X
Lost password?

Don't have an account?
Gain Access Now

X

Receive free daily analysis

NFL
NBA
NHL
NASCAR
CFB
MLB
MMA
PGA
ESPORTS
BETTING

Already have an account? Log In

X

Forgot Password


POPULAR FANTASY TOOLS

Expert Advice
Articles & Tools
Import Your Leagues
Draft Rankings
Draft Simulator
Enter League Settings
Value Picks
Player Comparisons
News and Alerts

NFL DFS Lineup Picks for FanDuel, DraftKings - 49ers vs Cardinals MNF Showdown

George Kittle - Fantasy Football Rankings, NFL Injury News, Draft Targets

Happy Monday, RotoBallers! I hope your Week 11 has gone well. I had a great day yesterday, going 4-1 on bets while cashing in all the DFS slates that I played. I'll look to keep the train rolling tonight as we have a short turnaround into a three-game slate on Thanksgiving Thursday. Tonight, though, we'll take a look at an NFC West Showdown as the San Francisco 49ers (5-4) take on the Arizona Cardinals (4-6) in Mexico City. It'll be an interesting slate considering Kyler Murray is a game-time decision in this one, and while it seems like Colt McCoy will end up being the starter in this one, I'll do my best to update should Murray suit up for this one.

We have been pretty successful so far with these showdown slates and hopefully, that trend continues from last year into this year. Most of us started our fantasy journeys with football, so it's always nice when it comes around and it's always a shame for it to come to an end. Thanks to the advanced analytics of today, I'll do my best to provide you with as much in-depth analysis as possible regarding positional matchups and the like to help put some lunch money in your pocket. Let's make some coin this season gang, and let's get right to it. 

I will be providing you with daily fantasy football picks on FanDuel and DraftKings for the 49ers vs Cardinals NFL DFS showdown slate on November 21st. These NFL DFS lineup picks can vary from higher-priced players and elite options to lower-priced players and value picks on both DraftKings and FanDuel. If you have any questions, you can follow me on Twitter @LucidMediaDFS and fire away, or sign up for a premium RotoBaller NFL package and chat with me and other NFL DFS analysts at any time you'd like!

Featured Promo: Get any DFS Premium Bundle for for 10% off using code BALLER! Win more with expert advice from proven winners and exclusive DFS tools. Get instant access to RotoBaller's Lineup Optimizers, Research Stations, daily picks and VIP chat rooms across 10 sports! Go Premium, Win More!

 

MVP/Captain Plays

Christian McCaffrey - RB, $17,100 (DK), $16,500 (FD)

Key Stats

  • 2022 Stats: 125 rushes, 563 rushing yards, 60 targets, 47 receptions, 395 rushing yards, seven touchdowns.
  • 2022 Offensive Rush DVOA: -8.9% (23rd), per Football Outsiders.
  • 2022 Opposing Defense Rush DVOA: -4.5% (16th), per Football Outsiders.

I'll start off tonight's slate with Christian McCaffery. I'll make it clear that I'm not picking McCaffery with the thought that he's going to light it up on the ground tonight. While the 49ers are 8.5-point favorites, the game script could lead to a breakout spot for him on the ground, and I'd have to assume that he'll end up splitting carries with Elijah Mitchell. With that said, the 49ers do have a projected 41.47% DVOA to running backs in the passing game, so I project CMC to do the majority of his damage in the passing game.

Jimmy Garoppolo - QB, $14,400 (DK), $14,500 (FD)

Key Stats

  • 2022 Stats: 1,931 passing yards, 11 touchdowns, four interceptions.
  • 2022 Offensive Pass DVOA: 23.3% (7th), per Football Outsiders.
  • 2022 Opposing Defense Pass DVOA: 8.2% (19th), per Football Outsiders.

Throwing CMC the ball will be Jimmy Garoppolo. I've mentioned in previous articles that Garoppolo isn't the "ideal" fantasy quarterback. However, the 49ers do have a relative passing funnel tonight -- with a projected pass DVOA of 22.11% and a projected rush DVOA of -10.09%. My model projects Jimmy G to complete 72.24% of his pass attempts tonight for 273.44 yards and 1.99 touchdowns. He's cheaper than your typical QB on a showdown slate, and that's why I have him slated in here.

