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San Francisco 49ers running back Christian McCaffrey continues to be a high-volume workhorse for the Niners early in the 2025 season. In the one-point win over the visiting Arizona Cardinals in Week 3 on Sunday, McCaffrey had 17 rushing attempts for 52 yards and caught 10 of his 15 targets for 88 yards through the air. CMC was unable to find the end zone, but his workhorse role and good health (so far) have been music to his fantasy managers' ears. The Niners have been leaning on the 29-year-old with quarterback Brock Purdy (toe, shoulder), tight end George Kittle (hamstring), and receiver Jauan Jennings (ankle, shoulder) injured. He has exceeded 100 scrimmage yards in all three games so far this year and will have a good chance to make it four in a row in Week 4 against the Jacksonville Jaguars, especially if Purdy can return. CMC still has league-winning dual-threat abilities, but he'll need to stay healthy.--Keith Hernandez
Source: ESPN.com
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REAL-TIME FANTASY NEWS

Tyrone Tracy Jr.

Ruled Out for Remainder of Week 3 Due to Shoulder Injury
Brandon Woodruff

has Moderate Lat Strain
Luther Burden III

Tops 100 Receiving Yards in Week 3, Scores First NFL Touchdown
James Conner

Ankle Injury Severe Enough to End His Season?
Courtland Sutton

Bounces Back With Monster Week 3 Performance
Tyrone Tracy Jr.

Questionable to Return With Shoulder Injury
Mac Jones

Aggravates PCL Sprain in Week 3 Win
CeeDee Lamb

Believes That He Can Play in Week 4
Najee Harris

Tests Indicate Najee Harris Tore Achilles
Caleb Williams

Throws for Four Touchdowns in Stellar Outing Sunday
CeeDee Lamb

Avoids Major Ankle Injury in Week 3 Loss
Najee Harris

Achilles Injury Confirmed for Najee Harris
Jeremy Peña

Jeremy Pena to Get Imaging Done
Nico Collins

Goes Over 100-Yard Mark
Jordan Mason

Rushes for Over 100 Yards, Two Touchdowns in Lead-Back Role
Hunter Henry

Scores Twice in Week 3
CeeDee Lamb

Won't Return Due to Ankle Injury
Anthony Davis

Participates in Five-on-Five Games
James Conner

Ruled Out with Ankle Injury
San Francisco 49ers

Nick Bosa Downgraded to Out in Week 3
Najee Harris

Ruled Out for Week 3 with Non-Contact Injury
Colston Loveland

Questionable to Return with Hip Injury Sunday
Najee Harris

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CeeDee Lamb

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Cedric Coward

"100% Cleared" for Basketball Activities
Trevor Megill

Unlikely to Return Until Playoffs
Brandon Woodruff

Goes on 15-Day Injured List With Lat Strain
CJ Abrams

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Wyatt Langford

Back in Lineup on Sunday
Charlie Morton

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the Favorite to Win at New Hampshire
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Recent Speed Downturn Could Continue at Loudon
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Ty Gibbs

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Kyle Busch

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Giancarlo Stanton

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CFB

Thomas Castellanos OK After Injury Scare
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LaNorris Sellers Upgraded to Probable for Saturday's Tilt Against Missouri
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Pablo López

Pablo Lopez Goes to Injured List
Tylor Megill

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Behren Morton Ruled Out vs. Utah
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Behren Morton Exits with Possible Concussion
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Jeremy Lauzon

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Jack Eichel

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Wyatt Langford

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Exits With Pectoral Tightness on Friday
Alec Bohm

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Matthew Coronato Expected to Make a Big Impact This Season
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Kevin Hayes

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Evgeni Malkin

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Misses Practice With Upper-Body Injury
Artemi Panarin

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Yordan Alvarez

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Kyle Finnegan

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Isaac Paredes

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Yuri Collins

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Charlotte Hornets

Hornets Sign Keyontae Johnson
Dennis Smith Jr.

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Undergoing Foot/Ankle Surgery
William Eklund

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Kevin Hayes

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CFB

LaNorris Sellers Upgraded to Probable for Saturday's Tilt Against Missouri
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Eric Singleton Jr. Questionable For Saturday
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NBA

Kai Jones Links Up With EuroLeague Team
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