October 10, 2025
Miami Dolphins running back
De'Von Achane has been one of the best running backs all season, despite his team's offense running hot and cold. Achane hasn't run for 100 yards in any game, but he has supplemented with great production in the passing game. He has at least six catches in three of his last four games after hauling in six of his seven targets for 30 yards and a touchdown last week. He has four total touchdowns in five games while averaging 65.5 rushing yards and 34.6 passing yards per contest. This week, he and the Dolphins will take on the Chargers, who have been very good against the run this season, but did give up two running back touchdowns and 124 rushing yards against the Commanders. Achane's consistently high volume and big-play ability have kept him an elite RB1 in every matchup. In RotoBaller's Week 6 rankings, he is the No. 3 RB in PPR leagues and the No. 8 RB in standard leagues.
--Zach ThompsonSource: NFL.com
October 10, 2025
Tampa Bay Buccaneers wide receiver
Tez Johnson is expected to have an increased role during Sunday's game against the San Francisco 49ers. The Bucs will be without
Mike Evans (hamstring) and
Chris Godwin (leg) for Sunday's game. That being said, Johnson figures to move into the No. 3 receiver role for this Week 6 contest. Last week, Johnson hauled in four receptions for 59 yards in the win over the Seattle Seahawks. The rookie wideout has been quiet outside of that, but showed a promising performance in Week 5. The increased playing time could sneak Johnson onto the flex radar in deep leagues for this weekend.
--Andy WebbSource: Pro Football Reference
October 10, 2025
Miami Dolphins quarterback
Tua Tagovailoa will face the Chargers in a tough test at home during Week 6. Last week, Tua had one of his best games of the year, even though he was playing his first game without top receiver
Tyreek Hill (knee). He completed 27-of-36 pass attempts for 256 passing yards and three touchdowns. He has thrown multiple touchdowns in four straight weeks and is up to 10 touchdowns on the year with just four interceptions. He's averaging just over 200 passing yards per game, while adding almost no rushing production. His recent success has been in favorable matchups, but this week, he'll face the Chargers, who have allowed the seventh-fewest fantasy points to the position. They have allowed just four passing scores all year and an average of only 188.2 passing yards per game. In the tough matchup, Tua is the No. 23 QB in RotoBaller's rankings, making him a borderline second QB but not a starter in most standard leagues.
--Zach ThompsonSource: NFL.com
October 10, 2025
Tampa Bay Buccaneers wide receiver
Sterling Shepard will move into the No. 2 role ahead of Sunday's matchup against the San Francisco 49ers. The Bucs will be without
Mike Evans (hamstring) and
Chris Godwin (leg) for Sunday's game. That means, Shepard will move up the depth chart this weekend. The 32-year-old has hauled in four receptions in three of the first five games. The problem has been the yardage as Shepard has 39 receiving yards or less in every game but one. There should be a handful of targets coming Shepard's way, but it's unclear what damage he'll do on the field. In most formats, Shepard should be viewed as a flex option for Week 6.
--Andy WebbSource: Pro Football Reference
October 10, 2025
Tampa Bay Buccaneers wide receiver
Emeka Egbuka was unstoppable during last week's game against the Seattle Seahawks. Egbuka hauled in all seven of his targets for 163 yards and a touchdown in the win. The rookie wideout has now posted back-to-back games with at least 100 receiving yards. The Bucs are going to be without
Mike Evans (hamstring) and
Chris Godwin (leg) for Sunday's game against the San Francisco 49ers. That being said, Egbuka is expected to serve as the focal point in the receiving game. The 22-year-old has shown no signs of slowing down so he belongs as a strong WR1 for Week 6.
--Andy WebbSource: Pro Football Reference
October 10, 2025
Cincinnati Bengals star wide receiver
Ja'Marr Chase (illness), who was listed as questionable for Week 6 on Sunday after missing Friday's practice due to an illness, is expected to play against the Green Bay Packers at Lambeau Field, sources told Matt Zenitz of CBS Sports. Chase was feeling a little under the weather on Friday, but he should be fine to play in a couple of days in what will be new quarterback
Joe Flacco's starting debut in Cincinnati. The 25-year-old Chase has had three quiet games and two 100-yard games so far in 2025. A 6-110-2 line in last week's loss to the Detroit Lions proves why Chase is still a must-start in fantasy despite quarterback
Joe Burrow (toe) potentially being out for the rest of the year. It remains to be seen what kind of chemistry Chase will have with Flacco, but the veteran signal-caller figures to target him heavily.
--Keith HernandezSource: CBS Sports - Matt Zenitz
October 10, 2025
Tampa Bay Buccaneers running back
Sean Tucker moved into the No. 2 role in the backfield during last week's game against the Seattle Seahawks. The assumption was that Tucker would see a handful of carries with
Bucky Irving (foot) sidelined. Tucker didn't see much of the field as
Rachaad White did most of the work on offense. Tucker rushed the ball three times for three yards while hauling in three passes for -4 yards in the win. The expectation is that Tucker will see a handful of touches this weekend, but isn't a trustworthy starter. Fantasy managers should keep Tucker on the bench for the Week 6 matchup against the San Francisco 49ers.
--Andy WebbSource: Pro Football Reference
October 10, 2025
Washington Commanders running back
Jeremy McNichols worked mostly behind rookie
Jacory Croskey-Merritt in Week 5, rushing just once for six yards and catching one of two targets for 12 yards. McNichols matched third-year running back
Chris Rodriguez Jr. in snaps against the Chargers, each playing 13 snaps, while Croskey-Merritt led the way with 28. The 29-year-old could be relied on more as Chris Rodriguez Jr. (calf) has yet to practice this week. McNichols' role in pass protection is highly valued by the Washington coaching staff and will keep him involved in Washington's backfield committee. Offensive coordinator Kliff Kingsbury mixes him in for touches, and he's been efficient with his opportunities, averaging 9.5 yards per touch. McNichols could take advantage of a favorable matchup on Monday night against a Chicago defense that is allowing 6.1 yards per carry on the season. If Rodriguez is unable to play, McNichols would upgrade to fringe flex territory for Week 6.
--Kyle McCarthySource: RotoBaller
October 10, 2025
Tampa Bay Buccaneers running back
Rachaad White is set to make another start this Sunday versus the San Francisco 49ers. White made his first start of the season during last week's win over the Seattle Seahawks. The 26-year-old rushed 14 times for 41 yards with two touchdowns. He also hauled in four receptions for an additional 30 yards through the air. White figures to remain a focal point on offense with
Bucky Irving (foot),
Mike Evans (hamstring), and
Chris Godwin (leg) all expected to miss Week 6. The Bucs really have no choice but to get White involved. He's a capable option in both the running and receiving game, which gives him borderline RB1 value for this weekend.
--Andy WebbSource: Pro Football Reference
October 10, 2025
The Athletic's Daniel Popper speculates that if the Los Angeles Chargers explore the trade market at running back with
Najee Harris (Achilles) done for the year and rookie first-rounder
Omarion Hampton (ankle) on Injured Reserve, two potential options could be New York Jets RB
Breece Hall and the Cleveland Browns'
Jerome Ford. Both Hall and Ford are on expiring deals and could bring the Bolts a compensatory draft pick if they make it to free agency in 2026. Even when Hampton returns from IR, L.A. is going to need a second back to pair with him as a team with a run-first identity under offensive coordinator Greg Roman. At least for Week 6 against the Miami Dolphins,
Hassan Haskins and
Kimani Vidal are expected to share the backfield equally, giving them both flex appeal in deeper fantasy leagues. How aggressive the Chargers are on bringing in an outside RB will depend on how Haskins and Vidal fare in the coming weeks.
--Keith HernandezSource: The Athletic - Daniel Popper
October 10, 2025
Tampa Bay Buccaneers quarterback
Baker Mayfield (knee, arm) was removed from the injury report ahead of the Week 6 matchup against the San Francisco 49ers. Mayfield has been nursing some minor injuries, but will be fine for this weekend. Last week, Mayfield threw for a season-high 379 yards with two touchdowns and zero interceptions in the win over the Seattle Seahawks. The Bucs are banged up on offense with
Bucky Irving (foot),
Mike Evans (hamstring), and
Chris Godwin (leg) likely all out this weekend. Despite that, Mayfield will find a way to succeed and remain an elite QB1 play.
--Andy WebbSource: Pro Football Reference
October 10, 2025
Las Vegas Raiders running back
Raheem Mostert struggled to make an impact in his change-of-pace role during Week 5, totaling just 22 yards on a season-high seven touches. While the 33-year-old veteran still flashes big-play ability--highlighted by a 37-yard run against the Bears earlier this year--his current workload leaves him well outside fantasy relevance. Mostert should be viewed strictly as a handcuff to rookie standout
Ashton Jeanty, who has firmly established himself as the lead back. Still, with
Dylan Laube and
Zamir White buried on the depth chart, Mostert remains the clear next man up if Jeanty were to miss time. For now, he's best left on the waiver wire outside of deeper leagues or as insurance for Jeanty managers looking to protect one of fantasy's rising assets.
--Shaun AlbinSource: Raiders.com
October 10, 2025
Washington Commanders running back
Jacory Croskey-Merritt broke out with his best game of the season in Week 5 against the Chargers, totaling 150 yards and two touchdowns on 16 touches. The Croskey-Merritt takeover finally happened in Week 5, posting a season-high 50.9% snap share, handling 50% of the team's rush attempts, and running 31.3% of the team's routes. All marks were the highest of any Washington back in Week 5, and he delivered with a remarkable performance. For the season, he's rushed 283 yards and four touchdowns on 43 carries, averaging a league-best 6.6 yards per carry. Offensive coordinator Kliff Kingsbury provided some reason to keep the optimism in check, saying that the rookie still has "ways to go" in terms of playing without the ball in his hands. His work in pass protection has improved, but that is still an area where veteran
Jeremy McNichols is most trusted. Third-year back
Chris Rodriguez Jr. saw his lowest snap count and fewest carries in a game since becoming active in Week 5, suggesting he may be slipping back into a depth role. Croskey-Merritt should be expected to handle the bulk of the touches again in Week 6 against a Bears defense that is allowing an absurd 6.1 yards per carry and the fourth-most PPR points per game to opposing running backs. He should be fired up as a high-upside RB2 on Monday night.
--Kyle McCarthySource: RotoBaller
October 10, 2025
Las Vegas Raiders rookie running back
Ashton Jeanty continues to earn a larger role in the offense, showing off his versatility once again in Week 5 against the Colts. Jeanty drew seven targets, catching five passes and racking up 109 total yards from scrimmage despite not finding the end zone. His growing involvement as both a runner and receiver provides a strong floor for fantasy managers, especially with the Raiders offense increasingly leaning on him amid
Geno Smith's turnover issues and
Brock Bowers' absence. Heading into Week 6, Jeanty gets a dream matchup against a Tennessee Titans defense that ranks 29th against the run. With consistent usage and an expanding role in the passing game, Jeanty should be viewed as a strong RB2 with RB1 upside in PPR formats and a must-start in all standard leagues.
--Shaun AlbinSource: Raiders.com
October 10, 2025
Buffalo Bills tight end
Dalton Kincaid (oblique) is dealing with an oblique injury and was limited in practice for the second straight day this week on Friday. Kincaid was seen wearing a no-contact jersey in practice on Thursday and again had his reps limited in practice on Friday, putting his status up in the air for Monday night's game against the Atlanta Falcons. If the 25-year-old doesn't go full in practice on Saturday, he could draw a questionable tag going into Monday's contest. Kincaid has already scored a career-high three times in his first five games in 2025 and is coming off his first 100-yard game in the Week 5 loss to the New England Patriots. As long as he's active, Kincaid should be considered a top-10 fantasy tight end, but a questionable tag this week could make for a difficult decision for fantasy managers in Week 6.
Dawson Knox would be in play as a TE2 streamer if Kincaid is unable to play this week.
--Keith HernandezSource: Buffalo Bills PR
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