X
Lost password?

Don't have an account?
Gain Access Now

X

Receive free daily analysis

NFL
NBA
NHL
NASCAR
CFB
MLB
MMA
PGA
ESPORTS
BETTING

Already have an account? Log In

X

Forgot Password


DraftKings, FanDuel Daily Fantasy Baseball Picks (9/22/22): MLB DFS Lineups

The top daily fantasy baseball lineup picks for FanDuel and DraftKings on September 22nd, 2022. John Brubaker's MLB DFS analysis and sleepers for building optimal DFS rosters.

Happy Thursday RotoBallers! This is John Brubaker dropping some of my favorite plays for today's slate. After a bit of a bigger slate last week relative to the weeks before, we have a very solid slate tonight, with an eight-game slate on DraftKings and FanDuel. It is nicer to have a bit of a larger player pool tonight than in previous weeks.

We don't have any slate differences tonight, which is always a good thing. That way I don't have to make selections that may be on one slate and not the other. I have big ideas for tonight's slate, so let's get right to it.

This article will provide my daily fantasy baseball lineup picks for DraftKings and FanDuel at 6:35 pm on 9/22/2022. The lineup picks will range from some elite players to mid-priced options, and value plays. You can also read more DFS advice and lineup picks for other sports here. It's also essential to monitor injury news and today's MLB starting lineups. Now that we got all of that out of the way, it's onto the picks!

Featured Promo! Save 50% on any PGA Premium Pass using discount code MASTERS, this week only! Win more with our DFS and Betting Packages, get expert tools and advice from proven winners including the Lineup Optimizer, Research Station, betting/props cheat sheet and more. GAIN FULL ACCESS HERE

 

DraftKings, FanDuel Pitchers - MLB DFS Lineup Picks

Shane Bieber, CLE at CWS ($10,100 DK, $10,800 FD)

We'll start tonight's slate off with Shane Bieber. Bieber has been on a heater of late, logging at least 25 DraftKings points and 45 FanDuel points in each of his last five starts. While my projections don't have him reaching those marks tonight, I'm still high on him this evening against a White Sox team that never seemed to get their footing this season. Bieber is 7-4 with a 2.66 ERA against the Sox in his career, and projects to a 3.26 xFIP and 26.31% strikeout rate against them tonight.

DraftKings Projection: 21.1

FanDuel Projection: 38.5

Hayden Wesneski, CHC at PIT ($6,900 DK, $8,100 FD)

I'll be taking a look at Hayden Wesneski tonight, who's making just his fourth start. He's had two really good starts and one not-so-good start thus far, but I'm projecting that he'll have one of those "good" starts tonight. I project Wesneski to a 3.64 xFIP and 25.64% strikeout rate this evening, and I expect him to silence the Pirates bats tonight en route to a quality start and potentially a win.

DraftKings Projection: 18.2

FanDuel Projection: 29.7

Also consider: Justin Verlander, Max Fried

Want more MLB DFS tools and content? Our MLB Premium package includes our daily DFS Cheat Sheets, Research Station, Optimizer, and access to our Premium Slack Chatrooms, where members can chat with our MLB analysts. Check out this recent big win from RotoBaller's Jon Anderson on DraftKings - join in on the winning!

🍾 BOOM!! A huge congrats to Jon, winning a juicy $50k last night!

Be sure to read his premium MLB #DFS articles 3x a week, all his other excellent analysis, and give a follow @JonPgh - all very much worth it 👌

Win Big With #RotoBaller ➡️ https://t.co/1uotAV6253 https://t.co/ipSgrl5dOr

— RotoBaller (@RotoBaller) May 10, 2022

 

DraftKings, FanDuel Infielders - MLB DFS Lineup Picks

Austin Riley - 3B, ATL vs. Ranger Suarez ($5,300 DK, $3,800 FD)

As far as hitters go, I'll start off with Austin Riley. I'll always make a point to make sure I play Riley whenever he faces a lefty. He's absolutely crushed left-handed pitchers this year, with a .854 wOBA + ISO against them. He projects to a 42.46% hard contact rate and .662 wOBA + ISO against Phillies starter Ranger Suarez's pitch types. Riley is just 2-9 with a double off of Suarez but has drawn three walks. He now has to see Riley and Braves for the second consecutive start, something that seems to never bode well for pitchers.

DraftKings Projection: 10.9

FanDuel Projection: 13.8

Willy Adames - SS, MIL vs. Hunter Greene ($4,700 DK, $3,500 FD)

I'll look at Willy Adames at the shortstop position tonight. Adames draws a solid matchup against Cincinnati right-hander Hunter Greene. He projects to a 36.98% hard contact rate and a whopping .763 wOBA + ISO against the fireballer. He's had some past success against Greene as well, going 2-6 with two homers and two walks against the 23-year-old righty.

DraftKings Projection: 10.3

FanDuel Projection: 13.1

Jonathan Aranda - 2B, TB  vs. Jose Berrios ($2,400 DK, $2,100 FD)

If we're looking for value, we don't need to look much further than Rays second baseman Jonathan Aranda. Aranda has logged just 50 at-bats this season and comes into this game hitting .260 with a .739 OPS. He projects to a 34.78% hard contact rate and .693 wOBA + ISO against Berrios's pitch types.

DraftKings Projection: 7.6

FanDuel Projection: 9.3

 

DraftKings, FanDuel Outfielders - MLB DFS Lineup Picks

Yordan Alvarez - OF, HOU vs. Kyle Bradish ($6,300 DK, $4,700 FD)

As far as outfielders go we'll go right back to where we went last week, Yordan Alvarez. Yordan had gone on a heater since I wrote him up last, going 10-24 with four homers in the last week. After a quiet night last night, he'll look to get back in form tonight against Baltimore righty Kyle Bradish, with whom he projects a 44.61% hard contact rate and .753 wOBA + ISO against his pitch types. He's 0-2 with a walk in just three at-bats against the righty, but that should change tonight.

DraftKings Projection: 12.1

FanDuel Projection: 15.8

Hunter Renfroe - OF, MIL vs. Hunter Greene ($4,000 DK, $2,900 FD)

I'll speak more on the Brewers as a whole in a bit, but I'll be taking a look at Hunter Renfroe tonight. Renfroe has been relatively quiet this season, coming into this game with a .248 average and .783 OPS. He projects to a whopping 16% home run rate, among the highest on the slate, as well as a 38.14% hard contact rate and .654 wOBA + ISO against Hunter Greene's pitch types. Renfroe's among the top of the board in terms of value tonight on both sites.

DraftKings Projection: 10.1

FanDuel Projection: 13.4

David Peralta - OF, TB vs. Jose Berrios ($3,100 DK, $2,500 FD)

I'll finish things off tonight with Rays outfielder David Peralta. Things haven't necessarily worked out for me when rostering Peralta this season, but I'll look for that to change tonight. He projects to a 35.06% hard contact rate and .635 wOBA + ISO against Jose Berrios's pitch types. Peralta's just 1-5 with a walk against Berrios in his career, but I think the Rays are a sneaky stack on this slate, and for me, where the Rays go, Peralta goes.

DraftKings Projection: 7.7

FanDuel Projection: 9.7

 

DraftKings, FanDuel MLB DFS Stacks

Milwaukee Brewers vs. Hunter Greene

I'll start off my favorite stack with the top-rated stack according to my model tonight, the Milwaukee Brewers. They'll take on Hunter Greene, a starter that has had his struggles against the Brew Crew this season. Greene is 0-2 with a 9.69 ERA against Milwaukee this season. The Brewers have done their part against righties this season as well, ranking 5th in OPS (.750) and wOBA (.326), tied for 9th in wRC+ (109).

Favorite Plays: Willy Adames, Hunter Renfroe, Christian Yelich, Rowdy Tellez, Tyrone Taylor

Houston Astros vs. Kyle Bradish

I'll look to Baltimore for the second stack of the night, the Houston Astros. The Astros technically rank fourth in terms of stack value on my model but have the all-around numbers including pitch-type data for me to bump them up to my second favorite on the slate. Orioles starter Kyle Bradish tossed his best start of the season against the Stros back on August 26, going eight shutout innings and allowing just two hits while striking out six. However, I'll back Houston here as they rank 7th in OPS (.732), 8th in wOBA (.319), and are tied with the Brewers and Cardinals for 6th in wRC+ (109).

Favorite Plays: Yordan Alvarez, Alex Bregman, Trey Mancini, Kyle Tucker, Jeremy Pena, Aledmys Diaz

Also Consider: Boston Red Sox, Tampa Bay Rays



Download Our Free News & Alerts Mobile App

Like what you see? Download our updated fantasy baseball app for iPhone and Android with 24x7 player news, injury alerts, sleepers, prospects & more. All free!



MLB DFS News and Injury Alerts

More DFS Lineup Picks and Analysis




REAL-TIME FANTASY NEWS

Joel Eriksson Ek

Missed Second Round Due to Heel Injury
Sam Merrill

Catches Fire in Game 7 Win
Evan Mobley

Posts Versatile Double-Double in Game 7
Jonas Brodin

Sat Out Round 2 Due to Toe Injury
Donovan Mitchell

Guides Cavaliers Into East Finals
Sam Malinski

Practices Fully Sunday
Jarrett Allen

Scores 23 in Cavs' Game 7 Rout of Pistons
Josh Manson

Rejoins Practice
Kevin Huerter

Active on Sunday Night
Caris LeVert

Duncan Robinson, Caris LeVert Available Sunday
Dean Wade

Max Strus Replaces Dean Wade in Starting Lineup Sunday
Luke Kornet

Iffy for Monday
Larry Nance Jr.

Won't Play Sunday
De'Aaron Fox

Listed as Questionable for Monday's Action
Jalen Williams

Officially Available for Game 1 Against Spurs
Shai Gilgeous-Alexander

Named MVP for Second Straight Year
Jonah Coleman

is an Intriguing Power Back to Target in Dynasty Leagues
Colt Emerson

Mariners Promoting Top Prospect Colt Emerson to Major Leagues
Darius Slayton

Lacking Long-Term Upside for Dynasty Managers
Keaton Mitchell

a Prime Dynasty Handcuff Option Entering First Season in L.A.
Jadarian Price

Looks Like the Running Back of the Future in Seattle
Isaiah Bond

Dynasty Outlook Clouded by Uncertain Role in Cleveland
James Cook III

Remains a High-End Dynasty RB1 Entering 2026
Lamar Jackson

Poised for Bounce Back Season in 2026
Bucky Irving

Expected to Be Ready for Training Camp
Kyle Williams

Deep Threat Kyle Williams Facing Uphill Battle for Playing Time
Michael Pittman Jr.

Could Receive Short-Term Value Uptick in PPR Leagues
Stefon Diggs

Chiefs, Commanders Could Make Sense for Stefon Diggs
Will Howard

Dynasty Value Dealt a Blow
Jaylen Warren

Should Benefit From Veteran QB's Return to Pittsburgh
Drew Allar

Could Continue to Hold Dynasty Value
Pat Freiermuth

Could See a Small Dynasty Bump With Veteran QB Returning
DK Metcalf

A Dynasty Sell Candidate With Veteran QB Returning?
Bones Hyland

Wants to Stay in Minnesota
Mike Conley

Hints He Will Continue Playing Next Season
Kevin Huerter

Iffy for Sunday Night
Caris LeVert

Questionable for Game 7
Duncan Robinson

Back on Injury Report Ahead of Game 7
Larry Nance Jr.

Likely Out Sunday Due to Illness
Munetaka Murakami

Fantastic First Season Continues With Two More Homers
Cristopher Sánchez

Cristopher Sanchez Dazzles With 13-Strikeout Complete Game on Saturday
Aaron Rodgers

Signs One-Year Deal With Steelers
Blake Snell

to Undergo Elbow Surgery on Tuesday
Clay Holmes

Could Miss Around Three Months
Jose Altuve

Exits After Swing
Corey Seager

Absent With Back Spasms on Saturday
Jeremy Lauzon

Misses Saturday's Practice
Mark Stone

Doesn't Practice Saturday
Josh Manson

Misses Practice, Considered Day-to-Day
Brent Burns

Day-to-Day Ahead of Conference Finals
Cale Makar

Considered Day-to-Day
Alex Lyon

Likely to Start Game 6 Against Canadiens
Owen Power

Available Saturday
Isaac TeSlaa

Can Isaac TeSlaa Carve Out a Larger Role in Detroit Going Forward?
Troy Franklin

Facing Uphill Battle for Playing Time in Denver
Trevor Lawrence

Should Trevor Lawrence Be Valued as a Dynasty QB1?
Courtland Sutton

in Line for Reduced Role in Denver?
Trevor Story

Hits the Injured List With Groin Injury
Blake Snell

Likely to Need Elbow Surgery
Duncan Robinson

Nets 14 Points With Four Triples
Cade Cunningham

Contributes 21 Points in Game 6 Win
Jalen Duren

Bounces Back With Double-Double
Kyle Schwarber

on a Heater, Hits Two More Homers to Take Major-League Lead
Clay Holmes

Suffers Fractured Fibula on Friday Night
Blake Snell

Heads to 15-Day Injured List
Blake Snell

Scratched From Start on Friday for Undisclosed Reasons
Max Fried

Heading to Injured List With Elbow Bone Bruise
CFB

Julian Sayin Looking To Build Off Of Strong Debut Season
CFB

College GameDay Set for First Three Weeks
CFB

Jeremiah Smith Aiming For Ohio State Receiving Records
CFB

Keshaun Singleton Projects as Auburn's WR1
CFB

Jeremiah Cobb Impresses New Auburn Staff
CFB

Alberto Mendoza Very Likely to Start for Georgia Tech
CFB

Charles Woodson Jr. Commits to Michigan
Jordan Westburg

to Have Season-Ending Elbow Surgery
Melquizael Costa

Set For UFC Vegas 117 Main Event
Arnold Allen

A Favorite At UFC Vegas 117
Daniel Santos

Set For UFC Vegas 117 Co-Main Event
MMA

Dohoo Choi Returns At UFC Vegas 117
Juan Diaz

Set To Make His UFC Debut
Malcolm Wellmaker

Looks To Bounce Back
Christian Edwards

Set For His UFC Debut
Modestas Bukauskas

Looks To Get Back In The Win Column
Tarik Skubal

Resumes Playing Catch, Ahead of Schedule?
Lane Hutson

Contributes Two Assists in Game 5 Victory
Nick Suzuki

Amasses Three Points in Crucial Victory Thursday
Juraj Slafkovsky

Dishes Out Three Assists in Game 5 Win
Carter Hart

Stops 31 Pucks in Series-Clinching Win
Pavel Dorofeyev

Enjoys Second Consecutive Multi-Goal Game
Shea Theodore

Records Two Points in Game 6 Win
Mitchell Marner

Scores Special Goal in Series-Clincher
Ryan Johnson

Takes Over as Canucks GM, Sedins Promoted to Co-Presidents
Drew Helleson

Won't Play Thursday
Radko Gudas

Unlikely to Play Thursday
CFB

Virginia Tech Lands Commitment from Four-Star QB Peter Bourque
Byron Buxton

Scratched on Thursday With Hip Soreness
Cal Raleigh

Heading to Injured List With Oblique Strain
Francisco Alvarez

has Knee Surgery, Expected to Miss Eight Weeks
Cal Raleigh

Exits With Apparent Side Injury on Wednesday Night
Juan Soto

X-Rays Come Back Negative on Juan Soto's Ankle
CFB

NFL Veteran Tom Moore Joins Iowa Coaching Staff
CFB

Can Cam Cook Dominate in Return to Big 12?
CFB

ACC, Big 12 Support 24-Team College Football Playoff
CFB

Anthony Colandrea Looking to Elevate Nebraska Back to National Contention
CFB

Kwazi Gilmer Set for Big Impact at Nebraska
Justin Thomas

Trending Well Ahead of PGA Championship Despite Concerning Form
J.J. Spaun

Trending Up Ahead of PGA Championship
Adam Scott

Riding Strong Form Into PGA Championship
Patrick Reed

Looking to Make Another Run at PGA Championship
PGA

Sungjae Im Looks to Build on Strong Finish at Truist Championship
Sam Burns

Must Keep Ball in Play at PGA Championship
Jordan Spieth

Looks to Complete Career Grand Slam at Aronimink
Brandt Snedeker

Not the Best Option for the PGA Championship
Rasmus Hojgaard

a Volatile Option at PGA Championship
Maverick McNealy

Seeking Better Start in Philadelphia
Harry Hall

a Boom-or-Bust Option at Aronimink
Hideki Matsuyama

Attempts to Improve Over 2025 PGA Championship
Scottie Scheffler

Looks to Defend PGA Championship at Aronimink
Nicolai Hojgaard

Wants to Keep Momentum Rolling in Philadelphia
Ben Griffin

Attempting to Bounce Back After Truist Championship
CFB

Transfer Defensive Lineman Devarrick Woods Commits to Clemson
Harris English

Will Need His Putter to Thrive at Aronimink
Akshay Bhatia

Creative Flair Could Show Itself in Philadelphia
Keegan Bradley

Knows the Aronimink Golf Club Well
Si Woo Kim

Struggles at Truist Championship
Gary Woodland

Can Continue Incredible 2026 Season at PGA Championship
Xander Schauffele

In Excellent Form Heading to PGA Championship
CFB

Isaac Brown Has All-American Upside in 2026
CFB

Nyck Harbor Heading into Breakout Year?
CFB

Notre Dame, USC in Discussions to Resume Rivalry Series
CFB

Jaron-Keawe Sagapolutele Has Eyes on ACC Title
CFB

Ahmad Hardy's Gunshot Wound Not Viewed as Career-Threatening
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF