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Sep 14, 2025, 9:24 AM ET

According to Adam Schefter, San Francisco 49ers quarterback Brock Purdy (toe) is unlikely to play in Week 3 against the Arizona Cardinals. Purdy will be absent in Week 2, and it sounds like he'll miss multiple games due to a turf-toe issue. There's a chance that Purdy misses as many as five games from this injury. Backup Mac Jones will be under center in Week 2, and it sounds like he'll be drawing multiple starts. Jones doesn't offer a ton of upside, but he has value in superflex fantasy formats for those desperate at the QB position already. It sounds like the 49ers are going to need to lean on him for at least two games.--Andy Webb
Source: Adam Schefter
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