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Fantasy football Start 'Em, Sit 'Em and lineup advice for all 2025 Week 10 matchups. Joey analyzes in-depth Week 10 matchups via game-by-game breakdowns.
Welcome back, RotoBallers, to our Week 10 matchups analysis and fantasy football Start 'Em, Sit 'Em picks! If you are new here, this is our main weekly matchups column where we cover all games. We will offer an in-depth analysis of every player in every game.
With four teams on bye this week (Dallas Cowboys, Cincinnati Bengals, Kansas City Chiefs, and Tennessee Titans), fantasy managers might have to start some players lower on their bench. This article is a way to help guide you in making winning start/sit decisions based on juicy matchups to target (or tough matchups to consider avoiding).
So, let's dive in and look at the best starts and sits of Week 10. Good luck with your fantasy teams this weekend!
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Matchups Analysis - Sunday 9:30 AM EST Games (Berlin)
Atlanta Falcons at Indianapolis Colts
Matchups We Love:
Jonathan Taylor had his worst game of the season last week, scoring just 7.7 PPR fantasy points. However, Taylor will continue to be a strong RB1 play for fantasy managers in Week 10 against the Falcons. Atlanta is allowing over 100 rush yards per game on the ground while also giving up the seventh-most fantasy points per game to opposing RBs.
tip toe Taylor pic.twitter.com/c147qvQdKG
— Indianapolis Colts (@Colts) October 27, 2025
Kyle Pitts has actually been a really solid TE1 option this year. He has averaged 10.9 PPR fantasy points per the first nine weeks and has finished as a top-12 fantasy TE in three of the past five games. Now, he gets a fantastic matchup against a Colts defense that has allowed a top-12 fantasy TE finish in four straight weeks. That makes Pitts a nice TE1 play in Week 10.
Matchups We Hate:
TE Tyler Warren
You aren't sitting Tyler Warren because of this matchup against the Falcons. Nonetheless, expectations should be tempered for him. Atlanta has allowed the fewest fantasy points, fewest receptions, and fewest receiving yards to opposing TEs this year. On top of that, not one TE has finished as a top-18 option against this defense in 2025. So, Warren will be a lower-end TE1 this week.
Other Matchups:
Michael Penix Jr. had one of his better fantasy games last week, scoring 22.7 PPR fantasy points behind a three-touchdown day. As a result, Penix could be started as a QB1 in deeper 16 or 18-team leagues this weekend. The Colts have allowed four QBs to finish with over 21 fantasy points since Week 2.
QB Daniel Jones
Daniel Jones will continue to be a solid QB1 option for fantasy managers. He has finished as a top-12 fantasy QB in three of the past four games and just threw for a season-high 342 yards in Week 9. While this matchup might not be the best, there is still some potential for Jones in this contest. The Falcons have allowed multiple passing touchdowns in four of the past five games.
You are starting Bijan Robinson in every format this week. Although he has rushed for under 50 yards in three straight games, his usage in the passing game has carried him in recent weeks. Robinson has finished as a top-12 fantasy RB in seven of eight contests this year.
Falcons WRs
The Colts entered the week as one of the easiest matchups for opposing WRs. Then, the front office decided to trade for Sauce Gardner. Therefore, Drake London will have a tougher matchup on the outside against Gardner, who ranks 23rd among all CBs in fantasy points allowed per game. Still, you are starting London as a WR1 in all formats after a three-touchdown game in Week 9.
As for Darnell Mooney, he should only be started in 14-plus team leagues. While he won't see Gardner much in coverage, it's too hard to trust him at this point in the season. Mooney has scored under four PPR fantasy points in back-to-back games.
Colts WRs
Michael Pittman Jr. has been fantastic for fantasy managers this year. He has scored above 20 PPR fantasy points in three straight games and currently ranks as the WR6 on the year. So, he should be in all lineups this week against the Falcons. The good news for Pittman is that A.J. Terrell Jr. hasn't really shadowed opposing WR1s this year, meaning we shouldn't downgrade the Colts' playmaker this week.
As for Josh Downs and Alec Pierce, both can be started in some 12-plus team leagues. Downs has scored above 11 PPR fantasy points in four straight games, and he just saw a season-high nine targets last week. Although the Falcons have allowed the eighth-fewest fantasy points to slot WRs, Downs is a solid flex option. Same with Pierce, who is more of a boom-or-bust WR4.
Injuries:
None
Matchups Analysis - Sunday 1:00 EST Games
Cleveland Browns at New York Jets
Matchups We Love:
Quinshon Judkins will be good to go after suffering a shoulder injury in Week 8 before the team's bye. While Judkins has been hit-or-miss for fantasy managers in recent weeks, he will be a strong RB start this week against the Jets. New York just traded away its best run-stopper in Quinnen Williams and currently ranks 26th in rush yards allowed per game.
