September 7, 2025
San Francisco 49ers tight end
George Kittle (hamstring) has been ruled out for the remainder of Sunday's Week 1 contest against the Seattle Seahawks. At the time of his departure, he had caught four passes for 25 yards and one touchdown. The star tight end is one of the focal points of San Francisco's offense, and he has been able to stay relatively healthy, missing just two games in 2024. His injury represents a major concern for the Niners in Week 1 and beyond. Fantasy managers should monitor Kittle's practice status next week, as it's too early to tell whether this might be a multi-week absence.
Luke Farrell will operate as the 49ers' primary tight end until Kittle can return.
--Andersen PickardSource: Field Yates
September 7, 2025
Los Angeles Rams wide receiver
Puka Nacua (head) was taken to the locker room to be evaluated for a concussion during the first quarter of Sunday's Week 1 contest against the Houston Texans. He is questionable to return. The injury appeared quite serious as Nacua had blood running down his face after taking a hit to the head from Henry To'oTo'o. At the time of his departure, Nacua had four targets, three catches, and 23 receiving yards. When healthy, he is a low-end fantasy WR1 in fantasy football.
Davante Adams will operate as
Matthew Stafford's primary target with Nacua sidelined, while
Colby Parkinson,
Tyler Higbee, and
Tutu Atwell also get involved in the passing game.
--Andersen PickardSource: Adam Grosbard
September 7, 2025
Tennessee Titans running back
Kalel Mullings (ankle) exited during the first quarter of Sunday's game against the Denver Broncos. He is officially questionable to return. The rookie had not registered a statistic prior to his departure. Mullings entered this weekend listed as questionable with an ankle injury, so it's possible that he re-aggravated an existing ailment. With
Tyjae Spears (ankle) on IR and Mullings sidelined for the moment, Tennessee's only healthy running backs are
Tony Pollard and
Julius Chestnut.
--Andersen PickardSource: Chris Tomasson
September 7, 2025
Las Vegas Raiders tight end
Brock Bowers (knee) told NFL Network's Tom Pelissero that he's fine and has no concerns about his injury going forward. The star tight end originally exited Sunday's game against the Patriots with a knee injury and was listed as questionable, but it sounds like he won't have any lingering effects going forward. Bowers finished Week 1 with eight targets, five catches, and 103 yards. He'll rank as a high-end TE1 heading into Week 2 against the Los Angeles Chargers. In two games against the Chargers last year, Bowers totaled 10 catches, 108 yards, and one touchdown.
--Andersen PickardSource: Tom Pelissero
September 7, 2025
Atlanta Falcons wide receiver
Drake London (shoulder) exited during the fourth quarter of Sunday's Week 1 contest against the Tampa Bay Buccaneers. He is officially questionable to return. At the time of his departure, he had caught eight of 15 targets for 55 yards. The Falcons were already playing without
Darnell Mooney (shoulder), so London's exit from the contest is a loss that Atlanta cannot afford.
Ray-Ray McCloud III,
Kyle Pitts Sr., and
Bijan Robinson will operate as
Michael Penix Jr.'s primary targets until London can return.
--Andersen PickardSource: Tori McElhaney
September 7, 2025
Minnesota Vikings safety Harrison Smith (illness) has been downgraded to out ahead of Monday Night Football against the Chicago Bears. Smith had been listed as doubtful after logging a limited practice on Friday. He will not travel with the team. The 36-year-old will have to wait at least one more week before kicking off his 14th NFL season. He made 16 starts last season, totaling 87 tackles, three interceptions, one fumble recovery, and one sack. Theo Jackson and Jay Ward should earn more defensive snaps in Smith's absence.
--Andersen PickardSource: Minnesota Vikings
September 7, 2025
New Orleans Saints wide receiver
Chris Olave (chest) exited during the fourth quarter of Sunday's Week 1 contest against the Arizona Cardinals. The team announced that he was questionable, but he quickly returned to the contest. Olave will re-assume his role as the Saints' No. 1 wide receiver ahead of
Rashid Shaheed. Given his role in a subpar
Spencer Rattler-led offense, Olave should merely be viewed as a high-end WR3/FLEX option in fantasy football.
--Andersen PickardSource: New Orleans Saints PR
September 7, 2025
Las Vegas Raiders tight end
Brock Bowers (knee) exited during the fourth quarter of Sunday's Week 1 contest against the New England Patriots. He is officially listed as questionable to return. The star second-year tight end was seen entering and exiting the medical tent, and he eventually returned to the sideline wearing his helmet. At the time of his departure, Bowers had caught five of his eight targets for 103 yards. Fantasy managers should continue to monitor for updates on the consensus TE1 in this year's drafts. For the time being,
Michael Mayer will operate as the Raiders' No. 1 tight end.
--Andersen PickardSource: Las Vegas Raiders
September 7, 2025
Indianapolis Colts running back
Jonathan Taylor (undisclosed) exited Sunday's game against the Miami Dolphins and was seen chatting with medical personnel on the sideline, according to Kevin Bowen of 1075 The Fan. After playing 100 percent of the offensive snaps in the first half, Taylor was not on the field for a scoring drive in the fourth quarter of Week 1. The severity of Taylor's injury is unknown, and it's possible that the Colts are being extra cautious with his management because they are leading by four possessions in the final quarter. Nevertheless, fantasy managers should continue to monitor his status. At the time of Taylor's departure, he had 18 carries for 71 rushing yards, plus 27 receiving yards.
D.J. Giddens has been handling backfield snaps in his absence.
--Andersen PickardSource: Kevin Bowen
September 7, 2025
Tennessee Titans running back
Kalel Mullings (ankle) is officially active for Sunday's Week 1 contest against the Denver Broncos. He had been listed as questionable after logging a limited practice session on Friday. The Michigan product rushed for 948 yards and 12 touchdowns during his final collegiate season last year. Although he was drafted as the Titans' projected No. 4 running back, he will carve out a larger role for the time being with
Tyjae Spears (ankle) on injured reserve. Mullings and
Julius Chestnut will likely rotate in as the backup options behind clear-cut starter
Tony Pollard on Sunday afternoon.
--Andersen PickardSource: Turron Davenport
September 7, 2025
San Francisco 49ers running back
Jordan James (finger) is officially inactive for Week 1 against the Seattle Seahawks. He had been listed as doubtful after logging three consecutive limited practices. James will have to wait at least one more week before making his NFL debut. The Oregon product was an effective runner in college, totaling 1,476 yards and 15 touchdowns during his final collegiate season. For now, San Francisco will operate with
Brian Robinson Jr. and
Isaac Guerendo in depth roles behind
Christian McCaffrey.
--Andersen PickardSource: Rob Lowder
September 7, 2025
Los Angeles Rams running back
Jarquez Hunter (coach's decision) is a healthy scratch for Week 1 against the Houston Texans. Although the rookie has fourth-round draft capital, it appears that the coaching staff wasn't ready to include him as a member of their gameday backfield. Hunter's absence is not necessarily a surprise, though. Yesterday, we noted that Hunter's position on the depth chart may be falling after the Rams elevated
Cody Schrader from the practice squad. Indeed, Schrader will operate behind
Kyren Williams and
Blake Corum, while Hunter watches from the sideline. He's a fine dynasty stash but should be dropped in all redraft leagues.
--Andersen PickardSource: Gary Klein
September 7, 2025
Green Bay Packers wide receivers
Jayden Reed (foot) and
Dontayvion Wicks (calf) are both officially active for Sunday's Week 1 contest against the Detroit Lions. They had been listed as questionable after logging limited practice sessions on Friday. Reed is coming off a decent 2024 season in which he caught 55 passes for 857 yards and seven total touchdowns, plus an additional 163 rushing yards. He's expected to operate as the Packers' No. 2 receiver alongside
Matthew Golden. His versatility allows him to rank as a modest WR3/FLEX option, and he should benefit from a potentially high-scoring game against the Lions. Wicks had 39 catches, 415 yards, and five touchdowns last season, but with a decent amount of competition in the passing game, he's tough to trust in fantasy football. Reed can be left on waivers in most leagues for now.
--Andersen PickardSource: Jason B. Hirschhorn
September 7, 2025
Green Bay Packers edge rusher Micah Parsons (back) is officially active for his team's Week 1 contest against the Detroit Lions, per Matt Schneidman of The Athletic. Parsons is dealing with a back injury and may be on a limited snap count in his first game with Green Bay, but he will be on the field in some capacity. The All-Pro edge rusher could make things difficult for Lions quarterback
Jared Goff and Detroit's passing game in Week 1.
--Will BradySource: The Athletic - Matt Schneidman
September 7, 2025
San Francisco 49ers running back
Christian McCaffrey (calf) is not listed among the team's inactives for Week 1 against the Seattle Seahawks, per David Lombardi of The San Francisco Standard. McCaffrey popped up on the team's injury report earlier this week with a calf injury, but it does not appear that the injury will keep him out of the lineup for the 49ers. McCaffrey battled through multiple injuries in 2024 that caused him to miss most of the season. As long as he's active and on the field, he's a must-start fantasy running back.
--Will BradySource: The San Francisco Standard - David Lombardi
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