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Dameon Pierce Poised For Large Role Against Panthers

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Oct 16, 2026, 5:33 PM ET

With running backs Saquon Barkley (hamstring), Tank Bigsby (abdomen, IR) and Will Shipley (foot, IR) all out, the Philadelphia Eagles may need to rely heavily on Dameon Pierce in a Week 6 matchup with the Carolina Panthers. In addition to the depleted depth at running back, the Eagles will also be without quarterback Jalen Hurts (calf) due to a superficial blood clot in his calf. The Eagles will start Tanner McKee at quarterback on Sunday against the Panthers. The injury situation is dire in Philadelphia. The Eagles signed Pierce off of the practice squad and added him to their active 53-man roster ahead of the Week 5 loss to the Jacksonville Jaguars in London. He played 48 offensive snaps, but Jacksonville held Pierce to just 11 carries for 14 yards (1.3 yards per attempt) and two receptions that lost a combined two yards in an extremely inefficient 2026 debut for Pierce. The Eagles will also have running back Carson Steele available, but expect Pierce to lead the backfield against the Panthers. Pierce could have a much easier time against a Carolina defense that allows 156.5 rushing yards per game (31st in the NFL). In 44 career games played, Pierce has recorded 430 attempts for 1,698 rushing yards (3.9 yards per carry) and eight touchdowns, while adding 47 receptions for 266 yards (5.7 yards per catch) and one receiving touchdown. Pierce ranks as RotoBaller's No. 32 running back for Week 6 and is projected to produce 6.7 fantasy points. He is a risky play, but should see enough volume to warrant flex upside.--Ryan O'Bleness
Source: RotoBaller

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