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Daily Fantasy Baseball Lineup Picks (9/21/17): MLB DFS Advice for FanDuel and DraftKings

Daniel Marcus' top daily fantasy baseball lineup picks for 9/21/17. Expert MLB DFS advice, sleepers & player recommendations for FanDuel and DraftKings.

The Thursday slate is once again dominated by the main slate, so those are the only games that will be highlighted in this article. Pitching is reasonably priced on the slate, making it possible to pay up at some spots with hitters while also having the chance to roster your favorite of the top tier of pitchers taking the mound.

In this article, I will be providing you with my daily fantasy baseball lineup picks for DraftKings and FanDuel on 9/21/17. The lineup picks will range from some of the elite players to mid-priced options and value plays. Let's get to it, shall we?

If you have any questions or comments, feel free to hit me up on Twitter @DanMarcus3.

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DFS Starting Pitchers to Consider

James Paxton vs. TEX (DK- $7,400, FD- $8,400)

Paxton had a rough outing against Houston in his first start back from injury, though he did stay in long enough to throw 50 pitches. That bodes well for him pitching fairly deep into his start tonight against the Rangers in what is a mediocre matchup. Though the Rangers have the reputation of being a hard-hitting offense, especially as the weather warms up, they have a 93 wRC+ over the past 30 days as a team and have just a 94 wRC+ against lefties for the season. Paxton is preferable in tournaments, but his price on DK is also appealing enough to take a chance on him in all formats.

Jake Arrieta, @ MIL (DK - $8,100, FD - $9,600)

Much like Paxton, Arrieta will be coming back from a few missed starts with the last time we saw him on the hill being quite unimpressive. However, the time off should be reason for optimism and he should be available to pitch fairly deep into the game. The matchup is not as worrisome as it would have been earlier in the season, however, as the Brewers have just an 82 wRC+ over the past 30 days.

 

DFS Infielders to Consider

Welington Castillo - C, vs. TAM (DK - $3,300, FD - $2,900)

Matt Andriese has struggled since returning from injury, as he has allowed 2.57 home runs per nine innings over his 14 innings post All-Star Break. That’s not an ideal sample size, but combined with Castillo’s torrid second-half and reasonable price, this is a good spot on Thursday.

Wil Myers - 1B, vs. COL (DK - $3,700, FD - $4,100)

In somewhat shocking splits, Tyler Anderson has allowed 2.54 HR per nine innings away from Coors field this season over 39 innings. Myers, too, has odd splits as he has been worse at home over the course of the season. However, he has also been tearing the cover off the ball to the tune of a .432 wOBA this month so his home splits are worth setting aside for the night.

Ian Kinsler - 2B, vs.  MIN (DK - $4,300, FD - $3,400)

Kinsler has had a disappointing season overall, but now is the time to jump on his bandwagon for daily fantasy. His six home runs on the month is already his best for the season. He has still managed just a .208 batting average, so he is an all or nothing proposition best suited for a tournament. He's got everything going for him on Thursday though, as he draws left-hander Adalberto Mejia and Kinsler has a 138 wRC+ on the season against lefties.

Josh Donaldson - 3B, vs. KC (DK - $5,500, FD - $4,100)

Donaldson has been on a tear of late, and that shows with his price tag. However, his production speaks for itself and makes him a great building block for the Thursday slate. His matchup is also a strong positive, as Jason Vargas has allowed 2.25 home runs per nine innings or higher every month since June.

Trevor Story - SS, @ SDP (DK - $3,900, FD - $3,400)

This is the slate for unexpected splits, as Trevor Story has been better on the road as measured by most advanced metrics. He has also absolutely torched lefties to the tune of a 168 wRC+ for the season, putting him in good position to produce in a matchup against Clayton Richard tonight.

 

DFS Outfielders to Consider

Randal Grichuk- OF, @ CIN (DK - $3,400, FD - $2,600)

Homer Bailey has been ineffective in nearly every split situation, but things get especially messy for him at home and against righties. Grichuk will have both of those factors working in his favor tonight, which makes him a nice option for salary relief on both sites in what should be a hitter friendly game.

Robbie Grossman - OF, @ DET (DK - $3,200, FD - $2,800)

The knock on Grossman all season has been his lack of power, but he has been able to take advantage of the influx of poor pitching. That said, his ISO in September is .316, well over double that of his season long mark. His price hasn’t adjusted for the uptick in production, making him a nice play late in the season.

Josh Reddick - OF,  vs. CHW (DK - $4,100, FD - $3,600)

Reddick hasn’t gotten the credit he deserves for a very strong season. He doesn’t have great pop as evidenced by his 13 home runs on the season, but a .608 slugging percentage in September shows that he has enough power in his bat to be a fantasy asset. Carson Fulmer has pitched well in his first three starts, but a good lineup like the Astros should still be able to take advantage of his inexperience.

 

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REAL-TIME FANTASY NEWS

Jackson Holliday

Orioles Reinstate Jackson Holliday From Injured List on Monday
Ronald Acuña Jr.

Braves Reinstate Ronald Acuna Jr. From Injured List on Monday
Jose Altuve

Astros Put Jose Altuve on Injured List With Oblique Strain
Larry Nance Jr.

is Questionable for Game 1 on Tuesday
OG Anunoby

is Probable for Tuesday's Game 1
Luke Kornet

is Cleared for Game 1
New Orleans Pelicans

Jamahl Mosley Agrees to Become Pelicans Next Head Coach
De'Aaron Fox

is Ruled Out for Game 1 on Monday
Ukko-Pekka Luukkonen

Set to Start Game 7
Corey Seager

Going on Injured List With Back Injury
Tage Thompson

Can Match Franchise Record With Another Multi-Point Game
Nick Suzuki

Seeks More Road Success Monday
Lane Hutson

Riding a Five-Game Assist Streak Into Game 7
Filip Gustavsson

Needs Offseason Surgery
Jeremy Peña

Jeremy Pena Reinstated and Starting on Monday Against Twins
Cam Skattebo

Dynasty Stock Rising Following NFL Draft
Kaleb Johnson

Logging First-Team Reps in OTAs
Evan Engram

Dynasty Value Fading After Production Decline in 2025
TreVeyon Henderson

Dynasty Outlook Clouded By Split Backfield in New England
Caleb Williams

' Dynasty Upside Remains Sky-High Entering 2026
Bijan Robinson

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Woody Marks

Should Have Plenty of Opportunities to Catch Passes
Drew Allar

Working as QB4 in First OTA Session
Aaron Rodgers

Reports to Steelers Facilities on Monday
Alvin Kamara

Saints Remain Non-Committal on Alvin Kamara's Future
Chris Olave

Saints Continue to Work on Extension With Chris Olave
Parker Washington

a Sneaky Trade Target in Dynasty Leagues?
Melquizael Costa

Drops Decision At UFC Vegas 117
Jarquez Hunter

Can Jarquez Hunter's Dynasty Outlook Improve in Year 2?
Arnold Allen

Bounces Back
James Conner

Off the Dynasty Radar Entirely?
Elijah Arroyo

Will Elijah Arroyo Continue to Have Trouble Getting on the Field?
Daniel Santos

Suffers Second-Round TKO Loss
Tre Tucker

Not a Long-Term Solution in Dynasty Leagues
MMA

Dohoo Choi Wins His Third Consecutive Fight
Malcolm Wellmaker

Suffers His Second Loss In A Row
Juan Diaz

Scores Second-Round Submission
Christian Edwards

Defeated At UFC Vegas 117
CFB

Transfer Running Back Arnold Barnes Visiting Iowa State on Monday
Modestas Bukauskas

Gets Split-Decision Win
Jack Bech

a Dynasty Hold as New-Look Raiders Offense Takes Shape
Jaydon Blue

a Low-Value Dynasty Stash Until Depth Charts are Settled
Makai Lemon

a Top-Five Pick in Dynasty Rookie Drafts
George Kittle

a Dynasty Buy with League-Winning Potential
Jhostynxon Garcia

Expected to Join the Pirates on Tuesday
Chris Rodriguez Jr.

a Dynasty Sleeper with High Touchdown Potential
Tobias Harris

Goes Cold in Game 7 Loss
Quinn Hughes

Open to Signing Extension This Offseason
Jalen Duren

Finishes Game 7 with Quiet Line
Cade Cunningham

Endures Cold Shooting Night Sunday
Joel Eriksson Ek

Misses Second Round Due to Heel Injury
Sam Merrill

Catches Fire in Game 7 Win
Evan Mobley

Posts Versatile Double-Double in Game 7
Jonas Brodin

Sits Out Round 2 Due to Toe Injury
Donovan Mitchell

Guides Cavaliers Into East Finals
Sam Malinski

Practices Fully Sunday
Jarrett Allen

Scores 23 Points in Cavs' Game 7 Rout of Pistons
Josh Manson

Rejoins Practice
Kevin Huerter

Active on Sunday Night
Caris LeVert

Duncan Robinson, Caris LeVert Available Sunday
Dean Wade

Max Strus Replaces Dean Wade in Starting Lineup Sunday
Luke Kornet

Iffy for Monday
Larry Nance Jr.

Won't Play Sunday
De'Aaron Fox

Listed as Questionable for Monday's Action
Jalen Williams

Officially Available for Game 1 Against Spurs
Shai Gilgeous-Alexander

Named MVP for Second Straight Year
Colt Emerson

Mariners Promoting Top Prospect Colt Emerson to Major Leagues
Bones Hyland

Wants to Stay in Minnesota
Munetaka Murakami

Fantastic First Season Continues With Two More Homers
Cristopher Sánchez

Cristopher Sanchez Dazzles With 13-Strikeout Complete Game on Saturday
Blake Snell

to Undergo Elbow Surgery on Tuesday
Clay Holmes

Could Miss Around Three Months
Jose Altuve

Exits After Swing
Corey Seager

Absent With Back Spasms on Saturday
Jeremy Lauzon

Misses Saturday's Practice
Mark Stone

Doesn't Practice Saturday
Josh Manson

Misses Practice, Considered Day-to-Day
Brent Burns

Day-to-Day Ahead of Conference Finals
Cale Makar

Considered Day-to-Day
Alex Lyon

Likely to Start Game 6 Against Canadiens
Owen Power

Available Saturday
Trevor Story

Hits the Injured List With Groin Injury
Blake Snell

Likely to Need Elbow Surgery
Kyle Schwarber

on a Heater, Hits Two More Homers to Take Major-League Lead
Clay Holmes

Suffers Fractured Fibula on Friday Night
Blake Snell

Heads to 15-Day Injured List
Blake Snell

Scratched From Start on Friday for Undisclosed Reasons
Max Fried

Heading to Injured List With Elbow Bone Bruise
CFB

Julian Sayin Looking To Build Off Of Strong Debut Season
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College GameDay Set for First Three Weeks
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Jeremiah Smith Aiming For Ohio State Receiving Records
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Keshaun Singleton Projects as Auburn's WR1
CFB

Jeremiah Cobb Impresses New Auburn Staff
CFB

Alberto Mendoza Very Likely to Start for Georgia Tech
CFB

Charles Woodson Jr. Commits to Michigan
Jordan Westburg

to Have Season-Ending Elbow Surgery
Melquizael Costa

Set For UFC Vegas 117 Main Event
Arnold Allen

A Favorite At UFC Vegas 117
Daniel Santos

Set For UFC Vegas 117 Co-Main Event
MMA

Dohoo Choi Returns At UFC Vegas 117
Juan Diaz

Set To Make His UFC Debut
Malcolm Wellmaker

Looks To Bounce Back
Christian Edwards

Set For His UFC Debut
Modestas Bukauskas

Looks To Get Back In The Win Column
Lane Hutson

Contributes Two Assists in Game 5 Victory
Nick Suzuki

Amasses Three Points in Crucial Victory Thursday
Juraj Slafkovsky

Dishes Out Three Assists in Game 5 Win
Carter Hart

Stops 31 Pucks in Series-Clinching Win
CFB

Virginia Tech Lands Commitment from Four-Star QB Peter Bourque
CFB

NFL Veteran Tom Moore Joins Iowa Coaching Staff
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Can Cam Cook Dominate in Return to Big 12?
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ACC, Big 12 Support 24-Team College Football Playoff
CFB

Anthony Colandrea Looking to Elevate Nebraska Back to National Contention
CFB

Kwazi Gilmer Set for Big Impact at Nebraska
Justin Thomas

Trending Well Ahead of PGA Championship Despite Concerning Form
J.J. Spaun

Trending Up Ahead of PGA Championship
Adam Scott

Riding Strong Form Into PGA Championship
Patrick Reed

Looking to Make Another Run at PGA Championship
PGA

Sungjae Im Looks to Build on Strong Finish at Truist Championship
Sam Burns

Must Keep Ball in Play at PGA Championship
Jordan Spieth

Looks to Complete Career Grand Slam at Aronimink
Brandt Snedeker

Not the Best Option for the PGA Championship
Rasmus Hojgaard

a Volatile Option at PGA Championship
Maverick McNealy

Seeking Better Start in Philadelphia
Harry Hall

a Boom-or-Bust Option at Aronimink
Hideki Matsuyama

Attempts to Improve Over 2025 PGA Championship
Scottie Scheffler

Looks to Defend PGA Championship at Aronimink
Nicolai Hojgaard

Wants to Keep Momentum Rolling in Philadelphia
Ben Griffin

Attempting to Bounce Back After Truist Championship
CFB

Transfer Defensive Lineman Devarrick Woods Commits to Clemson
Harris English

Will Need His Putter to Thrive at Aronimink
Akshay Bhatia

Creative Flair Could Show Itself in Philadelphia
Keegan Bradley

Knows the Aronimink Golf Club Well
Si Woo Kim

Struggles at Truist Championship
Gary Woodland

Can Continue Incredible 2026 Season at PGA Championship
Xander Schauffele

In Excellent Form Heading to PGA Championship
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF