October 12, 2025
New York Jets running back
Khalil Herbert and wide receiver
Allen Lazard are inactive ahead of the Week 6 matchup against the Denver Broncos. As expected, Lazard is out as he didn't make the trip to England due to personal reasons. His absence won't mean much for this offense given he has four receptions for 24 yards and one touchdown this season.
Arian Smith figures to see a majority of the snaps as the third wideout. As for Herbert, he's a healthy scratch as he's too far down on this depth chart to make a serious impact.
Kene Nwangwu figures to do the kick returning with Herbert out.
--Andy WebbSource: Zack Rosenblatt
October 12, 2025
Las Vegas Raiders tight end
Brock Bowers (knee) has already been ruled out ahead of the Week 6 matchup against the Tennessee Titans. According to Ian Rapoport, Bowers is unlikely to suit up for next week's matchup versus the Kansas City Chiefs. Bowers has been dealing with a PCL injury that he suffered Week 1. His timetable was revealed as week-to-week, so fantasy managers shouldn't be shocked if Bowers misses a third straight game. His absence means that
Michael Mayer will take over as the primary tight end on this offense. Mayer is worth a stash for tight end needy fantasy managers, but isn't a recommended streaming option in Week 6.
--Andy WebbSource: Ian Rapoport
October 12, 2025
San Francisco 49ers wide receiver
Ricky Pearsall (knee) has already been ruled out ahead of the Week 6 matchup against the Tampa Bay Buccaneers. He'll miss his second straight game due to a lingering knee issue. According to Adam Schefter, Pearsall could make his return to the field for the Week 7 matchup against the Atlanta Falcons. Given the injuries to this offense, Pearsall figures to be a focal point in the receiving game once he's healthy enough to play. Hopefully, fantasy managers will only be without him for one more week. His absence figures to mean more involvement for
Jauan Jennings (rib, ankle) and
Kendrick Bourne.
--Andy WebbSource: Adam Schefter
October 12, 2025
Dallas Cowboys wide receiver
Ryan Flournoy is coming off a fantastic performance in Week 5. Flournoy hauled in six of his nine targets for 114 yards in the win over the New York Jets. The 25-year-old came out of nowhere and posted a career-game last week. The assumption is that the Cowboys are going to keep him involved going forward. This offense remains without their top option in
CeeDee Lamb (ankle) for Week 6. That being said,
George Pickens figures to draw the most attention on defense, which could leave Flournoy in favorable coverage. The lack of prior success does make Flournoy a risky choice. He's more of a flex option in deep leagues because it's unclear if he can duplicate that performance.
--Andy WebbSource: Pro Football Reference
October 12, 2025
Dallas Cowboys running back
Jaydon Blue is set for an increase in playing time Sunday against Carolina after the team previously announced that
Miles Sanders (knee, ankle) would miss the rest of the season following surgery. The elevation, however, will still keep Blue behind starter
Javonte Williams, who is in the midst of a resurgent 2025 season. The rookie was a healthy inactive for the first month of the season, then played 11 snaps in his first game last week against the New York Jets. Although Blue will factor into the Dallas offense, he's not likely to earn enough volume to be playable yet, at least while Williams is healthy.
--Nick PiotrowiczSource: ESPN
October 12, 2025
Washington Commanders wide receiver
Terry McLaurin (quadriceps) could return to the lineup in Week 7, according to Tom Pelissero of NFL Network. The former Ohio State star is slated to miss his third consecutive game on Monday against the Chicago Bears, although it appears next week's game against the Dallas Cowboys could be in play. McLaurin has not yet had a breakout week this season after scoring a new contract, but he finished as PPR WR No. 7 last year and figures to be highly involved once back to full health.
--Nick PiotrowiczSource: NFL Network
October 12, 2025
On a Tampa Bay Buccaneers team hampered by injuries at wide receiver, veteran
Sterling Shepard has seen a rapid increase in fantasy value as his team prepares to play San Francisco in Week 6.
Chris Godwin (leg) and
Mike Evans (hamstring) already have been ruled out for the game, slotting in Shepard as the team's likely second receiver behind
Emeka Egbuka. Shepard has seen at least four targets in every game this season and scored his first touchdown of the year last week. The Niners are mid-tier against fantasy receivers, but Shepard should receive enough volume to be considered a flex option, especially in deeper leagues.
--Nick PiotrowiczSource: Pro Football Reference
October 12, 2025
Ian Rapoport of NFL Network is reporting that Dallas Cowboys cornerback Trevon Diggs (knee) is expected to play when his team takes on the Carolina Panthers on Sunday. The corner was listed as questionable on the final injury report. The Cowboys are also likely to have DaRon Bland (shoulder), who was also listed as questionable on the injury report, giving Dallas its top two corners against Carolina. Dallas is allowing 7.5 net yards per attempt this season, which ranks dead last in the NFL.
--Nick PiotrowiczSource: NFL Network
October 12, 2025
The Dallas Cowboys are likely to have cornerback DaRon Bland (shoulder) active when they take on the Carolina Panthers on Sunday, according to NFL Network's Ian Rapoport. Bland was limited in practice all week. The fourth-year corner missed a pair of games this season with a foot injury and is listed as questionable for Sunday, though it appears he will play. Rapoport also reported that Dallas is likely to have fellow corner Trevon Diggs (knee), giving the Cowboys another option to match against Carolina rookie wide receiver
Tetairoa McMillan.
--Nick PiotrowiczSource: NFL Network
October 12, 2025
San Francisco 49ers quarterback
Brock Purdy (toe) could return in Week 7, according to ESPN's Adam Schefter. Already ruled out for Week 6, Purdy will have missed four of six games going into next week.
Mac Jones (oblique) is expected to play on Sunday, which should provide stability for a 49ers team that ranks second in the league in passing yards. The irony is that fantasy managers who took Purdy because of his reliability have gotten anything but, as injury issues have made his availability a weekly guessing game. If Purdy is finally ready to return full-time next week, he should once again deserve lineup consideration, especially in two-quarterback formats.
--Nick PiotrowiczSource: ESPN
October 12, 2025
ESPN's Adam Schefter reports that San Francisco 49ers wide receiver
Jauan Jennings (ankle, rib) is expected to be available for Sunday's road matchup with the Tampa Bay Buccaneers. Jennings has been in and out of the lineup this season while battling through an ankle injury and other secondary injuries, but he's projected to gut it out in Week 6 against the hosting Buccaneers. San Francisco's offense still has a way to go before returning to full strength, but Jennings' return will also coincide with quarterback
Mac Jones (knee, oblique) getting the nod to play, so they won't be without all of their playmakers. With teammate
Ricky Pearsall (knee) still sidelined, fellow WRs
Kendrick Bourne and
Demarcus Robinson will continue to see extra playing time behind Jennings. It wouldn't be surprising to see the 28-year-old eased back in.
--Alex CiullaSource: Adam Schefter
October 12, 2025
According to ESPN's Adam Schefter, San Francisco 49ers quarterback
Mac Jones (knee, oblique) is expected to be active for his team's matchup with the hosting Tampa Bay Buccaneers. Jones has now dealt with knee and oblique injuries over the past few weeks, but will again get the start for the 49ers despite logging a week's worth of limited practices. Schefter also notes that teammate
Brock Purdy (toe) has a "chance" to return in Week 7. It's excellent news for San Francisco, as the team is dealing with a mess of injuries on both sides of the ball. Reportedly, the team should also have wide receiver
Jauan Jennings (ankle, rib) active, aiding Jones with
Ricky Pearsall (knee) still at least a week away.
--Alex CiullaSource: Adam Schefter
October 12, 2025
ESPN's NFL Insider Adam Schefter reports that Carolina Panthers tight end
Ja'Tavion Sanders (ankle) is unlikely to play in his team's home outing against the Dallas Cowboys in Week 6. Sanders' practice participation was up and down this week, leading up to the Panthers' matchup with Dallas, with a full session on Thursday being bookended by two limited ones. Per Schefter, he'll need another week to recover. Teammates
Tommy Tremble and
Mitchell Evans have operated as Carolina's first and second option at TE, respectively, in Sanders' absence, and they figure to do so again Sunday against the Cowboys. However, neither project to be a particularly enticing option for fantasy.
--Alex CiullaSource: Adam Schefter
October 12, 2025
Baltimore Ravens wide receiver
Zay Flowers (shoulder) is expected to be available for his team's matchup with the visiting Los Angeles Rams, according to ESPN's Adam Schefter. The Boston College alum was a limited participant in practice this week due to a shoulder injury. Despite the questionable designation, Flowers will prepare to play on Sunday, but will again be without quarterback
Lamar Jackson (hamstring), lowering the floor and ceiling of all Ravens' skill players. The 25-year-old was the team's leading receiver in Week 5 with
Cooper Rush at the helm, but it's unclear if his ailing shoulder will limit his snaps. If that's the case, teammates
DeAndre Hopkins and
Rashod Bateman are the most likely wideouts to see an uptick in targets, with tight end
Mark Andrews set to absorb more work as well.
--Alex CiullaSource: Adam Schefter
October 12, 2025
ESPN's Jeremy Fowler reports that Los Angeles Chargers wide receiver
Quentin Johnston (hamstring) is trending toward being inactive for Sunday's road meeting with the Miami Dolphins. Johnston picked up a hamstring injury that limited him at practice leading up to Sunday's outing, leaving him with a questionable tag. However, it appears he won't be healthy enough to suit up against the hosting Dolphins. Fellow wideouts
Keenan Allen and
Ladd McConkey figure to pick up a few extra looks in his absence, while rookies Tre Harris and
Keandre Lambert-Smith should benefit from an uptick in snaps. Tight end
Oronde Gadsden could also be in for an elevated workload with Johnston sidelined.
--Alex CiullaSource: Jeremy Fowler
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