Other Captains/MVPs: George Kittle, DeAndre Hopkins, 49ers D/ST

 

Want more NFL DFS tools and content? Our NFL Premium package includes our DFS Cheat Sheets, Research Station, Lineup Optimizer, access to our Premium Slack Chatrooms where members can chat with our NFL analysts, and so much more. Check out this big win from RotoBaller's RealTalkRaph using our Premium tools - join in on the winning!

 

DFS Flex Plays

DeAndre Hopkins - WR, $10,400 (DK), $15,000 (FD)

Key Stats

  • 2022 Stats: 46 targets, 36 receptions, 396 receiving yards, two touchdowns.
  • Individual Matchup (vs Deommodore Lenoir): 17% targets per route, 79% catch rate, 0.29 fantasy points per route, per PFF.

On the other side of the field, we have DeAndre Hopkins. I mentioned at the top of the article that Kyler Murray is a game-time decision for this one. Fortunately, Hopkins is seemingly QB-proof. He's logged at least 13 targets in three of his first four games since returning from suspension and hauled in 10 of his 14 targets for 98 yards last Sunday while Colt McCoy was under center. Hopkins is a bit too pricy for me on FanDuel, but I love him in this spot on DraftKings.

George Kittle - TE, $7,000 (DK), $10,000 (FD)

Key Stats

  • 2022 Stats: 41 targets, 29 receptions, 340 receiving yards, two touchdowns.
  • Individual Matchup (vs Isaiah Simmons): 12% targets per route, 89% catch rate, 0.24 fantasy points per route, per PFF.

One player that I absolutely LOVE on both sites tonight is George Kittle. The Cardinals have a projected 41.57% DVOA against tight ends in this matchup, and Kittle has a strong matchup advantage against Isaiah Simmons, according to PFF. My model projects Kittle to grab 6.21 of his 6.95 targets tonight for 70.33 yards and a 59% chance of scoring a touchdown. He's certainly an option in the 1.5x spot and he'll be in most if not all of my lineups.

Other Flex Options: Colt McCoy, Deebo Samuel, Brandon Aiyuk, Rondale Moore

 

DFS Value Plays

San Francisco 49ers - D/ST, $5,000 (DK), $9,500 (FD)

Key Stats

  • 2022 Stats: 17.66 targets, 29 sacks, seven interceptions, three fumble recoveries, two defensive touchdowns.
  • Projected DVOA: -22.22%

If there's any indication by now I'm writing this up, I'll be heavy 49ers on this slate tonight. If you're making a 49ers "stack," you'll want to have the defense in there as well. The 49ers project to an 8.94% sack rate tonight and a projected -26.84% defensive rushing DVOA. With that said, I do like this play a lot more if it's Colt McCoy under center, with the Niners not allowing the Cardinals to lean on the run game while putting consistent pressure on McCoy. I favor them regardless of who plays quarterback for Arizona tonight, but I'll give them a definite boost if it's McCoy.

Kyle Juszczyk - RB, $600 (DK), $5,000 (FD)

Key Stats

  • 2022 Stats: Three rushes, 10 rushing yards, 15 targets, 11 receptions, 153 rushing yards, one touchdown.
  • 2022 Offensive Rush DVOA: -8.9% (23rd), per Football Outsiders.
  • 2022 Opposing Defense Rush DVOA: -4.5% (16th), per Football Outsiders.

Last but not least, I'll finish things up with Kyle Juszczyk. Certainly a dart throw here, but he's just too cheap considering the upside he brings to the table. I mentioned when talking about CMC that the 49ers have a projected 41.47% passing DVOA when targeting running backs, and all we need is one reception that Juszczyk takes into the end zone for him to break the slate.

Other Value Plays: Elijah Mitchell, A.J. Green, Robbie Gould, Matt Prater

Enjoy your week and good luck everyone!



Download Our Free News & Alerts Mobile App

Like what you see? Download our updated fantasy football app for iPhone and Android with 24x7 player news, injury alerts, rankings, starts/sits & more. All free!




Win More With RotoBaller

Be sure to also check out all of our other daily fantasy football articles and analysis to help you set those winning lineups, including this new RotoBaller YouTube video:

More Weekly DFS Analysis

POPULAR FANTASY TOOLS

Expert Advice
Articles & Tools
Import Your Leagues
Draft Rankings
Draft Simulator
Enter League Settings
Value Picks
Player Comparisons
News and Alerts
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF

REAL-TIME FANTASY NEWS

Lane Thomas16 mins ago

Taking On-Field Batting Practice
Colson Montgomery17 mins ago

Continues Power Surge On Tuesday
Victor Robles22 mins ago

Returns From Injured List
Jacob Wilson26 mins ago

Perfect At The Plate On Tuesday
Drew Smyly27 mins ago

Jordan Wicks Throwing Bullpens Tuesday
Seiya Suzuki32 mins ago

Starting Rehab Assignment Wednesday
Grayson Rodriguez36 mins ago

Hopes To Return When Eligible
Ralphy Velazquez37 mins ago

Dominating At Single-A
Tyrese Haliburton39 mins ago

Picks Up Another Questionable Tag
Gerrit Cole41 mins ago

Throws Another Bullpen On Tuesday
Rory McIlroy42 mins ago

Looks To Continue Winning Ways At Quail Hollow
Jasson Domínguez44 mins ago

Jasson Dominguez To Begin Rehab Assignment Soon
Mitchell Robinson45 mins ago

Ruled Out For Game 2 Against Indiana
Gabriel Moreno46 mins ago

Out Sick Tuesday
Rudy Gobert52 mins ago

Ties NBA Record With Fourth Defensive Player Of The Year Award
J.P. Crawford54 mins ago

Swinging In A Batting Cage
Jarrett Allen1 hour ago

Remains Out On Tuesday
Cal Raleigh1 hour ago

Resting On Tuesday
Cristian Javier1 hour ago

To Return This Weekend
Luis Arraez1 hour ago

Absent On Tuesday
Chris Martin1 hour ago

Available On Tuesday
Jorge Soler2 hours ago

Remains Out On Tuesday
PGA2 hours ago

Can Alex Noren Finally Post A Good Finish At Quail Hollow?
OTT2 hours ago

Senators Hire Travis Green As New Head Coach
Sam Bennett2 hours ago

Expected To Return This Week
Adam Henrique2 hours ago

Set To Miss Game 1 Against Canucks
Jack Leiter2 hours ago

"Probably" Will Start Game 2 On Wednesday
Spencer Turnbull2 hours ago

To Pitch In Relief Tuesday
Elias Pettersson2 hours ago

Misses Practice Due To Illness
J.T. Realmuto3 hours ago

Alec Bohm Resting Tuesday
Mason Marchment3 hours ago

Absent For Sixth Consecutive Game
Taylor Ward3 hours ago

Luis Rengifo, Taylor Ward Out Tuesday
Jani Hakanpaa3 hours ago

Not Ready To Return On Tuesday
Rashee Rice3 hours ago

Under Investigation For Allegedly Hitting Photographer
Joel Kiviranta3 hours ago

Remains Sidelined On Tuesday
Dean Wade3 hours ago

Unavailable For Game 1 Against Boston Tuesday
Treylon Burks3 hours ago

A Trade Candidate?
Jamal Murray4 hours ago

Heat-Pack Toss In Game 2 Under League Review
Christian Wood4 hours ago

Exercises Player Option
Tommy Fleetwood5 hours ago

Looking To Bounce Back At Quail Hollow
Tyler Boyd7 hours ago

Joins Titans Improved Wide Receiver Room
PGA7 hours ago

Byeong Hun An Faces Poor Course History In Charlotte
Matt Fitzpatrick7 hours ago

Returns To Quail Hollow
Max Homa8 hours ago

Heads To Quail Hollow Aiming For Wells Fargo Trifecta
Aaron Gordon9 hours ago

Leads Nuggets In Scoring In Game 2 Loss
Nikola Jokic9 hours ago

Finishes Just Short Of Triple-Double Monday
Karl-Anthony Towns9 hours ago

Collects Impressive Double-Double In Game 2 Versus Denver
Anthony Edwards9 hours ago

