Wide Receiver Matchups to Target in Week 2 (2025) - Ja'Marr Chase, Cee'Dee Lamb, Ricky Pearsall, Chris Olave, Kayshon Boutte

Kyle's favorite WR vs. CB matchups to exploit for Week 2 of 2025 - DFS wide receivers to target on DraftKings and FanDuel. These WR/CB matchups are GPP and cash game opportunities.

Welcome to the Wide Receiver Matchups to Target column for Week 2 of the 2025 NFL season. We're now working with a tiny one-game sample size in 2025, so we'll factor that in while giving more weight to other factors like implied totals, projected pace, and Vegas lines. Week 1 wasn't pretty for a lot of top-tier receivers, but we're tackling Week 2 to come back with a vengeance in DFS lineups.

To identify the best plays, we’ll use Pro Football Focus (PFF) WR/CB matchup grades to highlight receivers in favorable spots, with an eye toward those most likely to hit the 3x DraftKings multiplier that’s crucial in DFS cash and tournament contests.

Below are my top five WR vs. CB matchups for this week’s DFS main slate. Use these insights to fine-tune season-long lineups, player props, and DFS builds. Let’s get to it already!

Ja'Marr Chase, Cincinnati Bengals

• $8.1k on DraftKings, $9k on FanDuel
• Vs. Jarrian Jones, Tyson Campbell, & Jourdan Lewis (Jacksonville)

Chase was vastly disappointing in Week 1, catching just 2-of-5 targets for 26 scoreless yards in an ugly game for the Bengals' offense against the Browns. Joe Burrow finished 14-for-23 with 113 passing yards, and it goes without saying that we shouldn't expect that type of performance to become a trend this season.

The Bengals will take on the Jaguars at home in a game with a 49-point implied total in Week 2, which is the highest implied total on the main slate. Jacksonville was surprisingly stout on defense in Week 1, but we have to take any performance against Bryce Young and the Panthers with a giant grain of salt. This secondary allowed the 9th-most fantasy points per game to WRs last season, and they allowed the fourth-most fantasy points per game to perimeter receivers.

the last time Ja'Marr Chase scored under 10 fantasy points he followed it up with a 33 point performance

dating back to 23' he is a zig-zag machine-

busts -> wk after result 🤯
8.1 -> 29.1
14.3 -> 55.2
14 -> 28.1
8.1 -> 26.4
12.1 -> 34.6
7.5 -> 32.8
11.3 -> 58.4 pic.twitter.com/SSGJhjzLPJ

— AP (@AP8809dfs) September 9, 2025

The cornerback group of Jarrian Jones (90th of 95 CBs), Tyson Campbell (39th of 95 CBs), and Jourdan Lewis (43rd of 95 CBs) doesn't stand a chance covering him, and I fully expect Cincinnati to prioritize getting the All-Pro involved early and often against this vulnerable secondary in Week 2. Tee Higgins is also in line for a major bounce-back spot here, and you can get him for $2,000 cheaper on DraftKings.

CeeDee Lamb, Dallas Cowboys

• $7.8k on DraftKings, $8.7k on FanDuel
• Vs. Paulson Adebo, Andru Phillips, & Cor'Dale Flott (NY Giants)

Lamb had an incredible game in Week 1, finishing with seven catches on 13 targets and 110 receiving yards (21 DK points) against the Eagles. He's going to continue to get a dominant target share due to the Cowboys' lackluster running game and only having George Pickens as a legitimate receiving threat to take away looks, and he's got a shot to put up a repeat performance in a golden matchup in Week 2.

The Giants will roll out Paulson Adebo (63rd of 95 CBs), Andru Phillips (65th of 95 CBs), and Cor'Dale Flott (36th of 95 CBs) to attempt to cover him. Flott, in particular, allowed the highest aDOT (average depth of target) and one of the highest yards per target (13) in Week 1. The group held Terry McLaurin in check in Week 1, but Deebo Samuel got loose for seven catches and 77 receiving yards in a game where Washington dominated with 220 rushing yards in a lopsided win.

🐑 CEEDEE LAMB BREAKING THE HEARTS OF COWBOYS ML BETTORSpic.twitter.com/Uwi9XFmnu8

— Action Network (@ActionNetworkHQ) September 5, 2025

This critical divisional matchup should be more competitive as the Cowboys are currently favored by just 4.5 points at home, so Lamb should see a boatload of targets against a secondary that is among the most vulnerable in the league (NYG ranked 28th in 'coverage' grade via PFF in Week 1).

Ricky Pearsall, San Francisco 49ers

• $5.3k on DraftKings, $6.2k on FanDuel
• Vs. Kool-Aid McKinstry & Isaac Yaidom (New Orleans)

Pearsall is in line for a monster game in Week 2. George Kittle was placed on the IR, and Jauan Jennings may not suit up due to a shoulder injury, so the second-year receiver should get all the work he can handle with retreads Marquez Valdes-Scantling and Kendrick Bourne behind him.

The CB matchups are a big positive here, too. Kool-Aid McKinstry (47th of 95 CBs) and Isaac Yiadom (49th of 95 CBs) represent exploitable matchups, and while the 49ers ranked well against WRs last season, they allowed perimeter threats Marvin Harrison Jr. (18.1 DK points) and Trey McBride (12.1 DK points) to thrive in Week 1.

Pearsall is very likely to build on the value-crushing 17.8 DK point performance he produced in Week 1 against the Seahawks due to the plus matchup and lack of receiving options in San Fran.

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Chris Olave, New Orleans Saints

• $4.9k on DraftKings, $6k on FanDuel
• Vs. Upton Stout, Renardo Green, & Deommodore Lenoir (San Francisco)

Olave isn't the sexiest name on the board, but he's ultra-cheap for a WR1 on an offense that's expected to have to pass to stay competitive. He recorded seven catches for 54 scoreless yards (12.4 DK points) in Week 1, and he finished with a respectable 26.1% target share and 28.7% air-yard share. He will continue to see the most volume in this receiver corps, and that has value at his low price tag.

Additionally, the individual CB matchup against the 49ers looks to be positive. Upton Stout (94th of 95 CBs) was awful in Week 1, and Olave should see a lot of him in coverage playing out of the slot. He's a short corner at just 5'8", which should allow Olave to eat him up when combined with his route-running ability. Green and Lenoir are tougher matchups for him, and the QB situation isn't great with Spencer Rattler slinging it to him, but those downsides have already been (more than) baked into his bargain-bin salary for Week 2.

Kayshon Boutte, New England Patriots

• $4.5k on DraftKings, $5.5k on FanDuel
• Vs. Jason Marshall Jr. (Miami)

Boutte is one of the top salary-saving WRs on the Week 2 main slate. The forgotten man in a remade receiving room for the Patriots went off in Week 1, catching 6-of-8 targets for 103 yards (19.3 DK points). His advanced metrics backed up his strong play, highlighted by his average depth of target (17.1, #12 among qualified WRs), first read targets (7, #11), and expected fantasy points (16.4, #19).

Pretty impressed with Kayshon Boutte after week 1.

He won in a lot of different ways. He's got the timing down with Drake Maye.

At least 7 targets and 90 yards in 3 of his last 4 games. pic.twitter.com/GykkIXVtCe

— Alfredo Brown (@AlfredoABrown) September 8, 2025

While the Patriots aren't likely to throw 46 times like they did in Week 1, we should see another fantasy-friendly game with the porous Dolphins defense contributing to the game's high 45.5-point implied total. Boutte will match up with Jack Jones (80th of 95 CBs), Rasul Douglas (77th of 95 CBs), or Jason Marshall Jr. (72nd of 95 CBs). This underwhelming group allowed Daniel Jones to throw for 272 yards and a touchdown, while leading receiver Michael Pittman Jr. went off for a 6/80/1 line.

Fire up Boutte as a cheap dart-throw and hope he can replicate the chemistry he showed in Week 1 with Drake Maye. Stefon Diggs and DeMario Douglas are also in play, as they're cheap and facing the same exploitable defense.

Thanks for reading, and good luck with your DFS contests!

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