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DraftKings Daily Fantasy Football Lineup Picks (Week 6): NFL DFS Advice

Welcome to RotoBaller's Daily Fantasy football DraftKings lineup picks for Week 6 of the NFL season. In this article, I, Jason Bales, will be taking you, the reader, through the best DraftKings DFS plays of the week for this upcoming Sunday.

These DraftKings lineup recommendations are based on matchups, recent performances, overall upside/talent levels, and other factors such as Vegas odds, home field advantage, and more. There are still quite a few great value plays available, so read on to find out which players are the best for Week 6. Good luck with your DraftKings DFS lineups!

Editor's Note: If you like DraftKings, be sure to also check out FantasyAces. New users that sign up on Fantasy Aces and make a $20 deposit will receive RotoBaller's full season NFL Premium Pass for free (including Premium DFS), normally a $59.99 value. Expert DFS research, sample lineups, matchup ratings and lots more!

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DraftKings Quarterbacks - Week 6 DFS Picks

Cam Newton (at NO, $8,100)

Cam Newton is recovering from a concussion, but it looks like he will be set to start for the Carolina Panthers this week against the New Orleans Saints. At home, Drew Brees is one of the best quarterbacks in the league, and the Panthers have been slipping since the beginning of the season. If they want to salvage their season, this is very close to a must win game. The Saints are going to score early and often. Newton is going to have to matchup them. The Saints' pass defense is horrendous, so the Panthers should not have too many issues finding open wide receivers, or tight ends. Newton has a rushing touchdown in two of his last four games, so fire him up due to his consistency and upside, in both 50/50 contests and tournaments.

 

DraftKings Running Backs - Week 6 DFS Picks

LeSean McCoy (vs SF, $6,900)

LeSean McCoy is one of the best running backs in the league right now. He has over 20 fantasy points in three straight games now, and this week, he gets a great matchup against the San Francisco 49ers and Chip Kelly's lightning speed offense. McCoy should have more carries and targets than he usually gets, and he has been producing with limited numbers. The Buffalo Bills are likely going to win this game, which means that McCoy will see a lot of carries in the fourth quarter. His price tag is very reasonable, and he has the upside of Le'Veon Bell and DeMarco Murray.

Carlos Hyde (at BUF, $5,100)

Carlos Hyde should not be used in the same lineup as LeSean McCoy, as both running backs are not likely going to see 20 plus carries, but he does make for a great roster move in tournaments. His upside is very high, as he has over 20 fantasy points in two of his last three starts. Against the Seattle Seahawks, a very tough rush defense, he posted 28.5 fantasy points on 21 carries. If he continues to get worked into the passing attack for the 49ers, he is going to be a semi-elite level running back within the next couple of weeks. His price tag is bound to come up at some point, so roster him while he is cheap.

 

DraftKings Wide Receivers - Week 6 DFS Picks

A.J. Green (at NE, $8,600)

A.J. Green has been fantastic so far this season with 36 receptions, 518 receiving yards, and two touchdowns. If he starts to find the end zone a little bit more frequently, he will quickly turn into a top five wide out. Two games ago, he posted over 35 fantasy points on 12 targets and 10 receptions. Unfortunately, he only does that every so often. In his last five starts, he has over 35 fantasy points twice. That upside is as high as Antonio Brown and Julio Jones, but his price tag is lower. The New England Patriots are going to score. The Bengals will be playing from behind, which should bode well for Green. After his poor performance last week, they should be attempting to get him involved in the game plan a little bit more often.

Jeremy Maclin (at OAK, $6,300)

According to Vegas, the Kansas City Chiefs are going to walk into Oakland and beat the Raiders. That is very surprising, but Vegas tends to know more than anyone else. Jeremy Maclin has been a very consistent fantasy option at the wide receiver position, so using him in 50/50 contests is the correct move. However, this week, he can also be used in tournaments. The Chiefs are going to have to score to beat the Raiders, and Maclin is their go-to target. He has over 10 fantasy points in three of his last four starts, and he only found the end zone once this season. Over 20 fantasy points is definitely possible, if he sniffs out the goal line early.

 

DraftKings Tight Ends - Week 6 DFS Picks

Coby Fleener (vs CAR, $3,500)

Coby Fleener is a very high-upside tight end option for tournaments this week against the Carolina Panthers. The Panthers are not good defensively against the tight end position, and Fleener recently posted over 25 fantasy points against the Atlanta Falcons. As previously mentioned, Drew Brees is outstanding at home, which increases Fleener's upside. He is starting to see more targets, and if the Saints are winning the game, he should see even more targets. The Saints tend to check down before running the ball. It is just how their offense works. Use Fleener in tournaments, but his consistency has not been there. As a side note, Vernon Davis (with Jordan Reed out of the Redskins' lineup) makes for a fantastic low-priced tight end option.

