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Our updated Week 1 fantasy football Flex rankings (RB, WR, TE) for 2021. Nick Mariano was ranked 9th and 11th overall out of 130 experts, follow his Flex ranks.
Welcome to Week 1 RotoBallers. Below are our updated consensus Week 1 Flex rankings for fantasy football, including some running notes on relevant injuries, player news and rankings updates. These Flex rankings are geared towards making decisions for your Flex spot (RB/WR or RB/WR/TE), which in most leagues consists of running backs, wide receivers and in many cases tight ends as well:
- Saquon Barkley Medically Cleared, Set To Return Week 1
- Austin Ekeler Expected To Play In Week 1
- Odell Beckham Jr. Likely To Play Against Chiefs
- Preston Williams Likely Out In Week 1
- A.J. Brown Good To Go For Week 1
- Kyle Rudolph Good To Go For Week 1
- Tests Confirm Torn ACL For Gus Edwards
- Le'Veon Bell Could Be Active In Week 1
- Curtis Samuel Heading To IR
- Jamison Crowder Out Week 1
- Latavius Murray Signs One-Year Deal With Baltimore
- Evan Engram Out Week 1
- Michael Gallup Out Up To Five Weeks
- Saquon Barkley Looks “Promising” Ahead Of Week 1
- Tre'Quan Smith Placed On Injured Reserve
- Jalen Hurd Ruled Out For Week 1
- Austin Ekeler Back At Practice
- Devonta Freeman Signs With Ravens Practice Squad
- Kenny Golladay Practicing Wednesday
- Clyde Edwards-Helaire 100 Percent Healthy And Ready To Go
- Darrell Henderson Fully Recovered From Thumb Injury
- Rhamondre Stevenson Not On The Injury Report
- Kadarius Toney Could Have “Significant Role” In Week 1
- Emmanuel Sanders Hopeful To Play In Opener
- Darnell Mooney Dealing With Back Injury
- Mecole Hardman Limited With Oblique Ailment
- Tre'Quan Smith No Longer On Injury Report
- Rashaad Penny Dealing With Calf Injury
- Adam Trautman Is Healthy For Week 1
These rankings are a consensus from four of our lead fantasy football columnists - Nick Mariano, Pierre Camus, Brandon Murchison and Scott Engel - who have all analyzed the NFL matchups and game slates for Week 1.
And in case you weren't aware, our very own Nick Mariano was ranked #11 overall in 2018 out of ~120 industry experts, and was ranked #9 overall the year before. So be sure to follow his rankings every week!
Be sure to check all of our fantasy football rankings for 2025:- 2025 fantasy football rankings
- Running back (RB) fantasy football rankings
- Wide receiver (WR) fantasy football rankings
- Tight end (TE) fantasy football rankings
- Quarterback (QB) fantasy football rankings
- Defense (D/ST) fantasy football rankings
- NFL rookie fantasy football rankings
- Best ball fantasy football rankings
- Superflex fantasy football rankings
- Dynasty fantasy football rankings
Week 1 Fantasy Football Flex Rankings
You can also see our full Week 1 ranks for PPR, Half-PPR and Standard scoring.
Last updated on Sunday 9/12 at 10:00 am ET:
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