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San Francisco 49ers pass-rusher Nick Bosa (knee) will not return to Sunday's Week 3 contest against the Arizona Cardinals. The team initially listed him as questionable before downgrading him to out during the second half. At the time of his departure, he had made two tackles and also forced a fumble. Bosa is the heart and soul of the 49ers' defense, so the unit might take a step backward for the duration of his absence. To make matters worse, San Francisco is also without Mykel Williams (wrist, questionable). Yetur Gross-Matos and Bryce Huff should earn more defensive snaps for the time being.--Andersen Pickard
Source: Adam Schefter
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