October 11, 2025
Los Angeles Rams running back
Kyren Williams is gearing up for a very favorable matchup against the Baltimore Ravens in Week 6. Williams is coming off his best game of the year, in which he totaled 65 rushing yards, 66 receiving yards, and two touchdowns on a season-high 91 percent snap share. He has double-digit fantasy points (PPR) in all five games so far, including strong outings against tough defenses like the Eagles and 49ers. His 91 percent snap share indicates that he has a firm grasp on the lead-back role, and he should be able to take advantage of a favorable matchup on Sunday. Baltimore has allowed the sixth-most rushing yards, third-most receptions, and third-most fantasy points to opposing running backs in 2025. As a result, Williams is a mid-range RB1 this week.
--Andersen PickardSource: RotoBaller
October 11, 2025
Dallas Cowboys wide receiver
George Pickens had only two catches in the Week 5 win over the Jets. While
Ryan Flournoy led the way with six receptions (nine targets), Pickens at least had a touchdown, finding the end zone off of a 43-yard pass from
Dak Prescott in the third quarter. With
CeeDee Lamb (ankle) and
KaVontae Turpin (foot) sidelined, Prescott will need others to step up once again in the Week 6 meeting with the Panthers. Although that could mean continued added involvement from Flournoy and
Jake Ferguson, who had two touchdowns versus New York, Pickens is still considered the No. 1 option on the depth chart against Carolina, making him worthy of a place in any fantasy lineup.
--Dennis ClausenSource: ESPN
October 10, 2025
Los Angeles Rams quarterback
Matthew Stafford will look to build on a strong stretch of games as he takes on the Baltimore Ravens in Week 6. Over his last two games, Stafford has completed 59 passes for 764 yards, six touchdowns, and zero interceptions, ranking as the overall QB1 during that span. The veteran quarterback has shown that he can produce against strong defenses, so his Week 6 matchup against a very poor Ravens defense is all the more exciting. Baltimore has allowed the second-most fantasy points, the third-most passing yards, and the most passing touchdowns to opposing quarterbacks in 2025. They also have just one interception. Seeing Stafford post a third consecutive game with three touchdowns and zero interceptions is not out of the picture. He should be started as a mid-to-low QB1 in fantasy football.
--Andersen PickardSource: RotoBaller
October 10, 2025
Pittsburgh Steelers wide receiver
Ben Skowronek (illness) was limited in practice earlier this week but carries no injury designation into a Week 6 showdown with the Cleveland Browns. Although the fifth-year pro has just one reception this season, he could be in line for additional opportunities on Sunday with
Calvin Austin III (shoulder) sidelined.
Scotty Miller and
Roman Wilson may also step into expanded roles, but Skowronek logged the most snaps of the three in Week 4 before the team's bye. He's also the only one with any meaningful fantasy output this year, taking his lone catch into the end zone for a 22-yard score back in Week 1. With the Browns stifling the run through the first five weeks, quarterback
Aaron Rodgers could be forced to throw the ball early and often. Skowronek can't be considered a viable option in most redraft formats, but he does have some sneaky appeal as a deep-league dart throw.
--Jorden HillSource: RotoBaller
October 10, 2025
Dallas Cowboys running back
Jaydon Blue logged 11 offensive snaps in the Week 5 win over the New York Jets after not getting any action through the first four weeks. However, despite the increased involvement, the rookie ended Week 5 with only four carries for seven yards. With
Miles Sanders (ankle, knee) now done for the remainder of the 2025 campaign, Blue will slide into the No. 2 spot on the depth chart behind
Javonte Williams. Without question, Williams has had a fantastic year, meaning he'll likely continue to handle the bulk of the snaps out of the backfield. As a result, Blue shouldn't be much of a factor offensively in Week 6 versus the Panthers, so he can be left out of all fantasy lineups. That probably won't change moving ahead unless Williams goes down with an injury.
--Dennis ClausenSource: ESPN
October 10, 2025
Kansas City Chiefs wide receiver
Marquise Brown will take on the Detroit Lions in Week 6. Brown was on the injury report with an ankle injury, but practiced fully all week and does not have an injury designation heading into the weekend. Brown has been a serviceable fantasy receiver this season, catching at least four passes or a touchdown in every game. In Week 5 against the Jacksonville Jaguars, Brown caught four of his eight targets for 48 yards. The 28-year-old has been a consistent possession receiver for Kansas City, but has lacked the explosive gains that the Chiefs turn to
Xavier Worthy and
Tyquan Thornton for. Despite not having any blowup games since Week 1, Brown could see a bump in production on Sunday night against Detroit. The Lions are the highest-scoring team in the league, and Kansas City will likely have to pass early and often to stay competitive. Worthy will be the focal point of the offense, but Brown could be a useful chain-mover in Week 6. Brown is ranked WR48 in our RotoBaller Half-PPR rankings, making him a deeper league flex option this week.
--Joshua CostelloSource: ESPN.com
October 10, 2025
Pittsburgh Steelers wide receiver
DK Metcalf is fresh off a Week 5 bye and set to take on the Cleveland Browns in Week 6. Two weeks ago, Metcalf came through with his best showing yet in the black and gold, hanging 126 yards and a touchdown on the Minnesota Vikings. With fellow wideout
Calvin Austin III (shoulder) inactive this week, Metcalf should command plenty of looks from quarterback
Aaron Rodgers. While Cleveland's defense has been stout this season, it has surrendered seven touchdowns and the eighth-most fantasy points per game to opposing receivers. Even in a matchup that is projected to be low-scoring, Pittsburgh may need to air it out with the Browns shutting down the run through the first five weeks. Fantasy managers can confidently start Metcalf as a WR2 with a relatively high ceiling on Sunday.
--Jorden HillSource: RotoBaller
October 10, 2025
Kansas City Chiefs wide receiver
Xavier Worthy will face the Detroit Lions on Sunday night in Week 6. Worthy was listed as a DNP on Thursday after practicing in full on Wednesday, leaving his status for the weekend in doubt heading into Friday. The young receiver then logged a full practice on Friday and does not have an injury designation for Sunday night's game. Worthy had six catches for 42 yards in last week's 28-31 loss to the Jacksonville Jaguars. The speedster led the team in targets but finished fourth in yardage, averaging just 7.0 yards per reception. Worthy has been battling shoulder and ankle injuries, but has still been the team's WR1 in the absence of
Rashee Rice. With Rice still suspended until Week 7, Worthy should lead the team in targets against Detroit. The Lions have scored the most points in the league this season, and the Chiefs will need to score often to keep up. In a game with a 52.5 O/U, Worthy should have plenty of opportunities to score fantasy points. Worthy is ranked WR11 in our RotoBaller Half-PPR rankings, making him an WR1 this week.
--Joshua CostelloSource: NFL.com
October 10, 2025
Tennessee Titans tight end
Chig Okonkwo was highly regarded by the fantasy community heading into the season. However, the 26-year-old hasn't lived up to expectations through the first five games of the 2025 campaign, catching 17 passes for 172 yards while failing to find the end zone. To be fair,
Cam Ward hasn't played the best, resulting in below-average showings from Okonkwo and
Calvin Ridley, among others. With Tennessee looking for a second-straight win, the team will head to Las Vegas for a meeting with the Raiders in Week 6. Although Okonkwo has a better chance of doing something meaningful for managers versus the struggling Raiders, his lack of production makes him hard to trust, even in multi-TE setups.
--Dennis ClausenSource: ESPN
October 10, 2025
Tennessee Titans wide receiver
Tyler Lockett was once considered a top wideout in the National Football League. Unfortunately, it appears those days are well behind him. In his first five games as a Titan, he's caught only seven passes (16 targets) for 52 yards. While the veteran had his first touchdown of the year in Week 5 against the Cardinals, it wasn't as a pass-catcher. Instead, it came after a wild sequence of events that included a
Cam Ward interception followed by a Dadrion Taylor-Demerson fumble. With the Titans coming off a win, their first of the 2025 campaign, the team will look for another victory on Sunday versus the Raiders. Like Tennessee, Las Vegas hasn't looked good throughout the season. With that in mind, despite the favorable matchup on tap, Lockett hasn't played well enough to be classified as a starting option in any fantasy format.
--Dennis ClausenSource: ESPN
October 10, 2025
Pittsburgh Steelers running back
Kenneth Gainwell played incredibly well in Week 4 and will return from a bye to face the Cleveland Browns in Week 6. Though he should still be involved, the return of
Jaylen Warren (knee) certainly puts a cap on Gainwell's upside. To make matters worse, Gainwell will need to overcome a Cleveland defense that has limited opposing backs to the third-fewest fantasy points per contest. Because he can contribute in the passing game, Gainwell isn't entirely touchdown-dependent, but it's difficult to expect another big performance. Fantasy managers should treat Gainwell as a low-end flex option that can be started in a pinch this week.
--Jorden HillSource: RotoBaller
October 10, 2025
Tennessee Titans wide receiver
Elic Ayomanor had a two-catch, 18-yard showing in the Week 5 meeting with the Arizona Cardinals. While that performance didn't sit well with fantasy managers, the rookie has played relatively well in an offense that's struggled throughout the 2025 campaign. In Ayomanor's first five games in the league, he's totaled 14 grabs (29 targets) for 169 yards. He also leads the team with two receiving touchdowns. With the Titans coming off their first win of the year, Tennessee will look to pick up another victory on Sunday against the Raiders. Without question, Las Vegas hasn't looked the best either, so
Cam Ward and company have a chance to get something going on the offensive end. However, even with a favorable opportunity on the horizon, Ayomanor's lack of volume this season means he'll need to find the end zone, or fantasy managers will likely be extremely disappointed. With that in mind, the 22-year-old can be viewed as a desperation flex choice in 12-team leagues and up.
--Dennis ClausenSource: ESPN
October 10, 2025
Kansas City Chiefs quarterback
Patrick Mahomes will take on the Detroit Lions on Sunday night in Week 6. Mahomes completed 29 of 41 pass attempts (71%) for 318 yards and a touchdown in last week's loss to the Jacksonville Jaguars. Despite the loss, the Chiefs superstar set a new season-high for passing yards and completion percentage. Mahomes also rushed six times for 60 yards and a touchdown in Week 5. Kansas City's offense hasn't quite hit its stride, but Mahomes has still been valuable for fantasy. The 30-year-old has recorded at least 57 rushing yards and a rushing touchdown three times in five weeks, giving him a strong floor to go along with his passing production. Mahomes should continue being a valuable fantasy asset against the Lions, who have scored the most points in the league this season. The Sunday night matchup has the highest total of the week, meaning that Mahomes and the Chiefs will need to score a lot to keep up with Detroit. Mahomes is ranked QB4 in our RotoBaller rankings, making him a strong QB1 this week.
--Joshua CostelloSource: NFL.com
October 10, 2025
Pittsburgh Steelers running back
Jaylen Warren (knee) is set to return to action in Week 6 against the division-rival Cleveland Browns. Though
Kenneth Gainwell impressed in Warren's absence, the latter is expected to reclaim RB1 duties immediately after practicing in full all week. Fantasy managers should keep expectations in check, however, as the Browns are allowing the fewest yards per carry and third-fewest fantasy points per game to opposing running backs. If Pittsburgh is forced to lean on the passing attack, Warren should remain involved as a key target for quarterback
Aaron Rodgers, especially with
Calvin Austin III (shoulder) sidelined. While this isn't the most appealing matchup, Warren still checks in as the RB26 in RotoBaller's half-PPR rankings and profiles as a high-end flex play in most formats.
--Jorden HillSource: RotoBaller
October 10, 2025
Pittsburgh Steelers quarterback
Aaron Rodgers is returning from a bye in Week 5 for an AFC North showdown against the Cleveland Browns on Sunday. Cleveland has been tough on opposing quarterbacks, holding the position to the sixth-fewest fantasy points per game. However, with the Browns even more dominant against the run, Pittsburgh may be forced to lean on Rodgers and the air attack despite
Jaylen Warren's return. Though receiver
Calvin Austin III (shoulder) has been ruled out, Rodgers could find success with his favorite target,
DK Metcalf, after the two displayed strong chemistry in Week 4. Still, this contest is expected to be a low-scoring defensive battle, keeping Rodgers in the low-end QB2 range in superflex leagues.
--Jorden HillSource: RotoBaller
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