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Who Should I Start for Week 16? Fantasy Football outlooks for Brian Thomas Jr., Omarion Hampton, Alec Pierce, Tetairoa McMillan, Tee Higgins, Xavier Worthy, Jameson Williams, Keenan Allen, Kareem Hunt.
Who Should I Start? Who Should I Sit? Some of the most common Week 16 fantasy football lineup decisions involve players like Brian Thomas Jr., Omarion Hampton, Alec Pierce, Tetairoa McMillan, Tee Higgins, Xavier Worthy, Jameson Williams, Keenan Allen, Kareem Hunt. However, don't worry, we are here to help you make these decisions and build winning lineups in Week 16. Set your optimal fantasy football lineups for Week 16 of the 2025 NFL season. Our free Who Should I Start? tool will help make your fantasy football lineup decisions. Compare up to four NFL players, and we tell you who to start... all free! Get your winning lineups set, and make the right decisions.
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Fantasy Football Matchup Outlooks
Below are some fantasy football outlooks written by our NFL team here at RotoBaller, bringing you their fantasy football analysis and advice on which players to consider starting in Week 16:
Brian Thomas Jr., WR, Jacksonville Jaguars
Though this has been an undoubtedly frustrating season for Brian Thomas Jr., the Jacksonville Jaguars wide receiver is coming off back-to-back solid performances as his team has ascended to the top of the AFC South. The second-year player, ranked as the No. 44 overall PPR receiver, is certainly in the conversation for the biggest fantasy disappointment of the season relative to draft position.
However, managers who weathered modest outputs and an injury may have a light at the end of the tunnel, as Thomas has looked more like his rookie self with 13 targets, 7 catches, 153 yards, and a touchdown during the past two weeks. The Jags have a tough Week 16 matchup against a Denver Broncos defense that ranks ninth against PPR receivers, but Jacksonville and quarterback Trevor Lawrence are on such a hot streak that Thomas should carry WR3/flex consideration for managers deep in the playoffs.
Omarion Hampton, RB, Los Angeles Chargers
However, managers who weathered modest outputs and an injury may have a light at the end of the tunnel, as Thomas has looked more like his rookie self with 13 targets, 7 catches, 153 yards, and a touchdown during the past two weeks. The Jags have a tough Week 16 matchup against a Denver Broncos defense that ranks ninth against PPR receivers, but Jacksonville and quarterback Trevor Lawrence are on such a hot streak that Thomas should carry WR3/flex consideration for managers deep in the playoffs.
Omarion Hampton, RB, Los Angeles Chargers
Los Angeles Chargers running back Omarion Hampton is beginning to assert himself in the backfield, leading the team with 15 carries and 54% of the rushing attempts last week. Even though Kimani Vidal ran the majority of routes and handled 100% of the two-minute offense, Hampton looked more explosive, averaging 4.1 yards per carry compared to Vidal's 2.8 against the Kansas City Chiefs. The Week 16 matchup against the Dallas Cowboys is promising, as Dallas is tied for second in rushing touchdowns allowed.
However, star defensive tackle Quinnen Williams (concussion) is off the injury report and is expected to play, adding an extra challenge for the backfield. As Hampton moves further away from his IR stint, his role in this run-heavy scheme could grow. RotoBaller projects him as the RB23 this week. He is a high-upside RB2 who could deliver a big performance if he maintains the lead in carries.
Alec Pierce, WR, Indianapolis Colts
However, star defensive tackle Quinnen Williams (concussion) is off the injury report and is expected to play, adding an extra challenge for the backfield. As Hampton moves further away from his IR stint, his role in this run-heavy scheme could grow. RotoBaller projects him as the RB23 this week. He is a high-upside RB2 who could deliver a big performance if he maintains the lead in carries.
Alec Pierce, WR, Indianapolis Colts
Indianapolis Colts wide receiver Alec Pierce caught his only target for 16 yards in the 18-16 loss to the Seattle Seahawks. Last week marked the first game Pierce has played without Daniel Jones, who tore his Achilles in Week 14. His connection with Jones was exceptional, as Pierce was having the best season of his career before the injury.
