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The Pittsburgh Steelers defense will have their hands full in a Week 5 road matchup against the Buffalo Bills. The Bills have been a brutal matchup for fantasy defenses in 2022, allowing the eighth-fewest fantasy points per game to the position through four games. Pittsburgh is installed as 14-point underdogs in a game with an over/under of 45.5 points. The Steelers have traditionally been a quality defense but this is not the week to use them in fantasy leagues.--Matt T - RotoBaller
Source: NFL.com
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