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Yahoo Daily Fantasy Football Lineup Picks (Week 16): NFL DFS Advice

Week 16 daily fantasy football lineup picks and NFL DFS cheat sheet for Yahoo. DFS lineup targets and sleepers for GPPs / cash games at RB, WR, QB, TE, and DEF.

Happy Holidays RotoBallers! In this article, I will be taking a look at some of my favorite Yahoo DFS lineups picks for the Week 16 slate. These DFS picks are based on a multitude of factors including matchup, talent, recent performance, Vegas odds, and pricing on Yahoo.

In a bit of a departure from their normal setup, Yahoo's main slate covers just the 12 games being played on Sunday. That leaves a few intriguing offenses, namely the Pittsburgh Steelers, off of the slate. As usual, the focus here isn't to point out that Rob Gronkowski and Le'Veon Bell are great plays because you already know that. Instead, the goal is to point out some good value plays along with some underpriced stars.

Good luck this week, hopefully Santa leaves a bag of cash in your account at the end of Sunday's action!

 

Quarterback Picks for Yahoo DFS

Cam Newton, Carolina Panthers vs. TB, $39

Newton turned in a huge game against the Packers in Week 15, slicing their defense for 242 yards and four passing touchdowns. The former league MVP is playing his best football since his MVP season back in 2015 and draws a fantastic matchup against a Tampa Bay pass defense that is one of the worst in the league. The Buccaneers are allowing 278 passing yards per game this season and their pass defense ranks 29th in the league in DVOA. Newton should have no trouble moving the ball in Week 16. As an added bonus, he has been rushing the ball more frequently lately, having taken 25 carries over the past two weeks.

Dak Prescott, Dallas Cowboys vs. SEA, $28

Prescott is in play for those who want to pay down at quarterback in cash games on a slate where there isn't a ton of value at the position unless you like Jameis Winston or trust Marcus Mariota against the Rams (I don't). Prescott will take on a banged up Seattle defense in a game that will see Ezekiel Elliott return to the offense. Prescott was playing MVP-level football earlier in the season before Elliott was suspended for six games. While the absence of Zeke can't fully explain Prescott's struggles, it will help to have the star runner back on the field. The Seahawks have allowed opposing quarterbacks to pass for either 268 yards or two touchdowns in three straight games.

 

Running Back Picks for Yahoo DFS

Dion Lewis, New England Patriots vs. BUF, $26

The injury to Rex Burkhead thrusts Lewis into a prime spot against what has been one of the worst run defenses in the league. While he may lose some passing work to James White, Lewis should operate as the Patriots' lead back in Week 16 against a Buffalo run defense that has allowed the most rushing touchdowns and the most fantasy points per game to opposing running backs. While the Patriots haven't used Lewis as a pass-catcher very frequently, he did show the ability to catch passes back in 2015 before he tore his ACL. At just $26, Lewis shapes up as an excellent option who would presumably see all the clock-killing carries when the Patriots inevitably get out to a big lead against Buffalo.

Kenyan Drake, Miami Dolphins @ KC, $21

Drake remains an excellent running back option who you will want to have plenty of exposure to this weekend. The second-year running back has operated as a true bell-cow back since Damien Williams got injured, having played in 93% of his team's offensive snaps over the past two weeks. Even if Williams returns this week, Drake has certainly shown enough to remain locked in as the team's starting running back. Yahoo has been slow to adjust Drake's price, meaning you can get a borderline RB1 at a significant discount. The Chiefs have struggled against the run this season, ranking 31st in run defense DVOA.

 

Wide Receiver Picks for Yahoo DFS

Michael Thomas, New Orleans Saints vs. ATL, $29

Thomas is significantly underpriced on Yahoo, checking in at a full $10 below Keenan Allen, the most expensive receiver on the slate. While we haven't seen a ton of ceiling games from Thomas in this new run-first New Orleans offense, he has been one of the most consistent receivers in the league this season. Thomas has seen at least eight targets in nine straight games while dipping below 70 receiving yards just twice over that span. The Falcons had no answer for him two weeks ago when these two teams met, allowing him to catch 10 passes for 117 yards and a touchdown. Thomas is one of the receivers who I am building cash lineups around this weekend.

Larry Fitzgerald, Arizona Cardinals vs. NYG, $26

Fitzgerald is another rock-solid cash game option who possesses enough upside to use in tournaments as well. Similar to Michael Thomas, Fitzgerald's target share is one of the most consistent in the league. The veteran pass catcher has seen at least seven targets in seven straight games while topping 60 receiving yards in five of those contests. He draws a tasty Week 16 matchup against a Giants defense that mailed it in a long time ago. New York's pass defense is allowing the second-most passing yards per game this season and ranks 25th in DVOA according to Football Outsiders.

 

Tight End Picks for Yahoo DFS

Delanie Walker, Tennessee Titans vs. LAR, $17

Walker brings overall TE1 upside to the table but at a fraction of the cost of Rob Gronkowski or Travis Kelce. While the Titans' pass offense has struggled at times this season, Walker has remained one of the more consistent options at a tight end position that can be tough to find players to trust. The matchup against the Rams isn't an easy one but the Titans will likely have to abandon their "exotic smash mouth" run-first offense early to keep up with an explosive Rams offense.

Cameron Brate, Tampa Bay Buccaneers @ CAR, $11

Brate stands to see a huge increase in target share with rookie tight end O.J. Howard landing on injured reserve earlier in the week. Without Howard around to steal targets from him, Brate should be on the field running pass routes for most of the game against the rival Carolina Panthers. He isn't a sure thing, but we know Jameis Winston likes to target him in the red zone. At just $1 over the minimum salary on Yahoo, Brate opens up plenty of funds to use on studs elsewhere when setting lineups.

 

Defense/Special Teams Pick for Yahoo DFS

Carolina Panthers vs. TB, $17

The Panthers are a strong play this week in a home game against a turnover-prone Jameis Winston. Tampa Bay's offense has been a huge disappointment this season. On the year, the Buccaneers have 21 giveaways, seventh-highest in the league. The Panthers are massive 10-point home favorites against a Buccaneers team that has an implied team total of 18.25 points. They are a strong play in both cash games and tournaments.

 

More Weekly DFS Analysis





REAL-TIME FANTASY NEWS

Keaton Mitchell

: Prime Dynasty Handcuff Option Entering First Season in Los Angeles
Jadarian Price

Looks Like the Running Back of the Future in Seattle
Isaiah Bond

Dynasty Outlook Clouded by Uncertain Role in Cleveland
James Cook III

Remains a High-End Dynasty RB1 Entering 2026
Lamar Jackson

Poised for Bounce Back Season in 2026
Bucky Irving

Expected to Be Ready for Training Camp
Kyle Williams

Deep Threat Kyle Williams Facing Uphill Battle for Playing Time
Michael Pittman Jr.

Could Receive Short-Term Value Uptick in PPR Leagues
Stefon Diggs

Chiefs, Commanders Could Make Sense for Stefon Diggs
Will Howard

Dynasty Value Dealt a Blow
Jaylen Warren

Should Benefit From Veteran QB's Return to Pittsburgh
Drew Allar

Could Continue to Hold Dynasty Value
Pat Freiermuth

Could See a Small Dynasty Bump With Veteran QB Returning
DK Metcalf

A Dynasty Sell Candidate With Veteran QB Returning?
Bones Hyland

Wants to Stay in Minnesota
Mike Conley

Hints He Will Continue Playing Next Season
Kevin Huerter

Iffy for Sunday Night
Caris LeVert

Questionable for Game 7
Duncan Robinson

Back on Injury Report Ahead of Game 7
Larry Nance Jr.

Likely Out Sunday Due to Illness
Munetaka Murakami

Fantastic First Season Continues With Two More Homers
Cristopher Sánchez

Cristopher Sanchez Dazzles With 13-Strikeout Complete Game on Saturday
Aaron Rodgers

Signs One-Year Deal With Steelers
Blake Snell

to Undergo Elbow Surgery on Tuesday
Clay Holmes

Could Miss Around Three Months
Jose Altuve

Exits After Swing
Corey Seager

Absent With Back Spasms on Saturday
Jeremy Lauzon

Misses Saturday's Practice
Mark Stone

Doesn't Practice Saturday
Josh Manson

Misses Practice, Considered Day-to-Day
Brent Burns

Day-to-Day Ahead of Conference Finals
Cale Makar

Considered Day-to-Day
Alex Lyon

Likely to Start Game 6 Against Canadiens
Owen Power

Available Saturday
Isaac TeSlaa

Can Isaac TeSlaa Carve Out a Larger Role in Detroit Going Forward?
Troy Franklin

Facing Uphill Battle for Playing Time in Denver
Trevor Lawrence

Should Trevor Lawrence Be Valued as a Dynasty QB1?
Courtland Sutton

in Line for Reduced Role in Denver?
KC Concepcion

Can KC Concepcion Immediately Assume the WR1 Role in Cleveland?
George Pickens

' Dynasty Outlook Clouded by Uncertain Future in Dallas
Trevor Story

Hits the Injured List With Groin Injury
Blake Snell

Likely to Need Elbow Surgery
Duncan Robinson

Nets 14 Points With Four Triples
Cade Cunningham

Contributes 21 Points in Game 6 Win
Jalen Duren

Bounces Back With Double-Double
Anthony Edwards

Finishes Season-Ending Loss With 24 Points
Victor Wembanyama

Tallies 19 Points in Friday's Win
De'Aaron Fox

Highly Effective in Blowout Win
Stephon Castle

Shines in Series-Clincher
Kyle Schwarber

on a Heater, Hits Two More Homers to Take Major-League Lead
Clay Holmes

Suffers Fractured Fibula on Friday Night
Blake Snell

Heads to 15-Day Injured List
Austin Reaves

Could Command $40M Per Year With New Contract
Jalen Duren

Available to Finish Game 6
Yanic Konan Niederhauser

Not Expected to Be Ready for Start of Next Season
Jalen Williams

Declares Himself Healthy for Conference Finals
Terrence Shannon Jr.

Will Play Friday Night
Kevin Huerter

is Available for Game 6
Duncan Robinson

is Returning for Game 6
Caris LeVert

is Cleared for Game 6 on Friday
Blake Snell

Scratched From Start on Friday for Undisclosed Reasons
Max Fried

Heading to Injured List With Elbow Bone Bruise
CFB

Julian Sayin Looking To Build Off Of Strong Debut Season
CFB

College GameDay Set for First Three Weeks
CFB

Jeremiah Smith Aiming For Ohio State Receiving Records
CFB

Keshaun Singleton Projects as Auburn's WR1
CFB

Jeremiah Cobb Impresses New Auburn Staff
CFB

Alberto Mendoza Very Likely to Start for Georgia Tech
CFB

Charles Woodson Jr. Commits to Michigan
Jordan Westburg

to Have Season-Ending Elbow Surgery
Melquizael Costa

Set For UFC Vegas 117 Main Event
Arnold Allen

A Favorite At UFC Vegas 117
Daniel Santos

Set For UFC Vegas 117 Co-Main Event
MMA

Dohoo Choi Returns At UFC Vegas 117
Juan Diaz

Set To Make His UFC Debut
Malcolm Wellmaker

Looks To Bounce Back
Christian Edwards

Set For His UFC Debut
Modestas Bukauskas

Looks To Get Back In The Win Column
Tarik Skubal

Resumes Playing Catch, Ahead of Schedule?
Lane Hutson

Contributes Two Assists in Game 5 Victory
Nick Suzuki

Amasses Three Points in Crucial Victory Thursday
Juraj Slafkovsky

Dishes Out Three Assists in Game 5 Win
Carter Hart

Stops 31 Pucks in Series-Clinching Win
Pavel Dorofeyev

Enjoys Second Consecutive Multi-Goal Game
Shea Theodore

Records Two Points in Game 6 Win
Mitchell Marner

Scores Special Goal in Series-Clincher
Ryan Johnson

Takes Over as Canucks GM, Sedins Promoted to Co-Presidents
Drew Helleson

Won't Play Thursday
Radko Gudas

Unlikely to Play Thursday
Jeremy Lauzon

Remains Out Thursday
Mark Stone

Misses Third Consecutive Game
EDM

Kris Knoblauch Fired as Oilers Head Coach
CFB

Virginia Tech Lands Commitment from Four-Star QB Peter Bourque
Byron Buxton

Scratched on Thursday With Hip Soreness
Cal Raleigh

Heading to Injured List With Oblique Strain
Francisco Alvarez

has Knee Surgery, Expected to Miss Eight Weeks
Quinn Hughes

Finishes Postseason With 15 Points
Cal Raleigh

Exits With Apparent Side Injury on Wednesday Night
Juan Soto

X-Rays Come Back Negative on Juan Soto's Ankle
Jacob Misiorowski

Pulled Early With Possible Leg Injury
CFB

NFL Veteran Tom Moore Joins Iowa Coaching Staff
CFB

Can Cam Cook Dominate in Return to Big 12?
CFB

ACC, Big 12 Support 24-Team College Football Playoff
CFB

Anthony Colandrea Looking to Elevate Nebraska Back to National Contention
CFB

Kwazi Gilmer Set for Big Impact at Nebraska
Justin Thomas

Trending Well Ahead of PGA Championship Despite Concerning Form
J.J. Spaun

Trending Up Ahead of PGA Championship
Adam Scott

Riding Strong Form Into PGA Championship
Patrick Reed

Looking to Make Another Run at PGA Championship
PGA

Sungjae Im Looks to Build on Strong Finish at Truist Championship
Sam Burns

Must Keep Ball in Play at PGA Championship
Jordan Spieth

Looks to Complete Career Grand Slam at Aronimink
Brandt Snedeker

Not the Best Option for the PGA Championship
Rasmus Hojgaard

a Volatile Option at PGA Championship
Maverick McNealy

Seeking Better Start in Philadelphia
Harry Hall

a Boom-or-Bust Option at Aronimink
Hideki Matsuyama

Attempts to Improve Over 2025 PGA Championship
Scottie Scheffler

Looks to Defend PGA Championship at Aronimink
Nicolai Hojgaard

Wants to Keep Momentum Rolling in Philadelphia
Ben Griffin

Attempting to Bounce Back After Truist Championship
CFB

Transfer Defensive Lineman Devarrick Woods Commits to Clemson
Harris English

Will Need His Putter to Thrive at Aronimink
Akshay Bhatia

Creative Flair Could Show Itself in Philadelphia
Keegan Bradley

Knows the Aronimink Golf Club Well
Si Woo Kim

Struggles at Truist Championship
Gary Woodland

Can Continue Incredible 2026 Season at PGA Championship
Xander Schauffele

In Excellent Form Heading to PGA Championship
CFB

Isaac Brown Has All-American Upside in 2026
CFB

Nyck Harbor Heading into Breakout Year?
CFB

Notre Dame, USC in Discussions to Resume Rivalry Series
CFB

Jaron-Keawe Sagapolutele Has Eyes on ACC Title
CFB

Ahmad Hardy's Gunshot Wound Not Viewed as Career-Threatening
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF