Fantasy Football Injury Reports For NFL RBs: Week 4 Updates for James Conner, Zach Charbonnet, Tyrone Tracy Jr., Najee Harris, more

RB fantasy football injury updates and reports for running backs in Week 4 (2025), as of September 24, including James Conner, Zach Charbonnet, Tyrone Tracy Jr., and Najee Harris.

Below is our fantasy football injuries report for running backs in Week 4, as of September 24. The injury statuses for various NFL running backs are up in the air for Week 4, including James Conner, Zach Charbonnet, Tyrone Tracy Jr., and Najee Harris.

As the fantasy football season gets underway, every decision, transaction, and lineup change matters. These are critical running back injuries to keep track of throughout the week. Being up-to-date on NFL injury news can give you an edge over your league mates in fantasy football.

To keep close tabs on all the news across the NFL, favorite or bookmark the fantasy football player news page, or download the free RotoBaller fantasy football mobile app with push notification alerts on all the latest news. Let's look at the updates for some running backs and see whether they may play in Week 4.

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James Conner Injury Update

Conner (ankle) suffered a season-ending injury during Sunday's loss to the 49ers. He will undergo surgery and has already been placed on injured reserve in a procedural move. Trey Benson will lead the Cardinals' backfield going forward, ranking as a low-end RB2 in fantasy football.

Cardinals RB James Conner did in fact suffer a season-ending injury to his right ankle that will require surgery, per source. The injury is considered “severe”, even if the team does not yet know the full extent of the damage. pic.twitter.com/IMktQeYBoz

— Adam Schefter (@AdamSchefter) September 22, 2025

Zach Charbonnet Injury Update

Charbonnet (foot) was estimated as a full participant on Tuesday, putting him on track to play in the Seahawks' primetime contest against the Cardinals. He'll continue to operate behind Kenneth Walker III, ranking as a mid-range RB4.

The Seahawks' estimated injury report for Tuesday is exactly the same as their estimated injury report for Monday: pic.twitter.com/LGDwPyX8Ok

— John Boyle (@johnpboyle) September 23, 2025

Tyrone Tracy Jr. Injury Update

Tracy (shoulder) dislocated his shoulder during Monday Night Football and will miss between two and four weeks. Rookie Cam Skattebo will lead the Giants' backfield going forward, while Devin Singletary should also get involved. Skattebo is a low-end RB2 in fantasy football as he climbs to the top of the depth chart.

Doctors believe Giants RB Tyrone Tracy Jr. is expected to be sidelined two to four weeks due to the dislocated shoulder injury he suffered Sunday night vs. Kansas City, per sources. With Tracy out, the Giants are expected to lean on rookie RB Cam Skattebo and veteran RB Devin… pic.twitter.com/pRUC4Vif8V

— Adam Schefter (@AdamSchefter) September 23, 2025

Najee Harris Injury Update

Harris (ankle) tore his Achilles on a non-contact play in the offensive backfield during Sunday's Week 3 victory. He has already been ruled out for the remainder of the season, leaving rookie Omarion Hampton alone at the top of the depth chart. Hampton will rank as a fringe top-25 fantasy running back going forward.

Here is Chargers RB Najee Harris suffering an Achilles injury before he was carted off: pic.twitter.com/0rV5YQYU1K

— Adam Schefter (@AdamSchefter) September 21, 2025

Will Shipley Injury Update

Shipley (ribs) was seen practicing last Friday. His status for Week 4 is uncertain, but the fact that he was able to get back on the field recently is a good sign. When he does eventually return, he'll operate as Saquon Barkley's backup alongside Tank Bigsby.

Will Shipley practicing again. pic.twitter.com/Un9GZqpbhd

— John McMullen (@JFMcMullen) September 19, 2025

Samaje Perine Injury Update

Perine (thumb) avoided a serious injury and will not require surgery. The Bengals are leaving the door open for him to play in Week 4, though we'll likely get more information on his status when the team's initial injury report comes out on Wednesday. As the backup to Chase Brown, Perine is off the fantasy radar in most leagues.

#Bengals RB Samaje Perine, who left the game with a thumb injury, had an MRI that did not reveal significant damage, source said. He’s not ruled out for this week.

— Ian Rapoport (@RapSheet) September 22, 2025

Sione Vaki Injury Update

Vaki (groin) picked up an injury against the Ravens and was unable to finish the game. He was visibly frustrated while limping off the field and being helped to the locker room. His status for Week 4 is uncertain, but even if he plays, he'd be off the fantasy radar. If Vaki misses extended time, Craig Reynolds would likely be active as the No. 3 running back behind Jahmyr Gibbs and David Montgomery.

#Lions Injury Update:

RB Sione Vaki (Groin) has been downgraded to Out.

— Detroit Lions PR (@LionsPR) September 23, 2025

Fantasy Football Injury Report Chart

Here's the full fantasy football injuries report, a quick hit list of all injured NFL players and their latest status. Be sure to also read the latest NFL injury news and updates for fantasy football.

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