👉 TAP TO SAVE 50% WITH CODE SPRING
X
Lost password?

Don't have an account?
Gain Access Now

X

Receive free daily analysis

NFL
NBA
NHL
NASCAR
CFB
MLB
MMA
PGA
ESPORTS
BETTING

Already have an account? Log In

X

Forgot Password


POPULAR FANTASY TOOLS

#1 Expert Projections
Save 50% Now
Import Your Leagues
Props Tool
Compare Any Players
Compare Any Players
24x7 News and Alerts

FanDuel MLB DFS Lineup Picks (9/22/21): Daily Fantasy Baseball Advice

Mike Schwarzenbach highlights the top FanDuel MLB DFS lineup picks for 9/22/21, and a couple of sleepers to consider while building daily rosters.

Welcome to another fun Wednesday slate! Whether you've been following along all season long or just getting back into DFS now that football is back we're glad to have you here.

It's looking like another high-scoring night in MLB as we're running out of season and the non-contenders really seem set on not contending, at least based on the caliber of starting pitcher some teams will roll out. There are plenty of offenses to target tonight, but they're relatively expensive so we'll need to decide if we want to pay up for Zack Wheeler or Chris Sale, or take a chance on a lower-priced arm and load up on the big bats.

I'll be providing you with my daily fantasy baseball lineup picks for the FanDuel main slate on 9/22/2021. Be sure to also check out all the MLB player news, including late scratches, and the projected and confirmed daily MLB lineups for each DFS slate. You can also check out today's DraftKings MLB DFS lineup picks, and read more DFS advice and lineup picks for other sports too. Let's get to it!

 

FanDuel DFS Pitchers

Cash Game/GPP Anchor Play:

Zack Wheeler – PHI vs BAL ($10,700)

Wheeler is the most expensive hurler on the slate tonight which makes sense as he's far and away the favorite to post the highest score of the evening. Wheeler has enormous upside every time he takes the mound as he's got seven double-digit strikeout games this season to go with a sterling 2.83 ERA as he's firmly in the NL Cy Young conversation. His ERA is fully supported by an xFIP of 2.87 which is tied with Gerrit Cole for the second-best mark in the Majors (Corbin Burnes is first at 2.31).

Want strikeouts? Wheeler does that too as he's sporting an excellent 28.9% strikeout rate on the season. What's more impressive is Wheeler has maintained a strikeout rate near 30% all season long while leading baseball in innings pitched at 200 1/3. He comes into this game in great form having allowed just two runs over his last three starts, spanning 17 2/3 innings. Given the matchup with Baltimore, no pitcher has a higher floor/ceiling combo than Wheeler. The fact he's under $11K is actually a discount given how thin the rest of the pitching pool is tonight.

Potential Alternate Play

Joe Ryan – MIN at CHC ($7,700)

As we discussed in the intro, we'll need to make choices with our allotted salary cap. It is very difficult to pay up for Wheeler and also get the bats we want from offenses with high implied run totals. Believe me, I tried. Ergo, if we want to target the Giants, Red Sox, and Phillies lineups, we'll need to sacrifice on the mound and that's where Joe Ryan comes in.

Ryan's ceiling is certainly lower than higher-priced options, but the rookie has looked good through three MLB starts and offers a crazy discount compared to the mid-tier pitching options. In his first three starts, Ryan has allowed just four runs through 17 innings and he completed the fifth inning in all three outings. The Cubs aren't an overly daunting matchup and Chicago has the highest strikeout rate as a team over the last 14 days at over 28%. If Ryan can get through five or six innings with a handful of K's, that's all we need to justify playing him at this price point.

 

Want more MLB DFS tools and content? Our MLB Premium package includes our daily DFS Cheat Sheets, Research Station, Optimizer, and access to our Premium Slack Chatrooms where members can chat with our MLB analysts. Check out this recent big win from RotoBaller's RealTalkRaph on DraftKings - join in on the winning!

 

FanDuel DFS Infielders

Brandon Belt – 1B, SFG at SDP ($3,900)

Belt has spent a lot of the season battling injuries, but when he's been healthy he's been one of the best hitters in the game according to his Statcast data. Belt is in the top seventh percentile in the league in wOBA and expected wOBA thanks to an elite 16.5% barrel rate. I'll take my chances with this hitter versus Vince Velasquez and his 5.01 ERA.

Enrique Hernandez – 2B/OF, BOS vs. NYM ($3,400)

Hernandes has five hits through his last three games and has scored exactly two runs in each game batting leadoff for a good Boston lineup. He homered last night and just missed another one as he launched a ball clear out of Fenway Park that was just foul. What's most encouraging is Hernandez has been hitting the ball in the air more lately as he's got a 48.7% fly-ball rate in September. Hernandez is locked in right now and a great floor/ceiling play in DFS.

Jean Segura – 2B/SS/3B, PHI vs. BAL ($3,400)

The Phillies offense has been scuffling lately but a matchup versus Keegan Akin should be just what the doctor ordered. Akin is a solid pitching prospect for Baltimore, but there's no dancing around how bad he's been this season. Akin has taken his lumps at the Big League level as he's sporting a 6.93 ERA through 90 innings pitched. He's allowing a 49% fly-ball rate in the second half so the Phillies offense is one we should target for homers. Segura has triple-eligibility and is batting .295 with four homers and nine steals. There are plenty of ways for Segura to return value in this matchup.

Brandon Crawford – SS, SFG at SEA ($2,300)

Targeting Velasquez is usually a solid strategy in DFS and Brandon Crawford has been on fire as he's slugging .649 over the last two weeks. There's not too much to analyze here, Crawford is hitting the ball hard all over the field and is facing a pitcher who allows a lot of fly balls and hard contact. Play him.

 

FanDuel DFS Outfielders

Bryce Harper – OF, PHI vs. BAL ($4,400)

Bryce Harper has been the best hitter on the planet over the last month or so and I'm not fading him because he's facing a lefty. First of all, we already detailed how bad Akin has been this year. Beyond that, it's almost funny how well Harper is hitting the ball. Over the last 14 days, he's got a .589 wOBA. The second-best mark in that span? Belt who is at "only" .528. In that same span, Harper is slugging a whopping .952, also the best in baseball. Let others fade the L/L matchup, play Harper versus one of the worst pitchers in baseball.

Adam Duvall – OF, ATL at ARI ($3,600)

Duvall has quietly had a phenomenal season as his 107 RBI rank fourth in the Majors. He's slugging .503 this season and has a solid matchup versus Merrill Kelly of the Diamondbacks. Kelly has shown reverse splits this season as right-handed batters are slugging .500 versus Kelly compared to .358 for lefties. Fire up Duvall batting in the middle of a good Braves lineup.

Jose Siri – OF, HOU at LAA ($2,700)

We need to save money somewhere and Siri offers tremendous upside in the sub-$3K price range. He's got four homers through 11 games and is facing rookie callup Janson Junk tonight. Siri is good value if stacking Astros, or as a one-off who has a chance to homer.

 

FanDuel DFS Stack Options

  • San Fransisco Giants
  • Philadelphia Phillies
  • Boston Red Sox



Download Our Free News & Alerts Mobile App

Like what you see? Download our updated fantasy baseball app for iPhone and Android with 24x7 player news, injury alerts, sleepers, prospects & more. All free!




MLB DFS News and Injury Alerts


More DFS Lineup Picks and Analysis




POPULAR FANTASY TOOLS

#1 Expert Projections
Save 50% Now
Import Your Leagues
Props Tool
Compare Any Players
Compare Any Players
24x7 News and Alerts

REAL-TIME FANTASY NEWS

Karl-Anthony Towns

Logs Sixth Double-Double of Postseason
Mike Conley

Ayo Dosunmu Replaces Mike Conley in Starting Unit Sunday
Miles McBride

Tallies Game-High 25 Points in Series Clincher
Tyrese Maxey

Settles for 17 Points Sunday
Joel Embiid

Scores Efficient 24 Points in Season-Ending Loss
Caris LeVert

Iffy for Monday Night
Kevin Huerter

Listed as Questionable for Game 4
Auston Matthews

Uncertain About Future With Maple Leafs
Frederik Andersen

Enjoying Special Postseason
Josh Manson

"Close" to Returning
Joel Kiviranta

Could Return to Action Monday
Radko Gudas

a Game-Time Call Sunday
Mark Stone

Unavailable Sunday
Sean Tucker

Dynasty Upside Remains Limited by Crowded Backfield Picture in Tampa Bay
Puka Nacua

Is Puka Nacua's Dynasty Value Impacted by Potential Off-Field Concerns?
Alec Pierce

Can Alec Pierce Build on Encouraging 2025 Production in 2026 and Beyond?
Keenan Allen

Dynasty Stock Falling with NFL Future in Limbo
Drake London

Remains a Dynasty WR1 Entering 2026
Connor Zilisch

Will Start Fifth in his First Watkins Glen Cup Series Race
Tyler Reddick

Is A Top DFS Option for Watkins Glen Lineups
Christopher Bell

Is Likely to Bounce Back This Week at Watkins Glen
Carlos Rodón

Carlos Rodon Activated for Season Debut on Sunday
William Byron

Is William Byron Playable in DFS Lineups at Watkins Glen?
Bucky Irving

Potentially Undervalued After Disappointing Sophomore Season
Austin Reaves

Nears Double-Double In Game 3 Loss
Davante Adams

a Dynasty Hold Who Could See His Value Slip
LeBron James

Facing Sweep With Game 4 on Monday
Emeka Egbuka

The Pendulum Swinging Back on Emeka Egbuka's Dynasty Value
Ajay Mitchell

Posts Career Playoff Night in Game 3
Chet Holmgren

Helps Thunder Move to Brink of Conference Finals
Michael Pittman Jr.

Undervalued in an Environment Fit for His Skill Set
Tobias Harris

Extends 20-Point Streak in Saturday's Loss
Evan Mobley

Keeps Defensive Production Rolling Saturday
Rhamondre Stevenson

a Quality Dynasty Target in a Still-Improving Offense
Golden State Warriors

Warriors Extend Steve Kerr into his 13th Season
Kyle Larson

May have A Positive Day at Watkins Glen
Chase Briscoe

May Compete for A Top-10 Finish at Watkins Glen
NASCAR

A.J. Allmendinger May have Another Solid Outing at Watkins Glen
Ty Gibbs

Should Fantasy Managers Roster Ty Gibbs at Watkins Glen?
Ross Chastain

Is Ross Chastain Worth Rostering for Watkins Glen Lineups?
Austin Cindric

Could Austin Cindric be A Sneaky Tournament Play for Watkins Glen?
Odell Beckham Jr.

Giants Not Looking to Sign Odell Beckham Jr. Right Now
Bo Nix

Will be Full Speed Before Training Camp
Shane Van Gisbergen

Shane van Gisbergen the Heavy Favorite at Watkins Glen
Chase Elliott

Is Chase Elliott a No-Brainer DFS Pick at Watkins Glen?
Chris Buescher

Qualifies 14th at Watkins Glen
Ryan Blaney

Has Upside at Watkins Glen After Signing Contract Extension
Michael McDowell

Still Searching for First Top-Five Finish at Watkins Glen
Carson Hocevar

Is Carson Hocevar Too Aggressive for Road-Course Racing?
Joey Logano

Needs a Good Run at Watkins Glen
Luis Castillo

Mariners Intend to Piggyback Luis Castillo, Bryce Miller
Duncan Robinson

Shines on Both Ends Saturday
Cade Cunningham

Records Second Career Postseason Triple-Double
Donovan Mitchell

Logs 35-Point Double-Double
James Harden

Plays Late Hero Saturday
OG Anunoby

Could Miss Another Game Sunday
Joel Embiid

Considered Probable for Sunday's Elimination Game
Jarred Vanderbilt

Active on Saturday Night
Logan Webb

Placed on 15-Day Injured List With Knee Bursitis
Bryce Miller

is Set to Return on Wednesday
Jeff Hoffman

Could Return to Closer Role
CHI

Blackhawks Bring in Roman Kantserov for Next Season
Mason McTavish

Set to Rejoin Ducks Lineup Sunday
Lukas Dostal

to Remain in Ducks Crease Sunday
Zach Bogosian

Back for Wild Saturday
Jesper Wallstedt

Starting Game 3 Against Avalanche
Joel Eriksson Ek

Not Ready to Return Saturday
Owen Tippett

Won't Play Saturday
Cooper Kupp

a Dynasty Hold into the Start of 2026 Season
Jaylen Warren

a Safe Dynasty Depth Piece with Insurance Upside
Christian McCaffrey

a Risky Dynasty Hold Who Still Exceeds His Trade Value
Brian Thomas Jr.

A Risky Buy-Low with Immense Upside
Tre' Harris

a Dynasty Hold That Could Require Patience
Taj Bradley

Hits the Injured List With Pectoral Inflammation
Braelon Allen

Dynasty Stock Takes a Hit After Teammate's Extension
Josh Allen

Still the Top Dynasty QB in his Prime
Kyler Murray

Suddenly a Rising Dynasty Target in Minnesota
Kyle Bradish

has Nice Bounce-Back Performance With 10 K's
Casey Mize

Throws Bullpen on Friday, Return Not Imminent
Ronald Acuña Jr.

