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Complete NFL Week 1 betting lines, point spreads, and betting odds analysis. Expert predictions on the best spreads to bet and Las Vegas totals for Sunday's games.
The NFL is back, baby, and my fellow bettors, do we have an incredible lineup of content planned out for you this season!
This article is intended to be a first look at every NFL game in Week 1, providing the spreads, totals, odds, and analysis that you need to start your research for your Week 1 NFL wagers.
Check back later in the week for our writers' favorite bets, props, and picks. But for now, here is a breakdown of every NFL game with some trends and data for your consideration!
Be sure to check all of our fantasy football rankings for 2025:- 2025 fantasy football rankings
- Running back (RB) fantasy football rankings
- Wide receiver (WR) fantasy football rankings
- Tight end (TE) fantasy football rankings
- Quarterback (QB) fantasy football rankings
- FLEX fantasy football rankings
- Defense (D/ST) fantasy football rankings
- Kicker (K) fantasy football rankings
- Dynasty fantasy football rankings
Thursday Night Football Betting Lines
Dallas Cowboys (+8.5) at Philadelphia Eagles (-300)
- Over/Under (47.5)
- Key Trend(s): Eagles swept season series 2-0 in 2024 with an average margin of victory of 31 points.
The defending champs open up the NFL schedule at home on national television, continuing a trend that we have seen from the NFL over the last several seasons. The Eagles host their NFC East rival, the Cowboys, and are favored by more than a touchdown as the line continues to move in their favor.
Initial Lean: Eagles -8.5
While 8.5 points is a lot to lay on a favorite, the Birds bring back just about everyone from their championship run, and they destroyed Dallas twice last season. The Cowboys just dealt away their best defensive player and could be in for a rough opener.
Friday Night Football Betting Lines
Kansas City Chiefs (-3) at Los Angeles Chargers (+150)
- Over/Under (45.5)
- Key Trend(s): Chiefs have won seven straight games against the Chargers; however, they have failed to cover the spread in the last three wins.
We get some Friday night football in the opening week and a big-time matchup in the AFC West. The Chiefs are fresh off a humiliating loss to the Eagles in the Super Bowl, while the Chargers also have a bad taste in their mouths after being eliminated by the Texans in the first round of the AFC playoffs last season.
KC has owned the matchup lately, but this Chargers team could be even better in year two of the Harbaugh era. Are the Chiefs on their way down from their peak, or can they return to glory?
Initial Lean: Chargers +3
The Chargers have played KC close the last few times, and I wouldn't be surprised if they pulled off the upset at home, but taking them with the points gives us some last-second field goal insurance if the Chiefs win a close one.
Sunday Early Games Betting Lines
Miami Dolphins (+1.5) at Indianapolis Colts (-110)
- Over/Under (46.5)
- Key Trend(s): Colts 5-3 ATS last season at home, Miami 4-5 ATS on the road last season.
Both teams enter with some controversies brewing. Is Tyreek Hill bought in this year, or will he want out of Miami before the deadline? Did the Colts make the right decision in starting Daniel Jones over Anthony Richardson Sr.? Is De'Von Achane healthy after missing the preseason with an injury?
Initial Lean: Colts -1.5
I actually think Jones makes the Colts better than people want to believe. They won't lean on him too much in the opener, likely featuring Jonathan Taylor in the run game and asking their defense to keep them in it. I have more questions about Miami on both sides of the ball than I do about Indy.
Carolina Panthers (+3.5) at Jacksonville Jaguars (-154)
- Over/Under (46.5)
- Key Trend(s): Panthers hit the over in 76.5% of games last season (13-4)
Two teams that badly want to improve their records from last season meet in Week 1. We expected the Panthers to struggle last year, but the Jags were a bit of a surprise as they spiraled downward after losing Trevor Lawrence for the season.
Liam Coen and Dave Canales are two of the best offensive minds in the NFL. They also have two of the worst defenses in the league. Expect Jacksonville vs Carolina to be a shootout. pic.twitter.com/aNhaI04OKz
— FNF NFL (@fnfantasyleeg) September 3, 2025
We get some exciting debuts from Travis Hunter (JAX) and Tetairoa McMillan (CAR) at the wide receiver position.
