NFL DFS Picks for Week 2 Monday Night Football - FanDuel, DraftKings Top Plays, Value Picks for Daily Fantasy Football Lineups (2025)

September 15, 2025

Koby' top NFL DFS picks for Week 2 MNF (2025) DraftKings and FanDuel lineup sleepers for the main slate. His top FD and DK plays and value picks to target for Week 2 DFS lineups.

What a snoozefest that Sunday Night Football was; both the Vikings and Falcons couldn't do a damn thing when it came to doing anything in opponent territory. It was a field goal fest, as only one touchdown was scored, and out of all players, it was Tyler Allgeier, and the Falcons were able to get the win.

On this slate, it'll be similar to your normal DFS slate rather than the typical showdowns that I have been writing up. We have the Tampa Bay Buccaneers traveling to Houston to take on the Texans, as well as the L.A. Chargers traveling to Vegas to take on the Raiders!

 In this article, I will be providing you with my Week 2 MNF daily fantasy football lineup picks for the 2025 NFL season. These lineups can vary from higher-priced players and elite options to lower-priced players and value picks on FanDuel. Be sure also to check out our weekly NFL DFS articles and NFL DFS tools to help you win big!

MNF Quarterbacks - NFL DFS Lineup Picks

Justin Herbert at LV ($5.9K DK/$8K FD) 

Justin Herbert balled out in Week 1, showing why he belongs in the top echelon of QBs in the league. He finished with a solid 30.9 fantasy points against a solid Chiefs defense, which we just saw keep Jalen Hurts under wraps. The Raiders' defense didn't show up against Drake Maye and the Patriots last week, who threw the ball 46 times and finished with almost 300 yards.

JUSTIN HERBERT CALLS GAME. WHAT A NIGHT.

KCvsLAC on YouTube https://t.co/JVXS9sMrs3 pic.twitter.com/SslSt8mKPd

— NFL (@NFL) September 6, 2025

Herbert has had decent success against the Raiders in past seasons, including last year's finale, where he threw 346 yards and two touchdowns. Herbert was able to get it done on the ground, too, which is good to see, because the more he runs, the more we score as well. Let's hope we can see a rushing touchdown or a few this season to bump up those fantasy numbers.

Also Consider: C.J. Stroud ($5.5K DK/$7.1K FD)

MNF Running Backs - NFL DFS Lineup Picks

Bucky Irving at HOU ($7.2K DK/$7.5K FD) 

Out of what's available on this slate, Bucky remains the clear RB1 option. He is used all around the field in the running game and passing game. It seems he has officially relegated Rachaad White to a very minor role in the offense, which is very good for us. Irving saw 14 carries compared to White's two. He also saw four targets in the passing game compared to White's one.

I think Irving brings the most opportunity here out of all the RBs available on this slate. Bucky only averaged 2.6 YPC in last week's game, which is well below his average from last season of 5.4 YPC. Houston has a tough defense, but I think Irving is going to get it done both in the rushing and receiving game.

Omarion Hampton at LV ($5.8K DK/6.4K FD) 

I was going to write up Ashton Jeanty, but touting the top two options isn't very fun. Hampton makes for a solid pivot, especially now that we know he is going to be RB1 in this offense. Najee Harris was non-existent. Hopefully, that stays that way, because Hampton has the potential to be a significant contributor in this offense. He saw 15 carries in Week 1 compared to the single carry that Harris had.

Hampton saw two targets in the passing game as well. The Raiders' defense gave up six receptions to TreVeyon Henderson in last week's matchup. Suppose that is any indication of how we could see Hampton used in this one. It would be huge, especially on DK, where it's PPR rather than half PPR. Expect Hampton's production to continue to rise as he becomes more comfortable in the offense.

Also Consider: Ashton Jeanty ($7K DK/$7K FD)

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MNF Wide Receivers - NFL DFS Lineup Picks

Jakobi Meyers vs. LAC ($4.9K DK/$6.7K FD) 

Geno Smith really only has two options to throw to consistently in the offense. Now, if he could find them in the end zone, it would be great for those of us who drafted him. Meyers saw a 30% target share in week one, where he had 10 targets! Meyers finished with eight receptions and 97 yards.

“I just like being on the field with my guys, man. That’s really my happy place.”

My @nflnetwork 1-on-1 with #Raiders WR Jakobi Meyers, who hasn’t gotten the contract or trade he wants, but played a key role in beating his old team today. pic.twitter.com/m9wkWJ8xRF

— Tom Pelissero (@TomPelissero) September 7, 2025

Last season, Meyers had a 25% target share and averaged 8.6 targets a game. With Xavier Worthy (shoulder) going down in Week 1, Marquise Brown took over as the WR1, and he finished with 10 receptions for 99 yards. Meyers should slot into that same spot and be able to smoke this Chargers secondary.

Emeka Egbuka at HOU ($5.8K DK/$6.4K FD) 

Emeka Egbuka quickly moved up the pricing ladder from near the minimum price last week to up with the big timers. He found himself in the endzone twice in last week's contest, finishing with 21 fantasy points. He is going up against the Texans' secondary, which allowed the seventh most fantasy points in Week 1.

Davante Adams and Puka Nacua were able to carve up the defense on their way to 181 combined yards.

Egbuka will likely line up against Derek Stingley Jr. on the left side. Stingley has given up .22 fantasy points per route and will have a tough time switching between Egbuka and Mike Evans. This Buccaneers WR core should be able to have a field day, and I'll go with the cheaper guy between the two, so that I can fill my lineup with top-of-the-line guys elsewhere.

Also Consider: Ladd McConkey ($6.9K DK/$7.5K FD), Quentin Johnston ($5.4K DK/$6K FD), Tre Tucker ($3.4K DK/$5.4K FD)

MNF Tight Ends - NFL DFS Lineup Picks

Brock Bowers/Michael Mayer – vs. LAC ($6.3K, $3.3K DK/$7.1K, 5.6K FD) 

This one could get a bit interesting. Brock Bowers has been limited all week to go with a couple of non-participants earlier in the week. He is expected to play in this one, but just in case he isn't, I listed Michael Mayer as an option. Mayer saw four targets while playing alongside Bowers in Week 1, so he should see more if Bowers misses this one.

Bowers, however, is the clear No. 1 option at TE. He will likely see 70% or higher ownership in this one. The only other option I would trust remotely at TE is Dalton Schultz, but for now, eat the chalk and take Bowers. He saw a 26% reception share in 2024, and that trend should continue here.

Also Consider: Dalton Schultz ($3.2K DK/$5.2K FD)

More DFS Analysis and Lineup Picks