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Should I start Kendre Miller, TreVeyon Henderson, Isiah Pacheco for Week 6? Fantasy football start 'em, sit 'em picks and recommendations for the 2025 NFL season.
The early part of the season can be frustrating for fantasy managers waiting for their young rookie RB to take over the backfield. That is why it's important to also have playable depth at RB to ensure you don't get into too big a hole early in the season. Then, once the young back's role expands over the course of the season, that dynamic piece can supercharge the rest of your roster and elevate it to the next level.
Then there are young running backs we like as prospects who don’t break out as rookies for one reason or another and get pushed aside. But these “post-hype” players can often make a significant impact once the situation aligns in their favor.
New Orleans Saints Kendre Miller has among the best rushing peripherals in the league, New England Patriots rookie TreVeyon Henderson's usage has been frustrating this season, and is Isiah Pacheco the lead back in Kansas City? So, should fantasy managers start Henderson, Miller, and Pacheco in Week 6? Let's dive in and find out.
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Should I Start Kendre Miller for Fantasy Football?
It's been exciting to see Miller get more usage this season behind veteran Alvin Kamara. As mentioned, he's been one of the most effective runners in the league on a per-touch basis. His 52.6% Avoided Tackle% is the best by a wide margin among qualified running backs, with Bijan Robinson being the next closest at 45.3%. He also ranks top five in Yards After Contact Per Attempt (3.7) and eighth in Explosive Run% (13.2%).
Kellen Moore on Kendre Miller:
“Kendre’s just done a phenomenal job since I’ve been here. I’ve really enjoyed this guy. I think he’s an awesome player.” pic.twitter.com/MMZfSnYvqV
— NOF (@nofnetwork) October 6, 2025
His remarkable quality of play has led to more and more snaps every week. He played a season-high 41% of the snaps in Week 5 against the Giants. And now, Kamara missed Wednesday's practice with an ankle injury. He was able to get in a limited practice on Thursday, but he is still day-to-day as of now.
It's a tougher matchup in Week 5 for Miller, facing a New England defense that has only given up 13.5 PPR points per game to opposing running backs, fifth lowest in the league. If Kamara is unable to go, then Miller would upgrade to must-start territory with the expectation that he would handle the full workload. If he's able to play, it'd likely leave Miller more in flex territory.
Should I Start TreVeyon Henderson for Fantasy Football?
Henderson has been among the most frustrating players to own for fantasy managers this season. It was to be expected that his role would gradually expand as the season went along, but now, with Antonio Gibson (knee) out for the season, his time is coming in Week 6.
Not to mention, Henderson has been seemingly put in the dog house for each mistake he's made in pass protection, but Rhamondre Stevenson is tied for the lead league with three fumbles and has been a consistent issue throughout his career, but has maintained the upper hand as the primary back for New England.
For fans who have patiently waited for more TreVeyon Henderson in the offense, here’s a nugget from the middle of McDaniels’ answer on the impact of Antonio Gibson’s injury:
“We’re trying to prepare every guy to have an opportunity to play when it’s his turn. So we’ll see how… pic.twitter.com/yG5BtNJdSU
— Tom Carroll (@yaboiTCfresh) October 9, 2025
It's worth pointing out that Henderson hasn't looked the best in his limited sample of touches. Among qualified rushers, his -1.3 RYOE/Attempt is the worst in the NFL, per NFL Pro. But he's still an incredibly explosive player with untapped upside as a receiver, which is hopefully put on display in Week 6. This could be Henderson's week to break out, and he's worth firing up as an RB2 with upside against a New Orleans defense that has been middle of the pack in terms of PPR points per game allowed to opposing running backs.
Should I Start Isiah Pacheco for Fantasy Football?
Pacheco had his most efficient outing of the year in Week 5 against Jacksonville, rushing for 36 yards on seven carries while catching all three of his targets for 20 yards. It was still an underwhelming fantasy day at 8.6 PPR points, but that's the second-best scoring game of the season so far for Pacheco.
The 26-year-old running back was not a target of mine during drafts, as his profile fits right into the "running back dead zone." He's not very efficient or dynamic with the ball in his hands and is reliant on the volume. For the season, he leads the Kansas City backfield with a 47.6% snap share, but actually has fewer touches on the season (48) than Kareem Hunt (49). And now, the rookie out of SMU, Brashard Smith, is starting to earn more work, although that's mostly been as a receiver.
Chiefs HC Andy Reid on RB Isiah Pacheco in Week 5: "I thought he did a good job, not only running, but catching the ball, blocking... everything that we asked of him."
— Charles Goldman (@goldmctNFL) October 8, 2025
The most concerning part for Pacheco is that the Chiefs have run the ball eight times inside the 10-yard line this season, and Hunt has handled seven of those carries, scoring three touchdowns. If he's not going to get the goal line work and he is maxing out around three targets per game at the high end, then it will be difficult for Pacheco to return value for fantasy managers. That leaves him as a recommended sit in Week 6 against Detroit.
Who Should I Start Tool
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Who Should I Start? Who Should I Sit? Some common Week 6 fantasy football lineup decisions are regarding players like Kendre Miller, TreVeyon Henderson, Isiah Pacheco. But not to worry, we are here to help make these decisions and build winning lineups in Week 6. Set your optimal fantasy football lineups for Week 6 of the 2025 NFL season. Our free Who Should I Start? tool will help make your fantasy football lineup decisions. Compare up to four NFL players, and we tell you who to start... all free! Get your winning lineups set, and make the right decisions.
Week 6 Player Decisions. Today's focus is on specific players - Kendre Miller, TreVeyon Henderson, Isiah Pacheco. These are some of the most common searches for fantasy football lineups in Week 6.
Using The Tool. This is a simple tool but very powerful. The first step is to enter the player names that you want to compare. In the first box, search for the first player's name. In the second box, search for the second player's name. Compare up to four NFL players at once, and then click the Who To Start? button to see who the recommended starts are based on weekly fantasy football matchups.
Improvements For Who Should I Start? You may have noticed, our Who Should I Start? tool has gotten an overhaul. We've added lots of great features for you to give you as much information as possible to win your fantasy football matchups each week. You'll see NFL player tiles with headshots and bye weeks, enhanced search results with data to compare, and a slick new interface. We hope you enjoy!
How It Works. Each week, our RotoBaller staff puts together their weekly fantasy football rankings and projections based on their research. That information is the core data that is powering the decision-making in this tool. When you search for player names, you will only see those players who are ranked. If someone is out for the week, they will not appear in the search results.
Scoring Formats. Fantasy football managers play in various types of leagues, and this tool allows you to choose whether it's PPR scoring, Half-PPR scoring, or Standard (Non-PPR) scoring. The second thing you want to do is to select the scoring format. There are three small radio buttons (small circles), so click on the scoring format you prefer. The results may vary based on the scoring format you select.
Popular Week 6 Searches. Curious to see some tough lineup decisions for Week 6 (2025)? Below you will find a list of some popular Who Should I Start? searches that RotoBaller readers are looking at this week. Click any of the links to see the result and recommendation.
Popular Week 6 Searches - Start/Sit Player Comparisons
Below are some popular Week 6 searches and comparisons from our 'Who To Start' tool for Kendre Miller, TreVeyon Henderson, Isiah Pacheco compared to others:
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