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DraftKings Daily Fantasy Baseball Lineup Picks (9/21/16): MLB DFS Advice

By Keith Allison on Flickr (Original version) UCinternational (Crop) [CC BY-SA 2.0 (http://creativecommons.org/licenses/by-sa/2.0)], via Wikimedia Commons

Justin Klein highlights the top daily fantasy baseball lineup picks for 9/21/16. These are the top value and sleeper plays for your DraftKings MLB DFS lineups.

It's a full slate of MLB games on DraftKings for Wednesday's contests, as three games take place in the early afternoon and the remaining 12 contests take place in the evening. Because there are so few day games I'm going to focus on the evening games so that you can apply this advice to all of the evening and late contests.

In this article, I will be providing you with my daily fantasy baseball MLB lineup picks for DraftKings on 9/21/16. The DFS lineup picks will range from high-priced to low-priced options and identify options who will out-perform their expectations, including sleepers and value plays on DraftKings. The following targets have been selected for all evening and late contests.

Editor's Note: Purchase a full season NFL Premium Pass (including DFS Premium), and also get MLB Premium + DFS for free through the playoffs. Premium DFS research, lineup picks, expert lineups, tools and more. You can see screenshots of our NFL Premium and MLB Premium and DFS tools. What are you waiting for?

 

DFS Lineup Stacks to Target on DraftKings

Detroit Tigers vs. Jose Berrios (RHP)

The Detroit Tigers have a stocked offensive lineup that lit up the Twins for for eight runs on Tuesday. The will look for more on Wednesday as they face Jose Berrios. While Berrios is a blue chip prospect with loads of talent and solid minor league statistics to back it up he's been horrible terrible in the major leagues thus far. Through 48 and 2/3 MLB innings pitched this season Jose has notched a horrific 8.88 ERA. Although he's been a bit unlucky his 6.55 FIP, 5.48 xFIP and 5.20 SIERA don't paint a much better picture. Berrios has been bad against both RHH and LHH so everyone on Detroit is in play. Miguel Cabrera, JD Martinez and Cameron Maybin are your best bets. Ian Kinsler and Victor Martinez are both solid options if they do in fact play. Both have been battling injuries the past couple of days so make sure you check the starting lineups.

New York Mets vs. Ryan Weber (RHP)

Twenty-six year old Ryan Weber hasn't been very good this season for the Mets as he's posted a 5.46 ERA across 31 and 1/3 innings pitched. Last season he wasn't very good either as he notched a 4.76 ERA in 28 and 1/3 innings pitched. This leads me to the Mets and their offense in a game against a poor SP and a bad bullpen. My favorite options are Yoenis Cespedes, Curtis Granderson, Jose Reyes and Asdrubsal Cabrera. If you really like to gamble you could also use Jay Bruce, who has been colder than Freddie Jackson sippin' a milkshake in a snowstorm.

 

DFS Starting Pitchers to Consider on DraftKings

Corey Kluber, KC at CLE - $11,900

Outside of Daniel Nava's 3/6 line against  Corey Kluber the player with the highest average against him over their career is Eric Hosmer with a .277 average. The next best guy is hitting a cool .250 and it's actually two guys with only eight at bats against Kluber each. To say that he's owned the Royals is an understatement as the Klub-inator has held KC to a .236/.291/.369 triple slash. And FWIW 331 at bats is not a small sample size. Although Kluber is fairly expensive he's worth paying up for today.

Zach Greinke, AZ at SD - $8,300

Zach Greinke has not been very good lately, but I simply cannot pass up the matchup with the Padres and their 25% strikeout rate on Wednesday. Greinke isn't exactly cheap, but his mediocre play has definitely lowered his price tag. While there is certainly the chance that Greinke could stumble yet again he should at the very least be a strong source of K's. Because of this I'm willing to take a chance with Zach and hope that he scores 25+ fantasy points. The last time he pitched in San Diego he had 22.4 FP.

 

DFS Infielders to Consider on DraftKings

Catcher (C)

Gary Sanchez, NYY at TB - $4,600

Release the Kracken! This season against RHP Gary Sanchez has triple slashed an amazing .382/.449/.780 and cranked out 13 HR. Over the past week those numbers are .364/.417/.864 with three HR. Today Gary and the rest of the Baby Bombers will face Alex Cobb, who just so happens to be right handed. You know what to do.