Matchups We Hate:
Jets QBs
Jets head coach Aaron Glenn has still not named a starter for Week 10. So, it remains to be seen if Justin Fields or Tyrod Taylor will start against the Browns. Whichever quarterback starts for the Jets this week, though, should be sat in most cases. Cleveland has allowed only two QBs to finish as top-14 options this year while also allowing the fifth-fewest rush yards to opposing QBs.
RB Breece Hall
It's really disappointing that Breece Hall did not get traded after all. To make matters worse, Hall is a risky RB2 option this week against the Browns. Cleveland has allowed the second-fewest fantasy points per game to opposing RBs, and only one RB has scored more than 13.5 PPR fantasy points against this defense this year.
Other Matchups:
Dillon Gabriel will come in as a low-end QB2 this week against the Jets. Gabriel has scored under 14 fantasy points in three straight games and shouldn't be started in most cases. Even though New York just traded away Gardner and Quinnen Williams earlier this week, it's too hard to trust a QB who has thrown for under 200 yards in three of his past four games.
WR Jerry Jeudy
With Gardner traded at the deadline, Jerry Jeudy's matchup on the outside will be a bit easier. However, fantasy managers can't trust him in most formats this week. He has scored in single digits in PPR formats in seven straight games, including a 0-point performance in Week 8 against the Patriots. As a result, Jeudy is a lower-end WR4 in Week 10.
Update: Wilson is listed as questionable.
Signs point to Garrett Wilson returning from his knee injury in Week 10. If he does return, he will come in as a middle-of-the-pack WR2. The Browns have allowed some solid fantasy performances to Mack Hollins (15.9 PPR fantasy points), DK Metcalf (19.5 PPR fantasy points), and Justin Jefferson (19.3 PPR fantasy points) in recent weeks. That's enough to start Wilson in most formats.
TE Mason Taylor
The last time we saw Mason Taylor, he caught five passes for 34 yards and one touchdown en route to a 14.4 PPR fantasy point day. Nevertheless, Taylor will be more of a TE2 this week against the Browns. Cleveland hasn't allowed a top-12 fantasy TE finish since Week 1 and is allowing the ninth-fewest receptions per game to opposing TEs.
Browns TEs
With David Njoku and Harold Fannin Jr. splitting targets in the middle of the field, neither will be a strong TE1 play in most 12-plus team leagues. However, Njoku and Fannin could be potential starts in deeper 16-plus team leagues this week. The Jets have allowed six receiving TDs to opposing TEs this year, and Gabriel likes throwing to both TEs.
Of the two Browns' TEs, Fannin is likely the better play. He caught six passes for 62 yards and one touchdown back in Week 8 and has seen 23 targets over his last three games. So, the rookie could even be started in some 14-plus team leagues.
Injuries:
- Garrett Wilson (knee)
Jacksonville Jaguars at Houston Texans
Matchups We Love:
QB Davis Mills
C.J. Stroud will not play in Week 10 due to a concussion. That means Davis Mills will draw his first start of the season. This start couldn't have been in a better matchup for the 27-year-old, considering the Jaguars have allowed the third-most fantasy points per game to opposing QBs this year. Given that Jacksonville has allowed a top-10 fantasy QB in four straight games, Mills is a potential start in 16-plus team leagues.
Last week, Brock Bowers torched this Jacksonville secondary for 12 catches for 127 yards and three touchdowns. Now, Dalton Schultz gets a crack at this defense in Week 10. Although Schultz only caught five passes for 39 yards in his last meeting against the Jaguars in Week 3, he will be a low-end TE1 this week. Schultz has finished as a top-10 fantasy TE in two of the past three games.
Matchups We Hate:
It's a good rule of thumb to sit all fantasy QBs against the Texans. Houston has allowed the fewest fantasy points per game, the fourth-fewest passing yards per game, and the sixth-fewest pass touchdowns per game to opposing QBs. This defense has also yet to allow a top-12 fantasy QB finish this year. That makes Lawrence an unstartable QB1 option this weekend.
Jaguars WRs
Update: Thomas will not play in Week 10. Avoid all Jaguars WRs.
It remains to be seen if Brian Thomas Jr. (ankle) will play in Week 10. However, it might be a smart idea to sit all Jacksonville WRs in this game. If Thomas plays, he will almost certainly be shadowed by Derek Stingley Jr. Parker Washington will remain in the slot, but the Texans have allowed the second-fewest fantasy points to slot WRs. Jakobi Meyers is also likely to be limited in his first game with the team.
Christian Kirk has not been a consistent fantasy option in 2025. He has finished outside the top-40 at the WR position in every game this season, and his 17.9% target share is extremely low. Unfortunately, things don't get easier for Kirk. The Jaguars are allowing the fewest fantasy points per game to slot WRs this year. That's enough reason to sit him in most formats.
Other Matchups:
Texans RBs
It's hard to trust Nick Chubb and Woody Marks in most formats this week. Chubb only scored 3.4 PPR fantasy points last week behind a 36% snap share, and Marks only scored 2.7 PPR fantasy points behind a 48% snap share. While Marks is the better play this week, he will be more of an RB3 against the Jaguars.
Jacksonville has allowed the third-fewest rushing yards per game to opposing RBs and hasn't allowed one RB to rush for more than 60 yards in a game this season. The main reason that Marks is a better play than Chubb this week, though, is because of the rookie's receiving upside. Jacksonville has allowed the ninth-most receptions and fifth-most receiving yards to opposing RBs.
Travis Etienne Jr. got a bit unlucky last week, as he got stopped at the one-yard line five different times. Still, Etienne had a strong fantasy performance by scoring 16.5 PPR fantasy points. For Week 10, the Jaguars RB will be a middle-of-the-pack RB2. He finished as the RB21 back in Week 3 against this same Texans team.
WR Nico Collins
Nico Collins has been one of the biggest disappointments in fantasy this year. But fantasy managers should continue to start him as a WR1 in Week 10. The Jaguars have allowed four different WR1s to finish top-6 at the position this year, including Collins -- who caught eight passes for 104 yards and one touchdown back in Week 3. So, make sure to keep him in all lineups.
Injuries:
- C.J. Stroud (concussion) - out
- Brian Thomas Jr. (ankle) - out
Buffalo Bills at Miami Dolphins
Matchups We Love:
QB Josh Allen
Josh Allen will remain a must-start QB1 in Week 10. He is the current QB2 in terms of fantasy points per game (23.7) and should be in all lineups this weekend. Allen scored 23 fantasy points against the Dolphins the last time he faced them in Week 3.
RB James Cook
Update: Cook will play.
James Cook is dealing with two different injuries (ankle/foot) right now. If he plays, though, you will continue to start him as an RB1. If he misses, then both Ray Davis and Ty Johnson will see a massive bump in usage. Davis is likely the better player to start of the two, as we saw last year. Davis scored 18.2 PPR fantasy points in the one game that Cook missed.
De'Von Achane will remain a must-start RB1 play this week. He has finished as a top-10 fantasy RB in three of the past four games, and his receiving usage gives him a higher ceiling and floor than most other RBs. With the Bills allowing the second-most rush touchdowns and the eighth-most fantasy points per game to the position, Achane is a strong option.
Dalton Kincaid continues to impress with his play on the field. He has totaled over 100 yards in two of his past three games and currently ranks as the TE6 in fantasy points scored per game. Now, he gets a fantastic matchup against a Dolphins defense that has allowed the fifth-most fantasy points to opposing TEs this year. That makes Kincaid a strong TE1.
Matchups We Hate:
Tua Tagovailoa has always struggled against the Bills' defense in his career. For that reason, Tagovailoa should only be started in extreme cases in Week 10. Buffalo has allowed the second-fewest fantasy points and the fewest passing touchdowns to opposing QBs this season. That's not great news for a QB who has finished outside the top-24 at the position in three of the past four weeks.
WR Keon Coleman
Keon Coleman is simply unstartable in all formats right now. He caught just two passes for 17 yards last week and hasn't topped more than 11 PPR fantasy points since Week 1. His matchup in Week 10 is against a Dolphins defense that has allowed the fewest fantasy points per game to outside WRs. So, sit Coleman in all formats.
Other Matchups:
Khalil Shakir is easily Allen's favorite target in the passing game. He has scored in double figures in PPR formats in six of eight games this season, and will remain a high-floor WR option in Week 10. The Dolphins have done a solid job against opposing slot WRs this year, but have also allowed slot WRs like Ladd McConkey (23 PPR fantasy points) to have big games. That makes him a lower-end WR2.
Jaylen Waddle has seen WR1 usage since Tyreek Hill (knee) went down with a season-ending injury. Waddle has scored above 14 PPR fantasy points in four of five games without Hill, and he'll come in as a high-end WR2 against the Bills this week. Buffalo has allowed a top-12 fantasy WR finish in four straight contests.
Injuries:
- James Cook (ankle/foot) - cleared to play
New England Patriots at Tampa Bay Buccaneers
Matchups We Love:
None
Matchups We Hate:
Buccaneers RBs
Update: Irving is listed as out.
It remains to be seen if Bucky Irving (foot/shoulder) will play in Week 10. If he does, he will be a riskier RB2 in his first game back. He will likely see limited snaps, and the Patriots are allowing the fewest rushing yards per game this season. If he misses, then Rachaad White would draw another start for Tampa Bay.
Whoever starts for the Buccaneers in Week 10 will have their hands full against a very good Patriots' run defense. But Irving/White still has potential as an RB2 this week. That's because New England has allowed the most receptions per game and the fifth-most receiving yards per game to opposing backs.
Other Matchups:
Baker Mayfield will come in as a low-end QB1 in Week 10. He has finished as a top-12 fantasy QB in six of his eight starts, and the Patriots have allowed multiple passing touchdowns in two straight games. Although New England has only allowed one top-12 fantasy QB finish this year, Mayfield has shown enough to stick with him as a QB1.
