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Isaac Guerendo Could be a Drop Candidate in Dynasty Leagues in 2026
San Francisco 49ers running back Isaac Guerendo had 84 rushing attempts for 420 yards and four touchdowns in 16 regular-season games (three starts) in 2024 after the Niners took him in the fourth round of the NFL draft out of Louisville. He also added 15 receptions for 152 yards as a pass-catcher. The 25-year-old fell out of favor in head coach Kyle Shanahan's offense in 2025, though, and All-Pro RB Christian McCaffrey stayed healthy all year long. Guerendo was limited to special teams duties and surprisingly didn't see a single touch on offense despite his elite speed. Brian Robinson Jr. handled the change-of-pace role to CMC. B-Rob is gone, but signs are pointing to Jordan Mason being the favorite for the RB2 job in the Bay Area in 2026, and rookie Kaelon Black could even jump Guerendo on the team's RB depth chart with a strong summer in training camp. McCaffrey could easily get hurt again in 20206, but even if he does, we can't say with any certainty that Guerendo would be next in line for a much bigger backfield role. A change of scenery might be what he needs to become relevant in dynasty leagues again. Guerendo has plummeted all the way to No. 99 in RotoBaller's RB dynasty rankings for the upcoming season.
Source: Pro Football Reference
Source: Pro Football Reference
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