X
Lost password?

Don't have an account?
Gain Access Now

X

Receive free daily analysis

NFL
NBA
NHL
NASCAR
CFB
MLB
MMA
PGA
ESPORTS
BETTING

Already have an account? Log In

X

Forgot Password


POPULAR FANTASY TOOLS

Expert Advice
Articles & Tools
Import Your Leagues
Draft Rankings
Draft Simulator
Compare Any Players
24x7 News and Alerts

DraftKings Daily Fantasy Football Picks (Week 16): NFL DFS Lineups

The top daily fantasy football lineup picks for DraftKings in Week 16. Ben Rolfe's NFL DFS analysis and sleepers for building optimal DFS rosters.

Two Saturday games on top of the usual prime time games has really left this slate a little devoid of options. However, more significantly is the loss of the Chiefs, Rams, Chargers and Saints to prime time slots on Thursday, Sunday and Monday.

That has left us looking more for defenses to pick against this week than looking at explosive offenses. Some prime examples are the Falcons and Bengals who have struggled to stop teams at all this year and have looked pretty ugly on defense. Below are my DraftKings DFS Lineup Picks for Week 16.

These DraftKings lineup recommendations are based on matchups, performances so far, overall upside/talent levels, opportunity, and other factors such as Vegas odds, home field advantage, and more. There are quite a few great value plays available, so read on to find out which players are the best for Week 16. Good luck with your DraftKings DFS lineups!

Editor's Note: The FFPC Baby Gorilla Tournament is now open, featuring a $100,000 grand prize and a $675,450 total prize pool! This 12-team, Tight End Premium contest uses a 20-round draft format, with the overall winners determined by total points scored during Weeks 15–17. Get $25 to use toward your first entry by signing up through our link. Grab your team now! Sign Up Now!

 

DraftKings DFS Quarterbacks - Week 16 Picks

Matt Ryan - ATL @ CAR (DK $6,100)

Ryan has sneakily been pretty good this year and despite this game being on the road I think he can have success. The Panthers defensive numbers have not been that bad at home this season but this week they are coming off a short week, in a game they gave everything to and lost. Cam Newton is essentially done for the season and that could have an effect in a number of ways. Firstly, as bad as the Falcons defense has been at times they should be able to shut down Taylor Heinicke for the majority of the game, meaning the Falcons offense should see plenty of the ball. Secondly, I worry that Newton sitting sends a message to this team that the season is over, and a tired defense getting negative signals from their coaching staff could lead to a flat performance and flat atmosphere in Carolina.

If you want to get really funky this week then you could gamble on Heinicke at $4,000 on DK. The Falcons defense has had trouble this year and if Heinicke gives you anything close to average at that price you could have had a loaded team elsewhere.

Josh Allen - BUF @ NE (DK $5,800)

Allen could be a fun play this week. Rookie quarterbacks do not generally have great amounts of success against the Patriots but there are some factors that interest me. Allen is on a hot streak lately and has scored over 20 fantasy points on DraftKings three of the last four weeks. In addition, the Patriots have had trouble with quarterbacks who can use their legs. Blake Bortles had 36 fantasy points against them in Week 2 and both Mitchell Trubisky and Marcus Mariota had success as well. The Patriots have a sluggish defense and Allen should be able to find plenty of space against them this week.

Sam Darnold - NYJ vs. GB (DK $4,900)

This is an option if you want to get a little bit creative this week. Darnold looked healthy for the first time in a while last week and his stats reflected that. The rookie quarterback had 21.68 fantasy points on DraftKings, his highest total of the season. He seems to finally have a connection going with Robbie Anderson and he just looked more comfortable, even against a very good defense. This week he faces a Packers defense allowing 20% more points to opposing quarterbacks than the league average over the last five weeks. In addition, Green Bay have allowed quarterbacks to average 19.9 fantasy points in their road games so far.

 

DraftKings DFS Running Backs - Week 16 Picks

Ezekiel Elliott - DAL vs. TB (DK $9,000)

Of the top three options this week Elliott actually feels like the safest. There are so many question marks surrounding both Todd Gurley and Christian McCaffrey that I am a little afraid to gamble on either of them. However, Elliott has little question marks and he has a nice matchup to boot. Over the last five weeks, the Buccaneers are allowing 31% more fantasy points to opposing running backs than the NFL average. In addition, they have been allowing an average of 24.3 fantasy points to opposing #1 backs when playing on the road this season.

