October 11, 2025
Washington Commanders wide receiver
Luke McCaffrey has made a handful of spectacular plays over the last few weeks, with star wide receiver
Terry McLaurin (quadriceps) injured. McLaurin is now ruled out for the third consecutive game and opens up more routes for McCaffrey, who has been taking advantage. The second-year wide receiver had one of the highlight plays of Week 5, making an incredibly difficult diving catch on a beautiful 50-yard deep pass from
Jayden Daniels. McCaffrey hasn't drawn a high number of targets, but his playmaking ability has been evident, and Daniels' faith in him appears to be growing by the week. McCaffrey will have a chance to stack his positive performances in Week 6 against the Bears, who have allowed the sixth most PPR points per game to opposing wide receivers. He is on the WR4-WR5 line for Week 6.
--Kyle McCarthySource: RotoBaller
October 11, 2025
Washington Commanders wide receiver
Deebo Samuel Sr. (heel) would be in line for another high number of targets on Monday night if he can play. Samuel is currently listed as questionable as he manages a heel issue. The veteran wide receiver has been the engine of Washington's passing attack with
Terry McLaurin (quadriceps) out and set to miss his third consecutive game. Samuel was limited in practice throughout the week, and it looks like the team will take the decision into Monday, which is frustrating for fantasy managers. If he can suit up, Samuel would be projected as a firm WR1 against a Chicago defense that is allowing the sixth most PPR points per game to opposing wide receivers. If unable to go, then second-year receiver
Luke McCaffrey and rookie
Jaylin Lane would be in line for more opportunities.
--Kyle McCarthySource: RotoBaller
October 11, 2025
According to ESPN's Adam Schefter, Arizona Cardinals quarterback
Jacoby Brissett is expected to start in Sunday's clash with the Colts.
Kyler Murray (foot) still has a chance to play. However, that's unlikely, although NFL Media's Ian Rapoport reported that a final decision won't come until Sunday morning. Unfortunately, there's belief Murray might miss extended time due to a mid-foot sprain, meaning Brissett could be under center in Week 6 and beyond. The signal-caller has been a reliable fantasy quarterback (at times) over the years. In 89 regular-season appearances, he has thrown for 11,400 yards, 53 touchdowns, and 24 picks, adding 15 scores on the ground. While Brissett potentially has a tough matchup on tap against a capable Colts' defense, the potential for Murray to be sidelined for more than a game makes him worth adding to fantasy rosters, mostly by those participating in deeper Superflex formats.
--Dennis ClausenSource: Adam Schefter
October 11, 2025
According to NFL Media's Ian Rapoport, the Arizona Cardinals "are leaving the door open" for quarterback
Kyler Murray (foot) to suit up on Sunday versus the Colts. However, the team is realistically "preparing" for
Jacoby Brissett to start in Week 6, although a final decision won't come until Sunday morning. The signal-caller is reportedly dealing with a "mid-foot sprain," with Rapoport adding that it's "a version of a Lisfranc injury." Unfortunately, that could sideline Murray for more than just one week. As far as Brissett is concerned, he's had some quality performances over the years. In 89 regular-season games, he's thrown for 11,400 yards, 53 touchdowns, and 24 interceptions, adding 15 more scores on the ground. With that said, Brissett has some value for managers in deeper superflex formats despite a tough matchup on the horizon, especially with injuries at the QB position and a few teams getting the week off.
--Dennis ClausenSource: Ian Rapoport
October 11, 2025
Carolina Panthers tight end
Tommy Tremble hasn't done much for fantasy managers this season. While he had five catches (eight targets) for 42 yards and a touchdown in the Week 4 loss to the New England Patriots, he has been nearly irrelevant from a production standpoint.
Ja'Tavion Sanders (ankle) is listed as questionable heading into the Week 6 meeting with the Dallas Cowboys, so there's a chance he won't be out there once again. Sure, the potential for added involvement should increase Tremble's fantasy potential. Still, even if Sanders remains sidelined, fantasy managers will be taking a gamble by rolling with the 25-year-old as their starting tight end for the favorable matchup with the Cowboys. especially with
Xavier Legette in the mix.
