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Complete NFL Week 3 betting lines, point spreads, and betting odds analysis. Expert predictions on the best spreads to bet and Las Vegas totals for Sunday's games.
The NFL season rolls on into Week 3, kicking off tonight with a Thursday night matchup between the Dolphins and the Bills in the AFC East. Multiple teams will be starting backup quarterbacks this week, as injuries have already begun to take their toll on rosters across the league. With only two games' worth of data to go off, we are still making some educated guesses as to how good (or bad) teams are this season.
This article is intended to be a first look at every NFL game in Week 3, providing the spreads, totals, odds, and analysis that you need to start your research for your NFL wagers this week.
Check back later in the week for our writers' favorite bets, props, and picks. But for now, here is a breakdown of every NFL game with some trends and data for your consideration!
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Thursday Night Football Betting Lines
Miami Dolphins (+11.5) at Buffalo Bills (-700)
- Over/Under (49.5)
- Key Trend(s): Bills have won 9 of their last 10 games against Miami. The Dolphins have not won in the series since 2022.
We have a potential blowout on tap tonight as the 2-0 Bills host the 0-2 Dolphins. Buffalo has owned their division rival, but Miami's offense showed a few flashes of life last week, even in a loss.
Initial Lean: Dolphins over 18.5 points team total
I think the Bills win in what should be a high-scoring game. You could target the game total over, or perhaps aim for the Dolphins team total, which feels a tad low based on the fact that Miami has gone over that number in 7 of their last 10 games, averaging 23.3 points per game in that stretch.
Sunday Early Games Betting Lines
Pittsburgh Steelers (-1.5) at New England Patriots (+115)
- Over/Under (44.5)
- Key Trend(s): Both teams rank in the bottom five of the league defensively through two weeks.
The Steelers are coming off a bad loss at home against Seattle, while New England picked up their first win of the season by holding off the Dolphins.
Initial Lean: Patriots ML and/or Over 44.5 total points
I am going to keep picking against Pittsburgh this year until they prove they deserve some respect. I also think we could get a lot of scoring here with both defenses struggling early in the season.
Atlanta Falcons (-5.5) at Carolina Panthers (+230)
- Over/Under (43.5)
- Key Trend(s):
The Falcons are coming off an impressive road win in Minnesota, while the Panthers fell to 0-2 after a failed comeback attempt in Arizona.
Initial Lean: Falcons -5.5
Atlanta's running game and defense should dictate this game. Carolina hasn't stopped anyone yet, and Bryce Young could be dealing with a lot of pressure as Carolina has some more injuries up front on the offensive line.
Cincinnati Bengals (+3) at Minnesota Vikings (-145)
- Over/Under (42.5)
- Key Trend(s): NONE
The battle of the backup quarterbacks takes place this week as Carson Wentz will start for Minnesota and Jake Browning for Cincinnati.
Initial Lean: Bengals +3
It's tough to get a good read on this game, but the Vikings will be down their starting QB and RB as Aaron Jones is also out. Jake Browning moved the Bengals' offense last week to a comeback win. I think Cincy can win or at least cover here.
Houston Texans (+1.5) at Jacksonville Jaguars (-120)
- Over/Under (44.5)
- Key Trend(s): Houston is 2-0 on unders this season, with their games going under by an average of 11.8 points per game. They have now gone under in seven straight games, going back to last season.
Houston is now 0-2 and has to face a divisional opponent on the road. Jacksonville has looked good, though they let one slip through their fingers last week against the Bengals.
Initial Lean: Under 44.5 total points, Jags ML
Houston plays solid defense, but the offense is stuck in neutral. I think the Jags have surpassed them in terms of talent now that they're fully healthy, and they're playing well on offense with their new coach's system in place.
Green Bay Packers (-8) at Cleveland Browns (+375)
- Over/Under (41.5)
- Key Trend(s): Green Bay 2-0 ATS this season.
Last time in Cleveland pic.twitter.com/6HZHQY4rnn
— Green Bay Packers (@packers) September 18, 2025
The Packers have looked like one of the most complete teams so far, while the Browns were throttled by their divisional rival Ravens, in Week 2. Both teams certainly feel like they are trending in opposite directions.
Initial Lean: Packers -8
I don't like laying more than a touchdown on any favorite, but I think the Packers match up quite well this week and will be able to both move the ball through the air and shut down Cleveland with their suffocating defense.
Indianapolis Colts (-4.5) at Tennessee Titans (+190)
- Over/Under (43.5)
- Key Trend(s): Colts are 2-0 ATS this season.
The Colts are one of the big surprises in the league so far, as not many believed they would be this good with Daniel Jones instead of Anthony Richardson. The Titans are 0-2 but have had two very tough matchups out of the gate with Denver and the Rams.
Initial Lean: Colts -4.5
Jones and the Indy offense have been incredibly efficient, and it's hard for me to see that stop here against Tennessee's defense. Perhaps the Titans keep it close, but I think the Colts could also dominate in the run game and force the rookie Cam Ward into some bad throws.
New York Jets (+7) at Tampa Bay Buccaneers (-295)
- Over/Under (43.5)
- Key Trend(s): Bucs are 2-0 ATS this season, but have been small favorites or underdogs, never this big of a favorite.
The Jets regressed in a big way, getting throttled at home by the Bills in Week 2. The Bucs moved to 2-0 with a late comeback win over the Texans.
Initial Lean: Tampa -7
Will the Jets' offense be any better with Tyrod Taylor under center this week instead of Justin Fields? Probably not. And their run game is going to face a big challenge against Tampa's imposing front seven. Look for the Bucs to take care of business and cover at home.
Las Vegas Raiders (+3.5) at Washington Commanders (-160)
- Over/Under (44.5)
- Key Trend(s): NONE
Washington is licking its wounds after getting thumped by the Packers last week. But the Raiders were also humbled by the Chargers, leaving both teams at 1-1.
Initial Lean: NO IDEA WHAT TO DO WITH THIS GAME
We could still see Marcus Mariota start this week, though Jayden Daniels has not been officially ruled out. It's hard to take a stand either way without knowing Daniels' status for this game.
Los Angeles Rams (+3.5) at Philadelphia Eagles (-175)
- Over/Under (44.5)
- Key Trend(s): Eagles have won and covered this spread in the last three meetings going back to 2023.
Initial Lean: Eagles -3.5
Everyone keeps saying the Eagles aren't the same this season, but they are 2-0 and have had great success against this Rams team. I think they'll figure out the passing game this week and their defense is absolutely good enough to slow down the Rams.
Sunday Afternoon Games Betting Lines
Denver Broncos (+2.5) at Los Angeles Chargers (-140)
- Over/Under (45.5)
- Key Trend(s): Chargers 2-0 ATS vs. Denver last season.
A big clash in the AFC West this week and a chance for the Broncos to tie the Chargers at 2-1 or for L.A. to move to 3-0 and put some distance between themselves and Denver, Kansas City, and Las Vegas.
On to Los Angeles:
If the Broncos simply beat the Chargers on Sunday, they will be the No. 1 team in the AFC West.
Big opportunity. pic.twitter.com/HBhAzMy0ti
— Zac Stevens (@ZacStevensDNVR) September 17, 2025
Initial Lean: Chargers -2.5
I don't know about you, but I think the Chargers look like the real deal. I have fewer questions about them than I do about Denver, which let one slip away last week.
New Orleans Saints (+7.5) at Seattle Seahawks (-340)
- Over/Under (41.5)
- Key Trend(s): Saints have covered a spread this big in 7 of their last 10 games.
The Seahawks are coming off a big win in Pittsburgh, moving to 1-1 on the season. Meanwhile, the Saints dropped to 0-2 with a loss to the Niners.
Initial Lean: Saints +7.5
As much as I like Seattle to win, I am not sure they will cover. New Orleans has been feisty this year, playing some better-than-expected defense and keeping games fairly close.
Arizona Cardinals (+1.5) at San Francisco 49ers (-120)
- Over/Under (43.5)
- Key Trend(s): Arizona won both matchups with the Niners last year after having dropped four straight the previous two seasons.
This game features two undefeated teams, and it's basically a coin flip as far as the odds go. We get Mac Jones again for the Niners, but he performed well in last week's win over the Saints.
Initial Lean: San Francisco ML
It feels odd for the 2-0 Cardinals to be underdogs here, but they haven't been winning "clean," and there are still some questions about how good they are against better competition.
Dallas Cowboys (-1) at Chicago Bears (+100)
- Over/Under (50.5)
- Key Trend(s): Chicago has gone over in both of their games by an average of 17.8 points.
The Bears are searching for their first win, while Dallas comes in 1-1 after an overtime comeback win against the Giants.
Initial Lean: Over 50.5 points
Neither team has been playing much defense, which sets us up for a potential shootout in this one.
Sunday Night Football Betting Lines
Kansas City Chiefs (-6) at New York Giants (+270)
- Over/Under (45.5)
- Key Trend(s): Chiefs have failed to cover the spread in four straight games, going back to last year's playoffs.
Past nights under the Sunday lights. pic.twitter.com/A2qfGgrf1m
— Kansas City Chiefs (@Chiefs) September 18, 2025
Kansas City badly needs a win after starting 0-2, and they get a good matchup this week against the lowly Giants, who are also winless.
Initial Lean: Giants +6
Call me crazy, but I feel like the Giants showed enough life last week for me to believe that they'll battle in this one. KC rarely covers as a favorite, and six points feels like a lot for a team that has struggled as much as the Chiefs have so far.
Monday Night Football Betting Lines
Detroit Lions (+5) at Baltimore Ravens (-220)
- Over/Under (52.5)
- Key Trend(s): Baltimore is 2-0 on the over this season. Detroit is just 1-1, but scored 50+ points in their win last week.
This should be an epic battle between two great teams that consider themselves Super Bowl contenders. One team will leave at 1-2 as both teams have already lost once this season.
Initial Lean: Ravens -5
Baltimore is the more physical team, and I think they'll take advantage of their physicality in this matchup. Detroit poured in on Chicago last week, but I still have concerns about how they will fare against better competition, and the Ravens look like one of the better teams in the league so far.
