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The Buffalo Bills' defense has not been a reliable fantasy option in 2025. The unit got off to a brutal start in a season-opening victory over the Baltimore Ravens before faring far better in a win against the New York Jets in Week 2. The Bills improved to 3-0 in beating the Miami Dolphins last week, but aside from a game-sealing Terrel Bernard interception in the fourth quarter, their defense underwhelmed. Despite that, the Bills' D/ST may be hard for fantasy managers to ignore going into a favorable matchup in Week 4. Buffalo will host the 0-3 New Orleans Saints, who will walk into a hostile environment, averaging a meager 15.7 points per game. While the Saints' offense doesn't score much or move the ball well (20th in yards per game), the group has only committed two turnovers and allowed six sacks to quarterback Spencer Rattler. For their part, the Bills haven't racked up a ton of takeaways (three) or sacks (six). That may limit their ceiling this week, especially with two top defenders (tackle Ed Oliver and linebacker Matt Milano) out with injuries. Nevertheless, with the Bills entering as heavy favorites against a much weaker opponent, their D/ST should at least have a high floor in Week 4.--Connor Byrne
Source: RotoBaller
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