--Dennis ClausenSource: ESPN
October 11, 2025
Carolina Panthers wide receiver
Hunter Renfrow had seven catches for 48 yards and two touchdowns in the Week 2 loss to the Cardinals. However, outside of that performance, he hasn't done much, most recently catching one pass for seven yards in the Week 5 win over the Dolphins.
Xavier Legette found the end zone in that one, so his stock is higher heading into the Week 6 meeting with the Dallas Cowboys, especially with
Jalen Coker (quadriceps) unable to make his professional debut. All things considered, none of the Panthers' wideouts can be trusted. Although
Tetairoa McMillan should still draw starting consideration versus a weak Cowboys defense, the same can't be said for Renfrow, even if
Ja'Tavion Sanders (ankle) doesn't suit up.
--Dennis ClausenSource: ESPN
October 11, 2025
Carolina Panthers wide receiver
Tetairoa McMillan remains the team's No. 1 option on the depth chart. He's logged 305 offensive snaps through the first five weeks of the 2025 campaign, with
Hunter Renfrow sitting behind him with 192. Unfortunately, that hasn't necessarily translated into consistent production from the rookie. McMillan currently has 24 catches (43 targets) for 351 yards. However, he still hasn't scored a touchdown. With that said, the Panthers may continue to rely mostly on
Rico Dowdle against Dallas, his former team, in Week 6. Although McMillan is the favorite to see the most attention from
Bryce Young on the receiving end versus a week Cowboys defense, fantasy managers will be taking a gamble by having him in their lineups. Still, the wideout has been a top-30 fantasy producer in standard and PPR formats, so he deserves starting consideration.
--Dennis ClausenSource: ESPN
October 11, 2025
Carolina Panthers quarterback
Bryce Young has shown signs of growth in his third season in the National Football League. While he hasn't been consistent, he's still had some favorable outings for fantasy managers. The signal-caller most recently threw for 198 yards, two touchdowns, and one interception off 19-for-30 passing in the Week 5 win over the Miami Dolphins. Although things could have gone better in that one, it's safe to say Young could have played much worse based on his volatile track record. Truth be told, he at least did enough to keep his team competitive in Week 5, with
Rico Dowdle handling the rest by amassing 206 yards and one touchdown on the ground. With that in mind, Young has work to do before earning the trust of fantasy managers. However, with injuries at the quarterback position and a few teams getting the week off, the 24-year-old can realistically occupy a spot in Superflex lineups versus a weak Cowboys defense, assuming managers are comfortable taking a gamble.
--Dennis ClausenSource: ESPN
October 11, 2025
According to NFL Media's Tom Pelissero, the Los Angeles Chargers elevated
Nyheim Hines off the practice squad ahead of the Week 6 meeting with the Miami Dolphins, marking his first taste of regular-season action since 2022.
Najee Harris (Achilles) is done for the rest of the season, and
Omarion Hampton (ankle) will miss at least the next four contests. As a result,
Hassan Haskins and
Kimani Vidal are expected to split carries out of the backfield, presumably leaving Hines with the leftover scraps. It's unknown how long Hines will suit up for the Bolts moving ahead, especially if the team brings in another running back sometime soon. Either way, Haskins, Vidal, and Hines won't be relevant from a fantasy standpoint once Hampton is cleared to return.
--Dennis ClausenSource: Tom Pelissero
October 11, 2025
According to NFL Media's Ian Rapoport, the Los Angeles Chargers are "in the market" for a running back.
Najee Harris (Achilles) is done for the remainder of the 2025 campaign. To make matters worse, rookie
Omarion Hampton (ankle) landed on the Injured Reserve list and will miss at least the next four games. As a result,
Hassan Haskins and
Kimani Vidal will presumably split carries on Sunday versus the Miami Dolphins. That arrangement may remain the same until Hampton can return. However, it may change depending on who plays better, or if the Bolts bring in another running back. It's also worth mentioning the Chargers elevated
Nyheim Hines, although he likely won't see much work in Week 6. With that in mind, fantasy managers should monitor things moving ahead. Still, it will be Hampton getting the bulk of the snaps at the position once he's back to full-strength no matter who's on the depth chart behim him.
--Dennis ClausenSource: Ian Rapoport
October 11, 2025
The Arizona Cardinals signed quarterback
Kedon Slovis off of the practice squad on Saturday. The 24-year-old has bounced around the league, suiting up for various practice squads in the last few years. While the signing won't directly impact fantasy managers, it could mean that
Kyler Murray (foot), who is still questionable, won't be out there in Week 6 versus the Indianapolis Colts. However, it's still too early to speculate. If Murray ends up suiting up on Sunday, Slovis may still stick around as an emergency quarterback. On the other hand,
Jacoby Brissett is in line to start if Murray gets ruled out. Either way, Slovis isn't worth adding to any fantasy roster.
--Dennis ClausenSource: Mike Garafolo
October 11, 2025
The Indianapolis Colts defense has been an excellent unit through the first five weeks of the NFL season. The Colts have given opposing offenses fits so far, ranking third in the league with just 17.8 points allowed per game while ranking fifth with 14 sacks and fourth with six interceptions. The Cardinals have been generous to opposing D/STs this season, allowing the ninth-most fantasy points per game to the position. Add in the fact that
Kyler Murray (foot) is dealing with a foot injury, and the Colts' defense is in an excellent spot in Week 6. Fantasy managers can trust them as a top-six option heading into Sunday's slate of games.
--Matt TerelleSource: NFL.com
October 11, 2025
Washington Commanders running back
Chris Rodriguez Jr. (calf) is currently listed as questionable ahead of the Week 6 matchup against the Chicago Bears. It doesn't look good for Rodriguez who has been able to practice all week due to a lingering calf issue. Despite that, Rodriguez still has a chance to suit up for Monday's game. When healthy, Rodriguez hasn't done much with 23 carries for 105 yards and zero touchdowns. If active, Rodriguez figures to play a reserve role with
Jeremy McNichols while
Jacory Croskey-Merritt serves as the lead back.
--Andy WebbSource: Washington Commanders
October 11, 2025
Washington Commanders wide receiver
Deebo Samuel Sr. (heel) is currently listed as questionable ahead of Monday's Week 6 game against the Chicago Bears. Samuel played through a bruised heel last week and has been limited in practice this week. Head coach Dan Quinn said the team will "take it into Monday" regarding Samuel's status for Monday's contest. That being said, it sounds like Samuel is going to be a legitimate game-time decision this weekend. That is a frustrating situation for fantasy managers as that will limit them in terms of options. The Commanders are going to be without
Terry McLaurin (quad) and
Noah Brown (quad, knee) for this game. If healthy, Samuel figures to have a big role in this game. He hauled in eight receptions for 96 yards and a touchdown last week. If he suits up, Samuel should be a viable WR2.
--Andy WebbSource: Washington Commanders
October 11, 2025
Chicago Bears wide receiver
D.J. Moore has gotten off to a sluggish start this season, recording just 16 catches on 21 targets for 173 yards and one touchdown through four games. The veteran wideout appears to have ceded the WR1 role to emerging second-year star
Rome Odunze, who has quickly become
Caleb Williams' favorite target. Before the bye week, Williams mentioned that Moore could serve as the "Deebo Samuel" of the Bears' offense, which has fantasy managers feeling uneasy. Fortunately, the Week 6 matchup against the Washington Commanders offers some hope. Washington has surrendered the eighth-most fantasy points to opposing wide receivers this season, providing Moore with a chance to bounce back. Still, Moore profiles as a low-end WR3 for Week 6, as his fantasy production will likely hinge on whether he finds the end zone.
--Nathan HarveySource: Pro Football Reference
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