Who Should I Start for Fantasy Football Week 6? Marvin Harrison Jr., Rachaad White, Khalil Shakir, DJ Moore, Rashid Shaheed, Jaylen Waddle, Breece Hall, Jameson Williams, Alvin Kamara, Kenneth Walker III

After rewatching the tape of the Week 5 loss to the Tennessee Titans on Sunday, Arizona Cardinals offensive coordinator Drew Petzing said he felt like he didn't do enough to get wide receiver Marvin Harrison Jr. the ball down the stretch, according to Theo Mackie of The Arizona Republic.

"Going back and looking at it, I think there's maybe a couple of things I could've done differently," Petzing said. Harrison had only five targets on the day, which tied for a season low, but he caught four of them to finish two yards shy of the century mark for the first time in 2025. He caught a season-high six passes on 10 targets in Week 4 for 66 yards and his second touchdown of the year.

The 23-year-old former first-rounder nearly had a 44-yard TD early in the game on Sunday and did most of his damage in the first half before Arizona's offense sat on their lead after halftime. Look for Arizona to feature Harrison early and often in Week 6 on the road against the Indianapolis Colts.

Tampa Bay Buccaneers running back Rachaad White is set to make another start this Sunday versus the San Francisco 49ers. White made his first start of the season during last week's win over the Seattle Seahawks.

The 26-year-old rushed 14 times for 41 yards with two touchdowns. He also hauled in four receptions for an additional 30 yards through the air. White figures to remain a focal point on offense with Bucky Irving (foot), Mike Evans (hamstring), and Chris Godwin (leg) all expected to miss Week 6.

The Bucs really have no choice but to get White involved. He's a capable option in both the running and receiving game, which gives him borderline RB1 value for this weekend.

Miami Dolphins wide receiver Jaylen Waddle will have an opportunity to step up as the team's top receiver the rest of the season after Tyreek Hill (knee) was lost for the season in Week 4. In Week 5, Waddle delivered a big game, hauling in six of his nine targets for 110 yards and a touchdown against the Panthers.

He set season highs in catches, targets, and yards, while scoring his third touchdown in the last four weeks. Waddle and the Dolphins will look to bounce back from last week's loss to Carolina, as they host the Chargers.

The Chargers' defense has done a good job against receivers this season, but Deebo Samuel did light them up for eight catches, 96 yards, and a touchdown last week. Waddle should be primed for another high-volume game and is the WR17 in RotoBaller's Week 6 rankings.

The Athletic's Daniel Popper speculates that if the Los Angeles Chargers explore the trade market at running back with Najee Harris (Achilles) done for the year and rookie first-rounder Omarion Hampton (ankle) on Injured Reserve, two potential options could be New York Jets RB Breece Hall and the Cleveland Browns' Jerome Ford.

Both Hall and Ford are on expiring deals and could bring the Bolts a compensatory draft pick if they make it to free agency in 2026. Even when Hampton returns from IR, L.A. is going to need a second back to pair with him as a team with a run-first identity under offensive coordinator Greg Roman.

At least for Week 6 against the Miami Dolphins, Hassan Haskins and Kimani Vidal are expected to share the backfield equally, giving them both flex appeal in deeper fantasy leagues. How aggressive the Chargers are on bringing in an outside RB will depend on how Haskins and Vidal fare in the coming weeks.

Detroit Lions wide receiver Jameson Williams has struggled to maintain a consistent role in his team's offense so far this season. Through five games, the 24-year-old has recorded just 11 catches for 223 yards and one touchdown on 21 targets.

Williams is averaging over 20 yards per reception and remains an explosive downfield threat, but his middling target volume makes him very difficult for fantasy managers to trust. Williams' Week 6 matchup against the Kansas City Chiefs does not appear to be a great spot for him to break out. The Chiefs have allowed the ninth-fewest passing yards (999) and the fourth-fewest number of passing touchdowns (five) in the NFL so far this season.

Additionally, the Lions could be without starting left tackle Taylor Decker (shoulder), which may make it difficult for quarterback Jared Goff to have the time to hit Williams for a big play down the field. Williams profiles as a low-end, boom/bust WR3/flex option in Week 6 against Kansas City.