Ronald Acuna Jr. Optimistic About Returning Next Wednesday
Mike Matheson

Leads by Example in Game 2 Win
Jakub Dobes

Rebounds After Loss Yet Again for Montreal
Rachaad White

Undervalued in Dynasty Leagues Despite a Path to Upside
Alex Newhook

Sets Tone in Big Montreal Victory
Lukas Dostal

Gets Pulled in Game 3 Loss on Friday
Brett Howden

Notches Sixth Goal of the Postseason
VEG

Mitch Marner Hat Trick Helps Vegas Take Series Lead
Tyler Glasnow

Dodgers Put Tyler Glasnow on Injured List With Back Spasms
Mats Zuccarello

Expected to Play Saturday
Joel Eriksson Ek

to Be a Game-Time Decision Saturday
Blake Snell

to Make Season Debut for Dodgers on Saturday
Cole Ragans

Royals Place Cole Ragans on Injured List With Elbow Impingement
Sean Strickland

An Underdog At UFC 328
Khamzat Chimaev

Set For UFC 328 Main Event
Tatsuro Taira

Can Become The New Flyweight Champion
Joshua Van

Set For His First Title Defense
Alexander Volkov

Looks To Win Back-To-Back Fights
MMA

Waldo Cortes-Acosta Looks To Extend His Win Streak
Nick Lodolo

Officially Activated, Making Season Debut on Friday
CFB

Walker Lyons Could be Go-To Target for Bear Bachmeier
CFB

Ty Benefield a Potential Game-Changer for LSU Defense
CFB

Hayden Lowe Set for Significant Role Following Miami's NFL Departures
CFB

Taylor Wein in Position for Big Season on Oklahoma's Defensive Line
CFB

Rasheem Biles an Instant Impact Player for Texas
Roman Anthony

Heading for the Injured List
CFB

Sam Leavitt Expected to Be Full-Go for Fall Camp
Tarik Skubal

Could Return in 4-6 Weeks After Successful Elbow Surgery
Cole Ragans

Royals Hopeful That Cole Ragans Makes his Next Start
Emilio Pagán

Emilio Pagan has Grade 2 Hamstring Strain, Expected to Miss 4-8 Weeks
Joe Ryan

Listed as Scheduled Starter for Saturday Against Cleveland
Tyler Glasnow

Not Expected to Land on the Injured List
Framber Valdez

Suspension Reduced to Five Games
Framber Valdez

Suspended Six Games
CFB

Brauntae Johnson the Next Star in Notre Dame's Secondary?
CFB

Ethan Barbour a Name to Know in Georgia's Tight End Room
CFB

Payton Pierce Next Up at Linebacker for Ohio State
CFB

Javin Gordon to Play Significant Role for Tennessee?
CFB

Tanook Hines Stepping into WR1 Role for USC
CFB

Rueben Owens II has "Star Potential" in Fourth Campaign
Collin Morikawa

Withdraws From Truist Championship
Xander Schauffele

Carries Elite Form Into Quail Hollow
Hideki Matsuyama

Looks to Bounce Back at Truist Championship
Matt Fitzpatrick

Secures Third Win of 2026 Season
Patrick Cantlay

Continues Playing Well Heading to Truist Championship
Ludvig Aberg

Returns to Action For Truist Championship
Justin Thomas

Searching for Consistency at Quail Hollow
Jordan Spieth

Looks to Break Through at Quail Hollow
Adam Scott

Brings Strong Form to Quail Hollow
Robert MacIntyre

a Steady Option at Truist Championship
Jason Day

Looks to Overcome Approach Struggles at Quail Hollow
Akshay Bhatia

Looks for Complete Game at Truist Championship
Justin Rose

to Continue Mid-Season Club Change at Truist Championship
Si Woo Kim

is Back to Peak Form Ahead of Truist Championship
Sam Burns

to Bounce Back at Truist Championship
Cameron Young

Looks to Carry Dominance to Quail Hollow
Rory McIlroy

Returns to Familiar Stomping Grounds This Week at Quail Hollow
Chris Gotterup

Looking to Bounce Back at Quail Hollow
Tommy Fleetwood

Looking For Better Iron Play at Quail Hollow
CFB

Mario Craver Enters No. 1 Wide Receiver Role for Marcel Reed
CFB

LaNorris Sellers a Strong Rebound Candidate in 2026
CFB

Cam Coleman Poised for Monster Year at Texas?
CFB

Will Hammond Pushing to Be Ready for Week 1
Alex Fitzpatrick

Looking to Keep Up Ball-Striking Output at Quail Hollow
CFB

Notre Dame Leads College Football in Returning Snaps
CFB

Two Ole Miss Football Players Arrested, Charged with DUI
Ben Griffin

Looks Solid on the Surface Heading to Charlotte
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF