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DraftKings Lineup Picks (Week 10) - NFL DFS Advice

RotoBallers, welcome to Week 10 of the daily fantasy football season. In this column, you will find my recommended DraftKings DFS Lineup Picks to target for Week 10 of the NFL season.

The goal is to identify players to start on DraftKings this week based on various factors including the opponent, the player's opportunity, analysis of the game's matchups, and the DraftKings price.

Let's find some DFS lineup sleepers, and win on DraftKings. Good luck in Week 10!

 

DraftKings Quarterbacks - Week 10 DFS Picks

Matthew Stafford - DET vs CLE (DK $6,800)

Stafford is looking like one of the best options at quarterback this week, and coming off a big game. He played on Monday night, so his price wasn't adjusted for his performance last week. This is somewhat minor, but still and edge to be gained and we want to jump on it. Stafford has put up 300 yards or more in three straight games, and has seven touchdowns in his last four games. Really strong numbers from the highest paid quarterback. With his price and recent performance you could use him in either cash or GPPs, since he has a favorable match up. Speaking of his opponent, let's talk about the Browns! The Browns have the 28th DVOA against the pass, and simply cannot not stop the ball via the air. You want to find them every week, and target against them. Get exposure to them by either the quarterback or the receivers. The Browns are actually very good vs the run, so nearly all of the Lions offense will come from Stafford.

Ryan Fitzpatrick - TB vs NYJ (DK $4,900)

If you are looking for a cheap quarterback that has a solid match up, key in on Fitzpatrick this week. Not only is this a nice revenge game for him, going up against his former team, but the Jets have the 21st DVOA against the pass, and haven't looked strong on defense. For his price, he really only needs to put up 14.7 DraftKings points in order to reach 3x value, which is what you are looking for in cash games. Anything more than that, and will make a good tournament play. Stacking him with someone like DeSean Jackson, makes a good play since he has plenty of touchdown upside.

 

DraftKings Running Backs - Week 10 DFS Picks

LeSean McCoy - BUF vs. NO (DK $8,300)

Seems like few people are talking about McCoy this week, and might be due to the fact he had such a bad showing last Thursday night. If no one is going to be rostering him, he makes a great tournament play, since he has multi touchdown upside, along with seeing plenty of targets out of the backfield. Getting the full point PPR on DraftKings is huge for a running back, and will have plenty of chances to break the 100 yard bonus in either rushing or receiving. He is $400 cheaper than he was in the two previous weeks, and is at home against the Saints who have the 28th DVOA against the rush. The Saints defense has improved a good amount since the beginning of the season, but it was mainly their secondary. They are still weak vs the run, and with this game set to be cold with a bit of weather, the Bills should be running the ball plenty.

Carlos Hyde - SF vs NYG (DK $6,300)

Hyde is looking to be one of the stone locks this week, for multiple reasons, so let's dive in. First off, he is at home against the Giants, who have have the 28th DVOA overall, and the 26th DVOA against the rush. We all know how bad the Giants are, and they simply cannot stop really anyone on defense. They are bad against the run, bad against the pass, and most importantly, bad against running backs in the passing game. Hyde has six or more targets in four straight weeks, including nine or more in the last two. A running back getting that volume is huge, just as I mentioned with McCoy. Hyde has also seen 12 or more rushing attempts in four straight weeks. They are feeding him the ball in all aspects of the game, and with how bad the 49ers quarterback situation is, he should be in for a very busy day.

 

DraftKings Wide Receivers - Week 10 DFS Picks

Cooper Kupp - LAR vs HOU (DK $4,600)

Kupp was a bit unlucky last week with the Rams putting up so many points, yet barley seeing the ball at all. He ended with three catches on five targets for 54 yards and no touchdowns. Yes, Jared Goff, only completed 14 passes, so Kupp didn't have a ton of chances. But this week Kupp has a good match up against the Texans, who have the 16th DVOA against the pass, and the 30th DVOA against WR2. With the inconsistency Sammy Watkins has been showing, Kupp is seeing the second most targets on the team, with 47 targets in the first nine weeks. The Texans defense really isn't as good as people think, and attacking them in this spot is a good call.

A.J. Green - CIN @ TEN (DK $7,700)

Green is simply too cheap this week. A player with his skill, and his potential ceiling of points should not be under $8K. Whenever a player is in a spot like this, you want to jump all over him, since he price won't stay this low. Yes, his ownership could get a bit out of hand in GPPs, but having legit two touchdown upside for under $8K is fantastic. Last week he was ejected from the game for a fight, so his stats are a bit out of wack. Without last game, he has 46 targets in the prior five, and four touchdowns over that span. Pretty straight forward spot, don't over think it because of last week.

 

DraftKings Tight End - Week 10 DFS Pick

Kyle Rudolph - MIN @ WAS (DK $4,600)

Rudolph is one of the more consistent tight ends in the league, and is viable for any format this week. He has seven or more targets in four straight weeks, and has two touchdowns over that span. He has become one of the favorite targets for backup quarterback Case Keenum, and gets the volume any DFS player loves. Rudolph also has a very favorable match up, since he is up against the Redskins, who have the 29th DVOA against tight ends. Really like him in this spot, just getting up to his price may be hard, if you are trying to roster two top end running backs.

 

DraftKings Defense - Week 10 DFS Pick

Chicago Bears vs Green Bay Packers (DK $3,000)

Bears are going to be one of the more popular options at defense this week, and it comes with good reason. They are up against at Brett Hundley led Packers team, who as we all saw on Monday night, are very bad. The Packers are having a ton of trouble moving the ball offensively, and picking on them in fantasy is a good call. The Bears have 14 sacks over the past four weeks, along with four interceptions. They are putting pressure on the quarterback, and forcing bad decisions. They aren't too expensive, and should have a good floor of points.

 

More Week 10 DFS Analysis

 

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REAL-TIME FANTASY NEWS

Ty Johnson

Could See More Work in Week 10
Marshawn Kneeland

Cowboys Defensive End Marshawn Kneeland Passes Away
K'Andre Miller

Could Return to Action Thursday
Sean Monahan

Injured in Wednesday's Loss
Tyler Bertuzzi

Pots Third-Period Hat Trick Wednesday
Macklin Celebrini

Leads Sharks Past Kraken
Jakob Chychrun

Records Three Assists Wednesday
Alex Ovechkin

Scores 900th Career Goal
Dillon Brooks

Misses Sixth Consecutive Game
Jalen Green

on Track to Make Suns Debut Thursday
Bradley Beal

Back in Action Thursday
Kawhi Leonard

Remains Out Thursday
James Harden

Won't Play on Thursday
LeBron James

to Miss at Least Five More Games
Emari Demercado

Set to Lead Arizona Backfield in Week 10?
Cedric Tillman

Goes Through Full Practice on Wednesday
Jorge Polanco

Declines his 2026 Option to Become a Free Agent
Darius Garland

Set to Suit Up On Wednesday
Anthony Edwards

Back in Action on Wednesday Night
Nick Chubb

Unable to Practice Due to Foot Injury
Zach LaVine

Ruled Out Versus Golden State
D'Andre Swift

Says he Will Play in Week 10
Jimmy Butler III

Sidelined Versus Sacramento
Domantas Sabonis

Sidelined on Wednesday
Brandon Aiyuk

49ers "Pretty Confident" Brandon Aiyuk Will Play This Year
Adam Gaudette

Available Against Kraken
Anthony Edwards

Probable for Wednesday's Matchup With Knicks
Scott Laughton

Set for Season Debut Wednesday
Justin Brazeau

Ruled Out for Four Weeks
Tristan Jarry

Expcted to Miss Three Weeks
Quinshon Judkins

Not on the Week 10 Injury Report
Johnny Furphy

Unavailable Wednesday
Conor Garland

Returns Against Blackhawks
Puka Nacua

Should Play in Week 10
Rasmus Sandin

Back for Capitals Wednesday
Trey Benson

Not Practicing Wednesday, Cardinals Taking it Day by Day
Denton Mateychuk

Out on Wednesday
Quenton Jackson

Unavailable on Wednesday
RayJ Dennis

Probable For Wednesday
Tobias Harris

Remains Out With Ankle Injury
Walker Kessler

Out For The Season
Ka'imi Fairbairn

Not Expected To Play in Week 10
Davis Mills

C.J. Stroud Will be Out in Week 10, Davis Mills to Start
Kyler Murray

Heading to Injured Reserve
TreVeyon Henderson

on Track to Lead Backfield in Week 10?
Rico Dowdle

Dealing With Quad Injury, Officially Misses Practice
Garrett Wilson

at Practice Wednesday After Missing Last Two Games
Chris Sale

Braves Picking Up Chris Sale's 2026 Option
Ray Davis

Could Have Expanded Role in Week 10
Jayden Daniels

Commanders Still Evaluating Jayden Daniels' Elbow Injury
Brian Thomas Jr.

Not Seen at Practice on Wednesday
James Cook

to Miss Practice With Ankle/Foot Injury
Michael Thorbjornsen

Poised to Continue Hot Play in Mexico
Davis Riley

Struggling to Find Form Ahead of World Wide Technology Championship
Taylor Montgomery

Leaning on Putter at World Wide Technology Championship
Stephan Jaeger

Offers Strong Value at World Wide Technology Championship
Ben Griffin

Looks to Stay Hot at El Cardonal
Nick Dunlap

Looking to Find His Game at El Cardonal
Wyndham Clark

Searching for Consistency at El Cardonal
Michael Brennan

Aims to Extend Fairytale Start at El Cardonal
Nathan MacKinnon

Extends Point Streak to Seven Games
Akira Schmid

Posts First Shutout of the Season
Jack Roslovic

Takes Point Streak to Four Games
Wyatt Johnston

Records Three Assists Against Oilers
Trevor Zegras

Dishes Out Two Assists in Tuesday's Win
Darcy Kuemper

Shuts Out Jets With 23 Saves
Cutter Gauthier

Erupts for Four Points Against Panthers
Zach LaVine

Questionable to Face Warriors
Domantas Sabonis

Iffy for Wednesday
Austin Reaves

Considered Questionable for Wednesday
Luka Dončić

Luka Doncic Available Wednesday
Shane Bieber

Staying in Toronto for 2026
Salvador Perez

Agrees to Two-Year Extension With Royals
Gustav Nyquist

Jets Move Gustav Nyquist to Injured Reserve
Trevor Story

Opts in for Remaining Two Years on his Contract
Yu Darvish

to Miss All of 2026 Following Flexor-Tendon Surgery
Jacoby Brissett

to Start Again in Week 10
Shota Imanaga

Becomes a Free Agent
Luis Robert Jr.

White Sox Pick Up 2026 Option on Luis Robert Jr.
CFB

LJ Martin Expected to Play in Top-10 Matchup Against Texas Tech
PGA

LIV Golf Expanding To 72-Hole Format In 2026
Atlanta Braves

Braves Hire Walt Weiss as Their Next Manager
Kris Bubic

Cleared to Begin a Throwing Program
Brandon Woodruff

Declines Mutual Option for 2026
Freddy Peralta

Brewers Exercise 2026 Option on Freddy Peralta
Lucas Giolito

Declines his 2026 Player Option
J.J. Spaun

Finishes Sixth at Procore Championship
PGA

Matti Schmid Finishes Tied for 46th at Baycurrent Classic
Keith Mitchell

Finishes Tied for 10th at Baycurrent Classic
Si Woo Kim

Finishes Tied for 21st at Genesis Championship
Mackenzie Hughes

Misses The Cut at Sanderson Farms Championship
Max Greyserman

Finishes Second at Baycurrent Classic
Austin Eckroat

Finishes Tied for 56th at Baycurrent Classic
Luke Clanton

Finishes Tied for 56th at Bank of Utah Championship
Pete Alonso

Officially Opts Out of his Contract With Mets
Alex Bregman

Opts Out of his Contract With Boston
Edwin Díaz

Edwin Diaz on the Open Market This Winter
Cody Bellinger

Becomes Free Agent After Opting Out
Robert Suarez

Opts Out, Becomes Free Agent
Kyle Larson

Wins His Second NASCAR Cup Series Championship at Phoenix
Ryan Blaney

Concludes the 2025 Season with A Win at Phoenix
William Byron

Strong Championship Effort Ends With Late-Race Flat-Tire Crash
Denny Hamlin

Overtime Four-Tire Call Costs Denny Hamlin the Championship
Chase Briscoe

Championship Bid Never Really Started After Two Tire Failures
Brad Keselowski

Nearly Steals Phoenix Race
David Onama

Suffers First-Round TKO Loss
Steve Garcia

Scores First-Round TKO Win
Ante Delija

Suffers His First UFC Loss
CFB

Dylan Raiola Suffers Season-Ending Injury
Waldo Cortes-Acosta

Gets Knockout Win
Themba Gorimbo

Drops Decision At UFC Vegas 110
Jeremiah Wells

Gets Back In The Win Column
Yadier del Valle

Remains Undefeated
Isaac Dulgarian

Cut By UFC Following Submission Loss
Daniel Frunza

Still Winless In The UFC
Charles Radtke

Dominates Daniel Frunza
Allan Nascimento

Gets Submission Win
Cody Durden

Suffers Second-Round Submission Loss
Max Scherzer

Doesn't Plan on Retiring
Michael King

Becomes Free Agent After Declining Mutual Option
Austin Cindric

is A Driver to Avoid for Phoenix DFS Lineups
Yoshinobu Yamamoto

Named World Series MVP
Alex Bowman

Could Alex Bowman be A Sneaky Tournament Play for Phoenix?
Noah Gragson

Should DFS Players Roster Noah Gragson At Phoenix?
Erik Jones

Is Erik Jones Worth Rostering for DFS at Phoenix?
Michael McDowell

an Easy Recommendation for DFS at Phoenix
Chase Briscoe

Probably Won't Win the Title
Joey Logano

Could Play Spoiler in Championship Battle at Phoenix
Tyler Reddick

Seeking to End Winless Drought, but Probably Won't Have the Speed
NASCAR

Bubba Wallace Looks to Protect Top-10 Points Finish at Phoenix
Brad Keselowski

Hasn't Been Fast at Phoenix With RFK Racing
Daniel Suarez

With Nothing at Stake, Expect Little From Daniel Suarez
Kyle Busch

Qualifies Well, but Will Probably Finish Worse Than he Starts
Chris Buescher

Ryan Preece has a Shot to Overtake Chris Buescher as RFK Racing's Lead Driver
Austin Dillon

Looks to Avoid Finishing Last in NASCAR Playoffs
AJ Allmendinger

A.J. Allmendinger Might be a Worthy DFS Option
David Onama

Set For UFC Vegas 110 Main Event
Steve Garcia

Returns At UFC Vegas 110
Waldo Cortes-Acosta

Set For Co-Main Event
Ante Delija

In Search For His Second UFC Win
Themba Gorimbo

A Favorite At UFC Vegas 110
Jeremiah Wells

Looks To Return To The Win Column

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