 




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REAL-TIME FANTASY NEWS

Jose Altuve

to Mainly Play Second Base
Jusuf Nurkić

Jusuf Nurkic Cleared to Suit Up on Saturday Night
Nolan Traoré

Nolan Traore Ruled Out on Sunday
Nicolas Hague

Out Week-to-Week
Yu Darvish

Considering Retirement
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Misses Second Straight Game
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Cleared for Original Six Matchup
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Won't Play on Sunday Against the Clippers
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Still Out Saturday
Drew Doughty

Set to Rejoin Kings Lineup Saturday
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Available on Saturday Night
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Expected to Return Saturday Night
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Available Saturday
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Steelers Finalizing Deal to Make Mike McCarthy Their Head Coach
Paul George

Set to Suit Up Against New York
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Facing Multi-Week Absence With Elbow Sprain
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On Track to Play vs. Knicks
Daniel Gafford

Expected to Play Saturday vs. Lakers
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Expected Back Saturday vs. Cavaliers
Khris Middleton

to Miss Saturday's Game Against Hornets
Bilal Coulibaly

Ruled Out for Fifth Straight Game
José Ramírez

Jose Ramirez Signs Seven-Year Extension With Guardians
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Misses Second Straight Game
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Will Not Play Saturday vs. Timberwolves
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Starting on Friday
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is Fully Healthy Heading into Spring Training
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is Returning on Friday
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Rejoining Islanders Lineup Saturday
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Out Friday
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Won't Play Friday
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Ready to End Three-Month Absence
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Misses Second Straight Game Friday
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Returns to Action Friday
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Available Friday
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Fernando Mendoza Officially Declares for NFL Draft
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Dalton Kincaid

Played Through Torn PCL
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Makes History With Three-Assist Effort
Anthony Mantha

Scores Twice Against Oilers
Jet Greaves

Keeps Stars Off Scoreboard With 28 Saves
David Pastrnak

Leads Bruins to Victory With Three-Point Effort
Jonathan Huberdeau

on Track to Return Friday
Darcy Kuemper

Cleared for the Weekend
Zach Benson

Hurt in Thursday's Win
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Ravens Hire Jesse Minter as Their Head Coach
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FBI Investigating the Death of Colts Owner Jim Irsay
MacKenzie Gore

Rangers Acquire MacKenzie Gore From the Nationals
Brandon Sproat

Dealt to Brewers in Four-Player Trade
Jett Williams

Brewers Acquire Jett Williams From Mets
Freddy Peralta

Mets Acquire Freddy Peralta From Brewers
Kyle Tucker

Expected to Bat Second or Third in Dodgers' Lineup
Brandon Aiyuk

has "Played his Last Snap as a Niner"
Cody Bellinger

Signs Five-Year, $162.5 Million Contract With Yankees
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Looks to Overcome Putting Woes at American Express
Billy Horschel

Looking to Rebound at The American Express
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Russell Henley

Looks to Build on Strong Start at The American Express
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Looking to Start 2026 Strong at The American Express
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Looking to Regain Form at The American Express
Sam Burns

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Looking to Flip the Script at The American Express
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Kurt Kitayama

Hopes To Continue Strong Start to 2026 Season at American Express
CFB

Princewill Umanmielen Expected to Sign with LSU
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Robert MacIntyre

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Outstanding Form Continues Heading Into American Express
Matt Fitzpatrick

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Patrick Cantlay

Looks to Get a Jump Start on His 2026 Season
Blades Brown

Set to Make First PGA Tour Appearance of 2026
Kevin Roy

Has Some Confidence Heading to Southern California
Min Woo Lee

Poised to Make Bigger Impact in 2026
Max Homa

Needs a Better Start for 2026
Tony Finau

Trying to Reverse Disturbing Trend
Cam Davis

Aims for More Accuracy at American Express
Luisangel Acuña

Luisangel Acuna Sent to White Sox in Trade
Luis Robert Jr.

Mets Acquire Luis Robert Jr. from White Sox
Los Angeles Chargers

Mike McDaniel Expected to Become Chargers Offensive Coordinator
Carlos Beltran

Andruw Jones Elected to Baseball Hall of Fame
CFB

Alberto Mendoza Expected to Land at Georgia Tech
Malik Nabers

Giants Hope Malik Nabers Will be Back for Start of Training Camp
CFB

Duke Suing Quarterback Darian Mensah
Cam Skattebo

Should be Ready by OTAs
George Kittle

Expects to Return "Well Before November"
CFB

Alberto Mendoza Entering Transfer Portal
Mookie Betts

Plans to Retire at the End of his Current Contract
Tennessee Titans

Titans Set to Hire Robert Saleh as Next Head Coach
Miami Dolphins

Dolphins Expected to Hire Jeff Hafley as Next Head Coach
Zach Charbonnet

has Torn ACL
Zach Charbonnet

Needs Knee Surgery, Out for Rest of Playoffs
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Mike McCarthy a Finalist for Titans Head-Coaching Job?
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Kyren Williams

Scores Two Touchdowns in Divisional Round Win
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Bills Fire Head Coach Sean McDermott

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