be sure to read the section below to learn the column's goal and how best to use this tool, while long-time RotoBallers can proceed to the guide. We wish you the best of luck with your fantasy baseball starting pitcher decisions, but ideally, we create our own luck with informed decision-making. September magnifies each decision, so don't take these lightly!

Be sure to check all of our fantasy baseball lineup tools and resources:

 

Start/Sit Data Overview

Ahead of each week of the fantasy baseball season, we publish the table below. We have the probable starters for every game of the week and a grade for them on a 0-100 scale. The intent is to give you advice and inspire confidence (or lack thereof) in your decisions to start or sit certain pitchers.

Please note that beyond the usual "Start" and "Sit" labels, we've expanded on the old "context-dependent" section to break it down further with "Lean Sit," "Lean Start," and true 50/50 "Coin Flip" designations. This is because different leagues call for different actions, and those in start-sit purgatory may be worth the gamble to some.

Also, we put the arms best projected to start or get bulk innings or actionable arms who may return from the injured list or be called up. Still, some situations are fluid, and we update ASAP to reflect accurate information. Rosters expanding could see teams get more bullish with bullpen games, so we'll be sure to stay on top of those assignments.

The "starts" category includes pitchers you'd likely start in every league. The "sits" are pitchers you likely sit in every league.

The 40-60 range will mean it is close, and it's up to you to decide based on your league settings or team needs (wins, strikeouts, etc.), how deep your league is, which roto/points categories are scored, and so on.

Here are your starts and sits for what we're calling Week 25 of the fantasy season and covers September 15 through September 21.

 

Week 25 Start/Sit Recommendations (September 15 - September 21)

Updated start/sit recommendations for this week's MLB games. This chart is updated daily as probable starters are constantly changing with postponements, injuries, etc. Scroll down further for a color-coded chart. If you can't see the chart below, click here to see the starts/sits on a separate page:

 

Start/Sit Color-Coded Matchups Chart (September 15 - September 21)

The below grid shows the same data but as a color-coded grid:

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POPULAR FANTASY TOOLS

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Import Your Leagues
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Compare Any Players
Compare Any Players
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24x7 News and Alerts

REAL-TIME FANTASY NEWS

Obi Toppin

Expected to Miss One Month
Andrew Nembhard

to Miss Third Straight Game Wednesday
Bennedict Mathurin

Out Week-to-Week
Jusuf Nurkić

Jusuf Nurkic Iffy for Wednesday
Zaccharie Risacher

Listed as Probable Against Nets
Jalen Johnson

Considered Probable for Wednesday
Dillon Brooks

to Remain Out Wednesday
Jalen Green

Could Make His Suns Debut Wednesday
Anthony Davis

Expected to Play Wednesday
Jaylen Brown

Listed as Probable for Wednesday
Zion Williamson

Uncertain for Wednesday
Alex Caruso

Returns to Thunder Lineup
Gary Trent Jr.

Available Against Knicks
Cole Anthony

Back in Bucks Lineup Tuesday
Miles McBride

Remains Unavailable Tuesday
Guerschon Yabusele

Unavailable Against Bucks
Karl-Anthony Towns

Good to Go Tuesday
Tre Mann

Available Versus Heat
Simone Fontecchio

Cleared for Action
Norman Powell

Out on Tuesday
Chet Holmgren

Won't Play Tuesday
Adam Gaudette

Could Miss Time
John Klingberg

Ready for Action Tuesday
Warren Foegele

to Miss "Some Time"
George Springer

Not in the Lineup for Game 4 of World Series
Brett Pesce

Expected to Be Out for One Month
Jake Neighbours

to Miss at Least Five Weeks
Hampus Lindholm

Expected to Return Tuesday
Jacob Markstrom

Returns to Devils Crease Tuesday
Quinn Hughes

Sits Out Second Consecutive Game
Malik Nabers

Should be Ready for Start of Next Season
Lamar Jackson

Says he's "Ready to Go Now"
Isiah Pacheco

Week-to-Week With MCL Sprain
Tyler Shough

Named Saints' Starting Quarterback
Drake Batherson

Picks Up Three Points in Monday's Win
Sidney Crosby

Becomes Ninth NHL Player With 1,700 Points
Michael Kesselring

Expected to Make Season Debut Tuesday
Shayne Gostisbehere

Could Return Tuesday
K'Andre Miller

Expected to Remain Out Tuesday
Pyotr Kochetkov

Close to Returning
Kareem Hunt

Scores Twice in Monday Night Win Over Washington
George Springer

Pulled Early in Game 3 With Side Injury
Terry McLaurin

Questionable to Return in Week 8 After Aggravating Quad Injury
Baltimore Orioles

Orioles Finalizing Deal to Hire Craig Albernaz as the Next Manager
William Byron

Dominates at Martinsville and Advances to the Championship Round
Kyle Larson

Advances to the Championship Round After Top-Five Finish
Ryan Blaney

Falls Short of the Victory and Title Contention at Martinsville
Chase Elliott

Eliminated From 2025 Title Contention Despite Strong Martinsville Run
William Nylander