Shines With 27-Point Effort In Game 2
Myles Turner9 hours ago

Leads Pacers In Scoring Monday
Josh Hart9 hours ago

Fills Stat Sheet In Game 1 Victory
Jalen Brunson9 hours ago

Continues Tear With Another 40-Point Effort
Victor Wembanyama22 hours ago

Wins Rookie Of The Year
Jamal Murray22 hours ago

Available On Monday Night
Rudy Gobert23 hours ago

Out For Game 2
Joe Burrow23 hours ago

Looks Great During Monday's Workout
Luka Doncic23 hours ago

Probable For Game 1
Jarrett Allen23 hours ago

Questionable Versus Boston
Tank Dell24 hours ago

Expected To Make A Full Recovery
Tyrese Haliburton1 day ago

Good To Go For Game 1 Against Knicks
Paul George1 day ago

On Track To Hit Unrestricted Free Agency
Pierre-Luc Dubois1 day ago

Kings Not Planning To Buy Out Pierre-Luc Dubois
WPG1 day ago

Rick Bowness Leaves Jets Bench, Retires From NHL
Sergei Bobrovsky1 day ago

Aims To End Bad Run Against Bruins Monday
Jeremy Swayman1 day ago

Set For Sixth Straight Start
Danton Heinen1 day ago

Remains Out On Monday
Brandon Carlo1 day ago

Bruins Hope To Have Brandon Carlo Available On Monday
Kyle Larson1 day ago

Gets Win In Kansas With Amazing Photo Finish
Chris Buescher1 day ago

Misses Victory At Kansas In Closest NASCAR Finish Ever
Chris Godwin1 day ago

Moving Back Into Slot Role
Tyler Reddick1 day ago

Unexpectedly Lackluster at Kansas
Ty Gibbs1 day ago

Had Speed But Was Foiled by Pit Strategy at Kansas
William Byron1 day ago

Unable to Fully Recover From Qualifying Crash at Kansas
Kyle Busch1 day ago

Showing Consistent Speed Again After Mediocre Short Track Stretch
Jeff Wilson Jr.1 day ago

Not A Lock To Make Final Roster
MarShawn Lloyd1 day ago

Packers Plan To Use MarShawn Lloyd A Lot
Joe Burrow1 day ago

Back On The Field
Zay Jones1 day ago

Visiting With Titans
Jalen Guyton1 day ago

Raiders Sign Jalen Guyton
Rashaad Penny1 day ago

To Sign With Panthers
Martin Truex Jr1 day ago

. Misses Out On Victory At Kansas
Chase Elliott1 day ago

Scores Hard-Fought Podium Finish At Kansas
Denny Hamlin1 day ago

Sees Win Slip Away Late At Kansas
Alexandre Pantoja1 day ago

Edges Out Competitive Decision At UFC 301
Steve Erceg1 day ago

Drops Decision Matchup
Ihor Potieria1 day ago

Gets Submitted At UFC 301
Michel Pereira1 day ago

Stops Ihor Potieria In The First Round
Paul Craig1 day ago

Gets Knocked Out At UFC 301
Sebastian Aho1 day ago

Delivers Two Assists In Game 1 Loss
Mika Zibanejad1 day ago

Starts Second Round With Three-Point Effort
Jake Oettinger1 day ago

Stops 22 Shots In Game 7 Victory
Radek Faksa1 day ago

Sends Defending Champs Packing
Sam Bennett1 day ago

Misses Game 1 Against Bruins
Noah Gragson1 day ago

Earns Third Top-10 Finish In Three Weeks With Ninth-Place Finish
Thatcher Demko1 day ago

Out For Game 1 Against Oilers
Alex Bowman1 day ago

Delivers Value In DFS At Kansas
Christopher Bell2 days ago

Takes Sixth Place On Sunday Night
Michael McDowell2 days ago

Ends Up 10th At Kansas
Marquez Valdes-Scantling2 days ago

To Visit The Chargers
Caio Borralho2 days ago

Scores Knockout Win At UFC 301
Vitor Petrino2 days ago

Suffers First Career Loss At UFC 301
MMA2 days ago

Anthony Smith Pulls Off Upset At UFC 301
Jonathan Martinez2 days ago

Has Winning Streak Snapped At UFC 301
Jose Aldo2 days ago

Gets Decision Win In Return At UFC 301
Dak Prescott2 days ago

Police Won't Pursue Assault Charges For Dak Prescott
NFL2 days ago

J.J. Watt Not Ruling Out A Return
Tyler Reddick2 days ago

Is One Of The Top Favorites To Win At Kansas
Michael McDowell2 days ago

Fade Michael McDowell At Kansas This Week
Corey Lajoie2 days ago

Corey LaJoie Could Compete For A Kansas Top-20 Finish
Noah Gragson2 days ago

Is Noah Gragson Worth Rostering At Kansas?
Ty Gibbs2 days ago

Will Start Sixth At Kansas
William Byron2 days ago

Is A Must-Play For Kansas Cash Games
Kyle Busch2 days ago

Is An Ideal Tournament Play For Kansas
Kyle Larson2 days ago

The Heavy Favorite To Win At Kansas
NYI4 days ago

Lou Lamoriello, Patrick Roy To Return Next Season
Mason Marchment4 days ago

A No-Go For Friday
Aaron Rodgers4 days ago

No Restrictions For Aaron Rodgers During Offseason Workouts
Mac Jones4 days ago

Jaguars Don't Pick Up Mac Jones' Fifth-Year Option
Jayden Daniels4 days ago

Has A Chance To Start Immediately
Chase Claypool4 days ago

Bills Sign Chase Claypool
Steve Erceg4 days ago

Has A Chance To Become A Champion
Alexandre Pantoja4 days ago

Looks To Defend Flyweight Title
Michel Pereira4 days ago

Ihor Potieria Faces Michel Pereira On UFC 301
Odell Beckham Jr.4 days ago

Signing One-Year Deal With Dolphins
Michel Pereira4 days ago

Looks To Extend Win Streak To Eight
Paul Craig4 days ago

Looking To Rebound At UFC 301
DJ Chark Jr.5 days ago

Signs With Chargers
Caio Borralho5 days ago

Gets Ranked Opponent At UFC 301
Vitor Petrino5 days ago

Puts Undefeated Record On The Line At UFC 301
Anthony Smith5 days ago

A Massive Underdog At UFC 301
Jonathan Martinez5 days ago

Faces A Legend At UFC 301
Jose Aldo5 days ago

Returns At UFC 301

MORE RECENT ARTICLES

 
Jaheim Bell - Fantasy Football Rankings, Draft Sleepers, NFL Injury News

Fantasy Football Rookie Spotlight: Jaheim Bell

The New England Patriots selected dynamic tight end Jaheim Bell with their final pick in the 2024 NFL Draft. Adding offensive players with seven of their eight draft picks, New England clearly had their eyes set on fixing what was one of the worst offenses in the league a season ago. The addition of Bell... Read More


Roman Wilson - Fantasy Football Rankings, Draft Sleepers, NFL Injury News

Fantasy Football Rookie Spotlight: Roman Wilson

Mike Wallace. Emmanuel Sanders. Antonio Brown. Martavis Bryant. JuJu Smith-Schuster. Diontae Johnson. George Pickens. Roman Wilson? The Pittsburgh Steelers have a lengthy history of drafting highly productive wide receivers in the middle-to-late rounds of the NFL Draft. They hope Michigan’s Roman Wilson is next in the lineage. There have been some misses (James Washington, Sammie... Read More


Caleb Williams - Fantasy Football Rankings, College FB, NFL Rookies, Draft Sleepers

Caleb Williams 2024 Fantasy Football Outlook And Predictions

Few rookie quarterbacks make an impact on fantasy football. Players such as Robert Griffin III, Andrew Luck, Justin Herbert, and C.J. Stroud are all outliers separated by several years. Stroud's recent success as a rookie has many fantasy managers wondering if Caleb Williams could experience similar success. For every C.J. Stroud, there are several Bryce... Read More


Updated 2024 Fantasy Football Rookie Rankings: Post-NFL Draft

What's up RotoBallers! It's always football season here, so let's have some fun now that the 2024 NFL Draft is officially in the books! In this article you'll find our NFL team's updated 2024 fantasy football rookie rankings -- the post-NFL Draft edition. Use these fantasy football rookies rankings for your rookie drafts, dynasty drafts, and... Read More


Michael Penix Jr. - CFB DFS Picks, Daily College Fantasy Football, NFL Draft Rookies

Why Did The Falcons Draft Michael Penix Jr? 2024 NFL Draft Analysis

Every fan of the NFL may be able to tell you where they were when they heard Michael Penix Jr.'s name called eighth overall to the Falcons. It was one of those moments that made me scream "WHAT!" and I am not even a fan of the Falcons. The Falcons are clearly in win-now mode and... Read More


Zay Jones - Fantasy Football Rankings, Draft Sleepers, Waiver Wire Pickups

Is Zay Jones a Free Agent? Top Landing Spots for Jones This Offseason

While most high-profile free agent wide receivers have already found new teams this offseason, there are still several WRs on the market who could have an impact on the 2024 fantasy football season. Following a career year in 2022, veteran wide receiver Zay Jones spent a large chunk of the 2023 season dealing with various... Read More


Adonai Mitchell - Fantasy Football Rankings, Draft Sleepers, NFL Injury News

Fantasy Football Rookie Spotlight: Adonai Mitchell

A debate breaks out at the bar: Is Adonai Mitchell a great NFL prospect? You point to his elite athleticism score at the NFL Combine. Your friend discusses his lack of finesse and consistency in his routes. The eavesdropping bartender points out that Mitchell never missed the College Football Playoff in his collegiate career, showing... Read More


Brian Thomas Jr. - Fantasy Football Rankings, Draft Sleepers, NFL Injury News

2024 Fantasy Football Dynasty Rookie Mock Draft: Two-Round Rankings For Non-Superflex Leagues

As the dust settles on the 2024 NFL Draft, it's time to shift our fantasy football focus to the fresh faces entering the league who are ready to shake up your dynasty rosters. This year's rookie class is brimming with talent that could immediately impact fantasy leagues. This draft has everything from speedster wideouts who... Read More


Colston Loveland - Fantasy Football Rankings, Draft Sleepers, NFL Injury News

2025 NFL Draft Prospects: Top 30 Rankings Big Board - An Early Look

Alright, team, soon we'll be cruising into the sunny days of summer, and it’s prime time to lay down my Top 30 Big Board for the 2025 NFL Draft. For all you draft junkies who’ve been riding shotgun with me through the mock drafts and scouting reports this season—a huge shoutout to you! Now that... Read More


Blake Corum - Fantasy Football Rankings, College FB, RB, NFL Draft Sleepers

Fantasy Football Rookie Spotlight: Blake Corum

Leading up to the 2024 NFL Draft, the widespread belief was that Jim Harbaugh would draft and reunite with his former Michigan running back Blake Corum. Instead, Harbaugh opted for a different Wolverine, linebacker Junior Colson, in the third round. Corum will at least play in the same stadium as his former mentor. The Rams... Read More


Bo Nix - College Football Rankings, NCAA CFB DFS Lineup Picks

Fantasy Football Rookie Spotlight: Bo Nix

The first 12 picks of the 2024 NFL Draft were heavy on the quarterbacks as six players heard their names called. Of those 12, former Oregon Ducks quarterback Bo Nix was the final selected when the Broncos took him at pick 12. Will Bo Nix start for the Broncos in 2024? What is the fantasy... Read More


Odell-Beckham-Jr-Fantasy-Football-Rankings-Draft-Sleepers-Waiver-Wire-Pickups-icon-rotoballer

Odell Beckham Jr. Signs With Miami Dolphins: 2024 Fantasy Football Impact

Early during the day on Friday, Odell Beckham Jr. signed a one-year contract with the Miami Dolphins. Sources say the deal is worth $3 million with incentives that can push Beckham's financial gains to $8.25 million for the 2024 NFL season. The former 12th overall pick in the 2014 NFL Draft has been a bit... Read More


Rome Odunze - College Football Rankings, NCAA CFB DFS Lineup Picks

Fantasy Football Dynasty Rookie Draft Mock 2024 For Superflex Leagues

Traditionally, quarterbacks go at the top of Superflex dynasty drafts. That is true in startups and rookie-only drafts. However, that rule has faltered over the past two years. The 2022 NFL Draft included zero high-end quarterback prospects, leading to a running back (Breece Hall) landing at 1.01. The next year was different. We had a... Read More