Now, 44-year-old Philip Rivers is the starting quarterback for the Colts, and his showing against the Seahawks didn't offer any relief for Pierce and his fantasy outlook. Rivers averaged 4.4 yards per attempt and only had two completions over 10 yards last week. Not ideal for Pierce, who currently leads the NFL in yards per completion this season. The fourth-year receiver is better left on the bench than in starting lineups this week, as he looks to overcome the lack of deep-passing ability that Rivers has.
Now, 44-year-old Philip Rivers is the starting quarterback for the Colts, and his showing against the Seahawks didn't offer any relief for Pierce and his fantasy outlook. Rivers averaged 4.4 yards per attempt and only had two completions over 10 yards last week. Not ideal for Pierce, who currently leads the NFL in yards per completion this season. The fourth-year receiver is better left on the bench than in starting lineups this week, as he looks to overcome the lack of deep-passing ability that Rivers has.
Tetairoa McMillan, WR, Carolina Panthers
Tetairoa McMillan will play in Week 16 after missing practices earlier in the week due to foot/ankle concerns. Last week against the Saints, McMillan had two receptions for 25 yards and finished with 4.5 PPR points, his lowest total this season. It was the third straight game in which McMillan had fewer than three receptions, and it was also the first time he did not catch a touchdown pass since Week 10. In Week 16, the Panthers will face the Tampa Bay Buccaneers.
Tampa Bay ranks 17th in Fantasy Points Per Game allowed to the WR position in 2025. McMillan has been Carolina's top overall receiver for the year, averaging 12.9 PPR points per game, but has been unreliable in recent weeks. The Carolina rookie has logged less than 12 PPR points in five of his last six starts, including each of his last three. This is a very crucial game for Carolina in the NFC South race this week, so McMillan should provide double-figure PPR totals, but he is certainly not an upside play.
Tee Higgins, WR, Cincinnati Bengals
Tampa Bay ranks 17th in Fantasy Points Per Game allowed to the WR position in 2025. McMillan has been Carolina's top overall receiver for the year, averaging 12.9 PPR points per game, but has been unreliable in recent weeks. The Carolina rookie has logged less than 12 PPR points in five of his last six starts, including each of his last three. This is a very crucial game for Carolina in the NFC South race this week, so McMillan should provide double-figure PPR totals, but he is certainly not an upside play.
Tee Higgins, WR, Cincinnati Bengals
Cincinnati Bengals wide receiver Tee Higgins (concussion) will be questionable for Sunday's game against the Miami Dolphins in Week 16, according to Mike Petraglia. Higgins was limited in practices on Wednesday and Thursday and still has one more hurdle to clear to pass through the league's concussion protocol. For context, the 26-year-old wideout has had two concussions in the last several weeks, and the Bengals could be extra hesitant to throw him back out there now that they've been eliminated from the playoffs.
Higgins' first concussion occurred late in the Week 12 loss to the New England Patriots, and he experienced more concussion symptoms following the Week 14 loss to the Buffalo Bills. He's missed two of the last three games and could miss another contest this Sunday. When active, Higgins is a must-start in fantasy with a 46-667-9 line on 81 targets this year.
Jameson Williams, Detroit Lions
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Higgins' first concussion occurred late in the Week 12 loss to the New England Patriots, and he experienced more concussion symptoms following the Week 14 loss to the Buffalo Bills. He's missed two of the last three games and could miss another contest this Sunday. When active, Higgins is a must-start in fantasy with a 46-667-9 line on 81 targets this year.
Jameson Williams, Detroit Lions
After a slow start to the 2025 season, Detroit Lions wide receiver Jameson Williams has exploded over the second half of the year. Across his last seven games, the 24-year-old has recorded 647 receiving yards and five touchdown catches. After earning more than seven targets just once over the season's first 12 weeks, he's been targeted by Lions quarterback Jared Goff at least nine times in three straight games.
Williams could have a chance to continue his emergence in Week 16 against the Pittsburgh Steelers, who profile as a favorable matchup on paper. Entering the week, Pittsburgh ranks 29th in the NFL in total receiving yards allowed (3,649). With Lions tight end Sam LaPorta (back) on Injured Reserve, Williams has emerged as the team's clear number two option in the passing game alongside wideout Amon-Ra St. Brown. Williams profiles as a low-end fantasy WR1 with high-end upside in Week 16.
Williams could have a chance to continue his emergence in Week 16 against the Pittsburgh Steelers, who profile as a favorable matchup on paper. Entering the week, Pittsburgh ranks 29th in the NFL in total receiving yards allowed (3,649). With Lions tight end Sam LaPorta (back) on Injured Reserve, Williams has emerged as the team's clear number two option in the passing game alongside wideout Amon-Ra St. Brown. Williams profiles as a low-end fantasy WR1 with high-end upside in Week 16.
Who Should I Start Tool
You can also see the Who Should I Start tool here.
Week 16 Player Decisions. Today's focus is on specific players - Brian Thomas Jr., Omarion Hampton, Alec Pierce, Tetairoa McMillan, Tee Higgins, Xavier Worthy, Jameson Williams, Keenan Allen, Kareem Hunt. These are some of the most common searches for fantasy football lineups in Week 16.
Using The Tool. This is a simple tool but very powerful. The first step is to enter the player names that you want to compare. In the first box, search for the first player name. In the second box, search for the second player name. Compare up to four NFL players at once, and then click the Who To Start? button to see who the recommended starts are based on weekly fantasy football matchups.
Improvements For Who Should I Start? You may have noticed that our 'Who Should I Start?' tool has gotten an overhaul. We've added lots of great features for you to give you as much information as possible to win your fantasy football matchups each week. You'll see NFL player tiles with headshots and bye weeks, stats, projections, strength of schedule, players news, and enhanced search results with data to compare with a slick new interface. We hope you enjoy!
How It Works. Each week our RotoBaller staff puts together their weekly fantasy football rankings and projections based on their research. That information is the core data that is powering the decision-making in this tool. When you search for player names, you will only see those players who are ranked. If someone is out for the week, they will not appear in the search results.
Scoring Formats. Fantasy football managers play in various types of leagues, and this tool allows you to choose whether it's PPR scoring, Half-PPR scoring, or Standard (Non-PPR) scoring. The second thing you want to do, is to select the scoring format. There are three small radio buttons (small circle), so click on the scoring format you prefer. The results may vary based on the scoring format you select.
Popular Week 16 Searches. Curious to see some tough lineup decisions for Week 16 (2025)? Below you will find a list of some popular Who Should I Start? searches that RotoBaller readers are looking at this week. Click any of the links to see the result and recommendation.
Popular Week 16 Searches - Start/Sit Player Comparisons
Below are some popular searches and comparisons from our Who To Start tool for Week 16 for Brian Thomas Jr., Omarion Hampton, Alec Pierce, Tetairoa McMillan, Tee Higgins, Xavier Worthy, Jameson Williams, Keenan Allen, Kareem Hunt:
Brian Thomas Jr.
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Tony Pollard
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Caleb Williams
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Jaylen Warren
Brian Thomas Jr.
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Michael Wilson
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Brian Thomas Jr.
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Marvin Harrison Jr.
Brian Thomas Jr.
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Christian Watson
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Brian Thomas Jr.
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CeeDee Lamb
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Amon-Ra St. Brown
Brian Thomas Jr.
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Justin Jefferson
Brian Thomas Jr.
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Drake London
Brian Thomas Jr.
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Malik Nabers
Brian Thomas Jr.
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Rashee Rice
Brian Thomas Jr.
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George Pickens
Brian Thomas Jr.
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Nico Collins
Omarion Hampton
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Derrick Henry
Omarion Hampton
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George Pickens
Omarion Hampton
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Rashee Rice
Omarion Hampton
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Chase Brown
Omarion Hampton
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Trey McBride
Omarion Hampton
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Nico Collins
Omarion Hampton
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Kenneth Walker III
Omarion Hampton
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Brock Bowers
Omarion Hampton
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Ashton Jeanty
Omarion Hampton
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Omarion Hampton
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Omarion Hampton
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Omarion Hampton
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Omarion Hampton
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Omarion Hampton
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Omarion Hampton
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Omarion Hampton
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Justin Jefferson
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Tee Higgins
Omarion Hampton
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Amon-Ra St. Brown
Omarion Hampton
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Tetairoa McMillan
Omarion Hampton
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Jonathan Taylor
Omarion Hampton
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A.J. Brown
Omarion Hampton
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Jahmyr Gibbs
Omarion Hampton
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Bijan Robinson
Omarion Hampton
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Christian McCaffrey
Omarion Hampton
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Omarion Hampton
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Breece Hall
Omarion Hampton
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Omarion Hampton
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Omarion Hampton
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Cam Skattebo
Omarion Hampton
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Omarion Hampton
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Omarion Hampton
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TreVeyon Henderson
Alec Pierce
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Alec Pierce
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Jordyn Tyson
Alec Pierce
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Courtland Sutton
Alec Pierce
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Tyler Warren
Alec Pierce
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Alec Pierce
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Alec Pierce
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David Montgomery
Alec Pierce
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Christian Watson
Alec Pierce
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Alec Pierce
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Chuba Hubbard
Alec Pierce
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Alec Pierce
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Alec Pierce
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Alec Pierce
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Alec Pierce
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Alec Pierce
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Alec Pierce
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Alec Pierce
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Alec Pierce
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Alec Pierce
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Alec Pierce
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Alec Pierce
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Alec Pierce
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Alec Pierce
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Alec Pierce
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Alec Pierce
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Rome Odunze
Alec Pierce
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Alec Pierce
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Alec Pierce
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Alec Pierce
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Alec Pierce
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Alec Pierce
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Alec Pierce
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Alec Pierce
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Malik Nabers
Alec Pierce
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Rashee Rice
Alec Pierce
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George Pickens
Alec Pierce
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Nico Collins
Tetairoa McMillan
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Tee Higgins
Tetairoa McMillan
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A.J. Brown
Tetairoa McMillan
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Devonta Smith
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Tetairoa McMillan
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Josh Allen
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Garrett Wilson
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Kyren Williams
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Davante Adams
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Josh Jacobs
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Brock Bowers
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Javonte Williams
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Nico Collins
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Ladd McConkey
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George Pickens
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Omarion Hampton
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Ja'Marr Chase
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CeeDee Lamb
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Amon-Ra St. Brown
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Justin Jefferson
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Malik Nabers
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Rashee Rice
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Jaylen Waddle
Tee Higgins
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Nico Collins
Tee Higgins
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Tee Higgins
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Chase Brown
Tee Higgins
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Tee Higgins
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Bucky Irving
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Omarion Hampton
Tee Higgins
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Tee Higgins
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Rashee Rice
Tee Higgins
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Jameson Williams
Tee Higgins
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Tee Higgins
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CeeDee Lamb
Tee Higgins
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Justin Jefferson
Tee Higgins
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Drake London
Tee Higgins
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Malik Nabers
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Tee Higgins
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Jaylen Waddle
Tee Higgins
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Mike Evans
Xavier Worthy
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Baker Mayfield
Xavier Worthy
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Matthew Golden
Xavier Worthy
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Khalil Shakir
Xavier Worthy
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Jacory Croskey-Merritt
Xavier Worthy
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Jake Ferguson
Xavier Worthy
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Travis Kelce
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Jalen Coker
Xavier Worthy
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Malik Willis
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George Kittle
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Romeo Doubs
Xavier Worthy
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Oronde Gadsden II
Xavier Worthy
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Tyler Shough
Xavier Worthy
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KC Concepcion
Xavier Worthy
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Jayden Higgins
Xavier Worthy
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Dallas Goedert
Xavier Worthy
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Kenneth Gainwell
Xavier Worthy
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Jared Goff
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Jalen McMillan
Xavier Worthy
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Jordan Love
Xavier Worthy
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Sam Darnold
Xavier Worthy
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Chris Rodriguez Jr.
Xavier Worthy
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Dalton Kincaid
Xavier Worthy
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Kenyon Sadiq
Xavier Worthy
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Kyler Murray
Xavier Worthy
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C.J. Stroud
Xavier Worthy
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Puka Nacua
Xavier Worthy
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Ja'Marr Chase
Xavier Worthy
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Jaxon Smith-Njigba
Xavier Worthy
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CeeDee Lamb
Xavier Worthy
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Amon-Ra St. Brown
Xavier Worthy
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Justin Jefferson
Xavier Worthy
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Drake London
Xavier Worthy
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Malik Nabers
Xavier Worthy
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Rashee Rice
Xavier Worthy
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George Pickens
Xavier Worthy
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Nico Collins
Jameson Williams
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Terry Mclaurin
Jameson Williams
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Colston Loveland
Jameson Williams
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Jameson Williams
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Lamar Jackson
Jameson Williams
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Bucky Irving
Jameson Williams
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Jameson Williams
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Javonte Williams
Jameson Williams
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Cam Skattebo
Jameson Williams
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Luther Burden III
Jameson Williams
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Jaylen Waddle
Jameson Williams
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Breece Hall
Jameson Williams
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Mike Evans
Jameson Williams
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Zay Flowers
Jameson Williams
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Jameson Williams
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Davante Adams
Jameson Williams
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DJ Moore
Jameson Williams
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Garrett Wilson
Jameson Williams
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Bhayshul Tuten
Jameson Williams
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Travis Etienne Jr.
Jameson Williams
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TreVeyon Henderson
Jameson Williams
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A.J. Brown
Jameson Williams
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Jayden Daniels
Jameson Williams
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Tetairoa McMillan
Jameson Williams
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Quinshon Judkins
Jameson Williams
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Tee Higgins
Jameson Williams
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Jadarian Price
Jameson Williams
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Puka Nacua
Jameson Williams
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Ja'Marr Chase
Jameson Williams
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Jaxon Smith-Njigba
Jameson Williams
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CeeDee Lamb
Jameson Williams
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Amon-Ra St. Brown
Jameson Williams
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Justin Jefferson
Jameson Williams
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Drake London
Jameson Williams
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Malik Nabers
Jameson Williams
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Rashee Rice
Jameson Williams
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George Pickens
Jameson Williams
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Nico Collins
Keenan Allen
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Rashod Bateman
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Troy Franklin
Keenan Allen
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Dontayvion Wicks
Keenan Allen
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Devaughn Vele
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Los Angeles Rams
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Keenan Allen
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Mike Washington Jr.
Keenan Allen
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Jason Myers
Keenan Allen
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Ka'imi Fairbairn
Keenan Allen
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Christian Kirk
Keenan Allen
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Malachi Fields
Keenan Allen
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Ja'Kobi Lane
Keenan Allen
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Jaylin Noel
Keenan Allen
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AJ Barner
Keenan Allen
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Sean Tucker
Keenan Allen
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Zachariah Branch
Keenan Allen
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Zach Charbonnet
Keenan Allen
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Eli Stowers
Keenan Allen
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Tank Dell
Keenan Allen
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Darnell Mooney
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Jordan James
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Tre Harris
Keenan Allen
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Alvin Kamara
Keenan Allen
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Colby Parkinson
Keenan Allen
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Pat Bryant
Keenan Allen
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Mike Gesicki
Keenan Allen
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Puka Nacua
Keenan Allen
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Ja'Marr Chase
Keenan Allen
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Jaxon Smith-Njigba
Keenan Allen
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CeeDee Lamb
Keenan Allen
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Amon-Ra St. Brown
Keenan Allen
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Justin Jefferson
Keenan Allen
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Drake London
Keenan Allen
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Malik Nabers
Keenan Allen
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Rashee Rice
Keenan Allen
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George Pickens
Keenan Allen
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Nico Collins
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