X
Lost password?

Don't have an account?
Gain Access Now

X

Receive free daily analysis

NFL
NBA
NHL
NASCAR
CFB
MLB
MMA
PGA
ESPORTS
BETTING

Already have an account? Log In

X

Forgot Password


POPULAR FANTASY TOOLS

Expert Advice
Articles & Tools
Import Your Leagues
Draft Rankings
Draft Simulator
Enter League Settings
Value Picks
Compare Any Players
News and Alerts

NFL DFS Lineup Picks for FanDuel, DraftKings - 49ers vs Cardinals MNF Showdown

George Kittle - Fantasy Football Rankings, NFL Injury News, Draft Targets

John's top NFL DFS lineup picks for FanDuel, DraftKings - 49ers vs Cardinals showdown slate on 11/21. His Monday Night Football daily fantasy football advice.

Happy Monday, RotoBallers! I hope your Week 11 has gone well. I had a great day yesterday, going 4-1 on bets while cashing in all the DFS slates that I played. I'll look to keep the train rolling tonight as we have a short turnaround into a three-game slate on Thanksgiving Thursday. Tonight, though, we'll take a look at an NFC West Showdown as the San Francisco 49ers (5-4) take on the Arizona Cardinals (4-6) in Mexico City. It'll be an interesting slate considering Kyler Murray is a game-time decision in this one, and while it seems like Colt McCoy will end up being the starter in this one, I'll do my best to update should Murray suit up for this one.

We have been pretty successful so far with these showdown slates and hopefully, that trend continues from last year into this year. Most of us started our fantasy journeys with football, so it's always nice when it comes around and it's always a shame for it to come to an end. Thanks to the advanced analytics of today, I'll do my best to provide you with as much in-depth analysis as possible regarding positional matchups and the like to help put some lunch money in your pocket. Let's make some coin this season gang, and let's get right to it. 

I will be providing you with daily fantasy football picks on FanDuel and DraftKings for the 49ers vs Cardinals NFL DFS showdown slate on November 21st. These NFL DFS lineup picks can vary from higher-priced players and elite options to lower-priced players and value picks on both DraftKings and FanDuel. If you have any questions, you can follow me on Twitter @LucidMediaDFS and fire away, or sign up for a premium RotoBaller NFL package and chat with me and other NFL DFS analysts at any time you'd like!

Featured Promo: Get any DFS Premium Bundle for for 30% off using code NEW! Win more with expert advice from proven winners and exclusive DFS tools. Get instant access to RotoBaller's Lineup Optimizers, Research Stations, daily picks and VIP chat rooms across 10 sports! Go Premium, Win More!

 

MVP/Captain Plays

Christian McCaffrey - RB, $17,100 (DK), $16,500 (FD)

Key Stats

  • 2022 Stats: 125 rushes, 563 rushing yards, 60 targets, 47 receptions, 395 rushing yards, seven touchdowns.
  • 2022 Offensive Rush DVOA: -8.9% (23rd), per Football Outsiders.
  • 2022 Opposing Defense Rush DVOA: -4.5% (16th), per Football Outsiders.

I'll start off tonight's slate with Christian McCaffery. I'll make it clear that I'm not picking McCaffery with the thought that he's going to light it up on the ground tonight. While the 49ers are 8.5-point favorites, the game script could lead to a breakout spot for him on the ground, and I'd have to assume that he'll end up splitting carries with Elijah Mitchell. With that said, the 49ers do have a projected 41.47% DVOA to running backs in the passing game, so I project CMC to do the majority of his damage in the passing game.

Jimmy Garoppolo - QB, $14,400 (DK), $14,500 (FD)

Key Stats

  • 2022 Stats: 1,931 passing yards, 11 touchdowns, four interceptions.
  • 2022 Offensive Pass DVOA: 23.3% (7th), per Football Outsiders.
  • 2022 Opposing Defense Pass DVOA: 8.2% (19th), per Football Outsiders.

Throwing CMC the ball will be Jimmy Garoppolo. I've mentioned in previous articles that Garoppolo isn't the "ideal" fantasy quarterback. However, the 49ers do have a relative passing funnel tonight -- with a projected pass DVOA of 22.11% and a projected rush DVOA of -10.09%. My model projects Jimmy G to complete 72.24% of his pass attempts tonight for 273.44 yards and 1.99 touchdowns. He's cheaper than your typical QB on a showdown slate, and that's why I have him slated in here.

Other Captains/MVPs: George Kittle, DeAndre Hopkins, 49ers D/ST

 

Want more NFL DFS tools and content? Our NFL Premium package includes our DFS Cheat Sheets, Research Station, Lineup Optimizer, access to our Premium Slack Chatrooms where members can chat with our NFL analysts, and so much more. Check out this big win from RotoBaller's RealTalkRaph using our Premium tools - join in on the winning!

 

DFS Flex Plays

DeAndre Hopkins - WR, $10,400 (DK), $15,000 (FD)

Key Stats

  • 2022 Stats: 46 targets, 36 receptions, 396 receiving yards, two touchdowns.
  • Individual Matchup (vs Deommodore Lenoir): 17% targets per route, 79% catch rate, 0.29 fantasy points per route, per PFF.

On the other side of the field, we have DeAndre Hopkins. I mentioned at the top of the article that Kyler Murray is a game-time decision for this one. Fortunately, Hopkins is seemingly QB-proof. He's logged at least 13 targets in three of his first four games since returning from suspension and hauled in 10 of his 14 targets for 98 yards last Sunday while Colt McCoy was under center. Hopkins is a bit too pricy for me on FanDuel, but I love him in this spot on DraftKings.

George Kittle - TE, $7,000 (DK), $10,000 (FD)

Key Stats

  • 2022 Stats: 41 targets, 29 receptions, 340 receiving yards, two touchdowns.
  • Individual Matchup (vs Isaiah Simmons): 12% targets per route, 89% catch rate, 0.24 fantasy points per route, per PFF.

One player that I absolutely LOVE on both sites tonight is George Kittle. The Cardinals have a projected 41.57% DVOA against tight ends in this matchup, and Kittle has a strong matchup advantage against Isaiah Simmons, according to PFF. My model projects Kittle to grab 6.21 of his 6.95 targets tonight for 70.33 yards and a 59% chance of scoring a touchdown. He's certainly an option in the 1.5x spot and he'll be in most if not all of my lineups.

Other Flex Options: Colt McCoy, Deebo Samuel, Brandon Aiyuk, Rondale Moore

 

DFS Value Plays

San Francisco 49ers - D/ST, $5,000 (DK), $9,500 (FD)

Key Stats

  • 2022 Stats: 17.66 targets, 29 sacks, seven interceptions, three fumble recoveries, two defensive touchdowns.
  • Projected DVOA: -22.22%

If there's any indication by now I'm writing this up, I'll be heavy 49ers on this slate tonight. If you're making a 49ers "stack," you'll want to have the defense in there as well. The 49ers project to an 8.94% sack rate tonight and a projected -26.84% defensive rushing DVOA. With that said, I do like this play a lot more if it's Colt McCoy under center, with the Niners not allowing the Cardinals to lean on the run game while putting consistent pressure on McCoy. I favor them regardless of who plays quarterback for Arizona tonight, but I'll give them a definite boost if it's McCoy.

Kyle Juszczyk - RB, $600 (DK), $5,000 (FD)

Key Stats

  • 2022 Stats: Three rushes, 10 rushing yards, 15 targets, 11 receptions, 153 rushing yards, one touchdown.
  • 2022 Offensive Rush DVOA: -8.9% (23rd), per Football Outsiders.
  • 2022 Opposing Defense Rush DVOA: -4.5% (16th), per Football Outsiders.

Last but not least, I'll finish things up with Kyle Juszczyk. Certainly a dart throw here, but he's just too cheap considering the upside he brings to the table. I mentioned when talking about CMC that the 49ers have a projected 41.47% passing DVOA when targeting running backs, and all we need is one reception that Juszczyk takes into the end zone for him to break the slate.

Other Value Plays: Elijah Mitchell, A.J. Green, Robbie Gould, Matt Prater

Enjoy your week and good luck everyone!



Download Our Free News & Alerts Mobile App

Like what you see? Download our updated fantasy football app for iPhone and Android with 24x7 player news, injury alerts, rankings, starts/sits & more. All free!

More Weekly DFS Analysis

POPULAR FANTASY TOOLS

Expert Advice
Articles & Tools
Import Your Leagues
Draft Rankings
Draft Simulator
Enter League Settings
Value Picks
Compare Any Players
News and Alerts
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF

REAL-TIME FANTASY NEWS

Patrick Rodgers

A Solid Value Play At TPC Craig Ranch
Jamal Murray

Explodes For 43 Points In Game 5
Carson Young

Looking To Recapture Form At CJ Cup
Jayson Tatum

Fires In 35 Points In Series-Clincher
Matt McCarty

An Intriguing Value Play At CJ Cup
Giannis Antetokounmpo

Logs Massive Triple-Double In Game 5
Maxi Kleber

Listed As Questionable For Game 5
Will Zalatoris

Searching For Putting Form At CJ Cup
Rob Dillingham

Out On Wednesday
Jae'Sean Tate

Still Out On Wednesday
Jimmy Butler III

Listed As Probable For Wednesday
Jack Eichel

Notches Two Assists In Game 5 Victory
Sam Stevens

A Risky Play With Upside At CJ Cup
PGA

Sungjae Im Riding Momentum Into CJ Cup
Sebastian Aho

Sends Hurricanes To Round 2
Ben Griffin

Looking To Stay Hot After First Career Win
Jake Knapp

Looking For More Success At TPC Craig Ranch
Linus Ullmark

Records Shutout In Elimination Game
Brady Tkachuk

Extends Point Streak To Four Games
Mackenzie Hughes

Is An Interesting Option At CJ Cup
Pavel Dorofeyev

Doesn't Finish Game 5
Filip Gustavsson

Exits Early Due To Illness
Aaron Ekblad

Slapped With Two-Game Suspension
Aldrich Potgieter

Trending Downward For CJ Cup
Taylor Pendrith

Plays Well In Houston Recently
PGA

Niklas Norgaard May Not Be Cut Out For Texas
Rasmus Hojgaard

Could Be Up Or Down In Texas
Ben Rice

Smacks Two Homers To End Slump
Jorge Polanco

Hits Two More Homers, Drives In Five
Scottie Scheffler

The Untouchable Favorite At CJ Cup
Tom Kim

A Popular Name To Avoid At TPC Craig Ranch
Austin Eckroat

Looking To Find Success Again At TPC Craig Ranch
Cristopher Sánchez

Cristopher Sanchez Set To Start Wednesday
Shota Imanaga

Exits With Leg Cramps
Ben Kohles

Finishes Tied For 59th At Corales Puntacana Championship
Joel Dahmen

Finishes Tied For Second At Corales Puntacana Championship
Beau Hossler

Finishes Tied For 60th At Valero Texas Open
Doug Ghim

Finishes Tied For 18th At the Valero Texas Open
Jordan Spieth

Finishes Tied For 18th At RBC Heritage
George Kirby

"Feeling Great," Could Throw Again On Sunday
Tyler Fitzgerald

Returning To Starting Nine
Josh Lowe

Progressing Well, Could Play In Rehab Games On Saturday
Shane McClanahan

Begins "Throwing-Like" Activities
Patrik Laine

Remains Day-To-Day
Gabriel Vilardi

On Track To Return Wednesday
Brandon Hagel

Ruled Out For Game 5
Marcus Johansson

Returns To Action Tuesday
Cole Ragans

Won't Start On Wednesday
Dylan Moore

Placed On 10-Day Injured List With Hip Inflammation
Jonas Siegenthaler

Considered A Game-Time Decision Tuesday
Brett Pesce

A Game-Time Call Tuesday
Yordan Alvarez

Back In Tuesday's Lineup
Frederik Andersen

Unavailable Tuesday
Aaron Nesmith

Upgraded To Available
Las Vegas Raiders

Jack Bech A Strong Candidate To Be An Immediate Starter
Las Vegas Raiders

Zamir White Competing For Depth Role
New York Jets

Mason Taylor To Immediately Be Atop Jets Tight End Depth Chart
Bennedict Mathurin

Cleared For Game 5
Buffalo Bills

Dalton Kincaid Setting Up As Post-Hype Sleeper In 2025?
Denver Broncos

Dre Greenlaw Expected To Be Ready For Training Camp
Seattle Seahawks

Sam Darnold To Take Over 90% Of The Snaps
Tennessee Titans

Titans In No Rush To Trade Will Levis
Daulton Varsho

Reinstated From Injured List And Starting On Tuesday
Minnesota Vikings

J.J. McCarthy Says He Knows He's Ready To Start For Vikings
Cincinnati Bengals

Bengals Picking Up Fifth-Year Option On Dax Hill
Los Angeles Chargers

Chargers Apply Unrestricted Free-Agent Tender To J.K. Dobbins
Seattle Seahawks

Jaren Hall Cut Loose By Seahawks
Kansas City Chiefs

Chiefs Compare Josh Simmons To Christian Darrisaw, Rashawn Slater
Denver Broncos

Pat Bryant Compared To Michael Thomas
Denver Broncos

RJ Harvey Could Do It All For Broncos
Carolina Panthers

Tetairoa McMillan Likely To Man The X Spot For Panthers
Green Bay Packers

Packers, Jaire Alexander Continue To Discuss Potential Reunion
Dallas Cowboys

Cowboys Discussed George Pickens With Steelers
Kansas City Chiefs

Chiefs To Pick Up Fifth-Year Option On Trent McDuffie, George Karlaftis
Washington Commanders

Matt Gays Signs One-Year Deal With Commanders
San Francisco 49ers

George Kittle Signs Four-Year Extension With 49ers
Alperen Sengün

Alperen Sengun Records Third Consecutive Double-Double
Brandin Podziemski

Hits Six Treys During 26-Point Performance
Jimmy Butler III

Leads Warriors In Scoring Monday Night
Jarrett Allen

Has Double-Double, Six Steals In Blowout Win
Brandon Boston Jr.

Recovering From Ankle Surgery
Kelly Olynyk

Undergoes Heel Procedure
Aaron Nesmith

Probable For Tuesday's Action
Nathan MacKinnon

Has Two Points In Losing Effort
Martin Necas

Records Two Assists In Game 5 Loss
Mikko Rantanen

Tallies Three Points In Monday's Win
Wyatt Johnston

Leads Stars To Game 5 Victory
Sergei Bobrovsky

Returns To Winning Ways
Anton Lundell

Earns Two Points Monday
Brandon Hagel

Departs Loss Early
Riley Greene

Homers Twice On Monday
Yordan Alvarez

Exits Monday's Win Early
Los Angeles Chargers

Tre Harris Expected To Fill X Role For Chargers
Jimmy Butler III

Officially Active For Game 4
Isaiah Stewart

Uncertain For Game 5
Michael Porter Jr.

Expected To Play In Game 5
Brandon Nimmo

Has Career Game
Russell Westbrook

Questionable For Tuesday Night
Tyler Glasnow

Going On The Injured List
Jaylen Brown

Back On The Injury Report
Luis Arraez

Expected To Return On Tuesday
Jordan Westburg

Placed On Injured List
William Byron

Ends With A Strong Top-Five Finish At Talladega
Ryan Blaney

Bad Luck Continues With Talladega Crash
Kyle Larson

Has A Career-Best Performance At Talladega
Ian Machado Garry

Gets Back On Track With UFC Kansas City Win
Brad Keselowski

Talladega Run Ends Early After Crashing
Carlos Prates

Suffers His First UFC Loss
Zhang Mingyang

Still Undefeated In The UFC
Anthony Smith

Retires After UFC Kansas City Loss
Giga Chikadze

Takes Unanimous Decision Loss
Giga Chikadze

Takes Unanimous-Decision Loss
David Onama

Extends Win Streak At UFC Kansas City
Michel Pereira

Drops Decision At UFC Kansas City
Abus Magomedov

Extends His Win Streak
Nicolas Dalby

Gets Finished For The First Time
Randy Brown

Gets Back In The Win Column
Ikram Aliskerov

Gets First-Round TKO Finish At UFC Kansas City
Andre Muniz

Gets TKO'd At UFC Kansas City
Chase Elliott

Recovers from Speeding Penalty to Finish Fifth
Joey Logano

Finishes Last at Talladega After Disqualification for Missing Spoiler Brace
Ryan Preece

Loses Talladega Race First in Photo Finish Then in Post-Race Inspection
NASCAR

Poor Toyota Strategy Arguably Cost Bubba Wallace Winning Chances at Talladega
Christopher Bell

Unhurt After Hard Contact with Inside Retaining Wall
Joe Ryan

Posts Stellar Outing
Nick Lodolo

Throws Seven Scoreless Innings
Tyler Glasnow

Removed Early On Sunday
Chase Elliott

Is One OF The Top Overall DFS Picks Of The Week
Joey Logano

Could Joey Logano Finish A Race With A Top Finish At Talladega?
NASCAR

DFS Players Should Like Bubba Wallace For Talladega This Week
Christopher Bell

Should DFS Players Roster Christopher Bell At Talladega?
Austin Cindric

Is Austin Cindric Worth Rostering For Talladega DFS Lineups?
Shane Van Gisbergen

Is A Solid, Safe, DFS Choice For Talladega Lineups
Austin Dillon

Is Austin Dillon A Viable DFS Play At Talladega This Week?
Josh Berry

Qualifies Too High At Talladega To Be Worth Rostering In DFS
Michael McDowell

Should DFS Players Take A Shot On Michael McDowell At Talladega?
Noah Gragson

Could Be A Sneaky DFS Play For Talladega
Denny Hamlin

Probably Qualified Too Well for DFS Consideration
Kyle Larson

Increasingly Undervalued Due to His Crashing, but Still a Great DFS Option
Carlos Prates

Looks To Remain Undefeated In The UFC
Ian Machado Garry

Set For UFC Kansas City Main Event
Zhang Mingyang

Scheduled For Co-Main Event
Anthony Smith

Set For His Final UFC Bout
David Onama

Set For Featherweight Bout
Giga Chikadze

Looks To Bounce Back
Abus Magomedov

Looks For His Third Consecutive Win
Michel Pereira

Returns To Action At UFC Kansas City