September 14, 2025
Seattle Seahawks cornerback Devon Witherspoon (knee) is officially inactive for Sunday's Week 2 contest against the Pittsburgh Steelers. His absence was widely expected; he missed all three practices this week and was listed as doubtful heading into the weekend. It's a crushing blow for the Seahawks' defense, especially as they prepare for a Steelers receiving corps led by old friend
DK Metcalf. Cornerback Josh Jobe, who allowed just one catch on five targets in Week 1, will likely step up as Witherspoon's replacement on defense.
--Andersen PickardSource: Seattle Seahawks PR
September 14, 2025
San Francisco 49ers left tackle Trent Williams (knee) is officially active for Sunday's Week 2 contest against the New Orleans Saints. He had been listed as questionable, and while there was some concern after he missed two practices this week, he was able to return in a limited capacity on Friday. Now, after testing his knee during pregame warmups Sunday, Williams is good to go. His presence will be key for the 49ers as he works to protect the backfield, as well as quarterback
Mac Jones' blindside. Williams being active is refreshing for the 49ers and their fans, who haven't received very much good news on the injury front lately.
Brandon Aiyuk (knee) opened the season on IR, and now
George Kittle (hamstring) and
Brock Purdy (shoulder) are both expected to miss time. This offense should run through
Christian McCaffrey, which is one of many reasons why it's good for the 49ers that Williams is active.
--Andersen PickardSource: San Francisco 49ers
September 14, 2025
Tennessee Titans rookie running back
Kalel Mullings (ankle) has officially been ruled out of Week 2 against the visiting Los Angeles Rams on Sunday. Mullings made his NFL debut in last week's loss to the Denver Broncos as the RB3 behind
Tony Pollard and
Julius Chestnut, but was quickly injured in the first half on special teams. The 22-year-old sixth-rounder didn't see a single touch on offense in the 20-12 loss in Denver. With
Tyjae Spears (ankle) on Injured Reserve and set to miss at least the first four weeks of the season, Tennessee's backfield depth behind Pollard and Chestnut is dangerously thin. Now that Mullings is out, the Titans were forced to bring up
Jordan Mims from the practice squad for Sunday's game against the Rams. He'll operate as the team's No. 3 RB in Week 2.
--Keith HernandezSource: Titans PR
September 14, 2025
Dallas Cowboys running back
Jaydon Blue (coach's decision) is inactive for Sunday's Week 2 contest against the New York Giants. The fifth-round rookie has now been a healthy scratch for each of the Cowboys' first two games of the season. In his absence,
Miles Sanders will serve as the backup running back behind
Javonte Williams. Sanders and Williams are the Cowboys' only two active running backs, but fullback
Hunter Luepke should also see some blocking work in the backfield. Fantasy managers in deeper leagues should be patient with Blue and hold onto him, as it's likely only a matter of time before he's active as the No. 3 running back or leapfrogs Miles Sanders for the backup job.
--Andersen PickardSource: Nick Harris
September 14, 2025
New York Giants left tackle Andrew Thomas (foot) is officially inactive for Sunday's game against the Dallas Cowboys. While Thomas did manage to log two limited practices this week, he still wasn't expected to play as the Giants listed him as doubtful. Thomas missed the season opener, too, so this is his second consecutive absence. James Hudson III will step in as the Giants' starting left tackle as New York looks to slow down Dallas' defense in a divisional rivalry contest.
--Andersen PickardSource: Dan Salomone
September 14, 2025
New York Giants wide receiver
Wan'Dale Robinson (ankle) is officially active for Sunday's Week 2 contest against the Dallas Cowboys. He had been listed as questionable after practicing in a limited capacity on Friday. Having Robinson available will be key for the Giants, as he's their second-best option in the passing game behind
Malik Nabers. The 24-year-old was productive in last week's season opener, catching six of eight targets for 55 yards. He should continue to deliver similar productivity this week against the Cowboys, as the Giants are expected to throw the ball a lot while playing from behind. He ranks as a mid-range WR3/flex, especially in PPR leagues.
--Andersen PickardSource: Dan Salomone
September 14, 2025
Chicago Bears wide receiver
Jahdae Walker (ankle) is officially inactive for Sunday's Week 2 contest against the Detroit Lions. He had been listed as doubtful after missing practice on Friday. The 23-year-old did suit up in last week's season opener, but he only played on special teams. Chicago should have no trouble replacing him on special teams this week, and his absence has no impact on the Bears' offense or fantasy managers' lineups.
--Andersen PickardSource: Chicago Bears
September 14, 2025
For the second straight week to begin the 2025 season, Cincinnati Bengals wide receiver
Jermaine Burton is a healthy inactive for the Week 2 contest against the Jacksonville Jaguars. Burton had a pretty rough rookie season in 2024 that involved some maturity issues, but he got rave reviews during training camp in the summer. For now, though,
Charlie Jones is ahead of him as the team's WR4 behind
Ja'Marr Chase,
Tee Higgins, and
Andrei Iosivas. The 24-year-old former third-rounder caught four passes for 107 yards on 14 targets in 14 games in his rookie season. Burton isn't anywhere close to the fantasy radar in redraft leagues right now.
--Keith HernandezSource: Cincinnati Bengals
September 14, 2025
Detroit Lions safety Kerby Joseph (knee) is active for Sunday's Week 2 contest against the Chicago Bears. He had been listed as questionable after popping up on Friday's injury report as a limited participant. The 24-year-old played every defensive snap last week but registered just one tackle. He'll look to make a bigger impact this week, and we expect him to return to his 2024 form soon. Last season, he intercepted nine passes and was named a First-Team All-Pro.
--Andersen PickardSource: Detroit Lions
September 14, 2025
Detroit Lions running back
Sione Vaki (hamstring) is officially inactive for Sunday's Week 2 contest against the Chicago Bears. He was limited in practice this week but was not expected to play after the Lions listed him as doubtful. The 24-year-old played in 16 games last year, totaling 51 scrimmage yards, but has not yet stepped on the field in his second pro campaign.
Craig Reynolds will continue to operate as the Lions' No. 3 running back behind
Jahmyr Gibbs and
David Montgomery.
--Andersen PickardSource: Detroit Lions
September 14, 2025
Detroit Lions left tackle Taylor Decker (shoulder) is active for Sunday's Week 2 contest against the Chicago Bears. Decker had been listed as questionable, and there was some concern about his availability after he didn't practice this past week. However, in the end, the veteran lineman is healthy enough to suit up. His presence will be quite impactful for the Lions' offensive line as they look to protect
Jared Goff,
Jahmyr Gibbs, and
David Montgomery on Sunday. Decker played all 67 snaps last week, allowing one sack.
--Andersen PickardSource: Detroit Lions
September 14, 2025
Cleveland Browns rookie running back
Quinshon Judkins is slated to see 10-15 snaps in his NFL debut on Sunday. While Judkins was able to practice with the team leading up to this contest against the Ravens, it appears the Browns will closely monitor his workload in this game. Judkins was unable to play in the preseason and participate in training camp as he was facing domestic violence charges. While his prosecutors eventually dropped their charges, he could still face a suspension from the league. However, for now, Judkins should remain a key part of the Cleveland backfield. In Week 1, the Browns relied on fellow rookie
Dylan Sampson and veteran
Jerome Ford. With Judkins now returning, managers should expect Sampson to remain the lead option, with Judkins seeing a few opportunities in short-yardage situations. As a result, Sampson still holds flex appeal while Judkins is a touchdown-dependent high-risk RB3.
--Andy SmithSource: Ian Rapoport
September 14, 2025
New Orleans Saints right tackle Taliese Fuaga (knee) is officially active for Sunday's Week 2 contest against the San Francisco 49ers. He had been listed as questionable but was trending in the right direction prior to gameday. Fuaga has started all 18 games since being drafted, allowing seven sacks and 43 pressures through 1,116 offensive snaps. He'll look to protect
Spencer Rattler and
Alvin Kamara from the impact of a strong 49ers defense.
--Andersen PickardSource: New Orleans Saints
September 14, 2025
San Francisco 49ers wide receiver
Jauan Jennings (shoulder) is officially active for Week 2 against the New Orleans Saints. Jennings had been listed as questionable, but there was increased optimism about his status heading into gameday. The shoulder issue limited Jennings to just 66 percent of the offensive snaps last Sunday as he caught two of five targets for 16 yards. This week, he'll be playing with a quarterback downgrade as
Mac Jones steps in for the injured
Brock Purdy (shoulder). Jones still has a solid arm, and a favorable matchup against the Saints bodes well for Jennings. Plus, the 49ers will also be without
George Kittle (hamstring), creating several vacated targets that could go Jennings' way. He's a solid WR3/flex option this week.
--Andersen PickardSource: Matt Maiocco
September 14, 2025
Los Angeles Rams tight end
Colby Parkinson (shoulder) is officially inactive for Sunday's Week 2 contest against the Tennessee Titans. He had been listed as doubtful after missing all three practices leading up to this weekend's game. Parkinson is working his way back from an AC joint sprain that he suffered last Sunday against the Houston Texans. Parkinson was actually able to finish last week's game after receiving medical attention, but evidently, the Rams aren't going to send him onto the field for Week 2.
Terrance Ferguson is active for his NFL debut and will assist in filling Parkinson's void alongside a tight end committee that also features
Tyler Higbee and
Davis Allen. None of these Rams tight ends can be trusted in fantasy football, but Ferguson is an intriguing stash in dynasty leagues.
--Andersen PickardSource: Gary Klein
September 14, 2025
According to Ian Rapoport of the NFL Network, Kansas City Chiefs wide receiver
Xavier Worthy (shoulder) is hoping to return next week when the Chiefs face the New York Giants. Rapoport noted that if Worthy can suit up, he would be playing with a torn labrum. However, the star wideout intends to wear a harness if he were to play. This week, Worthy was able to return to practice, which is an excellent sign that he is nearing a return. The second-year wideout suffered this injury during the opening possession of the first game of the season against the Chargers. As a rookie, Worthy flashed big-play upside in the Kansas City offense, totaling nine touchdowns with over 700 yards from scrimmage. This weekend,
Marquise Brown and
JuJu Smith-Schuster figure to lead the passing attack.
--Andy SmithSource: Ian Rapoport
September 14, 2025
The Baltimore Ravens planned to select quarterback
Shedeur Sanders with their fifth-round pick in the 2025 NFL Draft, but once the quarterback heard about the Ravens' plans, he nixed the pick. According to ESPN's Adam Schefter, Sanders "let it be known to Baltimore that he didn't want to be on a roster with
Lamar Jackson." The Ravens pivoted to offensive lineman Carson Vinson with the No. 141 pick, and Sanders landed with the Browns three selections later. Schefter's report seems to indicate that Sanders didn't have anything against Jackson in particular, and his concern was more about being stuck behind any quarterback who wasn't going to relinquish their starting role anytime soon. He likely would have had a similar reaction to being drafted by any team with an established starter, which is why Cleveland ended up being an ideal landing spot for him. While
Joe Flacco is the Browns' starter for the time being, Sanders has a chance to start games later this season if Flacco struggles or Cleveland's playoff hopes are destroyed.
--Andersen PickardSource: Adam Schefter
September 14, 2025
The Los Angeles Rams want to feature veteran wide receiver
Davante Adams more often during Sunday's Week 2 contest against the Tennessee Titans. "Sean McVay was pleased with what the Rams accomplished in the passing game in Week 1, but getting Davante Adams a bit more involved will be a goal against [the] Titans," writes Gary Klein of the Los Angeles Times. Adams finished his Rams debut with eight targets, four catches, and 51 yards. It was a fine showing for the veteran receiver, but certainly not on par with his full potential. Speaking with Klein, Adams said that he's trying to contribute however he can, and the number of targets he receives is not his concern. He noted that he thinks his and
Puka Nacua's roles will vary week by week. If one player is having a big game, they'll command more attention from the defense, leaving the other receiver with opportunities to make plays happen in one-on-one coverage. As it stands, both players are strong WR2 options with WR1 upside.
--Andersen PickardSource: Gary Klein
September 14, 2025
Cincinnati Reds catching prospect
Alfredo Duno and corner infield prospect
Cam Collier are two top 100 prospects for the Reds who will be participating in the Arizona Fall League (AFL) this year. The season kicks off on October 6, and these two, along with four other Reds prospects, will compete for the Peoria Javelinas. Duno, the Reds' third-ranked prospect, had a phenomenal year at Single-A, hitting .287 with 18 home runs and recording an elite .430 OBP because he was able to draw more walks (95) than strikeouts (91). Collier, the Reds' sixth-ranked prospect, had a down year compared to 2024 when he hit 20 home runs at High-A, as he hit just one home run in 71 games at Double-A while batting .252. The strikeout rate was high (27.6 percent), but he drew walks at a strong rate (15.0 percent). The 20-year-old former first-rounder missed the first couple of months of play due to a thumb injury suffered in spring training, so he can use the AFL to make up for lost time.
--Jarod RuppSource: MLB.com
September 14, 2025
Los Angeles Angels second baseman
Christian Moore was recalled from Triple-A Salt Lake on Saturday and drew the start at second base for the Halos. He batted fifth in the order and went 0-for-3 with a walk and a run scored in the contest. The 2024 first-rounder made quick work of the minors, making it all the way to the big leagues by mid-June this year, but struggled to a .195/.287/.336 slash line before getting sent back to Triple-A at the beginning of September. In his brief stint back in the minors, the 22-year-old was just 5-for-40 (.175), but hopefully he's able to get back on track with the big league club. For now, Moore can be left on the waiver wire.
--Jarod RuppSource: ESPN
September 14, 2025
Green Bay Packers wide receiver
Jayden Reed (collarbone) is looking at a multiple-month absence. According to Ian Rapoport, Reed was given a six-to-eight-week timetable to return. Reed suffered a broken collarbone during the Week 2 win over the Washington Commanders on Thursday night. This timeframe means that Reed is likely out until some point in November. Fantasy managers can go ahead and place Reed on their Injured Reserve if they haven't already. The good news is that Reed isn't going to be done for the season. His absence should mean increased roles for
Romeo Doubs,
Matthew Golden,
Dontayvion Wicks, and
Tucker Kraft.
--Andy WebbSource: Ian Rapoport
September 14, 2025
New Orleans Saints offensive tackle Taliese Fuaga (knee) remains listed as questionable heading into the Week 2 matchup against the San Francisco 49ers. Despite that, Nick Underhill reports that Fuaga is expected to suit up for this contest. Fuaga missed Wednesday's practice, but was able to get in two limited sessions to finish the week. The absence of Fuaga would certainly hurt the blindside of
Spencer Rattler. Asim Richards would likely be asked to take over if Fuaga is unable to go.
--Andy WebbSource: Nick Underhill
September 14, 2025
Cincinnati Reds pitching prospect
Rhett Lowder (oblique) began a rehab assignment on Saturday at Triple-A Louisville. The Reds' second-ranked prospect has dealt with both a forearm and an oblique injury this season, which has limited him to just three appearances at Triple-A this year, including Saturday's start. The right-hander allowed one earned run on two hits and no walks while striking out two over two innings of work in the rehab outing. The 23-year-old now has his sights on getting healthy and prepared for 2026, which should see him back in the majors at some point. The former seventh overall draft pick made six starts for the Reds in 2024, posting a 1.17 ERA (3.10 FIP), 1.27 WHIP, and just a 6.3 percent K-BB% in 30 2/3 innings. While the ERA was stellar, his FIP suggests the results may look better than they should have been, and his low strikeout rate is going to limit his fantasy value unless that rate goes up next time around.
--Jarod RuppSource: MLB Pipeline
September 14, 2025
San Francisco 49ers offensive tackle Trent Williams (knee) remains listed as questionable ahead of the Week 2 matchup against the New Orleans Saints. Williams made an early exit from the season opener due to a knee injury. He was able to return to the contest, but appears to still be dealing with the knee issue. The absence of Williams would be a huge loss to the 49ers' offensive line. It would be a major downgrade for the blind side of
Mac Jones. The plan is for Williams to test his knee pre-game before making a final decision. If he sits, Spencer Burford would be in line to take over at left tackle.
--Andy WebbSource: Adam Schefter
September 14, 2025
Los Angeles Angels infield prospect
Denzer Guzman was called up from Triple-A Salt Lake on Saturday for his major league debut. The Angels' ninth-ranked prospect was having a solid season, which began at Double-A and continued at Triple-A in early August, slashing .247/.343/.426 in all with a .359 wOBA and 119 wRC+, but had been hitting even better as of late. The 21-year-old was 9-for-23 (.391) over his last seven games before his call-up. With 17 home runs on the season and 14 steals as well, there is some pop and speed in his game, but fantasy managers may want to take a wait-and-see approach with Guzman before adding him to rosters. The right-handed slugger started at shortstop and batted seventh in his debut on Saturday, going 0-for-3 with two strikeouts.
--Jarod RuppSource: ESPN
September 14, 2025
Chicago Cubs outfield prospect
Owen Caissie (concussion) was recalled by the team on Saturday, but in his first game back, the Cubs' top-ranked prospect ran into the wall in the Wrigley outfield chasing down a ball in the third inning. He initially stayed in the game, but left in the sixth inning with concussion symptoms. The 23-year-old was 5-for-14 (.357) in the three games at Triple-A prior to his call-up, and was hitting .286 with 22 home runs on the season, but has yet to translate that success to the majors in his limited playing time. The left-handed slugger will likely head to the injured list, and although it appears he won't be of much use to fantasy managers in 2025, there is still hope for 2026 and beyond.
--Jarod RuppSource: MLB Pipeline
September 14, 2025
According to Adam Schefter, San Francisco 49ers wide receiver
Jauan Jennings (shoulder) is expected to suit up for the Week 2 matchup against the New Orleans Saints. Jennings is currently listed as questionable, but it sounds like he's trending towards suiting up. He was tagged as a game-time decision on Saturday, but it sounds like he has improved overnight. The 49ers could certainly use Jennings on the field with
George Kittle (hamstring) sidelined. Jennings will probably take a hit in value with
Brock Purdy (toe) out. However, the 49ers are so limited on options that Jennings should remain a viable fantasy option even with
Mac Jones under center.
--Andy WebbSource: Adam Schefter
September 14, 2025
According to Adam Schefter, San Francisco 49ers quarterback
Brock Purdy (toe) is unlikely to play in Week 3 against the Arizona Cardinals. Purdy will be absent in Week 2, and it sounds like he'll miss multiple games due to a turf-toe issue. There's a chance that Purdy misses as many as five games from this injury. Backup
Mac Jones will be under center in Week 2, and it sounds like he'll be drawing multiple starts. Jones doesn't offer a ton of upside, but he has value in superflex fantasy formats for those desperate at the QB position already. It sounds like the 49ers are going to need to lean on him for at least two games.
--Andy WebbSource: Adam Schefter
September 14, 2025
Milwaukee Brewers starting pitcher
Jacob Misiorowski didn't look like himself on the mound during Saturday's outing against the St. Louis Cardinals. Misiorowski had trouble keeping the ball in the yard as he allowed two home runs early. He wasn't really able to settle down at all during this outing. The right-hander tossed five innings, allowing four runs on seven hits while striking out four batters in the no-decision. Misiorowski has allowed three earned runs or more in five of his last six starts. He'll hope to get back on track in a rematch against the Cardinals next week.
--Andy WebbSource: mlb.com
September 14, 2025
San Diego Padres starting pitcher
Dylan Cease was excellent on the mound during Saturday's outing against the Colorado Rockies. The right-hander tossed six innings, allowing one run on five hits while striking out six batters in the win. Cease had good command in this one as he walked only one batter during this outing. That's the fewest number of batters he has walked in a start since August 3. He'll take a 4.59 ERA, 1.32 WHIP, and a 201/66 K/BB ratio across 30 starts into his next outing against the Chicago White Sox. Cease will be an elite fantasy option for that game.
--Andy WebbSource: mlb.com
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