QB Drake Maye
Fantasy managers can't possibly sit Drake Maye this week. He has thrown multiple passing touchdowns in four straight games while finishing as a top-10 fantasy QB in six of his last eight starts. The Buccaneers have also struggled to contain QBs on the ground, as they are allowing the fourth-most rush yards per game to the position. Maye is averaging 44 rush yards per game over the last three weeks.
Patriots RBs
Update: Stevenson is listed as out.
Rhamondre Stevenson did not play in last week's win over the Falcons. If he were to play this week, he would be a solid RB2 option against a Buccaneers defense that has allowed over 15 PPR fantasy points to an RB in three of the past four games. If Stevenson misses, then TreVeyon Henderson becomes a potential RB2 play. He saw 18 opportunities last week behind a 75% snap share.
WR Emeka Egbuka
Emeka Egbuka will continue to operate as the WR1 in this Tampa Bay offense. Even though Egbuka has cooled off a bit in recent weeks, he will remain almost a must-start WR in fantasy. He has seen 21 targets over the past two games, and this New England secondary just let London total nine catches for 118 yards and three touchdowns last week.
Patriots WRs
With Kayshon Boutte (hamstring) out for this week's game, both Stefon Diggs and DeMario Douglas get a slight boost in the passing game. Diggs will be a low-end WR2 after scoring in double figures in PPR formats in five of the past six games. However, Douglas is only worth starting in extremely deep leagues. He has played fewer than 20 snaps in five straight weeks.
TE Cade Otton
The Buccaneers have needed playmakers to step up on offense in recent weeks. One of those playmakers has been Cade Otton. He has caught at least four passes in four consecutive games and has finished as a top-16 fantasy TE in three of those four contests. Therefore, Otton can be a solid TE1 play this week against a Patriots' defense that has allowed six different TEs to finish top-12 at the position.
TE Hunter Henry
Hunter Henry hasn't been the best TE option over the past month. He has scored under 10 PPR fantasy points in five straight games, and his inconsistent target share on a week-to-week basis makes it tough to trust him. However, since the Buccaneers have allowed a top-12 fantasy TE finish in four of their past five games, Henry can be started in some 14-plus team leagues.
Injuries:
- Bucky Irving (shoulder/foot) - out
- Chris Godwin (foot) - out
- Rhamondre Stevenson (toe) - out
- Kayshon Boutte (hamstring) - out
New York Giants at Chicago Bears
Matchups We Love:
Caleb Williams had the best fantasy game of his career last week, scoring 38.7 fantasy points en route to an overall QB1 finish. Now, he will go up against a Giants defense that has given up the seventh-most fantasy points per game to opposing QBs this year. Given that New York has allowed a top-10 fantasy QB finish in three of the past four games, Williams is a nice QB1 this week.
QB Jaxson Dart
Jaxson Dart has been a top fantasy QB option since he was named the starter in New York. He has scored at least 19 fantasy points in five of his six starts and has scored over 23 fantasy points in three of the past four weeks. Therefore, Dart will be a strong QB1 option this week against the Bears. Chicago ranks 27th in fantasy points allowed and 24th in rush allowed per game to opposing QBs.
Update: Swift is listed as questionable.
All signs point to D'Andre Swift returning in Week 10 after practicing in full on Thursday. In his return, fantasy managers should be starting him as an RB2 in most formats. The Giants have allowed the second-most fantasy points per game and the second-most rush yards per game to opposing RBs this year. That also makes Kyle Monangai a potential flex play in 12-plus team leagues following a career game in Week 9.
Bears WRs
Both Rome Odunze and DJ Moore could be potential starts this week. Although Odunze was held catchless in last week's game, we should expect a much better game from him in Week 10. The Giants have allowed the fourth-most receiving yards per game to opposing WRs this year. That also makes Moore a solid WR3 start. He has totaled over 70 receiving yards in back-to-back contests.
Matchups We Hate:
None
Other Matchups:
Giants RBs
Everyone expected Tyrone Tracy Jr. to dominate New York's backfield with Cam Skattebo (ankle) out for the year. However, Tracy only played 44% of the team's offensive snaps, and Devin Singletary played a season-high 56% of the team's offensive snaps. For that reason, both are risky flex plays in 12-plus team leagues. Only one RB has rushed for over 65 yards against this Bears defense since Week 5.
Wan'Dale Robinson continues to be a security blanket for Dart in the middle of the field. He has scored above 13 PPR fantasy points in three of the past four games and has seen double-digit targets in two of the last three weeks. As a result, Robinson will be a top-30 play this week against the Bears. Chicago allowed three Bengals WRs to score over 17 PPR fantasy points last week.
Update: Kmet will play in Week 10.
Fantasy managers finally saw Colston Loveland break out last week. He caught six passes for 118 yards and two touchdowns en route to a TE2 fantasy finish. However, it is interesting to note that Cole Kmet left that contest early due to a concussion. With Kmet expected to clear the concussion protocol by Sunday, Loveland might be harder to trust as a TE1 this week.