Initial Lean: OVER 46.5 total points
Both teams had porous defenses last season, but should be better on offense in 2025. I expect to see a lot of scoring in this one.
New York Giants (+6) at Washington Commanders (-240)
- Over/Under (45.5)
- Key Trend(s): Washington 75% cover rate as home favorite in 2024 (6-2)
The Giants look to improve on one of the worst records in the NFL, but will have a challenge in Week 1 against a Commanders team that went on a surprising run all the way to the NFC Championship game.
Initial Lean: Commanders -6
The Giants covered this spread in both matchups last season, but Washington hit a different gear in the final month of the season and has major momentum coming into this one. Russell Wilson at quarterback is going to hold back this Giants offense, and they'd be wise to make the move to rookie Jaxson Dart sooner rather than later.
Arizona Cardinals (-6.5) at New Orleans Saints (+230)
- Over/Under (43)
- Key Trend(s): Saints just 3-4 ATS last season as home underdogs.
Most analysts expect the Saints to be among the worst teams in football this year, while the Cardinals have been projected by many to take another step forward towards being a playoff contender.
Initial Lean: Cardinals -6.5
It's tough to lay this many points on a road underdog, but I do think New Orleans could be very, very bad in 2025. Spencer Rattler gets the start in Week 1, but the Saints' offense was inept in the second half last season, while their defense got steamrolled.
Cleveland Browns (+6) at Cincinnati Bengals (-215)
- Over/Under (47.5)
- Key Trend(s): Bengals were 11-6 on overs last season (64.7% cover rate).
The Battle of Ohio kicks things off in the AFC North. The Bengals started slow last year and were unable to make up enough ground to get into the playoffs, but they did sweep the hapless Browns in two meetings.
Initial Lean: OVER 47.5 total points
While both meetings stayed under this number last year, I think the Browns offense with Joe Flacco can put up enough points to cover the over here, and the Bengals should be able to score through the air with their highly successful passing game.
Las Vegas Raiders (+2.5) at New England Patriots (-130)
- Over/Under (43.5)
- Key Trend(s): The Raiders' defense allowed 24+ points to opponents in 9/17 games in 2024.
This game is a tough one to predict as we have a whole new look Raiders team with Geno Smith at quarterback and a first-round running back, Ashton Jeanty, in the backfield. The Patriots have their own bevy of young talent with Drake Maye in his second year as the signal-caller and an exciting rookie back of their own in TreVeyon Henderson.
Initial Lean: Patriots over 23.5 point team total
The Pats offense should be massively improved this year with the addition of Stefon Diggs, Henderson, and even rookie wide receiver Kyle Williams. The Raiders struggled to stop teams last year, and win or lose, I like the Pats to put up some points in this one.
Tampa Bay Buccaneers (-1.5) at Atlanta Falcons (+120)
- Over/Under (47.5)
- Key Trend(s): Tampa Bay was 12-6 on overs last season with the third-highest cover rate (66%).
The Falcons beat the Bucs twice last season, but Tampa got the last laugh as they still won the division and made the playoffs. Both teams bring back the majority of their core and have playoff aspirations in 2025. Michael Penix Jr. takes over the reins at QB from Kirk Cousins this year in Atlanta, while the Bucs start the season a bit banged up without Chris Godwin or Jalen McMillan in their receiving core.
Initial Lean: OVER 47.5 points
These teams combined for 66 and 57 points in two meetings last year, and I expect more points in this matchup this year.
Pittsburgh Steelers (-2.5) at New York Jets (+140)
- Over/Under (38.5)
- Key Trend(s): NO TRENDS
This projects as one of the uglier matchups of Week 1 with only a 38.5 total. We have instant revenge games for QBs with Justin Fields and Aaron Rodgers facing their former teams, too, but the defenses should take center stage.
Initial Lean: Jets ML
My reaction when the Steelers lose Week 1 to the Jets on the road… pic.twitter.com/yGIxoEYsHT
— "Thunder Dan" Palyo (@ThunderDanDFS) August 21, 2025
Call me crazy, but the Steelers feel the biggest fake contenders out there. I am not sure they got better on either side of the ball despite a bunch of moves. The Jets, meanwhile, could surprise some people, and I like their chances of catching Pittsburgh off guard in Week 1.
Sunday Afternoon Games Betting Lines
San Francisco 49ers (-2.5) at Seattle Seahawks (+125)
- Over/Under (43.5)
- Key Trend(s): Seattle was just 1-5 ATS as home underdogs last season.
We have an NFC West showdown right out of the gate with Seattle hosting their division rival, San Francisco. Both teams have made some major changes to their personnel, and last season was a bit of a throwaway for the Niners as they hope to return to their former glory of years prior.
Initial Lean: Seattle ML
It's tough to predict what we see from each team, but I think folks are sleeping on Seattle (pun intended). I am going against last year's trend, but something tells me that Seattle could be better than advertised. The 49ers are going to be limited on offense with very few weapons available to Brock Purdy, while Seattle could thrive under new offensive coordinator Klint Kubiak.
Tennessee Titans (+8) at Denver Broncos (-340)
- Over/Under (42.5)
- Key Trend(s): Denver 100% cover rate as home favorite in 2024 (6-0)
The Broncos are one of the biggest favorites on the slate as they are coming off a playoff appearance in 2025 and hosting a Titans team that struggled and is starting a rookie quarterback in Cam Ward.
Initial Lean: Broncos -8
I like Tennessee this year, and I think they'll be a fun team to watch weekly, but this Denver defense was stifling and should prove to be a tough matchup for Ward in his debut. I think the Broncos win this one comfortably.
Detroit Lions (+2.5) at Green Bay Packers (-115)
- Over/Under (47)
- Key Trend(s): The Lions were only road underdogs once in the entire 2025 season, which was a win over Green Bay.
This should be one of the best games of the opening weekend. The Lions were a Super Bowl favorite last year before losing in the NFC Championship to Washington, while Green Bay had a solid season of its own, also qualifying for the playoffs.
Is this the year that the rest of the NFC North catches up to the Lions? Can the newly arrived Micah Parsons shift the odds in favor of the Packers?
Since taking over as QB1 in year two, Jared Goff is 8-0 ATS in season openers
The Lions are 2.5-point dogs against the Packers on Sunday @DKSportsbook pic.twitter.com/duVd05xMyM
— Barstool Gambling (@stoolgambling) September 2, 2025
Initial Lean: Packers ML
It's tough to go against the Lions, but this game feels like a toss-up, and I think Green Bay is going to be very tough this year, especially at home.
Houston Texans (+3) at Los Angeles Rams (-140)
- Over/Under (43.5)
- Key Trend(s): Texans games went under at a 62.6% rate last season (12-7).
Two playoff teams in their respective conferences battle it out in this one. The Texans had a great defense in 2025 and are looking to improve on offense, while the Rams are loaded with firepower on offense and need their young defense to take another step.
Initial Lean: Rams -3
This should be a great game, but I give the Rams a slight edge at home. The addition of Davante Adams is going to give them another big weapon on offense, and I still have some doubts about the Texans' offensive line and their ability to protect C.J. Stroud against a solid Rams pass rush.
Sunday Night Football Betting Lines
Baltimore Ravens (+1.5) at Buffalo Bills (-110)
- Over/Under (50.5)
- Key Trend(s): Buffalo was 6-3 ATS as home favorites in 2025, and Baltimore was just 0-1 as a road underdog.
We get a potential AFC Championship preview in Week 1 as both teams have been stalwarts in the conference for several years now and are loaded up in 2025 for another deep run.
Initial Lean: UNDER 50.5 total points
Buffalo has won three of the last four meetings, including a close win in the playoff last season. I am taking the under here based on how both teams want to run the football. Three of those four games went under the current 50.5 point total, too.
Monday Night Football Betting Lines
Minnesota Vikings (-1.5) at Chicago Bears (+105)
- Over/Under (44)
- Key Trend(s): Chicago was 2-1 ATS last season as a home underdog.
We see another divisional game on Monday night with the Bears hosting the Vikings. The Bears continue to add young talent to their core, but can they finally take the next step towards contending in 2025?
The Vikings were one of the best teams in the league last season, but their season ended with two crushing losses. Sam Darnold is gone, but can J.J. McCarthy keep this offense firing on all cylinders?
Initial Lean: Vikings -1.5
Minnesota has owned this matchup, winning seven of the last eight matchups. This should be a good game, but I think the Vikings are a bit better on both sides of the ball still.