Questionable for Tuesday
Rasmus Sandin

to Miss Third Straight Game
Lamar Jackson

Ravens Expect Lamar Jackson to Play on Thursday Night
Dylan Strome

Ruled Out for Tuesday
Brad Marchand

Won't Play on Tuesday
Alexey Toropchenko

Returns to Blues Lineup
Jake Neighbours

Unavailable Versus Penguins
Robert Thomas

Out on Monday
Michael Carter

Cardinals Release Michael Carter on Monday
Carson Wentz

to Undergo Season-Ending Shoulder Surgery
CFB

Behren Morton Will Start Against Kansas State
Nico Collins

Trending Toward a Week 9 Return
Puka Nacua

Expected to Practice Wednesday, Play in Week 9
CFB

Lane Kiffin Says Money Won't Impact his Decision-Making
Tony Pollard

Reportedly Available for Trade
CFB

Arch Manning in Concussion Protocol, Misses Practice Monday
Brian Thomas Jr.

Jaguars Not Planning on Trading Brian Thomas Jr.
Justin Fields

Jets Non-Committal on Justin Fields as the Starter Going Forward
Christopher Bell

Eliminated From Championship 4 After a Too Conservative Season
Joey Logano

Lack of Championship-Caliber Speed Leads to Elimination
Chase Briscoe

Finishes Last at Martinsville
Denny Hamlin

Don't Think Denny Hamlin's Engine Failure Affects his Championship Prospects
Cam Skattebo

Out for the Season With Dislocated Ankle
Ciryl Gane

Fight With Tom Aspinall Ends In No-Contest
Ciryl Gane

Tom Aspinall Vs. Ciryl Gane Ends in No-Contest
Virna Jandiroba

Suffers Unanimous-Decision Loss
Mackenzie Dern

Wins Vacant Strawweight Title
Mario Bautista

Gets Outclassed
Umar Nurmagomedov

Gets Back In The Win Column
Jailton Almeida

Drops Decision
Alexander Volkov

Wins Split Decision At UFC 321
Azamat Murzakanov

Remains Undefeated
Aleksandar Rakic

Suffers First-Round Knockout
Tucker Kraft

Dominates With 143 Yards, Two Touchdowns on Sunday Night
Troy Franklin

Explodes for Two Touchdowns Against Cowboys
J.K. Dobbins

Breaks 100 Yards Again but Doesn't Find the End Zone
Bo Nix

has a Season-Best Four Passing Touchdowns
Jalen Hurts

Matches Career High With Four Touchdown Passes in Week 8
RJ Harvey

R.J. Harvey Breaks Out With Three Touchdowns in Week 8
Chris Buescher

Is Chris Buescher A Playable DFS option for Martinsville?
Ryan Preece

is an Intriguing DFS Option For Martinsville
Daniel Suarez

May be Worth Rostering in DFS for Martinsville
Austin Dillon

Is Austin Dillon Worth Rostering in DFS for Martinsville This week?
Christopher Bell

Kyle Larson Should Advance to Championship 4
Joey Logano

Don't Expect Joey Logano to Significantly Contend for Championship 4
William Byron

A DFS Must-Start Due to Lap-Leader Points
Ross Chastain

Hail Melon Nostalgia Masks Ross Chastain's Martinsville Mediocrity
Josh Berry

a Top Contender for DFS Place-Differential Points
Brad Keselowski

an Intriguing Martinsville Option
Shane Van Gisbergen

Now Competent on Ovals, but Don't Start Him Here
Kyle Busch

Qualifies Well but Probably Won't Have Staying Power
Carson Hocevar

Lack of Finesse Makes Him a Risky Martinsville Pick
Bryce Harper

Phillies Aren't Planning to Trade Bryce Harper
Bo Bichette

Starting at Second, Batting Cleanup in Game 1 of World Series
Bo Bichette

Makes World Series Roster
Ciryl Gane

Scheduled For A Title Fight
Tom Aspinall

Set for First Official Title Defense
Mackenzie Dern

Can Become The New Strawweight Champion
Virna Jandiroba

Set For UFC 321 Co-Main Event
Mario Bautista

Aims To Extend His Win Streak
MMA

Umar Numagomedov A Favorite At UFC 321
Jailton Almeida

Hopes To Get A Title Shot With A Win
Alexander Volkov

Looks To Get Back In The Win Column
Azamat Murzakanov

Looks To Remain Undefeated
Aleksandar Rakic

In Dire Need Of Victory
CFB

Texas Tech QB Will Hammond Will Start vs. Oklahoma State Saturday
CFB

Kansas State RB Dylan Edwards Out For Sunflower Showdown
CFB

Arizona State WR Jordyn Tyson Will Not Play In Week 9
Zack Wheeler

Could be Ready for Opening Day in 2026
William Contreras

Could Need Finger Surgery
CFB

Utah QB Devon Dampier Listed as Questionable on Big 12 Injury Report

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