COLSTON LOVELAND ARE YOU KIDDING?
📺: CBS pic.twitter.com/OMOzjsl6vC
— Chicago Bears (@ChicagoBears) November 2, 2025
TE Theo Johnson
Theo Johnson has been a consistent TE1 option since Dart has taken over. He has three top-12 fantasy TE finishes since Week 5 and has caught five touchdown passes over his last six games. Therefore, fantasy managers can trust Johnson as a TE1 in 12-plus team leagues. The Bears have allowed double-digit fantasy points to opposing TEs in five of eight games this season.
Injuries:
- D'Andre Swift (groin) - questionable
- Cole Kmet (concussion) - cleared to play
Baltimore Ravens at Minnesota Vikings
Matchups We Love:
Vikings WRs
Both Jefferson and Jordan Addison are fantastic starts in Week 10. The Ravens have allowed the third-most fantasy points, fourth-most receptions, and the sixth-most receiving touchdowns per game to opposing WRs this year. That makes Jefferson a must-start WR1, and Addison more of a low-end WR2. Just two weeks ago, this Baltimore secondary allowed two Bears WRs to total over 70 yards.
Matchups We Hate:
WR Zay Flowers
Even though Lamar Jackson threw for four touchdowns in his return last week, Zay Flowers was held in check. He only caught five passes for 64 yards. Unfortunately, he has a tougher matchup in the slot this week against the Vikings. Minnesota has allowed the sixth-fewest fantasy points to opposing slot WRs this year. That makes Flowers more of a risky WR2.
Other Matchups:
QB Lamar Jackson
Fantasy managers should be starting Jackson in every format this week. He has scored over 25 fantasy points in four of his five starts this season and will remain a must-start QB1 in Week 10.
J.J. McCarthy has actually been a sneaky QB1 option this year. He has scored above 19 fantasy points in two of his three starts and carries some rushing upside each week. For that reason, McCarthy could be started as a QB1 in some 14-plus team leagues this week. Baltimore's defense has played better in recent weeks, but this is a unit allowing the sixth-most pass yards per game this year.
Vikings RBs
Update: Jones is listed as questionable.
Aaron Jones Sr. (shoulder/toe) is dealing with a few injuries ahead of Week 10. Assuming he suits up, though, Aaron Jones will be a better RB2 play than Jordan Mason this week. Aaron Jones dominated Minnesota's backfield before he left last week's contest early, pushing Mason to more of a reserve role. Now, he has a solid matchup against a Ravens defense that has allowed a top-16 fantasy RB finish in three straight games.
Derrick Henry is certainly starting to get going on the ground. He rushed for 122 yards in Week 6, totaled 71 yards and two touchdowns in Week 8, and rushed for 119 yards in last week's win over the Dolphins. With three straight nice rushing days, Henry should be in all lineups this week as an RB1.
It's hard to trust T.J. Hockenson as a TE1 this week. He has finished outside the top-14 at the position in five straight games and has only caught four combined passes over the past two games. Considering the Ravens have only let one TE finish as a top-14 option since Week 3, Hockenson is more of a TE2.
TE Mark Andrews
After last week's two-touchdown game, some fantasy managers could be looking Mark Andrews' way as a TE1 play. However, Andrews isn't the best TE1 option this week against the Vikings. Andrews only saw three targets in last week's win and will remain a touchdown-dependent option.
Injuries:
- Aaron Jones Sr. (toe/shoulder) - questionable
New Orleans Saints at Carolina Panthers
Matchups We Love:
None
Matchups We Hate:
WR Chris Olave
In his first game with Tyler Shough, Chris Olave had his worst fantasy performance of the season. He caught just three passes for 57 yards en route to a WR44 finish. Although the Saints traded away Rashid Shaheed earlier this week, Olave could be in store for another subpar fantasy game. The Panthers have allowed the fifth-fewest fantasy points and fourth-fewest receiving yards to opposing WRs this year.
Other Matchups:
QB Bryce Young
Fantasy managers can't trust Bryce Young in most formats this week. He has thrown for under 200 yards in six straight games and has scored under 13.5 fantasy points in five of the past six weeks. Therefore, Young should only be started in deeper Superflex formats. The Saints have let up a top-24 fantasy QB finish just once over the last three games.
RB Rico Dowdle
Rico Dowdle has fully taken over the Carolina backfield. He played 72% of the team's offensive snaps last week and rushed for 130 yards and two touchdowns. Although Dowdle is dealing with a quad injury, he will be good to go for Week 10. So, fantasy managers should be starting him as an RB1 this week against the Saints.
RB Alvin Kamara
Update: Kamara is listed as questionable.
Alvin Kamara has been hard to trust in recent weeks. He has scored under seven PPR fantasy points in three straight games and scored just 0.7 PPR fantasy points in last week's blowout loss. As a result, Kamara is a risky flex play in Week 10. He hasn't been involved in the passing game (three combined catches over the past two games) while rushing for under 35 yards in five consecutive weeks.
Update: McMillan is listed as questionable due to a hamstring injury.
Tetairoa McMillan has been a bit disappointing over the past month. He has caught four passes or fewer in three of the past four contests, and his 8.6 PPR fantasy points last week ranked as the WR45. So, McMillan will be more of a WR3 in this matchup against the Saints. The good news for him, though, is that New Orleans has allowed three WRs to finish top-5 at the position over the last four games.
Juwan Johnson could be a potential TE1 start in deeper leagues this week. He has scored over 10 PPR fantasy points in three straight games and caught three passes for 31 yards and one touchdown in Week 9. However, the bad news for Johnson is that the Panthers haven't allowed a top-20 TE finish in three straight games. That makes him only a start in 18-plus team leagues.
Injuries:
- Rico Dowdle (groin) - cleared to play
- Alvin Kamara (ankle) - questionable
Matchup Analysis - Sunday Afternoon Games
Arizona Cardinals at Seattle Seahawks
Matchups We Love:
TE Trey McBride
Fantasy managers should continue to start Trey McBride as a TE1. He has scored over 16 PPR fantasy points in all three starts with Jacoby Brissett this year and has a favorable matchup in Week 10 against the Seahawks. Seattle has allowed the sixth-most receptions per game to opposing TEs while also giving up the eighth-most receiving yards to the position.
TE AJ Barner
AJ Barner has some potential as a TE1 in 16-plus team leagues this week. He has scored in double figures in PPR formats in four of the past five games and has finished as a top-14 option in three of those contests. Now, he faces a Cardinals defense that has allowed the fifth-most receptions per game to opposing TEs.
Matchups We Hate:
Cardinals RBs
It wouldn't be wise to start any Cardinals RBs in this game. The Seahawks have allowed the second-fewest rushing yards per game and have only three rushing touchdowns on the ground all year. So, both Bam Knight and Emari Demercado are risky flex plays in all formats this week. Only one RB has scored more than 12.5 PPR fantasy points against this Seattle defense since Week 3.
Other Matchups:
QB Sam Darnold
Sam Darnold is playing at a high level right now. He has finished as a top-10 fantasy QB in three of his past four contests and is coming off a game in which he threw for 330 yards and four touchdowns. As a result, Darnold can be started as a low-end QB1 this week. The Cardinals have done a solid job against opposing QBs this year, but this defense also let Daniel Jones finish as the QB4 a few weeks ago.
Brissett has been a solid QB1 option in his three starts this year, finishing as the QB7, QB12, and QB10 in those starts. However, the veteran will be more of a QB2 option this week against the Seahawks. Seattle has one of the better secondaries in the league, and only two QBs have finished inside the top-14 at the position against this defense this year.
Seahawks RBs
It's been a headache rostering both Kenneth Walker III and Zach Charbonnet. Both RBs are splitting playing time almost evenly, and that hurts both their fantasy values. As a result, both Walker and Charbonnet are more in the RB3 territory this week. Walker has scored under 10 PPR fantasy points in four straight games, and Charbonnet hasn't rushed for more than 50 yards in a game.
Marvin Harrison Jr. had one of the best games of his young career last week, catching seven passes for 96 yards and one touchdown. Although the Seahawks have given up the ninth-fewest fantasy points per game to WRs, Harrison will still come in as a WR2. Seattle has allowed some big games to WRs like Egbuka (31.3 PPR fantasy points) and Thomas (23 PPR fantasy points) in recent weeks.
Seahawks WRs
Jaxon Smith-Njigba will remain a must-start WR1 for fantasy managers. He has totaled over 120 receiving yards in four straight games. As for Shaheed, he will be a lower-end flex play in most leagues. Shaheed will likely only see limited snaps in this game, as he continues to learn the playbook. So, fantasy managers should only start him in dire situations.
Injuries:
- Kyler Murray (foot) - IR
- Cooper Kupp (hamstring/heel) - questionable
- Tory Horton (groin) - doubtful
Detroit Lions at Washington Commanders
Matchups We Love:
QB Jared Goff
Jared Goff has a fantastic matchup in Week 10 against the Commanders. Washington has allowed a top-10 fantasy QB finish in four consecutive games, and this secondary has given up 10 passing touchdowns over the past three weeks. So, Goff can be started as a QB1 in most formats this week.
Deebo Samuel has definitely cooled off in recent weeks. He has scored under 10 PPR fantasy points in three straight games while totaling under 20 receiving yards in two of those three contests. However, Samuel will be a strong WR2 play against the Lions this week. Detroit is still missing some players in the secondary, and this defense has allowed over 15 PPR fantasy points to a WR in six of the past seven games.
Lions WRs
You are starting Amon-Ra St. Brown in all formats this week. He has scored at least 18 PPR fantasy points in six of his past seven games and will be a must-start WR1. As for Jameson Williams, he could be a sneaky flex option this week against the Commanders. No defense allows more yards per completion than this Washington secondary. With Marshon Lattimore out for the year, Williams is a solid WR3.
TE Sam LaPorta
Sam LaPorta is coming off his best game of the season, totaling six catches for 97 yards and one touchdown. As a result, fantasy managers should be starting him in all formats this week. This is also a fantastic matchup for the 24-year-old, considering the Commanders have allowed the sixth-most fantasy points per game to opposing TEs.
Matchups We Hate:
Fantasy managers shouldn't be starting Jacory Croskey-Merritt by any means. He has scored under six PPR fantasy points in four straight games, and this matchup against the Lions is a tougher one. Detroit has allowed the third-fewest fantasy points to the position through nine weeks, while allowing just one RB to finish top-16 this year.
Other Matchups:
Marcus Mariota has been more of a QB2 play in his three starts this year. He has finished outside the top-14 at the position in two of those three games and has only topped 17.5 fantasy points once (Week 3). So, Mariota is more of a QB2 this week in Superflex formats. Only two QBs have finished as top-12 fantasy options against this defense this year.
Lions RBs
Jahmyr Gibbs will continue to be a must-start RB1 for fantasy managers. As for David Montgomery, he will be a touchdown-dependent RB2 option. Montgomery is only averaging 5.9 PPR fantasy points in the four games he hasn't scored a touchdown this year. The bad news for him is that Washington has allowed just five rushing touchdowns all year.
TE Zach Ertz
Zach Ertz hasn't been a viable TE1 option whenever Mariota starts. In three games with him under center, Ertz is averaging just 7.2 PPR fantasy points per game. So, the veteran is more of a TE2 option against a Lions defense that has allowed the 12th-fewest fantasy points per game and the 10th-fewest receptions per game to TEs in 2025.
Injuries:
- Terry McLaurin (quad) - out
Los Angeles Rams at San Francisco 49ers
Matchups We Love:
None
Matchups We Hate:
49ers QBs
Update: Jones will start.
It remains to be seen if Brock Purdy (toe) will be healthy enough to play in Week 10. However, whichever QB starts for the 49ers this week should be sat in most one-quarterback leagues. The Rams have given up the fifth-fewest fantasy points per game to opposing QBs this year and haven't allowed a top-12 QB finish since Week 5.
Other Matchups:
Matthew Stafford has been a strong QB1 option this year. He has scored above 25 fantasy points in four of the past five games and currently ranks first in passing touchdowns through nine weeks (21). Therefore, Stafford will be a nice QB1 play in Week 10. San Francisco has allowed a top-12 QB finish in four of the last five weeks.
Although Kyren Williams' snap share has dipped a bit in recent weeks, he will remain a strong RB2 play in Week 10. He rushed for a season-high 114 yards and one touchdown last week and has finished as a top-12 fantasy RB in three of the past four games. So, you are starting him in almost all formats against the 49ers.
This matchup is definitely on the tougher side for Christian McCaffrey. The Rams have allowed the fewest fantasy points to the RB position and have yet to allow a rushing touchdown through nine weeks. However, McCaffrey will remain a must-start RB1 this week. He scored 27.9 PPR fantasy points against this Rams defense back in Week 5.
49ers WRs
With Ricky Pearsall (toe) ruled out, Jauan Jennings and Kendrick Bourne will lead this WR group once again. However, fantasy managers should only be looking to start Jennings of these two WRs.
Bourne has scored under eight PPR fantasy points in three straight games, and Jennings is coming off a solid game in which he caught four passes for 41 yards and one touchdown. Jennings will be a high-end WR3 this week against the Rams.
Rams WRs
Both Puka Nacua and Davante Adams should be in all lineups this week. Nacua is arguably the best fantasy WR when healthy, and Adams continues to be a red-zone threat. The veteran has caught five touchdown passes over his last two games. So, Nacua will be a WR1, while Adams will come in as a high-end WR2.
this Matthew Stafford no-look pass to Davante Adams was nasty pic.twitter.com/PL2TxIsW0H
— NFL (@NFL) November 2, 2025
George Kittle hasn't really been a dominant fantasy option since he returned from injured reserve. He only caught four passes for 43 yards and one touchdown in Week 8, and then caught just four passes for 32 yards last week. Still, you are starting Kittle as a TE1 in all formats this weekend.
Injuries:
- Ricky Pearsall (knee) - out
- Brock Purdy (toe) - out
Matchup Analysis - Sunday Night Football
Pittsburgh Steelers at Los Angeles Chargers
Matchups We Love:
Justin Herbert has been one of the best fantasy QBs over the last three weeks. He has finished as a top-4 QB in three consecutive games and thrown 10 touchdowns over his last four contests. For that reason alone, Herbert is a must-start QB1. He also gets a favorable matchup against a Steelers defense that is allowing over 345 passing yards per game since Week 7.
Chargers WRs
Both McConkey and Quentin Johnston are fantastic starts in Week 10. The Steelers have allowed the most fantasy points, most receiving yards, and most receptions to opposing WRs this year. That's enough to make McConkey and Johnston solid starts in most leagues. As for Keenan Allen, it might be best to avoid him after he saw just 18 snaps in Week 8 and 24 snaps in Week 9.
TE Oronde Gadsden II
Oronde Gadsden will remain a strong TE1 option for fantasy managers in Week 10. He has finished as a top-10 fantasy TE in three straight games, and his role in the offense continues to expand. Now, he gets a matchup against a Steelers defense that ranks 30th in fantasy points allowed, 29th in receiving yards allowed, and 30th in receiving touchdowns allowed per game to opposing TEs.
Matchups We Hate:
RB Kimani Vidal
Kimani Vidal has been a hit-or-miss fantasy option since Omarion Hampton has gone down. He has finished as a top-10 fantasy RB twice and outside the top-26 at the position twice as well. So, which Vidal will show up on Sunday?
Unfortunately, it might be the latter, considering the Steelers rank top-10 in both fantasy points allowed and rush touchdowns allowed to the position this year. So, Vidal is a lower-end RB2.
WR DK Metcalf
DK Metcalf has been a bit disappointing in recent weeks. He has finished outside the top-40 at the WR position in two of the past three games and only has three top-24 WR finishes through nine weeks. So, Metcalf will be more of a WR3 this week against a Chargers secondary that has let only two WRs finish as top-20 options since Week 6.
Other Matchups:
Aaron Rodgers will enter the week as a QB2 in Superflex formats. He has finished as a top-14 fantasy QB just once since Week 2, and his 211 passing yards per game rank as the QB22. So, fantasy managers shouldn't start him in most one-quarterback leagues.
Jaylen Warren will come in as a solid RB2 play against the Chargers. He is coming off his first career two-touchdown game and continues to lead this Pittsburgh backfield. Given that the Chargers have allowed seven rushing touchdowns since Week 5, Warren is in a good spot heading into Week 10.
Injuries:
None
Matchup Analysis - Monday Night Football
Philadelphia Eagles at Green Bay Packers
Matchups We Love:
Dallas Goedert has been a touchdown king through the first nine weeks. He has caught seven touchdown passes since Week 3 and currently ranks as the TE4 in terms of fantasy points per game. So, Goedert will be a TE1 this week. The Packers have also allowed the most receptions per game to opposing TEs.
Matchups We Hate:
This matchup isn't great for Saquon Barkley. The Packers have allowed the sixth-fewest fantasy points per game to opposing RBs and are allowing only 79.9 rush yards per game this season. However, Barkley will still be a must-start RB1 this week. Look at what Dowdle did to this Packers' front seven last week, rushing for 130 yards and two touchdowns.
With Tucker Kraft (knee) out for the season, Luke Musgrave will see more opportunities in the passing game. Nevertheless, this is not the week to start the 25-year-old. The Eagles haven't allowed a top-12 fantasy TE finish since Week 5 and have allowed the third-fewest fantasy points to opposing TEs this year. So, Musgrave is a riskier TE1 play.
Other Matchups:
QB Jalen Hurts
Fantasy managers should continue to start Jalen Hurts as a QB1. He has finished as a top-12 fantasy QB in six straight games, and his rushing upside gives him a higher ceiling and floor than most other QBs.
QB Jordan Love
Jordan Love hasn't been a reliable QB1 option this year. He has finished outside the top-14 at the position in three of the last four weeks and has only thrown five passing touchdowns since Week 6. Given that the Eagles have only allowed one QB to finish top-12 at the position since Week 5, Love is only worth starting in Superflex formats.
RB Josh Jacobs
Josh Jacobs will be an RB1 for fantasy managers this week. He has scored a touchdown in five straight games and is the clear workhorse back in this Packers offense. Jacobs should be in for a nice game, considering the Eagles have allowed some big fantasy games to RBs like Skattebo (31 PPR fantasy points) and Irving (25.5 PPR fantasy points) this season.
WR Romeo Doubs
Romeo Doubs is the only Packers WR worth starting this week. Doubs caught a season-high seven passes for 91 yards last week en route to a WR20 fantasy finish. While he might see the Mitchell shadow in this game, that shouldn't scare fantasy managers away from starting him. Just a few weeks ago, both Jefferson and Addison totaled over 75 receiving yards.
Eagles WRs
A.J. Brown (hamstring) will return in Week 10 after practicing in full on Thursday. Both Brown and DeVonta Smith will be solid starts in this Monday night clash against the Packers. Just a few weeks ago, this Green Bay secondary allowed both Metcalf (16.5 PPR fantasy points) and Roman Wilson (17.4 PPR fantasy points) to have solid fantasy days. So, both WRs are must-start WR2s.
Injuries:
- Matthew Golden (shoulder)
More Fantasy Football Analysis
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