First Base (1B)

Miguel Cabrera, DET @ MIN - $5,300

As I mentioned above the Tigers get to face Jose Berrios today and that's a good thing, because he's been awful this season. Miggy should be in for a very big day. It saddens me because I'm facing him in multiple head to head playoff matchups, but hopefully I can recoup some of that in DFS. This season against RHP Miggy has hit .311 and slugged .557. On the road his OBP is .399. In his last 5 games Cabrera has four walks and five hits including a double and two HR. There are a lot of good options at 1B, but I want Miggy in all of my lineups.

Second Base (2B)

 

Sean Rodriguez, PIT @ MIL - $4,000

Sean Rodriguez has been among the hottest hitters in baseball over the past two weeks as he's triple slashed an amazing .378/.441/.784. In his past six games he's slugging .840 with nine hits including four HR. Today he faces off with Jimmy Nelson at homer happy Miller Park. In case you're new to DFS a hot hitter in a good hitter's park is a good combination. At 4k Rodriguez seems like a bit of a steal so I'm more than happy to use him at that price.

Shortstop (SS)

Asdrubal Cabrera, NYM vs ATL - $4,200

Over the past month Asdrubal Cabrera has been white hot as he's managed to crank out 31 hits including seven doubles, a triple, seven HR and 3 SB while posting nearly as many walks as strikeouts (11:13). While Cabrera has been a better hitter against LHP this season it's important to note that 17 of his 20 HR have come against RHP. As I mentioned above I love the matchup with Ryan Weber today and I fully expect Asdrubal to stay hot and produce big numbers, so join me and get him in all of your Draftkings DFS lineups.

Third Base (3B) 

Todd Frazier, CHW @ PHI - $3,800

Todd Frazier has been blazing hot over the past week and extremely good in the month September. Over his last six games he's triple slashed .364/.400/.545 with eight hits including a double, a HR and a SB. While his season long numbers are still sketchy AF he's mashed 27 HR against RHP and 22 of his 37 HR on the road. That's seven more HR on the road despite only playing in three more road games. Today Frazier and the White Sox play the Phillies in the band box known as CItizen's Bank Park in Philadelphia and I believe Frazier stays hot and hits for extra bases.

 

DFS Outfielders to Consider on DraftKings

Chris Coghlan, CHI vs CIN - $2,800

Since you have to save some money somewhere I thought you might as well go with a red hot Chicago Cub. Although Coghlan's numbers on the year aren't great he's been solid of late. In his past five games (three starts) Chris has maanged five hits including a double and a HR while hitting .385 and slugging .692. Today he would have a nice matchup with RHP Robert Stephenson if he is in the starting lineup, but make sure that he is before deploying him. If he is in fact in the lineup I like him very much as a cheap value play.

J.D. Martinez, DET @ MIN - $4,400

Always using a hitter against Jose Berrios has been a fairly lucrative strategy this season in DFS. I love employing it today as the Tigers get to take batting practice twice at Target Field. It certainly helps that J.D martinez has been red hot of late as he's triple slashed a mean .368/.455/.632 over his past six games. Against RHP this season J.D. has cracked 23 doubles, two triples and 16 HR while slugging .564. I expect those numbers to rise today as Martinez gets to face Berrios and the Twins bullpen. At $4,400 I like J.D. even more so join me and get him into all of your DFS lineups on Draftkings today.

Marcell Ozuna, WAS @ MIA - $2,700

Marcell (the shell) Ozuna has been ice cold lately, but he does have 105 hits against RHP this season including 18 doubles, five triples (?!?) and 13 HR. In his career against Max Scherzer he's managed four hits across 17 at bats and all four of them went for extra bases as he clocked two doubles and smacked two HR. Also of note is that Marcell has been much better at home in the slugging department as his SLG is 76 points higher at home at Marlins Park. At just $2,700 Ozuna is nice all or nothing punt play in the OF today at Drafkings as he could deliver another extra base hit and he is surely a contrarian play in GPP formats.

 

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REAL-TIME FANTASY NEWS

Munetaka Murakami

Fantastic First Season Continues With Two More Homers
Cristopher Sánchez

Cristopher Sanchez Dazzles With 13-Strikeout Complete Game on Saturday
Aaron Rodgers

Signs One-Year Deal With Steelers
Blake Snell

to Undergo Elbow Surgery on Tuesday
Clay Holmes

Could Miss Around Three Months
Jose Altuve

Exits After Swing
Corey Seager

Absent With Back Spasms on Saturday
Jeremy Lauzon

Misses Saturday's Practice
Mark Stone

Doesn't Practice Saturday
Josh Manson

Misses Practice, Considered Day-to-Day
Brent Burns

Day-to-Day Ahead of Conference Finals
Cale Makar

Considered Day-to-Day
Alex Lyon

Likely to Start Game 6 Against Canadiens
Owen Power

Available Saturday
Isaac TeSlaa

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Troy Franklin

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Trevor Lawrence

Should Trevor Lawrence Be Valued as a Dynasty QB1?
Courtland Sutton

in Line for Reduced Role in Denver?
KC Concepcion

Can KC Concepcion Immediately Assume the WR1 Role in Cleveland?
George Pickens

' Dynasty Outlook Clouded by Uncertain Future in Dallas
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a Huge Question Mark for Dynasty Managers
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Now Only a Gadget Player/Kick Returner?
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Offseason Additions Hurt Elic Ayomanor's Dynasty Outlook
Tyler Warren

a Clear Top-Five Dynasty Tight End
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a Dynasty RB to Target Despite Injury History?
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Currently in a Dynasty Buy Window Amid Rollercoaster Offseason
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Is Jahmyr Gibbs the Dynasty RB1?
Isaiah Likely

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Duncan Robinson

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Cade Cunningham

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Jalen Duren

Bounces Back With Double-Double
Anthony Edwards

Finishes Season-Ending Loss With 24 Points
Victor Wembanyama

Tallies 19 Points in Friday's Win
De'Aaron Fox

Highly Effective in Blowout Win
Stephon Castle

Shines in Series-Clincher
Kyle Schwarber

on a Heater, Hits Two More Homers to Take Major-League Lead
Clay Holmes

Suffers Fractured Fibula on Friday Night
Blake Snell

Heads to 15-Day Injured List
Austin Reaves

Could Command $40M Per Year With New Contract
Jalen Duren

Available to Finish Game 6
Yanic Konan Niederhauser

Not Expected to Be Ready for Start of Next Season
Jalen Williams

Declares Himself Healthy for Conference Finals
Terrence Shannon Jr.

Will Play Friday Night
Kevin Huerter

is Available for Game 6
Duncan Robinson

is Returning for Game 6
Caris LeVert

is Cleared for Game 6 on Friday
OG Anunoby

Practices in Full on Friday
Terrence Shannon Jr.

is Tagged as Questionable for Friday
Blake Snell

Scratched From Start on Friday for Undisclosed Reasons
Luther Burden III

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MarShawn Lloyd

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Emanuel Wilson

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Max Fried

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Jaylin Noel

Playing-Time Outlook in Houston Remains Unclear
CFB

Julian Sayin Looking To Build Off Of Strong Debut Season
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College GameDay Set for First Three Weeks
CFB

Jeremiah Smith Aiming For Ohio State Receiving Records
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Keshaun Singleton Projects as Auburn's WR1
CFB

Jeremiah Cobb Impresses New Auburn Staff
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Alberto Mendoza Very Likely to Start for Georgia Tech
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Charles Woodson Jr. Commits to Michigan
Jordan Westburg

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Melquizael Costa

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Arnold Allen

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Daniel Santos

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MMA

Dohoo Choi Returns At UFC Vegas 117
Juan Diaz

Set To Make His UFC Debut
Malcolm Wellmaker

Looks To Bounce Back
Christian Edwards

Set For His UFC Debut
Modestas Bukauskas

Looks To Get Back In The Win Column
Tarik Skubal

Resumes Playing Catch, Ahead of Schedule?
Karl-Anthony Towns

Making an Impact as Playmaker in Playoffs
Jalen Duren

Determined to Improve
Kevin Huerter

Tagged as Questionable for Game 6 Against Cavaliers
Caris LeVert

Considered Questionable for Friday
Lane Hutson

Contributes Two Assists in Game 5 Victory
Nick Suzuki

Amasses Three Points in Crucial Victory Thursday
Juraj Slafkovsky

Dishes Out Three Assists in Game 5 Win
Carter Hart

Stops 31 Pucks in Series-Clinching Win
Pavel Dorofeyev

Enjoys Second Consecutive Multi-Goal Game
Shea Theodore

Records Two Points in Game 6 Win
Mitchell Marner

Scores Special Goal in Series-Clincher
Ryan Johnson

Takes Over as Canucks GM, Sedins Promoted to Co-Presidents
Drew Helleson

Won't Play Thursday
Radko Gudas

Unlikely to Play Thursday
Jeremy Lauzon

Remains Out Thursday
Mark Stone

Misses Third Consecutive Game
EDM

Kris Knoblauch Fired as Oilers Head Coach
CFB

Virginia Tech Lands Commitment from Four-Star QB Peter Bourque
Byron Buxton

Scratched on Thursday With Hip Soreness
Cal Raleigh

Heading to Injured List With Oblique Strain
Francisco Alvarez

has Knee Surgery, Expected to Miss Eight Weeks
Quinn Hughes

Finishes Postseason With 15 Points
Cal Raleigh

Exits With Apparent Side Injury on Wednesday Night
Juan Soto

X-Rays Come Back Negative on Juan Soto's Ankle
Jacob Misiorowski

Pulled Early With Possible Leg Injury
CFB

NFL Veteran Tom Moore Joins Iowa Coaching Staff
CFB

Can Cam Cook Dominate in Return to Big 12?
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ACC, Big 12 Support 24-Team College Football Playoff
CFB

Anthony Colandrea Looking to Elevate Nebraska Back to National Contention
CFB

Kwazi Gilmer Set for Big Impact at Nebraska
Justin Thomas

Trending Well Ahead of PGA Championship Despite Concerning Form
J.J. Spaun

Trending Up Ahead of PGA Championship
Adam Scott

Riding Strong Form Into PGA Championship
Patrick Reed

Looking to Make Another Run at PGA Championship
PGA

Sungjae Im Looks to Build on Strong Finish at Truist Championship
Sam Burns

Must Keep Ball in Play at PGA Championship
Jordan Spieth

Looks to Complete Career Grand Slam at Aronimink
Brandt Snedeker

Not the Best Option for the PGA Championship
Rasmus Hojgaard

a Volatile Option at PGA Championship
Maverick McNealy

Seeking Better Start in Philadelphia
Harry Hall

a Boom-or-Bust Option at Aronimink
Hideki Matsuyama

Attempts to Improve Over 2025 PGA Championship
Scottie Scheffler

Looks to Defend PGA Championship at Aronimink
Nicolai Hojgaard

Wants to Keep Momentum Rolling in Philadelphia
Ben Griffin

Attempting to Bounce Back After Truist Championship
CFB

Transfer Defensive Lineman Devarrick Woods Commits to Clemson
Harris English

Will Need His Putter to Thrive at Aronimink
Akshay Bhatia

Creative Flair Could Show Itself in Philadelphia
Keegan Bradley

Knows the Aronimink Golf Club Well
Si Woo Kim

Struggles at Truist Championship
Gary Woodland

Can Continue Incredible 2026 Season at PGA Championship
Xander Schauffele

In Excellent Form Heading to PGA Championship
CFB

Isaac Brown Has All-American Upside in 2026
CFB

Nyck Harbor Heading into Breakout Year?
CFB

Notre Dame, USC in Discussions to Resume Rivalry Series
CFB

Jaron-Keawe Sagapolutele Has Eyes on ACC Title
CFB

Ahmad Hardy's Gunshot Wound Not Viewed as Career-Threatening
Khamzat Chimaev

Suffers his First Loss
Sean Strickland

Recaptures Middleweight Title
Tatsuro Taira

Suffers Fifth-Round TKO Loss
Joshua Van

Defends Flyweight Title
MMA

Waldo Cortes-Acosta Drops Decision
Alexander Volkov

Wins Back-To-Back Fights
Shane Van Gisbergen

Dominates Watkins Glen for First Win of 2026
Michael McDowell

Finishes Second for Best Run of the Year At Watkins Glen
Ty Gibbs

Scores New Career-Best Finish of Third at Watkins Glen
Tyler Reddick

Continues His Strong Season With Fifth-Place Run at Watkins Glen
Austin Dillon

Earns his First Top-10 Finish of 2026 at Watkins Glen
CFB

Ahmad Hardy Sustains Gunshot Wound, in Stable Condition
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF