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Who Should I Start for Week 16? Fantasy Football outlooks for Brian Thomas Jr., Omarion Hampton, Alec Pierce, Tetairoa McMillan, Tee Higgins, Xavier Worthy, Jameson Williams, Keenan Allen, Kareem Hunt.
Who Should I Start? Who Should I Sit? Some of the most common Week 16 fantasy football lineup decisions involve players like Brian Thomas Jr., Omarion Hampton, Alec Pierce, Tetairoa McMillan, Tee Higgins, Xavier Worthy, Jameson Williams, Keenan Allen, Kareem Hunt. However, don't worry, we are here to help you make these decisions and build winning lineups in Week 16. Set your optimal fantasy football lineups for Week 16 of the 2025 NFL season. Our free Who Should I Start? tool will help make your fantasy football lineup decisions. Compare up to four NFL players, and we tell you who to start... all free! Get your winning lineups set, and make the right decisions.
Who Should I Start for 16?
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Fantasy Football Matchup Outlooks
Below are some fantasy football outlooks written by our NFL team here at RotoBaller, bringing you their fantasy football analysis and advice on which players to consider starting in Week 16:
Brian Thomas Jr., WR, Jacksonville Jaguars
Though this has been an undoubtedly frustrating season for Brian Thomas Jr., the Jacksonville Jaguars wide receiver is coming off back-to-back solid performances as his team has ascended to the top of the AFC South. The second-year player, ranked as the No. 44 overall PPR receiver, is certainly in the conversation for the biggest fantasy disappointment of the season relative to draft position.
However, managers who weathered modest outputs and an injury may have a light at the end of the tunnel, as Thomas has looked more like his rookie self with 13 targets, 7 catches, 153 yards, and a touchdown during the past two weeks. The Jags have a tough Week 16 matchup against a Denver Broncos defense that ranks ninth against PPR receivers, but Jacksonville and quarterback Trevor Lawrence are on such a hot streak that Thomas should carry WR3/flex consideration for managers deep in the playoffs.
Omarion Hampton, RB, Los Angeles Chargers
However, managers who weathered modest outputs and an injury may have a light at the end of the tunnel, as Thomas has looked more like his rookie self with 13 targets, 7 catches, 153 yards, and a touchdown during the past two weeks. The Jags have a tough Week 16 matchup against a Denver Broncos defense that ranks ninth against PPR receivers, but Jacksonville and quarterback Trevor Lawrence are on such a hot streak that Thomas should carry WR3/flex consideration for managers deep in the playoffs.
Omarion Hampton, RB, Los Angeles Chargers
Los Angeles Chargers running back Omarion Hampton is beginning to assert himself in the backfield, leading the team with 15 carries and 54% of the rushing attempts last week. Even though Kimani Vidal ran the majority of routes and handled 100% of the two-minute offense, Hampton looked more explosive, averaging 4.1 yards per carry compared to Vidal's 2.8 against the Kansas City Chiefs. The Week 16 matchup against the Dallas Cowboys is promising, as Dallas is tied for second in rushing touchdowns allowed.
However, star defensive tackle Quinnen Williams (concussion) is off the injury report and is expected to play, adding an extra challenge for the backfield. As Hampton moves further away from his IR stint, his role in this run-heavy scheme could grow. RotoBaller projects him as the RB23 this week. He is a high-upside RB2 who could deliver a big performance if he maintains the lead in carries.
Alec Pierce, WR, Indianapolis Colts
However, star defensive tackle Quinnen Williams (concussion) is off the injury report and is expected to play, adding an extra challenge for the backfield. As Hampton moves further away from his IR stint, his role in this run-heavy scheme could grow. RotoBaller projects him as the RB23 this week. He is a high-upside RB2 who could deliver a big performance if he maintains the lead in carries.
Alec Pierce, WR, Indianapolis Colts
Indianapolis Colts wide receiver Alec Pierce caught his only target for 16 yards in the 18-16 loss to the Seattle Seahawks. Last week marked the first game Pierce has played without Daniel Jones, who tore his Achilles in Week 14. His connection with Jones was exceptional, as Pierce was having the best season of his career before the injury.
Now, 44-year-old Philip Rivers is the starting quarterback for the Colts, and his showing against the Seahawks didn't offer any relief for Pierce and his fantasy outlook. Rivers averaged 4.4 yards per attempt and only had two completions over 10 yards last week. Not ideal for Pierce, who currently leads the NFL in yards per completion this season. The fourth-year receiver is better left on the bench than in starting lineups this week, as he looks to overcome the lack of deep-passing ability that Rivers has.
Now, 44-year-old Philip Rivers is the starting quarterback for the Colts, and his showing against the Seahawks didn't offer any relief for Pierce and his fantasy outlook. Rivers averaged 4.4 yards per attempt and only had two completions over 10 yards last week. Not ideal for Pierce, who currently leads the NFL in yards per completion this season. The fourth-year receiver is better left on the bench than in starting lineups this week, as he looks to overcome the lack of deep-passing ability that Rivers has.
Tetairoa McMillan, WR, Carolina Panthers
Tetairoa McMillan will play in Week 16 after missing practices earlier in the week due to foot/ankle concerns. Last week against the Saints, McMillan had two receptions for 25 yards and finished with 4.5 PPR points, his lowest total this season. It was the third straight game in which McMillan had fewer than three receptions, and it was also the first time he did not catch a touchdown pass since Week 10. In Week 16, the Panthers will face the Tampa Bay Buccaneers.
Tampa Bay ranks 17th in Fantasy Points Per Game allowed to the WR position in 2025. McMillan has been Carolina's top overall receiver for the year, averaging 12.9 PPR points per game, but has been unreliable in recent weeks. The Carolina rookie has logged less than 12 PPR points in five of his last six starts, including each of his last three. This is a very crucial game for Carolina in the NFC South race this week, so McMillan should provide double-figure PPR totals, but he is certainly not an upside play.
Tee Higgins, WR, Cincinnati Bengals
Tampa Bay ranks 17th in Fantasy Points Per Game allowed to the WR position in 2025. McMillan has been Carolina's top overall receiver for the year, averaging 12.9 PPR points per game, but has been unreliable in recent weeks. The Carolina rookie has logged less than 12 PPR points in five of his last six starts, including each of his last three. This is a very crucial game for Carolina in the NFC South race this week, so McMillan should provide double-figure PPR totals, but he is certainly not an upside play.
Tee Higgins, WR, Cincinnati Bengals
Cincinnati Bengals wide receiver Tee Higgins (concussion) will be questionable for Sunday's game against the Miami Dolphins in Week 16, according to Mike Petraglia. Higgins was limited in practices on Wednesday and Thursday and still has one more hurdle to clear to pass through the league's concussion protocol. For context, the 26-year-old wideout has had two concussions in the last several weeks, and the Bengals could be extra hesitant to throw him back out there now that they've been eliminated from the playoffs.
Higgins' first concussion occurred late in the Week 12 loss to the New England Patriots, and he experienced more concussion symptoms following the Week 14 loss to the Buffalo Bills. He's missed two of the last three games and could miss another contest this Sunday. When active, Higgins is a must-start in fantasy with a 46-667-9 line on 81 targets this year.
Jameson Williams, Detroit Lions
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Higgins' first concussion occurred late in the Week 12 loss to the New England Patriots, and he experienced more concussion symptoms following the Week 14 loss to the Buffalo Bills. He's missed two of the last three games and could miss another contest this Sunday. When active, Higgins is a must-start in fantasy with a 46-667-9 line on 81 targets this year.
Jameson Williams, Detroit Lions
After a slow start to the 2025 season, Detroit Lions wide receiver Jameson Williams has exploded over the second half of the year. Across his last seven games, the 24-year-old has recorded 647 receiving yards and five touchdown catches. After earning more than seven targets just once over the season's first 12 weeks, he's been targeted by Lions quarterback Jared Goff at least nine times in three straight games.
Williams could have a chance to continue his emergence in Week 16 against the Pittsburgh Steelers, who profile as a favorable matchup on paper. Entering the week, Pittsburgh ranks 29th in the NFL in total receiving yards allowed (3,649). With Lions tight end Sam LaPorta (back) on Injured Reserve, Williams has emerged as the team's clear number two option in the passing game alongside wideout Amon-Ra St. Brown. Williams profiles as a low-end fantasy WR1 with high-end upside in Week 16.
Williams could have a chance to continue his emergence in Week 16 against the Pittsburgh Steelers, who profile as a favorable matchup on paper. Entering the week, Pittsburgh ranks 29th in the NFL in total receiving yards allowed (3,649). With Lions tight end Sam LaPorta (back) on Injured Reserve, Williams has emerged as the team's clear number two option in the passing game alongside wideout Amon-Ra St. Brown. Williams profiles as a low-end fantasy WR1 with high-end upside in Week 16.
Who Should I Start Tool
You can also see the Who Should I Start tool here.
Week 16 Player Decisions. Today's focus is on specific players - Brian Thomas Jr., Omarion Hampton, Alec Pierce, Tetairoa McMillan, Tee Higgins, Xavier Worthy, Jameson Williams, Keenan Allen, Kareem Hunt. These are some of the most common searches for fantasy football lineups in Week 16.
Using The Tool. This is a simple tool but very powerful. The first step is to enter the player names that you want to compare. In the first box, search for the first player name. In the second box, search for the second player name. Compare up to four NFL players at once, and then click the Who To Start? button to see who the recommended starts are based on weekly fantasy football matchups.
Improvements For Who Should I Start? You may have noticed that our 'Who Should I Start?' tool has gotten an overhaul. We've added lots of great features for you to give you as much information as possible to win your fantasy football matchups each week. You'll see NFL player tiles with headshots and bye weeks, stats, projections, strength of schedule, players news, and enhanced search results with data to compare with a slick new interface. We hope you enjoy!
How It Works. Each week our RotoBaller staff puts together their weekly fantasy football rankings and projections based on their research. That information is the core data that is powering the decision-making in this tool. When you search for player names, you will only see those players who are ranked. If someone is out for the week, they will not appear in the search results.
Scoring Formats. Fantasy football managers play in various types of leagues, and this tool allows you to choose whether it's PPR scoring, Half-PPR scoring, or Standard (Non-PPR) scoring. The second thing you want to do, is to select the scoring format. There are three small radio buttons (small circle), so click on the scoring format you prefer. The results may vary based on the scoring format you select.
Popular Week 16 Searches. Curious to see some tough lineup decisions for Week 16 (2025)? Below you will find a list of some popular Who Should I Start? searches that RotoBaller readers are looking at this week. Click any of the links to see the result and recommendation.
Popular Week 16 Searches - Start/Sit Player Comparisons
Below are some popular searches and comparisons from our Who To Start tool for Week 16 for Brian Thomas Jr., Omarion Hampton, Alec Pierce, Tetairoa McMillan, Tee Higgins, Xavier Worthy, Jameson Williams, Keenan Allen, Kareem Hunt:
Brian Thomas Jr.
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Jaylen Warren
Brian Thomas Jr.
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DJ Moore
Brian Thomas Jr.
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Chris Godwin Jr.
Brian Thomas Jr.
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Stefon Diggs
Brian Thomas Jr.
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Xavier Worthy
Brian Thomas Jr.
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Ashton Jeanty
Brian Thomas Jr.
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Kyle Monangai
Brian Thomas Jr.
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Jayden Reed
Brian Thomas Jr.
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Jaylen Waddle
Brian Thomas Jr.
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Emeka Egbuka
Brian Thomas Jr.
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Devonta Smith
Brian Thomas Jr.
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Tony Pollard
Brian Thomas Jr.
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Harold Fannin Jr.
Brian Thomas Jr.
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Brock Bowers
Brian Thomas Jr.
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Wan'dale Robinson
Brian Thomas Jr.
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Kenneth Walker III
Brian Thomas Jr.
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Kyle Pitts Sr.
Brian Thomas Jr.
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Kenneth Gainwell
Brian Thomas Jr.
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Michael Carter
Brian Thomas Jr.
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Deebo Samuel Sr.
Brian Thomas Jr.
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Terry Mclaurin
Brian Thomas Jr.
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Colby Parkinson
Brian Thomas Jr.
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Ladd McConkey
Brian Thomas Jr.
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Puka Nacua
Brian Thomas Jr.
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Amon-Ra St. Brown
Brian Thomas Jr.
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CeeDee Lamb
Brian Thomas Jr.
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Ja'Marr Chase
Brian Thomas Jr.
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Jaxon Smith-Njigba
Brian Thomas Jr.
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Drake London
Brian Thomas Jr.
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Nico Collins
Brian Thomas Jr.
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Mike Evans
Brian Thomas Jr.
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George Pickens
Brian Thomas Jr.
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A.J. Brown
Omarion Hampton
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Tee Higgins
Omarion Hampton
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Ladd McConkey
Omarion Hampton
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Rico Dowdle
Omarion Hampton
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Terry Mclaurin
Omarion Hampton
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Justin Jefferson
Omarion Hampton
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Michael Carter
Omarion Hampton
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Tetairoa McMillan
Omarion Hampton
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Kyle Pitts Sr.
Omarion Hampton
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Tyrone Tracy Jr.
Omarion Hampton
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Wan'dale Robinson
Omarion Hampton
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D'Andre Swift
Omarion Hampton
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Harold Fannin Jr.
Omarion Hampton
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Jakobi Meyers
Omarion Hampton
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Devonta Smith
Omarion Hampton
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George Kittle
Omarion Hampton
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Jaylen Waddle
Omarion Hampton
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Zay Flowers
Omarion Hampton
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Kyle Monangai
Omarion Hampton
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Quinshon Judkins
Omarion Hampton
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Xavier Worthy
Omarion Hampton
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Jauan Jennings
Omarion Hampton
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Chris Godwin Jr.
Omarion Hampton
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Michael Wilson
Omarion Hampton
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Christian McCaffrey
Omarion Hampton
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Bijan Robinson
Omarion Hampton
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Jahmyr Gibbs
Omarion Hampton
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De'Von Achane
Omarion Hampton
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James Cook III
Omarion Hampton
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Saquon Barkley
Omarion Hampton
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Jonathan Taylor
Omarion Hampton
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Josh Jacobs
Omarion Hampton
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Chase Brown
Omarion Hampton
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Travis Etienne Jr.
Alec Pierce
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Jacory Croskey-Merritt
Alec Pierce
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T.J. Hockenson
Alec Pierce
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Ricky Pearsall
Alec Pierce
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Tyjae Spears
Alec Pierce
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Cade Otton
Alec Pierce
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Gunnar Helm
Alec Pierce
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Xavier Legette
Alec Pierce
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Evan Hull
Alec Pierce
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Pat Bryant
Alec Pierce
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Elic Ayomanor
Alec Pierce
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Andrei Iosivas
Alec Pierce
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Isaiah Likely
Alec Pierce
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Parker Washington
Alec Pierce
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Evan Engram
Alec Pierce
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Josh Downs
Alec Pierce
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Keaton Mitchell
Alec Pierce
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Mike Gesicki
Alec Pierce
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Jeremy McNichols
Alec Pierce
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Brenton Strange
Alec Pierce
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Kevin Austin Jr.
Alec Pierce
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Nick Chubb
Alec Pierce
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Brian Robinson Jr.
Alec Pierce
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Tre Harris
Alec Pierce
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Puka Nacua
Alec Pierce
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Amon-Ra St. Brown
Alec Pierce
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CeeDee Lamb
Alec Pierce
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Ja'Marr Chase
Alec Pierce
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Jaxon Smith-Njigba
Alec Pierce
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Drake London
Alec Pierce
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Nico Collins
Alec Pierce
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Mike Evans
Alec Pierce
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George Pickens
Alec Pierce
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A.J. Brown
Tetairoa McMillan
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Tyrone Tracy Jr.
Tetairoa McMillan
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Justin Jefferson
Tetairoa McMillan
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D'Andre Swift
Tetairoa McMillan
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Rico Dowdle
Tetairoa McMillan
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Jakobi Meyers
Tetairoa McMillan
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Tee Higgins
Tetairoa McMillan
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George Kittle
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Omarion Hampton
Tetairoa McMillan
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Zay Flowers
Tetairoa McMillan
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Ladd McConkey
Tetairoa McMillan
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Quinshon Judkins
Tetairoa McMillan
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Terry Mclaurin
Tetairoa McMillan
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Jauan Jennings
Tetairoa McMillan
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Michael Carter
Tetairoa McMillan
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Michael Wilson
Tetairoa McMillan
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Kyle Pitts Sr.
Tetairoa McMillan
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Breece Hall
Tetairoa McMillan
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Wan'dale Robinson
Tetairoa McMillan
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Derrick Henry
Tetairoa McMillan
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Harold Fannin Jr.
Tetairoa McMillan
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Courtland Sutton
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Devonta Smith
Tetairoa McMillan
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Aaron Jones Sr.
Tetairoa McMillan
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Puka Nacua
Tetairoa McMillan
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Amon-Ra St. Brown
Tetairoa McMillan
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CeeDee Lamb
Tetairoa McMillan
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Ja'Marr Chase
Tetairoa McMillan
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Jaxon Smith-Njigba
Tetairoa McMillan
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Drake London
Tetairoa McMillan
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Nico Collins
Tetairoa McMillan
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Mike Evans
Tetairoa McMillan
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George Pickens
Tetairoa McMillan
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A.J. Brown
Tee Higgins
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Rico Dowdle
Tee Higgins
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Omarion Hampton
Tee Higgins
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Justin Jefferson
Tee Higgins
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Ladd McConkey
Tee Higgins
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Tetairoa McMillan
Tee Higgins
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Terry Mclaurin
Tee Higgins
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Tyrone Tracy Jr.
Tee Higgins
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Michael Carter
Tee Higgins
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D'Andre Swift
Tee Higgins
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Kyle Pitts Sr.
Tee Higgins
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Jakobi Meyers
Tee Higgins
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Wan'dale Robinson
Tee Higgins
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George Kittle
Tee Higgins
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Harold Fannin Jr.
Tee Higgins
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Zay Flowers
Tee Higgins
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Devonta Smith
Tee Higgins
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Quinshon Judkins
Tee Higgins
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Jaylen Waddle
Tee Higgins
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Jauan Jennings
Tee Higgins
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Kyle Monangai
Tee Higgins
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Michael Wilson
Tee Higgins
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Xavier Worthy
Tee Higgins
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Breece Hall
Tee Higgins
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Puka Nacua
Tee Higgins
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Amon-Ra St. Brown
Tee Higgins
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CeeDee Lamb
Tee Higgins
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Ja'Marr Chase
Tee Higgins
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Jaxon Smith-Njigba
Tee Higgins
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Drake London
Tee Higgins
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Nico Collins
Tee Higgins
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Mike Evans
Tee Higgins
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George Pickens
Tee Higgins
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A.J. Brown
Xavier Worthy
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Kyle Monangai
Xavier Worthy
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Chris Godwin Jr.
Xavier Worthy
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Jaylen Waddle
Xavier Worthy
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Jaylen Warren
Xavier Worthy
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Devonta Smith
Xavier Worthy
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Brian Thomas Jr.
Xavier Worthy
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Harold Fannin Jr.
Xavier Worthy
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DJ Moore
Xavier Worthy
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Wan'dale Robinson
Xavier Worthy
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Stefon Diggs
Xavier Worthy
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Kyle Pitts Sr.
Xavier Worthy
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Ashton Jeanty
Xavier Worthy
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Michael Carter
Xavier Worthy
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Jayden Reed
Xavier Worthy
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Terry Mclaurin
Xavier Worthy
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Emeka Egbuka
Xavier Worthy
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Ladd McConkey
Xavier Worthy
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Tony Pollard
Xavier Worthy
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Omarion Hampton
Xavier Worthy
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Brock Bowers
Xavier Worthy
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Tee Higgins
Xavier Worthy
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Kenneth Walker III
Xavier Worthy
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Rico Dowdle
Xavier Worthy
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Puka Nacua
Xavier Worthy
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Amon-Ra St. Brown
Xavier Worthy
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CeeDee Lamb
Xavier Worthy
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Ja'Marr Chase
Xavier Worthy
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Jaxon Smith-Njigba
Xavier Worthy
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Drake London
Xavier Worthy
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Nico Collins
Xavier Worthy
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Mike Evans
Xavier Worthy
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George Pickens
Xavier Worthy
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A.J. Brown
Jameson Williams
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Travis Etienne Jr.
Jameson Williams
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Javonte Williams
Jameson Williams
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Chase Brown
Jameson Williams
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Bucky Irving
Jameson Williams
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Josh Jacobs
Jameson Williams
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George Pickens
Jameson Williams
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Mike Evans
Jameson Williams
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A.J. Brown
Jameson Williams
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Jonathan Taylor
Jameson Williams
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Kyren Williams
Jameson Williams
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Trey McBride
Jameson Williams
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Chris Olave
Jameson Williams
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Nico Collins
Jameson Williams
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Woody Marks
Jameson Williams
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Saquon Barkley
Jameson Williams
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RJ Harvey
Jameson Williams
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James Cook III
Jameson Williams
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DK Metcalf
Jameson Williams
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Drake London
Jameson Williams
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TreVeyon Henderson
Jameson Williams
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Jaxon Smith-Njigba
Jameson Williams
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Aaron Jones Sr.
Jameson Williams
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De'Von Achane
Jameson Williams
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Puka Nacua
Jameson Williams
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Amon-Ra St. Brown
Jameson Williams
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CeeDee Lamb
Jameson Williams
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Ja'Marr Chase
Jameson Williams
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Courtland Sutton
Jameson Williams
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Michael Wilson
Jameson Williams
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Jauan Jennings
Jameson Williams
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Zay Flowers
Jameson Williams
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Jakobi Meyers
Jameson Williams
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Justin Jefferson
Keenan Allen
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Dalton Schultz
Keenan Allen
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David Montgomery
Keenan Allen
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Adonai Mitchell
Keenan Allen
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Kareem Hunt
Keenan Allen
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Jordan Addison
Keenan Allen
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Darren Waller
Keenan Allen
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Christian Watson
Keenan Allen
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Blake Corum
Keenan Allen
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Marvin Harrison Jr.
Keenan Allen
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Travis Kelce
Keenan Allen
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Michael Pittman Jr.
Keenan Allen
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Khalil Shakir
Keenan Allen
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Dallas Goedert
Keenan Allen
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Jordan Mason
Keenan Allen
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Colby Parkinson
Keenan Allen
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Kimani Vidal
Keenan Allen
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Deebo Samuel Sr.
Keenan Allen
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Audric Estime
Keenan Allen
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Kenneth Gainwell
Keenan Allen
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Oronde Gadsden II
Keenan Allen
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Kenneth Walker III
Keenan Allen
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Jalen Coker
Keenan Allen
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Brock Bowers
Keenan Allen
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Puka Nacua
Keenan Allen
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Amon-Ra St. Brown
Keenan Allen
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CeeDee Lamb
Keenan Allen
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Ja'Marr Chase
Keenan Allen
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Jaxon Smith-Njigba
Keenan Allen
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Drake London
Keenan Allen
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Nico Collins
Keenan Allen
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Mike Evans
Keenan Allen
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George Pickens
Keenan Allen
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A.J. Brown
Kareem Hunt
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David Montgomery
Kareem Hunt
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Darren Waller
Kareem Hunt
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Keenan Allen
Kareem Hunt
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Blake Corum
Kareem Hunt
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Dalton Schultz
Kareem Hunt
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Travis Kelce
Kareem Hunt
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Adonai Mitchell
Kareem Hunt
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Khalil Shakir
Kareem Hunt
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Jordan Addison
Kareem Hunt
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Jordan Mason
Kareem Hunt
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Christian Watson
Kareem Hunt
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Kimani Vidal
Kareem Hunt
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Marvin Harrison Jr.
Kareem Hunt
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Audric Estime
Kareem Hunt
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Michael Pittman Jr.
Kareem Hunt
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Oronde Gadsden II
Kareem Hunt
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Dallas Goedert
Kareem Hunt
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Jalen Coker
Kareem Hunt
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Colby Parkinson
Kareem Hunt
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Colston Loveland
Kareem Hunt
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Deebo Samuel Sr.
Kareem Hunt
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Rashid Shaheed
Kareem Hunt
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Kenneth Gainwell
Kareem Hunt
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Christian McCaffrey
Kareem Hunt
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Bijan Robinson
Kareem Hunt
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Jahmyr Gibbs
Kareem Hunt
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De'Von Achane
Kareem Hunt
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James Cook III
Kareem Hunt
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Saquon Barkley
Kareem Hunt
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Jonathan Taylor
Kareem Hunt
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Josh Jacobs
Kareem Hunt
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Chase Brown
Kareem Hunt
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Travis Etienne Jr.
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