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Casey Wilson's top DraftKings and FanDuel MLB DFS picks for today, Tuesday, 4/21/26. His favorite daily fantasy baseball lineup sleepers and value picks for DFS on DraftKings and FanDuel.
We have an awesome eight-game slate on tap tonight in MLB. I have a game stack I am raving about for tonight's slate and a pitcher in an elite spot at a cheap price point. This is one of my favorite slates of the year.
If you have not had a chance to check out my model, I will refer to it throughout this article. To get a better sense of where I am at not only on today's slate but every slate, please give it a look. My plays are solely based on numbers, and this model is the brain behind the operation.
This article will provide my daily fantasy baseball lineup picks for DraftKings and FanDuel on 4/21/2026, with the slate starting at 7:10 p.m. ET on DraftKings and FanDuel. The lineup picks will showcase elite players, mid-priced options, and value plays. You can also read more DFS advice and lineup picks for other sports here. Monitoring injury news and today's MLB starting lineups is always essential.
Top MLB DFS Pitcher for DraftKings, FanDuel
Nolan McLean, SP - NYM ($8.5K DK/$10.2K FD)
Nolan McLean is my top arm on tonight's slate and is my SP1 on both sites. My model has him projected for a 31.7% K% and 7.05 strikeouts against this Twins team. It will be 45 degrees at first pitch in Citi Field tonight, making this a tremendous spot for pitchers.
This season, McLean has posted a 2.89 xFIP, 31.5% K%, 0.76 WHIP, and a 0.38 HR/9. He has allowed a 21.2% Hard Hit%, which is absurd. His xK% is 32.6%, which surprises me given his 9.9% SwStr%. This dude is elite.
Nastiness from Nolan McLean 🤢 pic.twitter.com/IaRpDcIeA1
— MLB (@MLB) April 15, 2026
The Twins this season have a 24.7% K% and a .718 OPS against RHP, with a 104 wRC+. Over the L14, they have a 22.7% K%, .731 OPS, and s 109 wRC+. My model has the Twins projected for 3.3 runs, which is one of the lowest on the slate.
Top MLB DFS Stack for DraftKings, FanDuel
Arizona Diamondbacks (Model Projected IRT (Implied Run Total)- 4.8) vs. Sean Burke
The roof will be open tonight at Chase Field, and it will be around 90 degrees at first pitch. There will also be a 20+ mph wind blowing out to right field, and although this stadium will limit the wind, there will still be an impact, making this a great-hitting weather.
Sean Burke has struggled mightily over his last two starts, pitching to a 5.23 xFIP, 3.8% SwStr%, 1.35 WHIP, and a 1.74 HR/9. He has allowed a 31.3% FB% and a 32.4% Hard Hit% during that span.
The Snakes are starting to heat up. They have a .705 OPS and a 94 wRC+ against RHP over the last 14 days. My model has the Diamondbacks projected for 4.8 runs tonight. I love this game stack, and, as you will find out later in this article, I will be all over both sides of it.
Favorite Targets: Corbin Carroll, Ketel Marte, Geraldo Perdomo, Adrian Del Castillo, Ildemaro Vargas
Top MLB DFS Hitter for DraftKings, FanDuel
Munetaka Murakami, 1B - CHW ($4.8K DK/$3.5K FD)
Munetaka Murakami is on fire to start his MLB career and is going to be a star. He is slashing .231/.412/.529 with a .931 OPS and five HRs against RHP so far this season. We have wind blowing out to his pull side tonight, and Merrill Kelly has gotten crushed by LHH this season. He has allowed a .455 SLG, .273 ISO, 33.3% Brl%, and a 55.6% Hard Hit% to the split in 2026.
