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DraftKings Daily Fantasy Football Picks (Week 16): NFL DFS Lineups

The top daily fantasy football lineup picks for DraftKings in Week 16. Ben Rolfe's NFL DFS analysis and sleepers for building optimal DFS rosters.

Two Saturday games on top of the usual prime time games has really left this slate a little devoid of options. However, more significantly is the loss of the Chiefs, Rams, Chargers and Saints to prime time slots on Thursday, Sunday and Monday.

That has left us looking more for defenses to pick against this week than looking at explosive offenses. Some prime examples are the Falcons and Bengals who have struggled to stop teams at all this year and have looked pretty ugly on defense. Below are my DraftKings DFS Lineup Picks for Week 16.

These DraftKings lineup recommendations are based on matchups, performances so far, overall upside/talent levels, opportunity, and other factors such as Vegas odds, home field advantage, and more. There are quite a few great value plays available, so read on to find out which players are the best for Week 16. Good luck with your DraftKings DFS lineups!

 

DraftKings DFS Quarterbacks - Week 16 Picks

Matt Ryan - ATL @ CAR (DK $6,100)

Ryan has sneakily been pretty good this year and despite this game being on the road I think he can have success. The Panthers defensive numbers have not been that bad at home this season but this week they are coming off a short week, in a game they gave everything to and lost. Cam Newton is essentially done for the season and that could have an effect in a number of ways. Firstly, as bad as the Falcons defense has been at times they should be able to shut down Taylor Heinicke for the majority of the game, meaning the Falcons offense should see plenty of the ball. Secondly, I worry that Newton sitting sends a message to this team that the season is over, and a tired defense getting negative signals from their coaching staff could lead to a flat performance and flat atmosphere in Carolina.

If you want to get really funky this week then you could gamble on Heinicke at $4,000 on DK. The Falcons defense has had trouble this year and if Heinicke gives you anything close to average at that price you could have had a loaded team elsewhere.

Josh Allen - BUF @ NE (DK $5,800)

Allen could be a fun play this week. Rookie quarterbacks do not generally have great amounts of success against the Patriots but there are some factors that interest me. Allen is on a hot streak lately and has scored over 20 fantasy points on DraftKings three of the last four weeks. In addition, the Patriots have had trouble with quarterbacks who can use their legs. Blake Bortles had 36 fantasy points against them in Week 2 and both Mitchell Trubisky and Marcus Mariota had success as well. The Patriots have a sluggish defense and Allen should be able to find plenty of space against them this week.

Sam Darnold - NYJ vs. GB (DK $4,900)

This is an option if you want to get a little bit creative this week. Darnold looked healthy for the first time in a while last week and his stats reflected that. The rookie quarterback had 21.68 fantasy points on DraftKings, his highest total of the season. He seems to finally have a connection going with Robbie Anderson and he just looked more comfortable, even against a very good defense. This week he faces a Packers defense allowing 20% more points to opposing quarterbacks than the league average over the last five weeks. In addition, Green Bay have allowed quarterbacks to average 19.9 fantasy points in their road games so far.

 

DraftKings DFS Running Backs - Week 16 Picks

Ezekiel Elliott - DAL vs. TB (DK $9,000)

Of the top three options this week Elliott actually feels like the safest. There are so many question marks surrounding both Todd Gurley and Christian McCaffrey that I am a little afraid to gamble on either of them. However, Elliott has little question marks and he has a nice matchup to boot. Over the last five weeks, the Buccaneers are allowing 31% more fantasy points to opposing running backs than the NFL average. In addition, they have been allowing an average of 24.3 fantasy points to opposing #1 backs when playing on the road this season.

Nick Chubb - CLE vs. CIN (DK $7,300)

Chubb had a tough week in Denver last Saturday but this game against the Bengals should be much nicer for him. The Bengals defense has had a lot of issues this season, especially when it comes to making tackles. Over the last five weeks, they have been allowing nearly 25% more points to opposing running backs than the league average. Over the course of the season, they have allowed 19.2 fantasy points to opposing #1 running backs meaning Chubb could be in line for a good week.

The Bengals have been allowing 29.9 fantasy points overall to the running back position on the road this season. Therefore, if you are looking for a bargain basement play this week, you might want to consider Duke Johnson at a price of $3,800 on DraftKings.

Lamar Miller - HOU @ PHI (DK $5,000)

Miller is coming off the back of a couple of tough weeks but he is only four weeks removed from a 162-yard game and he has scored two touchdowns in the last four weeks. Additionally, over the last five weeks, the Eagles defense has allowed a whopping 41% more points to running backs than the league average. Realistically, on the road, the Texans need to get the run game going and I think we see them lean heavily on it this week, which could lead to a big week for Miller.

Miller has been banged up lately and if he does look likely to miss this game then Alfred Blue at a price of $4,500 on DraftKings could be a really interesting play.

John Kelly - LAR @ ARI (DK $4,000)

This one is a real gamble and it will depend on the news later in the week. If Gurley is out then Kelly is the healthiest running back who knows the playbook well available on the Rams roster. There are other names in the mix which might cause concern but with a juicy matchup, this play is tempting in GPP formats. Over the last five week,s the Cardinals are allowing 26% fantasy points above the average against opposing running backs and were ripped apart by Tevin Coleman last week in Atlanta.

 

DraftKings DFS Wide Receivers - Week 16 Picks

Julio Jones - ATL @ CAR (DK $8,700)

This has almost become an automatic pick for me this season and I am not veering away from it now. There are a number of aspect in play here that make Jones an interesting play despite being the highest priced pass catcher. Firstly, there is a chance that Jones will have contract talks this summer and I believe Ryan also wants to help him get paid so may force the ball his way a little down the stretch. Secondly, I think there is a chance Dan Quinn's job is still in the air a little and he needs his star receiver to feature strongly down the stretch. Thirdly, Jones has over 20 fantasy points on DraftKings in all but four weeks this season. Finally, the Panthers are allowing 24% more points to opposing receivers over the last few weeks, and that is great news for Jones in a game I can see the Falcons scoring plenty of points in.

Jones has had some niggles recently and if he is sat down for this week then there are two potential options. To match his price I would lean on DeAndre Hopkins against the Eagles at $8,600, and if I wanted a receiver from the Falcons I would be tempted by Calvin Ridley at $5,100 with the chance to be the leading receiver for the first time in his NFL career.

Davante Adams - GB @ NYJ (DK $8,500)

I was wavering with the news that Aaron Rodgers may not play in Week 16. However, it seems likely that he will and therefore I would be very tempted by Adams. Adams has been one of the most consistent players in fantasy this season, despite the Packers troubles, and now he gets a juicy matchups in this game. The Jets are allowing a huge 45% more points to opposing receivers than the league average in the last five weeks. They also allow nearly 20 fantasy points per game to opposing number one wide receivers. It feels like there is a good chance this could be a high scoring game and I might find myself playing pass catchers on both sides.

Robby Anderson - NYJ vs. GB (DK $4,500)

In fact here is a pass catcher on the other side who is a very tempting play this week. There appears to be a real connection developed between Anderson and Darnold recently and it has shown up big time in the last two games. I do not see why that stops this week, facing a team allowing 15% more points than league average to opposing wide receivers in the last five games. I think there is a real chance that this game goes over the over/under line of 46.5 and maybe even into the low- to mid-50s, in what could be a shootout style game in the fourth quarter.

 

DraftKings DFS Tight Ends - Week 16 Picks

David Njoku - CLE vs. CIN (DK $3,900)

Tight end is a pretty ravaged landscape this week for the main slate on Sunday. A number of top tight end targets are missing from the slate due to their game times. In addition, question marks of Zach Ertz and Rob Gronkowski have us looking deeper this week. The Bengals have been one of the worst teams against the tight end, who are playing on this slate, allowing 18% more points than the league average in the last five weeks. Njoku's value has been up and down but I am hoping he can find the end zone this week.

Austin Hooper - ATL @ CAR (DK $3,700)

Hooper is coming off a terrible week but it was a tough matchup and he has had struggles in those tough matchups before. However, he has also had nice performances this season against teams who struggle with the tight end. That is exactly the case for the Panthers who have allowed an average of 10.1 fantasy points to opposing #1 tight ends this season. Nothing is ever a guarantee when it comes to the tight end position, but what should be important is that the Falcons are likely to play hard in the last couple of weeks, against division opponents, to make sure they end the season with a bang.

 

DraftKings DFS Defenses - Week 16 Picks

Chicago Bears @ San Francisco (DK $3,500)

I always look to try and save a few hundred dollars here but I do not see a team with better potential for turnovers. There are a number of teams who I expect to play stout defense, Miami and Detroit for example, but I do not trust them to get turnovers. Therefore, I am going to look to the Bears, who nearly always force turnovers, against an offense which has been extremely turnover prone. I could potentially see a defensive score or two coming in this game...

More Weekly DFS Analysis




REAL-TIME FANTASY NEWS

Andrew Nembhard

Out Again on Sunday Night
Giannis Antetokounmpo

Expected to Play Versus Cleveland
Cam Skattebo

Exits Week 8 Early Due to Serious Ankle Injury
Derrick White

Good to Go Against Detroit
Cam Thomas

Available on Sunday
Luka Dončić

Luka Doncic Dealing with a Finger Injury
Anthony Richardson Sr.

Underwent Eye Surgery Last Monday
D'Andre Swift

Cleared to Play in Week 8
Michael Penix Jr.

Officially Inactive on Sunday
Dalton Kincaid

Active for Week 8 Against Panthers
Mason Taylor

Suiting Up in Week 8
Breece Hall

Active for Week 8 Against Bengals
David Njoku

Suiting Up for Week 8 Against Patriots
Drake London

Inactive with Hip Injury
Matthew Golden

Expected to Play Against Steelers
Tua Tagovailoa

Added to Injury Report, Will Play Sunday
Chris Buescher

Is Chris Buescher A Playable DFS option for Martinsville?
Ryan Preece

is an Intriguing DFS Option For Martinsville
J.J. McCarthy

Expected to Return in Week 9
Daniel Suarez

May be Worth Rostering in DFS for Martinsville
Drake London

Falcons to Determine Availability of Drake London in the Morning
Austin Dillon

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Robert Thomas

Sustains Upper-Body Injury
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Hurt Versus Blue Jackets
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Injured on Saturday
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Exits Early Saturday
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Josh Berry

a Top Contender for DFS Place-Differential Points
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an Intriguing Martinsville Option
Shane Van Gisbergen

Now Competent on Ovals, but Don't Start Him Here
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Lack of Finesse Makes Him a Risky Martinsville Pick
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Missing Martinsville Mastery
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Expected to Play Against Cincinnati
D'Andre Swift

Likely to Suit Up in Week 8
A.J. Brown

"Expected to Have a Realistic Chance to Return" in Week 10
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"Officially" Starting in Week 8
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"Has a Real Chance" to Return in Week 9
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Hopeful to Play in Week 9
Patrik Laine

Ruled Out for 3-4 Months
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Ready to Face Oilers
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Available Saturday
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Set to Rejoin Kings Lineup Saturday
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Good to Go Saturday
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Returns to Action Saturday
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Out Again on Saturday
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Ruled Out on Saturday
Chet Holmgren

Available to Face the Hawks
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Expected to Remain Out Saturday
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Undergoes Surgery
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to Miss Rematch With Maple Leafs
William Nylander

Injured on Friday
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Rejoins Maple Leafs
Bryce Harper

Phillies Aren't Planning to Trade Bryce Harper
Josh Hart

Available Versus the Celtics
Karl-Anthony Towns

Cleared to Face the Celtics
De'Andre Hunter

Sidelined on Friday Night
Kristaps Porzingis

Won't Play on Friday
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Set to Miss Time
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Umar Numagomedov A Favorite At UFC 321
Jailton Almeida

Hopes To Get A Title Shot With A Win
Caris LeVert

Probable for Friday's Game
Alexander Volkov

Looks To Get Back In The Win Column
Azamat Murzakanov

Looks To Remain Undefeated
Aleksandar Rakic

In Dire Need Of Victory
CFB

Texas Tech QB Will Hammond Will Start vs. Oklahoma State Saturday
CFB

Kansas State RB Dylan Edwards Out For Sunflower Showdown
CFB

Arizona State WR Jordyn Tyson Will Not Play In Week 9
Zack Wheeler

Could be Ready for Opening Day in 2026
William Contreras

Could Need Finger Surgery
CFB

Utah QB Devon Dampier Listed as Questionable on Big 12 Injury Report
San Francisco Giants

Tony Vitello Named New Manager of the Giants
Francisco Lindor

has Elbow Surgery, Expected to be Ready for Spring Training
PGA

Alex Noren is a Smash Play at Bank of Utah Championship
Maverick McNealy

Look Out For Maverick McNealy This Week in Utah
Justin Lower

Unlikely to Flip The Script at Bank of Utah Championship
Stephan Jaeger

Looking for Repeat Performance in Utah
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Behren Morton Will be Listed as Questionable on Wednesday
Max McGreevy

a Longer Shot to Contend in Utah
Jackson Suber

on the Bubble for the PGA in 2026
Greyson Sigg

Improving at the Right Time This Fall
Seamus Power

Hopes to Make More Birdies This Week
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Looking to Find the Weekend in Utah
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Enjoying the Fall Golf Season
Tom Hoge

Sputtering into Bank of Utah Championship
Sahith Theegala

On the Upswing Heading into Utah
Andrew Putnam

Looks to Find Form in Utah
Matt McCarty

Looks to Defend Title in Utah
Ben Kohles

a Strong Value Play at Bank of Utah Championship
Max Homa

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Nick Dunlap

Searching for Spark at Bank of Utah Championship
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Struggling to Find Form Ahead of Bank of Utah Championship
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Kurt Suzuki to be the Angels' Next Manager
Bo Bichette

Plans to be Ready for World Series
Brandon Woodruff

Expects to Be Ready for Opening Day

RANKINGS

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