Nick Chubb - CLE vs. CIN (DK $7,300)

Chubb had a tough week in Denver last Saturday but this game against the Bengals should be much nicer for him. The Bengals defense has had a lot of issues this season, especially when it comes to making tackles. Over the last five weeks, they have been allowing nearly 25% more points to opposing running backs than the league average. Over the course of the season, they have allowed 19.2 fantasy points to opposing #1 running backs meaning Chubb could be in line for a good week.

The Bengals have been allowing 29.9 fantasy points overall to the running back position on the road this season. Therefore, if you are looking for a bargain basement play this week, you might want to consider Duke Johnson at a price of $3,800 on DraftKings.

Lamar Miller - HOU @ PHI (DK $5,000)

Miller is coming off the back of a couple of tough weeks but he is only four weeks removed from a 162-yard game and he has scored two touchdowns in the last four weeks. Additionally, over the last five weeks, the Eagles defense has allowed a whopping 41% more points to running backs than the league average. Realistically, on the road, the Texans need to get the run game going and I think we see them lean heavily on it this week, which could lead to a big week for Miller.

Miller has been banged up lately and if he does look likely to miss this game then Alfred Blue at a price of $4,500 on DraftKings could be a really interesting play.

John Kelly - LAR @ ARI (DK $4,000)

This one is a real gamble and it will depend on the news later in the week. If Gurley is out then Kelly is the healthiest running back who knows the playbook well available on the Rams roster. There are other names in the mix which might cause concern but with a juicy matchup, this play is tempting in GPP formats. Over the last five week,s the Cardinals are allowing 26% fantasy points above the average against opposing running backs and were ripped apart by Tevin Coleman last week in Atlanta.

 

DraftKings DFS Wide Receivers - Week 16 Picks

Julio Jones - ATL @ CAR (DK $8,700)

This has almost become an automatic pick for me this season and I am not veering away from it now. There are a number of aspect in play here that make Jones an interesting play despite being the highest priced pass catcher. Firstly, there is a chance that Jones will have contract talks this summer and I believe Ryan also wants to help him get paid so may force the ball his way a little down the stretch. Secondly, I think there is a chance Dan Quinn's job is still in the air a little and he needs his star receiver to feature strongly down the stretch. Thirdly, Jones has over 20 fantasy points on DraftKings in all but four weeks this season. Finally, the Panthers are allowing 24% more points to opposing receivers over the last few weeks, and that is great news for Jones in a game I can see the Falcons scoring plenty of points in.

Jones has had some niggles recently and if he is sat down for this week then there are two potential options. To match his price I would lean on DeAndre Hopkins against the Eagles at $8,600, and if I wanted a receiver from the Falcons I would be tempted by Calvin Ridley at $5,100 with the chance to be the leading receiver for the first time in his NFL career.

Davante Adams - GB @ NYJ (DK $8,500)

I was wavering with the news that Aaron Rodgers may not play in Week 16. However, it seems likely that he will and therefore I would be very tempted by Adams. Adams has been one of the most consistent players in fantasy this season, despite the Packers troubles, and now he gets a juicy matchups in this game. The Jets are allowing a huge 45% more points to opposing receivers than the league average in the last five weeks. They also allow nearly 20 fantasy points per game to opposing number one wide receivers. It feels like there is a good chance this could be a high scoring game and I might find myself playing pass catchers on both sides.

Robby Anderson - NYJ vs. GB (DK $4,500)

In fact here is a pass catcher on the other side who is a very tempting play this week. There appears to be a real connection developed between Anderson and Darnold recently and it has shown up big time in the last two games. I do not see why that stops this week, facing a team allowing 15% more points than league average to opposing wide receivers in the last five games. I think there is a real chance that this game goes over the over/under line of 46.5 and maybe even into the low- to mid-50s, in what could be a shootout style game in the fourth quarter.

 

DraftKings DFS Tight Ends - Week 16 Picks

David Njoku - CLE vs. CIN (DK $3,900)

Tight end is a pretty ravaged landscape this week for the main slate on Sunday. A number of top tight end targets are missing from the slate due to their game times. In addition, question marks of Zach Ertz and Rob Gronkowski have us looking deeper this week. The Bengals have been one of the worst teams against the tight end, who are playing on this slate, allowing 18% more points than the league average in the last five weeks. Njoku's value has been up and down but I am hoping he can find the end zone this week.

Austin Hooper - ATL @ CAR (DK $3,700)

Hooper is coming off a terrible week but it was a tough matchup and he has had struggles in those tough matchups before. However, he has also had nice performances this season against teams who struggle with the tight end. That is exactly the case for the Panthers who have allowed an average of 10.1 fantasy points to opposing #1 tight ends this season. Nothing is ever a guarantee when it comes to the tight end position, but what should be important is that the Falcons are likely to play hard in the last couple of weeks, against division opponents, to make sure they end the season with a bang.

 

DraftKings DFS Defenses - Week 16 Picks

Chicago Bears @ San Francisco (DK $3,500)

I always look to try and save a few hundred dollars here but I do not see a team with better potential for turnovers. There are a number of teams who I expect to play stout defense, Miami and Detroit for example, but I do not trust them to get turnovers. Therefore, I am going to look to the Bears, who nearly always force turnovers, against an offense which has been extremely turnover prone. I could potentially see a defensive score or two coming in this game...

More Weekly DFS Analysis




POPULAR FANTASY TOOLS

Expert Advice
Articles & Tools
Import Your Leagues
Draft Rankings
Draft Simulator
Compare Any Players
24x7 News and Alerts

REAL-TIME FANTASY NEWS

Ashton Jeanty

a Top-Five Dynasty RB Despite Disappointing Rookie Campaign
Devin Neal

the Potential RB2 in New Orleans in his Sophomore Season
Ricky Pearsall

Does Ricky Pearsall Still Have Breakout Potential for Fantasy Managers?
Tory Horton

Dynasty Stock on the Decline Despite Big-Play Ability
Tank Dell

Improving, But Not 100 Percent Yet
Karl-Anthony Towns

Logs Sixth Double-Double of Postseason
Mike Conley

Ayo Dosunmu Replaces Mike Conley in Starting Unit Sunday
Miles McBride

Tallies Game-High 25 Points in Series-Clincher
Tyrese Maxey

Settles for 17 Points Sunday
Joel Embiid

Scores Efficient 24 Points in Season-Ending Loss
Caris LeVert

Iffy for Monday Night
Kevin Huerter

Listed as Questionable for Game 4
Auston Matthews

Uncertain About Future With Maple Leafs
Frederik Andersen

Enjoying Special Postseason
Josh Manson

"Close" to Returning
Joel Kiviranta

Could Return to Action Monday
Radko Gudas

a Game-Time Call Sunday
Mark Stone

Unavailable Sunday
Sean Tucker

Dynasty Upside Remains Limited by Crowded Backfield Picture
Puka Nacua

Is Puka Nacua's Dynasty Value Impacted by Potential Off-Field Concerns?
Alec Pierce

Can Alec Pierce Build on Encouraging 2025 Production in 2026 and Beyond?
Keenan Allen

Dynasty Stock Falling with NFL Future in Limbo
Drake London

Remains a Dynasty WR1 Entering 2026
Connor Zilisch

Will Start Fifth in his First Watkins Glen Cup Series Race
Tyler Reddick

Is A Top DFS Option for Watkins Glen Lineups
Christopher Bell

Is Likely to Bounce Back This Week at Watkins Glen
Carlos Rodón

Carlos Rodon Activated for Season Debut on Sunday
William Byron

Is William Byron Playable in DFS Lineups at Watkins Glen?
Bucky Irving

Potentially Undervalued After Disappointing Sophomore Season
Austin Reaves

Nears Double-Double In Game 3 Loss
Davante Adams

a Dynasty Hold Who Could See His Value Slip
LeBron James

Facing Sweep With Game 4 on Monday
Emeka Egbuka

The Pendulum Swinging Back on Emeka Egbuka's Dynasty Value
Ajay Mitchell

Posts Career Playoff Night in Game 3
Chet Holmgren

Helps Thunder Move to Brink of Conference Finals
Michael Pittman Jr.

Undervalued in an Environment Fit for His Skill Set
Tobias Harris

Extends 20-Point Streak in Saturday's Loss
Evan Mobley

Keeps Defensive Production Rolling Saturday
Rhamondre Stevenson

a Quality Dynasty Target in a Still-Improving Offense
Golden State Warriors

Warriors Extend Steve Kerr into his 13th Season
Kyle Larson

May have A Positive Day at Watkins Glen
Chase Briscoe

May Compete for A Top-10 Finish at Watkins Glen
NASCAR

A.J. Allmendinger May have Another Solid Outing at Watkins Glen
Ty Gibbs

Should Fantasy Managers Roster Ty Gibbs at Watkins Glen?
Ross Chastain

Is Ross Chastain Worth Rostering for Watkins Glen Lineups?
Austin Cindric

Could Austin Cindric be A Sneaky Tournament Play for Watkins Glen?
Odell Beckham Jr.

Giants Not Looking to Sign Odell Beckham Jr. Right Now
Bo Nix

Will be Full Speed Before Training Camp
Shane Van Gisbergen

Shane van Gisbergen the Heavy Favorite at Watkins Glen
Chase Elliott

Is Chase Elliott a No-Brainer DFS Pick at Watkins Glen?
Chris Buescher

Qualifies 14th at Watkins Glen
Ryan Blaney

Has Upside at Watkins Glen After Signing Contract Extension
Michael McDowell

Still Searching for First Top-Five Finish at Watkins Glen
Carson Hocevar

Is Carson Hocevar Too Aggressive for Road-Course Racing?
Joey Logano

Needs a Good Run at Watkins Glen
Luis Castillo

Mariners Intend to Piggyback Luis Castillo, Bryce Miller
Duncan Robinson

Shines on Both Ends Saturday
Cade Cunningham

Records Second Career Postseason Triple-Double
Donovan Mitchell

Logs 35-Point Double-Double
James Harden

Plays Late Hero Saturday
OG Anunoby

Could Miss Another Game Sunday
Joel Embiid

Considered Probable for Sunday's Elimination Game
Jarred Vanderbilt

Active on Saturday Night
Logan Webb

Placed on 15-Day Injured List With Knee Bursitis
Bryce Miller

is Set to Return on Wednesday
Jeff Hoffman

Could Return to Closer Role
CHI

Blackhawks Bring in Roman Kantserov for Next Season
Mason McTavish

Set to Rejoin Ducks Lineup Sunday
Lukas Dostal

to Remain in Ducks Crease Sunday
Zach Bogosian

Back for Wild Saturday
Jesper Wallstedt

Starting Game 3 Against Avalanche
Joel Eriksson Ek

Not Ready to Return Saturday
Owen Tippett

Won't Play Saturday
Cooper Kupp

a Dynasty Hold into the Start of 2026 Season
Jaylen Warren

a Safe Dynasty Depth Piece with Insurance Upside
Christian McCaffrey

a Risky Dynasty Hold Who Still Exceeds His Trade Value
Brian Thomas Jr.

A Risky Buy-Low with Immense Upside
Taj Bradley

Hits the Injured List With Pectoral Inflammation
Kyle Bradish

has Nice Bounce-Back Performance With 10 K's
Casey Mize

Throws Bullpen on Friday, Return Not Imminent
Ronald Acuña Jr.

Ronald Acuna Jr. Optimistic About Returning Next Wednesday
Mike Matheson

Leads by Example in Game 2 Win
Jakub Dobes

Rebounds After Loss Yet Again for Montreal
Alex Newhook

Sets Tone in Big Montreal Victory
Lukas Dostal

Gets Pulled in Game 3 Loss on Friday
Brett Howden

Notches Sixth Goal of the Postseason
VEG

Mitch Marner Hat Trick Helps Vegas Take Series Lead
Tyler Glasnow

Dodgers Put Tyler Glasnow on Injured List With Back Spasms
Mats Zuccarello

Expected to Play Saturday
Joel Eriksson Ek

to Be a Game-Time Decision Saturday
Blake Snell

to Make Season Debut for Dodgers on Saturday
Cole Ragans

Royals Place Cole Ragans on Injured List With Elbow Impingement
Sean Strickland

An Underdog At UFC 328
Khamzat Chimaev

Set For UFC 328 Main Event
Tatsuro Taira

Can Become The New Flyweight Champion
Joshua Van

Set For His First Title Defense
Alexander Volkov

Looks To Win Back-To-Back Fights
MMA

Waldo Cortes-Acosta Looks To Extend His Win Streak
Nick Lodolo

Officially Activated, Making Season Debut on Friday
CFB

Walker Lyons Could be Go-To Target for Bear Bachmeier
CFB

Ty Benefield a Potential Game-Changer for LSU Defense
CFB

Hayden Lowe Set for Significant Role Following Miami's NFL Departures
CFB

Taylor Wein in Position for Big Season on Oklahoma's Defensive Line
CFB

Rasheem Biles an Instant Impact Player for Texas
Roman Anthony

Heading for the Injured List
CFB

Sam Leavitt Expected to Be Full-Go for Fall Camp
Tarik Skubal

Could Return in 4-6 Weeks After Successful Elbow Surgery
Cole Ragans

Royals Hopeful That Cole Ragans Makes his Next Start
Emilio Pagán

Emilio Pagan has Grade 2 Hamstring Strain, Expected to Miss 4-8 Weeks
Joe Ryan

Listed as Scheduled Starter for Saturday Against Cleveland
Tyler Glasnow

Not Expected to Land on the Injured List
Framber Valdez

Suspension Reduced to Five Games
Framber Valdez

Suspended Six Games
CFB

Brauntae Johnson the Next Star in Notre Dame's Secondary?
CFB

Ethan Barbour a Name to Know in Georgia's Tight End Room
CFB

Payton Pierce Next Up at Linebacker for Ohio State
CFB

Javin Gordon to Play Significant Role for Tennessee?
CFB

Tanook Hines Stepping into WR1 Role for USC
CFB

Rueben Owens II has "Star Potential" in Fourth Campaign
Collin Morikawa

Withdraws From Truist Championship
Xander Schauffele

Carries Elite Form Into Quail Hollow
Hideki Matsuyama

Looks to Bounce Back at Truist Championship
Matt Fitzpatrick

Secures Third Win of 2026 Season
Patrick Cantlay

Continues Playing Well Heading to Truist Championship
Ludvig Aberg

Returns to Action For Truist Championship
Justin Thomas

Searching for Consistency at Quail Hollow
Jordan Spieth

Looks to Break Through at Quail Hollow
Adam Scott

Brings Strong Form to Quail Hollow
Robert MacIntyre

a Steady Option at Truist Championship
Jason Day

Looks to Overcome Approach Struggles at Quail Hollow
Akshay Bhatia

Looks for Complete Game at Truist Championship
Justin Rose

to Continue Mid-Season Club Change at Truist Championship
Si Woo Kim

is Back to Peak Form Ahead of Truist Championship
Sam Burns

to Bounce Back at Truist Championship
Cameron Young

Looks to Carry Dominance to Quail Hollow
Rory McIlroy

Returns to Familiar Stomping Grounds This Week at Quail Hollow
Chris Gotterup

Looking to Bounce Back at Quail Hollow
Tommy Fleetwood

Looking For Better Iron Play at Quail Hollow
CFB

Mario Craver Enters No. 1 Wide Receiver Role for Marcel Reed
CFB

LaNorris Sellers a Strong Rebound Candidate in 2026
CFB

Cam Coleman Poised for Monster Year at Texas?
CFB

Will Hammond Pushing to Be Ready for Week 1
Alex Fitzpatrick

Looking to Keep Up Ball-Striking Output at Quail Hollow
CFB

Notre Dame Leads College Football in Returning Snaps
CFB

Two Ole Miss Football Players Arrested, Charged with DUI
Ben Griffin

Looks Solid on the Surface Heading to Charlotte
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF