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Andy's top DraftKings and FanDuel MLB DFS picks for today, Monday, 4/21/25. His favorite daily fantasy baseball lineup sleepers and value picks for DFS on DraftKings and FanDuel.
Welcome to another Monday edition of the RotoBaller MLB DFS picks! In this piece, I will break down my top pitchers and hitters to target on this slate. On the hitting side of the slate, the Detroit Tigers, Atlanta Braves, and San Francisco Giants have top matchups.
On the pitching side, we will see emerging ace Spencer Schwellenbach take on the St. Louis Cardinals, and early-season AL Cy Young favorite, Hunter Brown, look to make his fifth-straight quality start against the Toronto Blue Jays.
This article will provide my daily fantasy baseball lineup picks for DraftKings and FanDuel on 4/21/2025, with the slate starting at 6:40 p.m. EDT. The lineup picks will feature elite players, mid-priced options, and value plays. You can also read more DFS advice and lineup picks for other sports here. Monitoring injury news and today's MLB starting lineups is always essential.
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DraftKings, FanDuel Pitchers - MLB DFS Lineup Picks
Hunter Brown, HOU vs. Toronto Blue Jays ($9K DK/$10.5K FD)
Hunter Brown has posted a quality start in each of his first four outings and will be a popular play on this smaller slate. Through his first four starts, Brown has logged 24 innings to the tune of a 1.50 ERA with a 0.83 WHIP. He has struck out 22 batters and served up just five free passes.
This evening, he will face the Blue Jays, who have generated the lowest ISO (.097) against right-handed pitching this season.
Hunter Brown leads American League starting pitchers in ERA dating back to May 1st of last season (min. 120 IP) 📊@Astros | #BuiltForThis pic.twitter.com/vRLz5OQSns
— MLB Network (@MLBNetwork) April 16, 2025
Max Meyer, MIA vs. Cincinnati Reds ($7.6K DK/$10.1K FD)
My other pitcher to target comes at a cheaper price on DraftKings, Max Meyer. After batting injuries throughout most of his young career, the former top prospect is healthy and pitching quite well. Through his first 24 frames, the right-hander has struck out 27 batters while holding a 2.63 ERA.
Tonight, he will face a Cincinnati offense that has posted the 10th-highest strikeout rate and the ninth-lowest ISO against right-handed pitching.
Others To Consider (Cash/GPP):
- Nick Lodolo, CIN ($8.7K DK/$8.7K FD)
- Spencer Schwellenbach, ATL ($9.5K DK/$9.8K FD)
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DraftKings, FanDuel Infielders - MLB DFS Lineup Picks
Spencer Torkelson, 1B, DET ($4.5K DK/$3.5K FD)
Spencer Torkelson has enjoyed an incredible start to the campaign and is finally living up to his prospect pedigree. Entering Sunday, Torkelson carried an elite .286/.353/.786 line with two doubles and four long balls over his last eight games.
He will have a great opportunity again, thus evening facing San Diego right-hander Randy Vasquez. Torkelson mashes cutters from a right-handed pitcher (Vasquez's primary pitch). This season, he has generated an incredible 1.113 xSLG when facing cutters from right-handers.
Spencer Torkelson breakout szn
▫️7 HR
▫️.289 AVG
▫️21 RBI
▫️1.043 OPS(via @tigers)pic.twitter.com/sIeQn3Wg5h
— FOX Sports: MLB (@MLBONFOX) April 19, 2025
Matt Chapman, 3B, SFG ($4.5K DK/$3.1K FD)
Matt Chapman enters Monday swinging a hot bat and is worth targeting on this slate. Entering Sunday's game, Chapman posted an elite .429/.538/.762 slash line with one double and two round-trippers.
This evening, he will face Milwaukee right-hander Quinn Priester. Priester relies heavily on his sinker (40.4 percent usage), which should put Chapman in a great position to succeed. When facing sinkers from right-handers, Chapman has generated a .615 xSLG with a .506 xwOBA.
Ozzie Albies, 2B, ATL ($4.9K DK/$3.2K FD)
My final infielder to highlight is Ozzie Albies of the Atlanta Braves. Albies has begun to find his swing, holding a .303/.395/.606 line over his last nine games, entering Sunday.
This evening, he will face St. Louis right-hander Erick Fedde. Fedde relies primarily on two pitches (a sinker and a cutter), and Albies has great success against the latter. When facing cutters from right-handers this season, the switch-hitting second baseman has posted an incredible 1.874 xSLG with a 1.099 xwOBA.
Others To Consider (Cash/GPP):
- Wilmer Flores, 1B/3B, SFG ($3.8K DK/$3.2K FD)
- Austin Riley, 3B, ATL ($5K DK/$3.3K FD)
- Rhys Hoskins, 1B, MIL ($3.9K DK/$2.6K FD)
DraftKings, FanDuel Outfielders - MLB DFS Lineup Picks
Riley Greene, OF, DET ($4.3K DK/$2.9K FD)
Similar to Torkelson, Riley Greene should be in a prime position for success against Vasquez. When facing cutters from right-handed pitchers, Greene has generated a strong 1.035 xSLG with a .538 xwOBA.
Greene has slowly begun to snap his recent skid and should stay hot at the plate this evening.
Marcell Ozuna, OF, ATL ($4.7K DK/$3.8K FD)
While his teammate Albies has great success against Fedde's second-most-used pitch, the power-hitting Marcell Ozuna should find it against Fedde's primary pitch. When facing sinkers from right-handers this season, the 34-year-old has generated a strong .471 xSLG.
Since the start of April, Ozuna has been one of the most productive hitters in the game, holding a .341/.435/.591 line with two doubles and three long balls.
MARCELL OZUNA’S OPS IS BACK OVER 1.000 pic.twitter.com/dPrcH1oo1H
— Kevin Keneely (@KevinKeneely1) April 20, 2025
Brandon Nimmo, OF, NYM ($4.2K DK/$2.7K FD)
Brandon Nimmo and the New York Mets will play host to the Philadelphia Phillies and Aaron Nola. Nola comes into this game holding an underwhelming 6.65 ERA with a 0-4 record.
Throughout his career, Nimmo has found success against Nola, particularly in terms of power. He has gone deep twice and posted a strong .794 OPS in 52 at-bats against him. In addition, when facing fastballs from right-handed pitching this season, Nimmo has performed very well, posting a .520 xSLG.
Others To Consider (Cash/GPP):
- Kerry Carpenter, OF, DET ($4.2K DK/$3K FD) *DTD with a hamstring injury*
- Juan Soto, OF, NYM ($5.7K DK/$3.8K FD)
- Jung Hoo Lee, OF, SFG ($4.8K DK/$3.7K FD)
- Gavin Sheets, 1B (FanDuel Only)/OF, SDP ($3.4K DK/$2.7K FD)
DraftKings, FanDuel MLB DFS Stacks
1. Detroit Tigers vs. Randy Vasquez
Even though Vasquez enters this contest with a 1.74 ERA and a 1.35 WHIP, do not let his "base" statistics fool you. Under the hood, the 26-year-old carried a hefty 5.72 xERA with a .262 xBA.
His primary pitch, his cutter, has generated a .571 xSLG, which is significantly higher than the .381 SLG it currently holds. He is due for massive regression.
Favorite Combo: Torkelson, Greene, Carpenter, Keith
2. San Francisco Giants vs. Quinn Priester
Similar to Vasquez, do not let Priester's stat line fool you. The former 18th overall pick enters Monday's showdown carrying a 0.90 ERA with a 1.20 WHIP. However, he has generated a 5.40 xERA and a .281 xBA, which place him in the 19th and 21st percentile, respectively.
His primary pitch, his sinker, has outperformed its expected stats by nearly 300 points as well (357 SLG - .603 xSLG).
Favorite Combo: Flores, Chapman, Lee, Yastrzemski
3. Atlanta Braves vs. Erick Fedde
The Atlanta Braves will face Fedde this evening, who enters this matchup with a modest 3.43 ERA and a 1.14 WHIP. Under the hood, his metrics suggest that the 32-year-old could be in line for significant positive regression. He has generated a high 5.00 xERA and a .271 xBA.
In addition, several Atlanta hitters have had great success against sinkers from right-handed pitchers, which is Fedde's most frequently used pitch. As mentioned above, Ozuna has generated a strong .471 xSLG while third baseman Austin Riley has posted a .682 xSLG.
When facing his second-most-used pitch, his cutter, Albies should succeed as he has generated a 1.874 xSLG against this pitch from right-handers.
Favorite Combo: Albies, Riley, Ozuna, Murphy
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